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The map label for this gene is ppx [C]

Identifier: 119714739

GI number: 119714739

Start: 506536

End: 507471

Strand: Direct

Name: ppx [C]

Synonym: Noca_0475

Alternate gene names: 119714739

Gene position: 506536-507471 (Clockwise)

Preceding gene: 119714735

Following gene: 119714740

Centisome position: 10.16

GC content: 73.93

Gene sequence:

>936_bases
ATGCGGCTGGGCGTCCTCGACATCGGGTCCAACACCGGACACCTGCTCGTCGTCGACGCCCACGGGGGCGCCGCGCCGCT
GCCGGCGTACTCCTACAAGCAGCCGTTGCGCCTCGCCGAGCACCTCGACGACGAGGGAGCGGTCACCCGGCTCGGGGTCG
ATTCGCTGACGGCGTTCACCGCGCAGGCCCTGGTGGTCGCGGAGGACAAGGGCTGCCAGGACATGCTCGCGTTCGCGACG
TCCGCGGTGCGCGACGCGGTCAACACCGATGCGGTGCTCGACCACGTGCACGCGGCGACCGGCGTGCGGATCGAGGTGCT
CCCCGGGGAGGACGAGGCCCGGCTGACCTTCCTCGCCGTACGACGGTGGTTCGGCTGGTCCGCCGGGCGGCTGGCCGTCT
TCGACATCGGTGGCGGCTCGCTGGAGATCGCCGGCGGCGCCGACGAGTCGCCCGACGTCGCCTGGTCGCTGCCGATCGGA
GCCGGCCGCCTGGCGCGGCAGTTCTTCAGCGGGGGGCCGCCCGACGACGAGGCGATCCGTGGGCTGCGCAAGCAGCTTCG
TGCCGAGATCGCCCGCGACGCGGGGCACCTGCTGCGGGCGGGGACGCCGGACCACGCGGCGGCCACGTCCAAGACGTTCC
GCTCGCTGGCCCGGATCTGTGGGGCCGCGCCGTCGGCGGACGGTCCCCTGGTCCCGCGGGTCCTGGAGCGCGAGGTGCTG
CGCGAGTGGATCCCGAAGCTGGTCACGATGGCCCCGGAGGCGCTGGCGCACCTCCCGGGCGTCTCCCCGAGCCGGGCCCA
CCAGATCGTGACCGGCGCGCTCGTGGCCGAGGCGGCGATGGACATCTTCGGGCTCGAGCTCCTGGAGGTCTGCCCCTGGG
CCCTGCGGGAGGGCGTGATCCTCGAACGGCTCGACCAGATCAGCGTGCTCGGCTAG

Upstream 100 bases:

>100_bases
CTCCACGTAGGCGCGGGGGAAGACCAGATCGACTTCGGGCACCCGTCAACCCTACGTGCCGTCCGGGGCCGTCCCCGCCG
CCGTTGGGTACGTTGGACCC

Downstream 100 bases:

>100_bases
CCATGGCCCCACGCGTCGGACTCTCCACCGTCTCGGTCTACCCCGAGTCCTCCGCCCATGCCTTCGCCTACGCGAGTGCG
CTCGGTTACGACACCATCGA

Product: Ppx/GppA phosphatase

Products: polyphosphate; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MRLGVLDIGSNTGHLLVVDAHGGAAPLPAYSYKQPLRLAEHLDDEGAVTRLGVDSLTAFTAQALVVAEDKGCQDMLAFAT
SAVRDAVNTDAVLDHVHAATGVRIEVLPGEDEARLTFLAVRRWFGWSAGRLAVFDIGGGSLEIAGGADESPDVAWSLPIG
AGRLARQFFSGGPPDDEAIRGLRKQLRAEIARDAGHLLRAGTPDHAAATSKTFRSLARICGAAPSADGPLVPRVLEREVL
REWIPKLVTMAPEALAHLPGVSPSRAHQIVTGALVAEAAMDIFGLELLEVCPWALREGVILERLDQISVLG

Sequences:

>Translated_311_residues
MRLGVLDIGSNTGHLLVVDAHGGAAPLPAYSYKQPLRLAEHLDDEGAVTRLGVDSLTAFTAQALVVAEDKGCQDMLAFAT
SAVRDAVNTDAVLDHVHAATGVRIEVLPGEDEARLTFLAVRRWFGWSAGRLAVFDIGGGSLEIAGGADESPDVAWSLPIG
AGRLARQFFSGGPPDDEAIRGLRKQLRAEIARDAGHLLRAGTPDHAAATSKTFRSLARICGAAPSADGPLVPRVLEREVL
REWIPKLVTMAPEALAHLPGVSPSRAHQIVTGALVAEAAMDIFGLELLEVCPWALREGVILERLDQISVLG
>Mature_311_residues
MRLGVLDIGSNTGHLLVVDAHGGAAPLPAYSYKQPLRLAEHLDDEGAVTRLGVDSLTAFTAQALVVAEDKGCQDMLAFAT
SAVRDAVNTDAVLDHVHAATGVRIEVLPGEDEARLTFLAVRRWFGWSAGRLAVFDIGGGSLEIAGGADESPDVAWSLPIG
AGRLARQFFSGGPPDDEAIRGLRKQLRAEIARDAGHLLRAGTPDHAAATSKTFRSLARICGAAPSADGPLVPRVLEREVL
REWIPKLVTMAPEALAHLPGVSPSRAHQIVTGALVAEAAMDIFGLELLEVCPWALREGVILERLDQISVLG

Specific function: Degradation Of Inorganic Polyphosphates. Orthophosphate Is Released Progressively From The Ends Of Polyphosphate Of Circa 500 Residues Long, While Chains Of Circa 15 Residues Compete Poorly With Polyphosphate As Substrate. [C]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=308, Percent_Identity=26.9480519480519, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: 3.6.1.11 [C]

Molecular weight: Translated: 32896; Mature: 32896

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLGVLDIGSNTGHLLVVDAHGGAAPLPAYSYKQPLRLAEHLDDEGAVTRLGVDSLTAFT
CEEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECHHHHHHHH
AQALVVAEDKGCQDMLAFATSAVRDAVNTDAVLDHVHAATGVRIEVLPGEDEARLTFLAV
HHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
RRWFGWSAGRLAVFDIGGGSLEIAGGADESPDVAWSLPIGAGRLARQFFSGGPPDDEAIR
HHHHCCCCCCEEEEEECCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHHHHH
GLRKQLRAEIARDAGHLLRAGTPDHAAATSKTFRSLARICGAAPSADGPLVPRVLEREVL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
REWIPKLVTMAPEALAHLPGVSPSRAHQIVTGALVAEAAMDIFGLELLEVCPWALREGVI
HHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCHH
LERLDQISVLG
HHHHHHHHCCC
>Mature Secondary Structure
MRLGVLDIGSNTGHLLVVDAHGGAAPLPAYSYKQPLRLAEHLDDEGAVTRLGVDSLTAFT
CEEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECHHHHHHHH
AQALVVAEDKGCQDMLAFATSAVRDAVNTDAVLDHVHAATGVRIEVLPGEDEARLTFLAV
HHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
RRWFGWSAGRLAVFDIGGGSLEIAGGADESPDVAWSLPIGAGRLARQFFSGGPPDDEAIR
HHHHCCCCCCEEEEEECCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHHHHH
GLRKQLRAEIARDAGHLLRAGTPDHAAATSKTFRSLARICGAAPSADGPLVPRVLEREVL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
REWIPKLVTMAPEALAHLPGVSPSRAHQIVTGALVAEAAMDIFGLELLEVCPWALREGVI
HHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCHH
LERLDQISVLG
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Polyphosphate; H2O [C]

Specific reaction: (Polyphosphate)n + H2O = (polyphosphate)n + phosphate [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]