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The map label for this gene is dxr

Identifier: 119386704

GI number: 119386704

Start: 1135470

End: 1136642

Strand: Direct

Name: dxr

Synonym: Pden_3997

Alternate gene names: 119386704

Gene position: 1135470-1136642 (Clockwise)

Preceding gene: 119386703

Following gene: 119386705

Centisome position: 65.63

GC content: 72.29

Gene sequence:

>1173_bases
ATGCGCAGCATATCCGTGCTGGGCGCGACCGGGTCGGTCGGCGAAAGCGCATTCGATCTGTTGATGGGGGCCGGCGGCCC
CGAGCGCTTCCGCACCGTCGCCCTGACCGGCGGCGCCAATGTCGCGCGGCTGGCCCAGATGGCCCGCGCGCTGCGGGCCG
AACTCGCCGTCACCGCATGGCCGGAGCGCCTGGCCGATCTGCGCGCGGCACTTGCCGGCAGCGGGATCGAGGCCGCGGCG
GGACCGCAGGCCGTGGCCGAGGCCGCCGCCCGCCCGGCCGACTGGACGCTGTCCGCCATCGTCGGCGCCGCCGGCCTGCC
GCCGGGGCTTGAGGTGCTGAACCGAGGCGGCACCCTGGCGCTGGCGAACAAGGAAACCCTGGTGGCCGCCGGACCGCTGG
TCATGGCCCGCGCCCGGGAGACCGGCGCACGCATCCTGCCGGTTGATTCCGAGCATTCCGCGATCTTTCAGGCACTTCAC
GGCGAAAACCTCGATTCCGTCGAGCATGTGACCATCACCGCCTCGGGCGGCGCATTCCGCGACTGGCCGCTGGAGCGGCT
GGCACGCGCGACGGTGGCCGAGGCCAGCCGGCATCCGAACTGGGACATGGGCCAGCGCATCACCATCGACAGCGCCAGCA
TGTTCAACAAGGCGCTGGAAGTCATCGAGGCGCATGAATTCTTCGGCCTGGGCGTCGACCGCCTGCGGGTGCTGGTGCAT
CCGCAATCGATCATCCATGCCATGGTCACGCATCGCGACGGCGGCAGCATCGCGCATCTGGGGGCGCCGGACATGCGCCA
TGCCATCGGCTATGCGCTGAACTGGCCCGCGCGCGCCGCCCTGCCGGTGCCGGCGCTGGACCTGGCGGCGCTTGGCAGCC
TGACCTTTGCCCAGCCGGACGAGGTGCGCTGGCCTGCCCTGCGGCTGGCGCGCGAGGCGATCGGGGCCGGCGGTGCCGCG
GGTGCGGTGCTGAACGCCGCCAAGGAGCAGGCGCTGGACGACTTCATCGCCGGGCGCATCCGCTTTACCGACATGGCGCC
CGCGGTCGAGCACGCGCTGGCGCTGGCCGCGCGCGAGGCCGGCTTTGCGCAAAGTCCGCGCGACCTTGGCGAAGTGCTGC
ATTGGGACGATTTCGCGCGGCGGGCGGCAGCGCAATGGCAGGGGGCGGCATGA

Upstream 100 bases:

>100_bases
GGCGGCGTCCTGGACCGTTTCGACGCCATGTCCGGGGCGTTGCTCATGGCGCTGCTGCTTTTGATCGGCGATCTCTTACC
CGTTATCGGAGGCTGAGACG

Downstream 100 bases:

>100_bases
GCCTGGTTCTGGACATGATGGGCGGGTTCGTGTGGACCGTGGCGGCCTTCATCGTCGCGCTGTCGGTCATCGTCACCGTG
CATGAATACGGCCATTACAT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MRSISVLGATGSVGESAFDLLMGAGGPERFRTVALTGGANVARLAQMARALRAELAVTAWPERLADLRAALAGSGIEAAA
GPQAVAEAAARPADWTLSAIVGAAGLPPGLEVLNRGGTLALANKETLVAAGPLVMARARETGARILPVDSEHSAIFQALH
GENLDSVEHVTITASGGAFRDWPLERLARATVAEASRHPNWDMGQRITIDSASMFNKALEVIEAHEFFGLGVDRLRVLVH
PQSIIHAMVTHRDGGSIAHLGAPDMRHAIGYALNWPARAALPVPALDLAALGSLTFAQPDEVRWPALRLAREAIGAGGAA
GAVLNAAKEQALDDFIAGRIRFTDMAPAVEHALALAAREAGFAQSPRDLGEVLHWDDFARRAAAQWQGAA

Sequences:

>Translated_390_residues
MRSISVLGATGSVGESAFDLLMGAGGPERFRTVALTGGANVARLAQMARALRAELAVTAWPERLADLRAALAGSGIEAAA
GPQAVAEAAARPADWTLSAIVGAAGLPPGLEVLNRGGTLALANKETLVAAGPLVMARARETGARILPVDSEHSAIFQALH
GENLDSVEHVTITASGGAFRDWPLERLARATVAEASRHPNWDMGQRITIDSASMFNKALEVIEAHEFFGLGVDRLRVLVH
PQSIIHAMVTHRDGGSIAHLGAPDMRHAIGYALNWPARAALPVPALDLAALGSLTFAQPDEVRWPALRLAREAIGAGGAA
GAVLNAAKEQALDDFIAGRIRFTDMAPAVEHALALAAREAGFAQSPRDLGEVLHWDDFARRAAAQWQGAA
>Mature_390_residues
MRSISVLGATGSVGESAFDLLMGAGGPERFRTVALTGGANVARLAQMARALRAELAVTAWPERLADLRAALAGSGIEAAA
GPQAVAEAAARPADWTLSAIVGAAGLPPGLEVLNRGGTLALANKETLVAAGPLVMARARETGARILPVDSEHSAIFQALH
GENLDSVEHVTITASGGAFRDWPLERLARATVAEASRHPNWDMGQRITIDSASMFNKALEVIEAHEFFGLGVDRLRVLVH
PQSIIHAMVTHRDGGSIAHLGAPDMRHAIGYALNWPARAALPVPALDLAALGSLTFAQPDEVRWPALRLAREAIGAGGAA
GAVLNAAKEQALDDFIAGRIRFTDMAPAVEHALALAAREAGFAQSPRDLGEVLHWDDFARRAAAQWQGAA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=42.9292929292929, Blast_Score=282, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_PARDP (A1B969)

Other databases:

- EMBL:   CP000490
- RefSeq:   YP_917759.1
- ProteinModelPortal:   A1B969
- SMR:   A1B969
- STRING:   A1B969
- GeneID:   4582548
- GenomeReviews:   CP000490_GR
- KEGG:   pde:Pden_3997
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   A1B969
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 40792; Mature: 40792

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: BINDING 124-124 BINDING 151-151 BINDING 175-175 BINDING 198-198 BINDING 220-220

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSISVLGATGSVGESAFDLLMGAGGPERFRTVALTGGANVARLAQMARALRAELAVTAW
CCCEEEEECCCCCCHHHHHHHHCCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
PERLADLRAALAGSGIEAAAGPQAVAEAAARPADWTLSAIVGAAGLPPGLEVLNRGGTLA
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHCCCCEEE
LANKETLVAAGPLVMARARETGARILPVDSEHSAIFQALHGENLDSVEHVTITASGGAFR
EECCCEEEEECCHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
DWPLERLARATVAEASRHPNWDMGQRITIDSASMFNKALEVIEAHEFFGLGVDRLRVLVH
CCHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHEEEEC
PQSIIHAMVTHRDGGSIAHLGAPDMRHAIGYALNWPARAALPVPALDLAALGSLTFAQPD
HHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCC
EVRWPALRLAREAIGAGGAAGAVLNAAKEQALDDFIAGRIRFTDMAPAVEHALALAAREA
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHC
GFAQSPRDLGEVLHWDDFARRAAAQWQGAA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRSISVLGATGSVGESAFDLLMGAGGPERFRTVALTGGANVARLAQMARALRAELAVTAW
CCCEEEEECCCCCCHHHHHHHHCCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
PERLADLRAALAGSGIEAAAGPQAVAEAAARPADWTLSAIVGAAGLPPGLEVLNRGGTLA
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHCCCCEEE
LANKETLVAAGPLVMARARETGARILPVDSEHSAIFQALHGENLDSVEHVTITASGGAFR
EECCCEEEEECCHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
DWPLERLARATVAEASRHPNWDMGQRITIDSASMFNKALEVIEAHEFFGLGVDRLRVLVH
CCHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHEEEEC
PQSIIHAMVTHRDGGSIAHLGAPDMRHAIGYALNWPARAALPVPALDLAALGSLTFAQPD
HHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCC
EVRWPALRLAREAIGAGGAAGAVLNAAKEQALDDFIAGRIRFTDMAPAVEHALALAAREA
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHC
GFAQSPRDLGEVLHWDDFARRAAAQWQGAA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA