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The map label for this gene is ghrA [H]

Identifier: 119386744

GI number: 119386744

Start: 1187055

End: 1187975

Strand: Direct

Name: ghrA [H]

Synonym: Pden_4037

Alternate gene names: 119386744

Gene position: 1187055-1187975 (Clockwise)

Preceding gene: 119386743

Following gene: 119386745

Centisome position: 68.61

GC content: 72.42

Gene sequence:

>921_bases
ATGAAGGTCCTGTTCGCCGCCCCCGCACGGCTGTGGGATGCCTGGTCCCCCGCCCTGCGCAATGCCTGCTCCGAGATGGA
GCTGTGCCGCGAGGGCGATCCCGCCGGCTTCGACGCGCTGATCTATGCGCCGGGCTATCCCGAGGACGGCACGGTGCTGG
ATTTCACGCCCTTCACCCGCGCCCGGCTGGTGCAAAGCCTCTGGGCCGGGGTCGAGCGCATCGTGACCAATCCGACCCTG
ACCCAACCGCTCTGCCGCATGGTCGATCCGGGGCTGGCGCAGGGCATGGTGGACTATTGCGCCGGCTGGGCGATGCGGGC
GCATCTGGGCATGGACCGCTATGCCCAGGACGGCATCTGGCGCAACCACCTGACCCCACCGCTGGCACGCGAGCGCGGCG
TGACCGTGCTGGGCATGGGCGAGTTGGGCCGGGCGGTGGCATCGGCGCTGACGGGTCTGGGCTTTCGCGTTACCGGCTGG
TCGCAATCGGGGCGCCCGGTGCCGGGGATCGAGGCTCTGGCCGGCGCGGCCCTGCCCGAGGCACTGCGCCGCGCCGAGGT
GCTGATCTGCCTGCTGCCCGACACGCCCGAGACGCGCAACCTGCTCGACGCCGACCGGCTGGCGCTGCTGCCGCAGGGCG
CGACGGTGATCAATGCCGGGCGCGGCACGCTGATCGACGAGAGGGCCTTGCTGGCCGCGCTGGACCAGGGCCGGCCGGGC
CATGCCGTGCTGGACGTTTTCCGCAGCGAGCCCTTGCCGCCCGACCACCCGTTCTGGGCCCATCCCGGGGTCACCGTCAC
GCCCCATGTCGCGGCCGAGACCCGGCCGGTCAGCGCCGCCCCGGTCGTGGCCGAAAACCTGCGCCGCGCCATGCGGGACG
AGCCGCTTCTGCATCTGGTGGACCGGACGCGCGGCTATTGA

Upstream 100 bases:

>100_bases
CCTGGTCAGTTACGGAGGAACCTCGCTGATGATCCTGTTGATGGCCTTTGGCATCGTCCAATCCGCCCATGTCCATCGCC
CCCGGGGCTGAGGCGCGGCG

Downstream 100 bases:

>100_bases
CGACCCGGCGCGGCATATTTTGCGGCCGCAATCCCGGGCATCCTGACGTTTTGCGCAACTTGCGCGCGCAGGGAAGCCGC
CGGATAACGAAAGCGTATGG

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKVLFAAPARLWDAWSPALRNACSEMELCREGDPAGFDALIYAPGYPEDGTVLDFTPFTRARLVQSLWAGVERIVTNPTL
TQPLCRMVDPGLAQGMVDYCAGWAMRAHLGMDRYAQDGIWRNHLTPPLARERGVTVLGMGELGRAVASALTGLGFRVTGW
SQSGRPVPGIEALAGAALPEALRRAEVLICLLPDTPETRNLLDADRLALLPQGATVINAGRGTLIDERALLAALDQGRPG
HAVLDVFRSEPLPPDHPFWAHPGVTVTPHVAAETRPVSAAPVVAENLRRAMRDEPLLHLVDRTRGY

Sequences:

>Translated_306_residues
MKVLFAAPARLWDAWSPALRNACSEMELCREGDPAGFDALIYAPGYPEDGTVLDFTPFTRARLVQSLWAGVERIVTNPTL
TQPLCRMVDPGLAQGMVDYCAGWAMRAHLGMDRYAQDGIWRNHLTPPLARERGVTVLGMGELGRAVASALTGLGFRVTGW
SQSGRPVPGIEALAGAALPEALRRAEVLICLLPDTPETRNLLDADRLALLPQGATVINAGRGTLIDERALLAALDQGRPG
HAVLDVFRSEPLPPDHPFWAHPGVTVTPHVAAETRPVSAAPVVAENLRRAMRDEPLLHLVDRTRGY
>Mature_306_residues
MKVLFAAPARLWDAWSPALRNACSEMELCREGDPAGFDALIYAPGYPEDGTVLDFTPFTRARLVQSLWAGVERIVTNPTL
TQPLCRMVDPGLAQGMVDYCAGWAMRAHLGMDRYAQDGIWRNHLTPPLARERGVTVLGMGELGRAVASALTGLGFRVTGW
SQSGRPVPGIEALAGAALPEALRRAEVLICLLPDTPETRNLLDADRLALLPQGATVINAGRGTLIDERALLAALDQGRPG
HAVLDVFRSEPLPPDHPFWAHPGVTVTPHVAAETRPVSAAPVVAENLRRAMRDEPLLHLVDRTRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=166, Percent_Identity=31.9277108433735, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI6912396, Length=169, Percent_Identity=29.585798816568, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI145580578, Length=172, Percent_Identity=31.9767441860465, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI4557499, Length=172, Percent_Identity=31.9767441860465, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI61743967, Length=172, Percent_Identity=30.8139534883721, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI4557497, Length=172, Percent_Identity=30.8139534883721, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87081824, Length=321, Percent_Identity=34.5794392523364, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI87082289, Length=169, Percent_Identity=34.3195266272189, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789279, Length=166, Percent_Identity=28.3132530120482, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=215, Percent_Identity=28.8372093023256, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=148, Percent_Identity=29.0540540540541, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=167, Percent_Identity=26.9461077844311, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322116, Length=167, Percent_Identity=26.9461077844311, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=164, Percent_Identity=34.7560975609756, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574286, Length=219, Percent_Identity=29.6803652968037, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45552429, Length=201, Percent_Identity=27.8606965174129, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571528, Length=175, Percent_Identity=29.1428571428571, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585514, Length=201, Percent_Identity=27.8606965174129, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574282, Length=201, Percent_Identity=27.8606965174129, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574284, Length=201, Percent_Identity=27.8606965174129, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551003, Length=201, Percent_Identity=27.8606965174129, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33149; Mature: 33149

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLFAAPARLWDAWSPALRNACSEMELCREGDPAGFDALIYAPGYPEDGTVLDFTPFTR
CCEEECCCHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEEECCCHH
ARLVQSLWAGVERIVTNPTLTQPLCRMVDPGLAQGMVDYCAGWAMRAHLGMDRYAQDGIW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
RNHLTPPLARERGVTVLGMGELGRAVASALTGLGFRVTGWSQSGRPVPGIEALAGAALPE
HHCCCCCHHHHCCCEEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHH
ALRRAEVLICLLPDTPETRNLLDADRLALLPQGATVINAGRGTLIDERALLAALDQGRPG
HHHHHCEEEEECCCCCCHHHHHCHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCC
HAVLDVFRSEPLPPDHPFWAHPGVTVTPHVAAETRPVSAAPVVAENLRRAMRDEPLLHLV
HHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHH
DRTRGY
HHHCCC
>Mature Secondary Structure
MKVLFAAPARLWDAWSPALRNACSEMELCREGDPAGFDALIYAPGYPEDGTVLDFTPFTR
CCEEECCCHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCEEEECCCHH
ARLVQSLWAGVERIVTNPTLTQPLCRMVDPGLAQGMVDYCAGWAMRAHLGMDRYAQDGIW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
RNHLTPPLARERGVTVLGMGELGRAVASALTGLGFRVTGWSQSGRPVPGIEALAGAALPE
HHCCCCCHHHHCCCEEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHH
ALRRAEVLICLLPDTPETRNLLDADRLALLPQGATVINAGRGTLIDERALLAALDQGRPG
HHHHHCEEEEECCCCCCHHHHHCHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCC
HAVLDVFRSEPLPPDHPFWAHPGVTVTPHVAAETRPVSAAPVVAENLRRAMRDEPLLHLV
HHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHH
DRTRGY
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA