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The map label for this gene is pyrC [H]

Identifier: 119387172

GI number: 119387172

Start: 1681035

End: 1682078

Strand: Direct

Name: pyrC [H]

Synonym: Pden_4467

Alternate gene names: 119387172

Gene position: 1681035-1682078 (Clockwise)

Preceding gene: 119387170

Following gene: 119387173

Centisome position: 97.16

GC content: 67.91

Gene sequence:

>1044_bases
ATGACCAAATCCGTGACGCTCCGACGCCCCGACGACTGGCACCTGCACCTGCGCGATGGCGCCATGCTGCAGGCAGTGGC
TTCATTTTCCGGCCATTTTGGCCGGGCGATCATCATGCCGAACCTGGTGCCGCCCGTGGTGACGGGGGCGCAGGCGGCCG
CCTATCGCGACCGGATCCGGGCCGCGCTGGGTCCGAAAGTGACGTTGCGTCCATTGATGACGCTCTACCTGACCGAAACC
ACCGATCCGGCCGATGTGGTGGCCGCCCATGCCGGGGGAATCATCTCGGCCGTCAAGCTTTATCCGGCCGGGGCGACCAC
CAATTCGGCCTCGGGCGTGCGCGACTTCGACAAGGTGCGAGGCGTGCTGGAAGCCATGGCCGAAGCCGGCATCCCGCTGC
TCTTCCATGGCGAGGTCACCGATCCGGCGGTGGACATCTTCGACCGCGAGGCGGCGTTCATCGACCGCGTGCTGGACCCG
ATCCGCCGCGCCACGCCCGGCCTGCGCGTGGTGATGGAACATATCACCACGTCGGACGGCGTGGATTATGTCGCCGCCAA
CGACGATATCGGCGCGACCATCACCACCCACCACCTGGTCATCAACCGCAACCACATCCTGGCGGGCGGCATCCGGCCGC
ATTACTACTGCCTGCCGGTCGCCAAGCGCGAAACCCACCGGCTGGCGCTGCGCAAAGCGGCGGTCTCGGGCGATGGGCGC
TTCTTCCTCGGCACCGACTCGGCGCCGCATCCCGACCGCGCCAAGGAAGCGGCCTGCGGCTGCGCCGGCTGCTTCACCGC
GCCGAACACCATGTCCATCCTGGCGCAGGTCTTCGAGGAGGAAGGCGCGCTCGACCGGCTCGAAGGCTTCGCCTCGCTCA
ACGGCGCCGCCTTCTACGGCATGGAGCCGAACCAGGACCGCATCCGGCTGGTCCGGCGCGACACGCCCGCCGAATATCCG
ACCCATATCGCCGCCGGCGACGAAACCGTCACCGTCTTCGACCCCGGCTTCCCGCTCTACTGGCACGTTGAGGACCCCGC
ATGA

Upstream 100 bases:

>100_bases
CGAGAGAGGCTGCGCCCATGGCGACGAAATGCCAAGAGGCCGGCTGGGACGGATCTTTGCCCTATGGCCTTGCTGCCGCA
CCCGGTATACAGGAAAAATC

Downstream 100 bases:

>100_bases
CCCTGCCCTTCCCTCCGCATGAGGAAATCGCCCGGCTGACCGCCCGCATGCTGCTGGAGATCAAGGCGGTGCACTTCAAC
GCGGCCGAGCCCTTTACCTA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTKSVTLRRPDDWHLHLRDGAMLQAVASFSGHFGRAIIMPNLVPPVVTGAQAAAYRDRIRAALGPKVTLRPLMTLYLTET
TDPADVVAAHAGGIISAVKLYPAGATTNSASGVRDFDKVRGVLEAMAEAGIPLLFHGEVTDPAVDIFDREAAFIDRVLDP
IRRATPGLRVVMEHITTSDGVDYVAANDDIGATITTHHLVINRNHILAGGIRPHYYCLPVAKRETHRLALRKAAVSGDGR
FFLGTDSAPHPDRAKEAACGCAGCFTAPNTMSILAQVFEEEGALDRLEGFASLNGAAFYGMEPNQDRIRLVRRDTPAEYP
THIAAGDETVTVFDPGFPLYWHVEDPA

Sequences:

>Translated_347_residues
MTKSVTLRRPDDWHLHLRDGAMLQAVASFSGHFGRAIIMPNLVPPVVTGAQAAAYRDRIRAALGPKVTLRPLMTLYLTET
TDPADVVAAHAGGIISAVKLYPAGATTNSASGVRDFDKVRGVLEAMAEAGIPLLFHGEVTDPAVDIFDREAAFIDRVLDP
IRRATPGLRVVMEHITTSDGVDYVAANDDIGATITTHHLVINRNHILAGGIRPHYYCLPVAKRETHRLALRKAAVSGDGR
FFLGTDSAPHPDRAKEAACGCAGCFTAPNTMSILAQVFEEEGALDRLEGFASLNGAAFYGMEPNQDRIRLVRRDTPAEYP
THIAAGDETVTVFDPGFPLYWHVEDPA
>Mature_346_residues
TKSVTLRRPDDWHLHLRDGAMLQAVASFSGHFGRAIIMPNLVPPVVTGAQAAAYRDRIRAALGPKVTLRPLMTLYLTETT
DPADVVAAHAGGIISAVKLYPAGATTNSASGVRDFDKVRGVLEAMAEAGIPLLFHGEVTDPAVDIFDREAAFIDRVLDPI
RRATPGLRVVMEHITTSDGVDYVAANDDIGATITTHHLVINRNHILAGGIRPHYYCLPVAKRETHRLALRKAAVSGDGRF
FLGTDSAPHPDRAKEAACGCAGCFTAPNTMSILAQVFEEEGALDRLEGFASLNGAAFYGMEPNQDRIRLVRRDTPAEYPT
HIAAGDETVTVFDPGFPLYWHVEDPA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=346, Percent_Identity=50.2890173410405, Blast_Score=347, Evalue=9e-97,
Organism=Saccharomyces cerevisiae, GI6323452, Length=368, Percent_Identity=34.7826086956522, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 37510; Mature: 37379

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSVTLRRPDDWHLHLRDGAMLQAVASFSGHFGRAIIMPNLVPPVVTGAQAAAYRDRIR
CCCCEEEECCCCCEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHCCCHHHHHHHHHH
AALGPKVTLRPLMTLYLTETTDPADVVAAHAGGIISAVKLYPAGATTNSASGVRDFDKVR
HHCCCCEECCEEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHH
GVLEAMAEAGIPLLFHGEVTDPAVDIFDREAAFIDRVLDPIRRATPGLRVVMEHITTSDG
HHHHHHHHCCCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
VDYVAANDDIGATITTHHLVINRNHILAGGIRPHYYCLPVAKRETHRLALRKAAVSGDGR
CEEEEECCCCCCEEEEEEEEEECCEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCE
FFLGTDSAPHPDRAKEAACGCAGCFTAPNTMSILAQVFEEEGALDRLEGFASLNGAAFYG
EEEECCCCCCCCHHHHHHCCCHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEC
MEPNQDRIRLVRRDTPAEYPTHIAAGDETVTVFDPGFPLYWHVEDPA
CCCCHHHEEEEECCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCC
>Mature Secondary Structure 
TKSVTLRRPDDWHLHLRDGAMLQAVASFSGHFGRAIIMPNLVPPVVTGAQAAAYRDRIR
CCCEEEECCCCCEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHCCCHHHHHHHHHH
AALGPKVTLRPLMTLYLTETTDPADVVAAHAGGIISAVKLYPAGATTNSASGVRDFDKVR
HHCCCCEECCEEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHH
GVLEAMAEAGIPLLFHGEVTDPAVDIFDREAAFIDRVLDPIRRATPGLRVVMEHITTSDG
HHHHHHHHCCCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
VDYVAANDDIGATITTHHLVINRNHILAGGIRPHYYCLPVAKRETHRLALRKAAVSGDGR
CEEEEECCCCCCEEEEEEEEEECCEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCE
FFLGTDSAPHPDRAKEAACGCAGCFTAPNTMSILAQVFEEEGALDRLEGFASLNGAAFYG
EEEECCCCCCCCHHHHHHCCCHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEC
MEPNQDRIRLVRRDTPAEYPTHIAAGDETVTVFDPGFPLYWHVEDPA
CCCCHHHEEEEECCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA