Click here to switch to the map view.

The map label for this gene is upp

Identifier: 119714542

GI number: 119714542

Start: 297539

End: 298180

Strand: Reverse

Name: upp

Synonym: Noca_0275

Alternate gene names: 119714542

Gene position: 298180-297539 (Counterclockwise)

Preceding gene: 119714546

Following gene: 119714541

Centisome position: 5.98

GC content: 71.65

Gene sequence:

>642_bases
ATGCGTACGCACGTCGTCGACCACCCCCTCGTCGCCCACAAGCTGACCCACCTGCGGAACGAGGAGACCGACTCGCCGAC
GTTCCGACGGCTCGCCGACGAGCTGGTCACGCTGCTGGCCTACGAGGCCACCCGCGACGTCCGGGTCGAGCCCATCGACG
TGGTCACCCCGGTCTCCCCGACCACCGGCGTCCAGCTGGCCAAGCCGCGGCCGCTCGTGGTGCCGATCCTCCGGGCGGGA
CTGGGGATGCTGGACGGGATGATGCGGCTGCTGCCCACCGCGGAGGTCGGCTTCCTCGGGATGATCCGCAACGAGGAGAC
GCTGCAGGCATCGACGTACGCCGAGCGCCTGCCCGAGGACCTCTCCGGGCGCCAGTGCTACGTCCTGGACCCGATGCTCG
CCACCGGCGGCACCCTCGCCGCGGCGATCCGCTTCCTCACCGACCGCGGCGCCGACCACATCACCGCGATCTGCCTGCTC
GCCGCGCCCGAGGGCTGCGCCCGCCTGGAGCAGGAGCTCGACGGCCTCGACGTCCCGGTCACGATCGTCACTGCGGCGAT
GGACGAGCGGCTCAACGAGAAGGGCTACATCGTCCCCGGTCTCGGAGACGCCGGCGACCGGCTCTACGGCATCGTCGGCT
GA

Upstream 100 bases:

>100_bases
CGTTGCGTCCAGTCCGTCGCTCTCCAGGGTGTCAGACCAGACGGGTGCGGCCAACCCCCTTTCGGCCTGTCACCGGCCTG
GCTCCACTAGGGTCTGGAGC

Downstream 100 bases:

>100_bases
CGCCCGGGCGGTTTCCCCGGTTAACCGGGGAAGTTGGAACTGTTGGCCCGAAGTTTCGGCCCAACAGTTCCGGTATCCCC
GGTTAACCGGGGAAACCAAC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MRTHVVDHPLVAHKLTHLRNEETDSPTFRRLADELVTLLAYEATRDVRVEPIDVVTPVSPTTGVQLAKPRPLVVPILRAG
LGMLDGMMRLLPTAEVGFLGMIRNEETLQASTYAERLPEDLSGRQCYVLDPMLATGGTLAAAIRFLTDRGADHITAICLL
AAPEGCARLEQELDGLDVPVTIVTAAMDERLNEKGYIVPGLGDAGDRLYGIVG

Sequences:

>Translated_213_residues
MRTHVVDHPLVAHKLTHLRNEETDSPTFRRLADELVTLLAYEATRDVRVEPIDVVTPVSPTTGVQLAKPRPLVVPILRAG
LGMLDGMMRLLPTAEVGFLGMIRNEETLQASTYAERLPEDLSGRQCYVLDPMLATGGTLAAAIRFLTDRGADHITAICLL
AAPEGCARLEQELDGLDVPVTIVTAAMDERLNEKGYIVPGLGDAGDRLYGIVG
>Mature_213_residues
MRTHVVDHPLVAHKLTHLRNEETDSPTFRRLADELVTLLAYEATRDVRVEPIDVVTPVSPTTGVQLAKPRPLVVPILRAG
LGMLDGMMRLLPTAEVGFLGMIRNEETLQASTYAERLPEDLSGRQCYVLDPMLATGGTLAAAIRFLTDRGADHITAICLL
AAPEGCARLEQELDGLDVPVTIVTAAMDERLNEKGYIVPGLGDAGDRLYGIVG

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=205, Percent_Identity=28.780487804878, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI57863312, Length=205, Percent_Identity=28.780487804878, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87082118, Length=210, Percent_Identity=43.8095238095238, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17539892, Length=204, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=204, Percent_Identity=25.4901960784314, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321920, Length=199, Percent_Identity=35.1758793969849, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45550449, Length=139, Percent_Identity=33.0935251798561, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28573516, Length=201, Percent_Identity=28.8557213930348, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28573514, Length=201, Percent_Identity=28.8557213930348, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28573512, Length=201, Percent_Identity=28.8557213930348, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_NOCSJ (A1SDD5)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921507.1
- ProteinModelPortal:   A1SDD5
- SMR:   A1SDD5
- STRING:   A1SDD5
- GeneID:   4596159
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0275
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   VYVLDPM
- PhylomeDB:   A1SDD5
- ProtClustDB:   PRK00129
- BioCyc:   NSP35761:NOCA_0275-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23091; Mature: 23091

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 197-197 BINDING 203-203

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTHVVDHPLVAHKLTHLRNEETDSPTFRRLADELVTLLAYEATRDVRVEPIDVVTPVSP
CCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
TTGVQLAKPRPLVVPILRAGLGMLDGMMRLLPTAEVGFLGMIRNEETLQASTYAERLPED
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCHH
LSGRQCYVLDPMLATGGTLAAAIRFLTDRGADHITAICLLAAPEGCARLEQELDGLDVPV
CCCCEEEEECCHHHCCHHHHHHHHHHHHCCCHHHHEEHEEECCHHHHHHHHHHCCCCCCH
TIVTAAMDERLNEKGYIVPGLGDAGDRLYGIVG
HHHHHHHHHHCCCCCEEECCCCCCCCCEEECCC
>Mature Secondary Structure
MRTHVVDHPLVAHKLTHLRNEETDSPTFRRLADELVTLLAYEATRDVRVEPIDVVTPVSP
CCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
TTGVQLAKPRPLVVPILRAGLGMLDGMMRLLPTAEVGFLGMIRNEETLQASTYAERLPED
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCHH
LSGRQCYVLDPMLATGGTLAAAIRFLTDRGADHITAICLLAAPEGCARLEQELDGLDVPV
CCCCEEEEECCHHHCCHHHHHHHHHHHHCCCHHHHEEHEEECCHHHHHHHHHHCCCCCCH
TIVTAAMDERLNEKGYIVPGLGDAGDRLYGIVG
HHHHHHHHHHCCCCCEEECCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA