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The map label for this gene is pyrE [H]

Identifier: 119387173

GI number: 119387173

Start: 1682075

End: 1682746

Strand: Direct

Name: pyrE [H]

Synonym: Pden_4468

Alternate gene names: 119387173

Gene position: 1682075-1682746 (Clockwise)

Preceding gene: 119387172

Following gene: 119387174

Centisome position: 97.22

GC content: 65.92

Gene sequence:

>672_bases
ATGACCCTGCCCTTCCCTCCGCATGAGGAAATCGCCCGGCTGACCGCCCGCATGCTGCTGGAGATCAAGGCGGTGCACTT
CAACGCGGCCGAGCCCTTTACCTATGCCTCGGGGCTGAAGGGACCGACCTATATCGACTGCCGCAAGCTGATCAGCTTTC
CGCGCATCCGCTCGACGCTGATGGATTTCCTGGCGGCGACCGTGCTGCGCGAAGCGGGCTTTGCCGCCTTCGACAATGTC
GCCGGCGGCGAGACGGCGGGCATCCCCTTCGCCGCCTTCGTGGCCGAGCGGCTGGAACTGCCGATGACCTATGTGCGCAA
GAAGCCCAAGGGCTACGGCCGCAACGCGCGGATCGAAGGCGCCATGACCGAGGGCCAGCGGGTGCTGCTGGTCGAGGACC
TGACCACCGACGGCGGCTCGAAGCTGAGCTTCGTCGATGCGATCCGCGAGACCGGCGCGACCTGCGCCGATACGGCGGTG
ATCTTCTATTACGGCATCTTCCCCGAAACCACGCAGCGCCTGGCCGACCATGGCGTCCGGCTGCACTATCTCTGCACCTG
GTGGGACGTGCTGGCCGAAGCCAAGGCGCAAGGCTTCTATGACGAGGCGACGCTCACCGAAGTCGAAAGCTTCCTGACCG
ATCCCCGCGCCTGGCAAGCCGCGCATCCCTGA

Upstream 100 bases:

>100_bases
ACACGCCCGCCGAATATCCGACCCATATCGCCGCCGGCGACGAAACCGTCACCGTCTTCGACCCCGGCTTCCCGCTCTAC
TGGCACGTTGAGGACCCCGC

Downstream 100 bases:

>100_bases
AATCCCCGCGGCGGCTGCAGTGAGCTTCCGCACGGTCGCATGGGTATTTAGGAAACGGAAAGGCCGGGTGCCGCACCTTG
TCTTTTCCGTTTTTCAAATA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MTLPFPPHEEIARLTARMLLEIKAVHFNAAEPFTYASGLKGPTYIDCRKLISFPRIRSTLMDFLAATVLREAGFAAFDNV
AGGETAGIPFAAFVAERLELPMTYVRKKPKGYGRNARIEGAMTEGQRVLLVEDLTTDGGSKLSFVDAIRETGATCADTAV
IFYYGIFPETTQRLADHGVRLHYLCTWWDVLAEAKAQGFYDEATLTEVESFLTDPRAWQAAHP

Sequences:

>Translated_223_residues
MTLPFPPHEEIARLTARMLLEIKAVHFNAAEPFTYASGLKGPTYIDCRKLISFPRIRSTLMDFLAATVLREAGFAAFDNV
AGGETAGIPFAAFVAERLELPMTYVRKKPKGYGRNARIEGAMTEGQRVLLVEDLTTDGGSKLSFVDAIRETGATCADTAV
IFYYGIFPETTQRLADHGVRLHYLCTWWDVLAEAKAQGFYDEATLTEVESFLTDPRAWQAAHP
>Mature_222_residues
TLPFPPHEEIARLTARMLLEIKAVHFNAAEPFTYASGLKGPTYIDCRKLISFPRIRSTLMDFLAATVLREAGFAAFDNVA
GGETAGIPFAAFVAERLELPMTYVRKKPKGYGRNARIEGAMTEGQRVLLVEDLTTDGGSKLSFVDAIRETGATCADTAVI
FYYGIFPETTQRLADHGVRLHYLCTWWDVLAEAKAQGFYDEATLTEVESFLTDPRAWQAAHP

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=204, Percent_Identity=31.3725490196078, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508631, Length=130, Percent_Identity=34.6153846153846, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=171, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17933654, Length=201, Percent_Identity=28.3582089552239, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 24730; Mature: 24599

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPFPPHEEIARLTARMLLEIKAVHFNAAEPFTYASGLKGPTYIDCRKLISFPRIRSTL
CCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCCCCCHHHHHHHHCCHHHHHHH
MDFLAATVLREAGFAAFDNVAGGETAGIPFAAFVAERLELPMTYVRKKPKGYGRNARIEG
HHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEEC
AMTEGQRVLLVEDLTTDGGSKLSFVDAIRETGATCADTAVIFYYGIFPETTQRLADHGVR
EECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHEEEEECCCHHHHHHHHHCCCE
LHYLCTWWDVLAEAKAQGFYDEATLTEVESFLTDPRAWQAAHP
EEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TLPFPPHEEIARLTARMLLEIKAVHFNAAEPFTYASGLKGPTYIDCRKLISFPRIRSTL
CCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHCCCCCCCHHHHHHHHCCHHHHHHH
MDFLAATVLREAGFAAFDNVAGGETAGIPFAAFVAERLELPMTYVRKKPKGYGRNARIEG
HHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCEEEC
AMTEGQRVLLVEDLTTDGGSKLSFVDAIRETGATCADTAVIFYYGIFPETTQRLADHGVR
EECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHEEEEECCCHHHHHHHHHCCCE
LHYLCTWWDVLAEAKAQGFYDEATLTEVESFLTDPRAWQAAHP
EEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA