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The map label for this gene is mrdA [H]

Identifier: 119386742

GI number: 119386742

Start: 1183956

End: 1185899

Strand: Direct

Name: mrdA [H]

Synonym: Pden_4035

Alternate gene names: 119386742

Gene position: 1183956-1185899 (Clockwise)

Preceding gene: 119386741

Following gene: 119386743

Centisome position: 68.43

GC content: 68.72

Gene sequence:

>1944_bases
ATGCGCAAGTCGGAACGCGAAATCGTCGAAAGCGGCCGCCTGATCACCCGCCGGGTGCTGATGCTGGGCGCGATCCAGGC
GGCGGTCGTCTCGGCGCTGGGGCTGAAGCTGCGCTCGATGCAGGTCGAGCATGCCGACGAATACCGCATGCTGTCGGACG
GCAACTCGATCAAGATCCGGCTGCTGCCACCGGCGCGCGGGCTGATCCTGGACCGCCACGGCACCATCATCGCGGGGAAC
GAGCAGAACTATCGCGTCACCCTGACCCGCGAGGAGGCGGGCGACGTCTCGGCCGTGATCGCGCGGCTGCGTCACATCAT
CCCGATGAGCGACCGCCAGATCGCCGATATCCTGGAAGAGATCCGCAAGCGCAGCGCCGTCACCCCGGTTCTGGTCGCCG
ACCGGCTGAGCTGGGCCGAATTTTCCTCGATCGCGCTCAACGCCCCTGCCCTGCCCGGCGTCACGCCCGAGGCCGGGCTG
TCGCGCAGCTATCCGCGCGCCGGCGATTTCGCGCATGTGCTGGGCTATGTCGGCCCGGTCTCGGATTACGACCTCTCGAA
GATCGAGAACCCCGACCCGGTGCTGCGCCTGCCCGAGTTCCAGCTGGGCAAGGTCGGCATGGAGGCGAAGCTGGAGGAAC
CTCTGCGCGGCAAGGCCGGTTCGCGCCGGGTCGAGGTGAACAGCGCCGGGCGCGAGATGCGCGAGCTGTCGCGGCAAGAG
GGCCAGCAGGGCGCCACGGTTCAAACCACGCTGGATGCGGGCCTGCAGAATTTCGCCACCCAGCGGCTGGGCAGCGAAAG
CGCCGCCGCGGTGGTGATCGATGTCACGAATGGCGACATCCTGGCGATCTCCTCCTCGCCGGTCTTCGATCCGAACAAGT
TCGTGCGCGGCATCTCGGGGCCGGATTACCGGGCGCTGATGAACCACGACCACCGGCCGCTGGCCGACAAGACCGTGCAG
GGCGTCTATCCTCCCGGCTCGACCTTCAAGATGGTGACGCTTCTGGCCGGGCTGGAGGCGGGCGTGATCAATGCCGGCTC
GCGCTTCTATTGCCCCGGCTATACCCAGGTCGCCGGGCGGCGTTTCCATTGCTGGAGCCGCGGCGGCCACGGCATGGTCG
ACGCCCTGGGCAGCCTCGAACATTCCTGCGACGTCTATTATTACGAGCTGGCGCAGCGCGTCGGCATCGACCGCATCGCT
GCCATGGCGCGCAAGCTGGGCATCGGCGTGCGCCATGAGTTGCCCATGTCCGCCATCGCCGAGGGCATCGCCCCGGACCG
CGCCTGGAAACGGGCCCGCTACGACCAGGAATGGCAGGTCGGCGATTCATTGAACGCCTCGATCGGCCAGGGCTATGTGC
TGGCCTCGCCGCTGCAACTGGCGGTGATGACGGCGCGGGTCGCGACGGGACGCGCGGTCTCCCCGCGGCTGGTGCGCGCC
ATCGACGGCCAGCCCGAGCCGGTGCCGGAATGGCCCGAACTCGACATCAACCCGCTGAACCTGCGCACGGCACGGGCAGG
CATGGATGCGGTGATGAACGGCAGCCGCGGCACCGCGCGGCGGGCGCGCATCATCGCGCCGGAATGGCAGATGGCGGGCA
AGACCGGCACCAGCCAGGTGCGCAACATCACCGCCGCCGAACGCGCGCGCGGCGTGATCTCGAACGAACAACTGCCCTGG
AACCGCCGCGACCACGCGCTTTTCGTCTGTTTCGCGCCCTATGACATGCCGCGCTATGCGGTTTCGCTGGTGGTCGAGCA
TGGCGGCGGCGGCTCGGCCGTGGCTGCGCCCATCGCCCGCGACATCCTGCTTTACGCACTGGCGGACGGGCTGCCGCCGC
TGACCGCCTATCCCGAGAGCGAACGCGCCAAGGTCCAGGAAATATGGTCGCGCATGAACCTGACCCCCTCGGCCCGCAAG
GGCGAGGGCCGCGCGAGGGCCTGA

Upstream 100 bases:

>100_bases
CGCGACGGTTGCCGCCTATCCGCTGGTCGCGGGACTTGCCGGCTGGGCGCTTGGCCTGCCGCGGGGCCGCGTCGAACGAG
ACACGAGGCATCGCTGAGCC

Downstream 100 bases:

>100_bases
CGCATGAGCTATCTGAACTATCACGTCGCGCAGGTGCCGACGGGCTGGCGCAAGATCCTGCACCTGAACTGGCCGCTGGT
GTTCCTGGTCACCGCCGTCA

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MRKSEREIVESGRLITRRVLMLGAIQAAVVSALGLKLRSMQVEHADEYRMLSDGNSIKIRLLPPARGLILDRHGTIIAGN
EQNYRVTLTREEAGDVSAVIARLRHIIPMSDRQIADILEEIRKRSAVTPVLVADRLSWAEFSSIALNAPALPGVTPEAGL
SRSYPRAGDFAHVLGYVGPVSDYDLSKIENPDPVLRLPEFQLGKVGMEAKLEEPLRGKAGSRRVEVNSAGREMRELSRQE
GQQGATVQTTLDAGLQNFATQRLGSESAAAVVIDVTNGDILAISSSPVFDPNKFVRGISGPDYRALMNHDHRPLADKTVQ
GVYPPGSTFKMVTLLAGLEAGVINAGSRFYCPGYTQVAGRRFHCWSRGGHGMVDALGSLEHSCDVYYYELAQRVGIDRIA
AMARKLGIGVRHELPMSAIAEGIAPDRAWKRARYDQEWQVGDSLNASIGQGYVLASPLQLAVMTARVATGRAVSPRLVRA
IDGQPEPVPEWPELDINPLNLRTARAGMDAVMNGSRGTARRARIIAPEWQMAGKTGTSQVRNITAAERARGVISNEQLPW
NRRDHALFVCFAPYDMPRYAVSLVVEHGGGGSAVAAPIARDILLYALADGLPPLTAYPESERAKVQEIWSRMNLTPSARK
GEGRARA

Sequences:

>Translated_647_residues
MRKSEREIVESGRLITRRVLMLGAIQAAVVSALGLKLRSMQVEHADEYRMLSDGNSIKIRLLPPARGLILDRHGTIIAGN
EQNYRVTLTREEAGDVSAVIARLRHIIPMSDRQIADILEEIRKRSAVTPVLVADRLSWAEFSSIALNAPALPGVTPEAGL
SRSYPRAGDFAHVLGYVGPVSDYDLSKIENPDPVLRLPEFQLGKVGMEAKLEEPLRGKAGSRRVEVNSAGREMRELSRQE
GQQGATVQTTLDAGLQNFATQRLGSESAAAVVIDVTNGDILAISSSPVFDPNKFVRGISGPDYRALMNHDHRPLADKTVQ
GVYPPGSTFKMVTLLAGLEAGVINAGSRFYCPGYTQVAGRRFHCWSRGGHGMVDALGSLEHSCDVYYYELAQRVGIDRIA
AMARKLGIGVRHELPMSAIAEGIAPDRAWKRARYDQEWQVGDSLNASIGQGYVLASPLQLAVMTARVATGRAVSPRLVRA
IDGQPEPVPEWPELDINPLNLRTARAGMDAVMNGSRGTARRARIIAPEWQMAGKTGTSQVRNITAAERARGVISNEQLPW
NRRDHALFVCFAPYDMPRYAVSLVVEHGGGGSAVAAPIARDILLYALADGLPPLTAYPESERAKVQEIWSRMNLTPSARK
GEGRARA
>Mature_647_residues
MRKSEREIVESGRLITRRVLMLGAIQAAVVSALGLKLRSMQVEHADEYRMLSDGNSIKIRLLPPARGLILDRHGTIIAGN
EQNYRVTLTREEAGDVSAVIARLRHIIPMSDRQIADILEEIRKRSAVTPVLVADRLSWAEFSSIALNAPALPGVTPEAGL
SRSYPRAGDFAHVLGYVGPVSDYDLSKIENPDPVLRLPEFQLGKVGMEAKLEEPLRGKAGSRRVEVNSAGREMRELSRQE
GQQGATVQTTLDAGLQNFATQRLGSESAAAVVIDVTNGDILAISSSPVFDPNKFVRGISGPDYRALMNHDHRPLADKTVQ
GVYPPGSTFKMVTLLAGLEAGVINAGSRFYCPGYTQVAGRRFHCWSRGGHGMVDALGSLEHSCDVYYYELAQRVGIDRIA
AMARKLGIGVRHELPMSAIAEGIAPDRAWKRARYDQEWQVGDSLNASIGQGYVLASPLQLAVMTARVATGRAVSPRLVRA
IDGQPEPVPEWPELDINPLNLRTARAGMDAVMNGSRGTARRARIIAPEWQMAGKTGTSQVRNITAAERARGVISNEQLPW
NRRDHALFVCFAPYDMPRYAVSLVVEHGGGGSAVAAPIARDILLYALADGLPPLTAYPESERAKVQEIWSRMNLTPSARK
GEGRARA

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=612, Percent_Identity=33.1699346405229, Blast_Score=334, Evalue=9e-93,
Organism=Escherichia coli, GI1786272, Length=622, Percent_Identity=22.8295819935691, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70487; Mature: 70487

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSEREIVESGRLITRRVLMLGAIQAAVVSALGLKLRSMQVEHADEYRMLSDGNSIKIR
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCCCEEEEE
LLPPARGLILDRHGTIIAGNEQNYRVTLTREEAGDVSAVIARLRHIIPMSDRQIADILEE
EECCCCCEEEECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
IRKRSAVTPVLVADRLSWAEFSSIALNAPALPGVTPEAGLSRSYPRAGDFAHVLGYVGPV
HHHHCCCCCCHHHHCCCHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
SDYDLSKIENPDPVLRLPEFQLGKVGMEAKLEEPLRGKAGSRRVEVNSAGREMRELSRQE
CCCCHHHCCCCCCEEECCCCCCCCCCCHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHHC
GQQGATVQTTLDAGLQNFATQRLGSESAAAVVIDVTNGDILAISSSPVFDPNKFVRGISG
CCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCHHHHHCCCCC
PDYRALMNHDHRPLADKTVQGVYPPGSTFKMVTLLAGLEAGVINAGSRFYCPGYTQVAGR
CCHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCEECCCCEEECCCHHHHCCC
RFHCWSRGGHGMVDALGSLEHSCDVYYYELAQRVGIDRIAAMARKLGIGVRHELPMSAIA
EEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHH
EGIAPDRAWKRARYDQEWQVGDSLNASIGQGYVLASPLQLAVMTARVATGRAVSPRLVRA
HCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCHHHHHH
IDGQPEPVPEWPELDINPLNLRTARAGMDAVMNGSRGTARRARIIAPEWQMAGKTGTSQV
HCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHCCCCCCCCCEEEECCCHHHCCCCCHHHH
RNITAAERARGVISNEQLPWNRRDHALFVCFAPYDMPRYAVSLVVEHGGGGSAVAAPIAR
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHH
DILLYALADGLPPLTAYPESERAKVQEIWSRMNLTPSARKGEGRARA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRKSEREIVESGRLITRRVLMLGAIQAAVVSALGLKLRSMQVEHADEYRMLSDGNSIKIR
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCCCEEEEE
LLPPARGLILDRHGTIIAGNEQNYRVTLTREEAGDVSAVIARLRHIIPMSDRQIADILEE
EECCCCCEEEECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
IRKRSAVTPVLVADRLSWAEFSSIALNAPALPGVTPEAGLSRSYPRAGDFAHVLGYVGPV
HHHHCCCCCCHHHHCCCHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCC
SDYDLSKIENPDPVLRLPEFQLGKVGMEAKLEEPLRGKAGSRRVEVNSAGREMRELSRQE
CCCCHHHCCCCCCEEECCCCCCCCCCCHHHCCCCCCCCCCCCEEEECHHHHHHHHHHHHC
GQQGATVQTTLDAGLQNFATQRLGSESAAAVVIDVTNGDILAISSSPVFDPNKFVRGISG
CCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCHHHHHCCCCC
PDYRALMNHDHRPLADKTVQGVYPPGSTFKMVTLLAGLEAGVINAGSRFYCPGYTQVAGR
CCHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCEECCCCEEECCCHHHHCCC
RFHCWSRGGHGMVDALGSLEHSCDVYYYELAQRVGIDRIAAMARKLGIGVRHELPMSAIA
EEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHH
EGIAPDRAWKRARYDQEWQVGDSLNASIGQGYVLASPLQLAVMTARVATGRAVSPRLVRA
HCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCHHHHHH
IDGQPEPVPEWPELDINPLNLRTARAGMDAVMNGSRGTARRARIIAPEWQMAGKTGTSQV
HCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHCCCCCCCCCEEEECCCHHHCCCCCHHHH
RNITAAERARGVISNEQLPWNRRDHALFVCFAPYDMPRYAVSLVVEHGGGGSAVAAPIAR
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHH
DILLYALADGLPPLTAYPESERAKVQEIWSRMNLTPSARKGEGRARA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]