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The map label for this gene is mrdB [H]

Identifier: 119386743

GI number: 119386743

Start: 1185903

End: 1187045

Strand: Direct

Name: mrdB [H]

Synonym: Pden_4036

Alternate gene names: 119386743

Gene position: 1185903-1187045 (Clockwise)

Preceding gene: 119386742

Following gene: 119386744

Centisome position: 68.55

GC content: 64.22

Gene sequence:

>1143_bases
ATGAGCTATCTGAACTATCACGTCGCGCAGGTGCCGACGGGCTGGCGCAAGATCCTGCACCTGAACTGGCCGCTGGTGTT
CCTGGTCACCGCCGTCAGCTGCATCGGCTTTCTGATGCTCTATTCCGTCTCGGGCGGCGATATCGACAGATGGGCCGGCC
CGCAGATGGAGCGCTTTGCCGTCGGCATGGTGCTGATGTTCGCGCTGGCCTTCGTGCCGATCTGGTTCTGGCGCTCGATC
TCGGTGGCCTCCTATGTGATCTGCGTGGGCCTGCTGGTGCTGGTCGAGGTGATCGGCCATGTCGGCATGGGCGCGCAGCG
CTGGCTGGTGCTGGGGCCGGTGCGCATCCAGCCGTCCGAGCTGACCAAGGTCGCCTTCGTGATGACTCTGGCGGCCTATT
ACGACTGGCTGCCGGTCGAAAAGGTCTCGCGCCCGTTCTGGGTGCTGATCCCGGTCATCCTGATCCTGCTGCCGACCGGG
CTGGTGCTGATGCAGCCCGACCTGGGCACCTCGATCATGCTGGTCGCCGGCGGCGGCATCGTCATGTTCGCGGCGGGCGT
CAGCCTGTGGTATTTCGCCGGCGTCATCGCCATCGTCGTCGCCGGCGTCACCACAGTGATGGAAAGCCGCGGCACCGACT
GGCAATTGCTGCACGACTATCAGTTCCGCCGCATCGACACCTTCCTCGACCCGGGCTCGGACCCGCTGGGTGCGGGATAC
AACATCGCGCAGGCGCAGATCGCGCTGGGATCGGGCGGCTGGTCGGGGCGCGGCTTCATGCAGGGCACGCAATCGCGGCT
GAACTTCCTGCCCGAAAAGCACACCGACTTCATCTTCACCTCGCTGGCCGAGGAATTCGGCTTCGTCGGCGCCTTCAGCC
TGCTGATGCTCTATGTGCTGATCCTGGGGTTCTGCATGTATTCGGCGCTGACCAACCGCGACCGCTTCGCCAGCCTGCTG
ACCATTGGCATCGCCGGGACGTTCTTCCTTTACTTTTCCATCAACATGGCCACGGTGATGGGCATGCTGCCCGCCAAGGG
CTCGCCCCTGCCCCTGGTCAGTTACGGAGGAACCTCGCTGATGATCCTGTTGATGGCCTTTGGCATCGTCCAATCCGCCC
ATGTCCATCGCCCCCGGGGCTGA

Upstream 100 bases:

>100_bases
CTATCCCGAGAGCGAACGCGCCAAGGTCCAGGAAATATGGTCGCGCATGAACCTGACCCCCTCGGCCCGCAAGGGCGAGG
GCCGCGCGAGGGCCTGACGC

Downstream 100 bases:

>100_bases
GGCGCGGCGATGAAGGTCCTGTTCGCCGCCCCCGCACGGCTGTGGGATGCCTGGTCCCCCGCCCTGCGCAATGCCTGCTC
CGAGATGGAGCTGTGCCGCG

Product: rod shape-determining protein RodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSYLNYHVAQVPTGWRKILHLNWPLVFLVTAVSCIGFLMLYSVSGGDIDRWAGPQMERFAVGMVLMFALAFVPIWFWRSI
SVASYVICVGLLVLVEVIGHVGMGAQRWLVLGPVRIQPSELTKVAFVMTLAAYYDWLPVEKVSRPFWVLIPVILILLPTG
LVLMQPDLGTSIMLVAGGGIVMFAAGVSLWYFAGVIAIVVAGVTTVMESRGTDWQLLHDYQFRRIDTFLDPGSDPLGAGY
NIAQAQIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTSLAEEFGFVGAFSLLMLYVLILGFCMYSALTNRDRFASLL
TIGIAGTFFLYFSINMATVMGMLPAKGSPLPLVSYGGTSLMILLMAFGIVQSAHVHRPRG

Sequences:

>Translated_380_residues
MSYLNYHVAQVPTGWRKILHLNWPLVFLVTAVSCIGFLMLYSVSGGDIDRWAGPQMERFAVGMVLMFALAFVPIWFWRSI
SVASYVICVGLLVLVEVIGHVGMGAQRWLVLGPVRIQPSELTKVAFVMTLAAYYDWLPVEKVSRPFWVLIPVILILLPTG
LVLMQPDLGTSIMLVAGGGIVMFAAGVSLWYFAGVIAIVVAGVTTVMESRGTDWQLLHDYQFRRIDTFLDPGSDPLGAGY
NIAQAQIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTSLAEEFGFVGAFSLLMLYVLILGFCMYSALTNRDRFASLL
TIGIAGTFFLYFSINMATVMGMLPAKGSPLPLVSYGGTSLMILLMAFGIVQSAHVHRPRG
>Mature_379_residues
SYLNYHVAQVPTGWRKILHLNWPLVFLVTAVSCIGFLMLYSVSGGDIDRWAGPQMERFAVGMVLMFALAFVPIWFWRSIS
VASYVICVGLLVLVEVIGHVGMGAQRWLVLGPVRIQPSELTKVAFVMTLAAYYDWLPVEKVSRPFWVLIPVILILLPTGL
VLMQPDLGTSIMLVAGGGIVMFAAGVSLWYFAGVIAIVVAGVTTVMESRGTDWQLLHDYQFRRIDTFLDPGSDPLGAGYN
IAQAQIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTSLAEEFGFVGAFSLLMLYVLILGFCMYSALTNRDRFASLLT
IGIAGTFFLYFSINMATVMGMLPAKGSPLPLVSYGGTSLMILLMAFGIVQSAHVHRPRG

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=372, Percent_Identity=42.4731182795699, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1786277, Length=353, Percent_Identity=35.4107648725212, Blast_Score=169, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 41690; Mature: 41559

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLNYHVAQVPTGWRKILHLNWPLVFLVTAVSCIGFLMLYSVSGGDIDRWAGPQMERFA
CCCCHHHHHHCCHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
VGMVLMFALAFVPIWFWRSISVASYVICVGLLVLVEVIGHVGMGAQRWLVLGPVRIQPSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEECHHH
LTKVAFVMTLAAYYDWLPVEKVSRPFWVLIPVILILLPTGLVLMQPDLGTSIMLVAGGGI
HHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCH
VMFAAGVSLWYFAGVIAIVVAGVTTVMESRGTDWQLLHDYQFRRIDTFLDPGSDPLGAGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCC
NIAQAQIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTSLAEEFGFVGAFSLLMLYVL
CHHEEEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
ILGFCMYSALTNRDRFASLLTIGIAGTFFLYFSINMATVMGMLPAKGSPLPLVSYGGTSL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHH
MILLMAFGIVQSAHVHRPRG
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SYLNYHVAQVPTGWRKILHLNWPLVFLVTAVSCIGFLMLYSVSGGDIDRWAGPQMERFA
CCCHHHHHHCCHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
VGMVLMFALAFVPIWFWRSISVASYVICVGLLVLVEVIGHVGMGAQRWLVLGPVRIQPSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEECHHH
LTKVAFVMTLAAYYDWLPVEKVSRPFWVLIPVILILLPTGLVLMQPDLGTSIMLVAGGGI
HHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCH
VMFAAGVSLWYFAGVIAIVVAGVTTVMESRGTDWQLLHDYQFRRIDTFLDPGSDPLGAGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCC
NIAQAQIALGSGGWSGRGFMQGTQSRLNFLPEKHTDFIFTSLAEEFGFVGAFSLLMLYVL
CHHEEEEEECCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
ILGFCMYSALTNRDRFASLLTIGIAGTFFLYFSINMATVMGMLPAKGSPLPLVSYGGTSL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHH
MILLMAFGIVQSAHVHRPRG
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]