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The map label for this gene is gloB [H]

Identifier: 119714604

GI number: 119714604

Start: 360390

End: 361157

Strand: Direct

Name: gloB [H]

Synonym: Noca_0338

Alternate gene names: 119714604

Gene position: 360390-361157 (Clockwise)

Preceding gene: 119714603

Following gene: 119714606

Centisome position: 7.23

GC content: 76.69

Gene sequence:

>768_bases
GTGCTCGCCGCCAACCCCGGCCCGATGACCCTCGACGGGACCAACACCTGGGTGCTGCGGGAACCCGGGGCGCGCCGCTC
GGTCGTCGTGGACCCGGGCCCGGCCCTCCCCGCCCACCTCGACGCGATCGCGGCGGAGGCCGGCGAGGTCGGCGTGGTCC
TGCTGACCCACCACCACGCGGACCATGCCGAGGCGGCACGGGCGTTCGCCGAGCGGGTGGGGTGCGGCGTCCGGGCCCTG
GACCCGGCGTACCGCCTCGGCGCCGAGGGGCTCGGCGACGGAGACGTCGTCGCCGTCGACGGCCTGGAGATCCGGGTGGT
CGGCACGCCGGGGCACACCGCCGACTCGCTGTCCTTCCTGCTGCCCGCGGAGGGGGCGGTGCTCACGGGAGACACCGTGC
TCGGCCGCGGAACCACCGTCGTCGCGCACCCCGACGGCCAGCTGGGCGCCTACCTCGGCTCGCTCGACCGGCTGCACGCG
CTCGCCGAGGCGCACGAGGTCGCGTCGATCTGGCCCGGCCACGGCCCGGTCATCGTCAACGCGCTCGGCGCCCTGGACCA
CTACCTCGCCCACCGCCAGGAGCGGCTCGAGCAGGTGCGCGCCGCGGTGGAGACGCTGCAGGCCGCGCACCGTCCCGAGG
GGATCGCGGCCGAGGAGCTGCCCCGCAGGGTGGTCGAGATCGTCTACGCCGACGTCGACCCGGTGCTCTGGGGTGCCGCC
GAGCTGTCCGTGCGGGCGCAGCTGGCCTACCTGGCCGAGCCGCGCTGA

Upstream 100 bases:

>100_bases
CCGGCCCACCACCGCTCGATCCTGGCCGCGCACCGCGGCGCCTGACGTGGCGCCCGACGCGGCCTGGGCCGGCGGCGCCT
TCGGGGCGCGGGGTAGGTGC

Downstream 100 bases:

>100_bases
CGGCGTGGCCGCCAGGGTCGGTTTCCCCGGTTCACCGGGGATGTTGGAACTTCTGGCCCGAAGTTTCGGCCCAACAGTTC
CGGTTTCCCCGGTTCACCGG

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MLAANPGPMTLDGTNTWVLREPGARRSVVVDPGPALPAHLDAIAAEAGEVGVVLLTHHHADHAEAARAFAERVGCGVRAL
DPAYRLGAEGLGDGDVVAVDGLEIRVVGTPGHTADSLSFLLPAEGAVLTGDTVLGRGTTVVAHPDGQLGAYLGSLDRLHA
LAEAHEVASIWPGHGPVIVNALGALDHYLAHRQERLEQVRAAVETLQAAHRPEGIAAEELPRRVVEIVYADVDPVLWGAA
ELSVRAQLAYLAEPR

Sequences:

>Translated_255_residues
MLAANPGPMTLDGTNTWVLREPGARRSVVVDPGPALPAHLDAIAAEAGEVGVVLLTHHHADHAEAARAFAERVGCGVRAL
DPAYRLGAEGLGDGDVVAVDGLEIRVVGTPGHTADSLSFLLPAEGAVLTGDTVLGRGTTVVAHPDGQLGAYLGSLDRLHA
LAEAHEVASIWPGHGPVIVNALGALDHYLAHRQERLEQVRAAVETLQAAHRPEGIAAEELPRRVVEIVYADVDPVLWGAA
ELSVRAQLAYLAEPR
>Mature_255_residues
MLAANPGPMTLDGTNTWVLREPGARRSVVVDPGPALPAHLDAIAAEAGEVGVVLLTHHHADHAEAARAFAERVGCGVRAL
DPAYRLGAEGLGDGDVVAVDGLEIRVVGTPGHTADSLSFLLPAEGAVLTGDTVLGRGTTVVAHPDGQLGAYLGSLDRLHA
LAEAHEVASIWPGHGPVIVNALGALDHYLAHRQERLEQVRAAVETLQAAHRPEGIAAEELPRRVVEIVYADVDPVLWGAA
ELSVRAQLAYLAEPR

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI7705793, Length=251, Percent_Identity=32.6693227091633, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17537503, Length=213, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI193205216, Length=213, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=8e-26,
Organism=Drosophila melanogaster, GI20129357, Length=276, Percent_Identity=30.7971014492754, Blast_Score=111, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 26656; Mature: 26656

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAANPGPMTLDGTNTWVLREPGARRSVVVDPGPALPAHLDAIAAEAGEVGVVLLTHHHA
CCCCCCCCEEECCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCC
DHAEAARAFAERVGCGVRALDPAYRLGAEGLGDGDVVAVDGLEIRVVGTPGHTADSLSFL
CHHHHHHHHHHHHCCCCEECCHHHHHCCCCCCCCCEEEECCEEEEEEECCCCCCCCEEEE
LPAEGAVLTGDTVLGRGTTVVAHPDGQLGAYLGSLDRLHALAEAHEVASIWPGHGPVIVN
ECCCCCEEECCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALGALDHYLAHRQERLEQVRAAVETLQAAHRPEGIAAEELPRRVVEIVYADVDPVLWGAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCHH
ELSVRAQLAYLAEPR
HHHHHHEEEEECCCC
>Mature Secondary Structure
MLAANPGPMTLDGTNTWVLREPGARRSVVVDPGPALPAHLDAIAAEAGEVGVVLLTHHHA
CCCCCCCCEEECCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCC
DHAEAARAFAERVGCGVRALDPAYRLGAEGLGDGDVVAVDGLEIRVVGTPGHTADSLSFL
CHHHHHHHHHHHHCCCCEECCHHHHHCCCCCCCCCEEEECCEEEEEEECCCCCCCCEEEE
LPAEGAVLTGDTVLGRGTTVVAHPDGQLGAYLGSLDRLHALAEAHEVASIWPGHGPVIVN
ECCCCCEEECCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
ALGALDHYLAHRQERLEQVRAAVETLQAAHRPEGIAAEELPRRVVEIVYADVDPVLWGAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHCHH
ELSVRAQLAYLAEPR
HHHHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA