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The map label for this gene is yngG [H]

Identifier: 119714416

GI number: 119714416

Start: 165252

End: 166199

Strand: Direct

Name: yngG [H]

Synonym: Noca_0149

Alternate gene names: 119714416

Gene position: 165252-166199 (Clockwise)

Preceding gene: 119714415

Following gene: 119714417

Centisome position: 3.31

GC content: 73.31

Gene sequence:

>948_bases
ATGCGCACCCCTGCCGTCGTACCCGCCCTCCCGGTGTCGGCCGCGCCGATGCCGGACCGCGTCACGATCTACGAGGTCGG
CCCCCGCGACGGTCTCCAGAACGAGAAGTCGCTGGTCCCGACCGACGTCAAGGCGGAGTTCGTACGCCGGCTCCTCGCCG
CCGGCCTGCCGATCGTCGAGGCGACCAGCTTCGTCCACCCCAAGTGGGTGCCCCAGCTCGCCGACGCCGCCGAGCTGATG
GCTCTGCTCGGCCCGGCCGGGCGGGACTGCCCGGTGCTGGTGCCCAACGAGCGCGGCCTGGACCGGGCCCTCGAGCTGGG
CGTCCGGCACGTCGCGATCTTCGGGTCGGCGACCGAGACCTTCGCGCAGAAGAACCTCAACCGCAGCCTGGACGAGCAGT
TCGCGATGTTCGAACCGACCGTGCGCCGGGCCCGCGACGCCGGGCTGGACGTGCGGGCCTACGTCAGCATGTGCTTCGGC
GACCCGTGGGAGGGCGCCGTACCGATCGAGCAGGTCGTCGGCGTCGGCAAGCGGCTCTTCGACCTCGGCGCCAGCCAGCT
CAGCATCGGCGACACCATCGGCGTCGGCACCGCCGGCCACGTCACCGCCCTGGTCCGGGCCTTCGACGAGGTCGGCCTGG
GCACCGACCGTCTCGCGCTGCACTTCCACGACACCTTCGGCCAGGCCCTCGCGAACACCTACGCGGCGCTCCAGGCCGGG
ATCACCACCTTCGACGCGAGCGCCGGCGGGCTGGGCGGGTGCCCCTACGCCAAGAGCGCCACCGGCAACCTCGCCACCGA
GGACCTGGTGTGGATGCTGCGTGGCCTCGGCATCGAGACCGGCGTCGACCTGGAGGAGGTGGCCGCGACCAGCGTCTGGA
TGGCCGCCCACCTCGGCCGGCCCAGCCCCTCCGCCGTGGTCCGCGCCCTGGCGCCGTCCGCGTCCTGA

Upstream 100 bases:

>100_bases
TCAGCCAGGTCGGGGCCACCATCGGCGCCCAGGTCGCGCTCGGCGCCCGGCTGTTCGTGGTCGAGCCGCACGCCGAGGCC
GAGGAAGAGGAGGCCGGCTG

Downstream 100 bases:

>100_bases
TCTTGAGTGGCCCGCCCCGGCCGGCTGTCACGCTCGCTGTAACGCCGTGTTACCTGTTCTGCCGCCCCTGTTGCAACCGG
GTCGGAGGAGCGGGTAACAC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRTPAVVPALPVSAAPMPDRVTIYEVGPRDGLQNEKSLVPTDVKAEFVRRLLAAGLPIVEATSFVHPKWVPQLADAAELM
ALLGPAGRDCPVLVPNERGLDRALELGVRHVAIFGSATETFAQKNLNRSLDEQFAMFEPTVRRARDAGLDVRAYVSMCFG
DPWEGAVPIEQVVGVGKRLFDLGASQLSIGDTIGVGTAGHVTALVRAFDEVGLGTDRLALHFHDTFGQALANTYAALQAG
ITTFDASAGGLGGCPYAKSATGNLATEDLVWMLRGLGIETGVDLEEVAATSVWMAAHLGRPSPSAVVRALAPSAS

Sequences:

>Translated_315_residues
MRTPAVVPALPVSAAPMPDRVTIYEVGPRDGLQNEKSLVPTDVKAEFVRRLLAAGLPIVEATSFVHPKWVPQLADAAELM
ALLGPAGRDCPVLVPNERGLDRALELGVRHVAIFGSATETFAQKNLNRSLDEQFAMFEPTVRRARDAGLDVRAYVSMCFG
DPWEGAVPIEQVVGVGKRLFDLGASQLSIGDTIGVGTAGHVTALVRAFDEVGLGTDRLALHFHDTFGQALANTYAALQAG
ITTFDASAGGLGGCPYAKSATGNLATEDLVWMLRGLGIETGVDLEEVAATSVWMAAHLGRPSPSAVVRALAPSAS
>Mature_315_residues
MRTPAVVPALPVSAAPMPDRVTIYEVGPRDGLQNEKSLVPTDVKAEFVRRLLAAGLPIVEATSFVHPKWVPQLADAAELM
ALLGPAGRDCPVLVPNERGLDRALELGVRHVAIFGSATETFAQKNLNRSLDEQFAMFEPTVRRARDAGLDVRAYVSMCFG
DPWEGAVPIEQVVGVGKRLFDLGASQLSIGDTIGVGTAGHVTALVRAFDEVGLGTDRLALHFHDTFGQALANTYAALQAG
ITTFDASAGGLGGCPYAKSATGNLATEDLVWMLRGLGIETGVDLEEVAATSVWMAAHLGRPSPSAVVRALAPSAS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=299, Percent_Identity=47.4916387959866, Blast_Score=284, Evalue=9e-77,
Organism=Homo sapiens, GI109150422, Length=295, Percent_Identity=46.4406779661017, Blast_Score=280, Evalue=8e-76,
Organism=Homo sapiens, GI109150427, Length=295, Percent_Identity=46.4406779661017, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI260654708, Length=136, Percent_Identity=50.7352941176471, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17510563, Length=299, Percent_Identity=44.8160535117057, Blast_Score=253, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24582381, Length=294, Percent_Identity=46.9387755102041, Blast_Score=263, Evalue=1e-70,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 33163; Mature: 33163

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTPAVVPALPVSAAPMPDRVTIYEVGPRDGLQNEKSLVPTDVKAEFVRRLLAAGLPIVE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
ATSFVHPKWVPQLADAAELMALLGPAGRDCPVLVPNERGLDRALELGVRHVAIFGSATET
HHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHCHHHEEEECCHHHH
FAQKNLNRSLDEQFAMFEPTVRRARDAGLDVRAYVSMCFGDPWEGAVPIEQVVGVGKRLF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
DLGASQLSIGDTIGVGTAGHVTALVRAFDEVGLGTDRLALHFHDTFGQALANTYAALQAG
HCCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHC
ITTFDASAGGLGGCPYAKSATGNLATEDLVWMLRGLGIETGVDLEEVAATSVWMAAHLGR
CCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
PSPSAVVRALAPSAS
CCHHHHHHHHCCCCC
>Mature Secondary Structure
MRTPAVVPALPVSAAPMPDRVTIYEVGPRDGLQNEKSLVPTDVKAEFVRRLLAAGLPIVE
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
ATSFVHPKWVPQLADAAELMALLGPAGRDCPVLVPNERGLDRALELGVRHVAIFGSATET
HHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHCHHHEEEECCHHHH
FAQKNLNRSLDEQFAMFEPTVRRARDAGLDVRAYVSMCFGDPWEGAVPIEQVVGVGKRLF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
DLGASQLSIGDTIGVGTAGHVTALVRAFDEVGLGTDRLALHFHDTFGQALANTYAALQAG
HCCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHC
ITTFDASAGGLGGCPYAKSATGNLATEDLVWMLRGLGIETGVDLEEVAATSVWMAAHLGR
CCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
PSPSAVVRALAPSAS
CCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]