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The map label for this gene is pyrH

Identifier: 119386700

GI number: 119386700

Start: 1132498

End: 1133232

Strand: Direct

Name: pyrH

Synonym: Pden_3993

Alternate gene names: 119386700

Gene position: 1132498-1133232 (Clockwise)

Preceding gene: 119386697

Following gene: 119386701

Centisome position: 65.46

GC content: 64.9

Gene sequence:

>735_bases
ATGTCGGAAAGCGCGTCCAAGACCCCCGGAAGCTATTCGCGCGTGATGCTGAAGATTTCGGGCGAGGCGCTCATGGGGGA
CCAGGGCTACGGCCTGCACCCGCCGACCGTCGCCCGCATCGCGCAAGAGGTCAAATCCGTCCATGACATGGGCATCGAGA
TCTGCATGGTCATCGGCGGCGGCAATATCTTCCGCGGGCTTCAGGGCAGCGCCCAGGGCATGGAGCGGGCGACCGCCGAC
TATATGGGGATGCTCGCCACGGTGATGAACGCGCTGGCCATGCAGGCGGCGCTGGAGGCGCTGAAGATCCATACCCGCGT
GATCTCGGCCATCCGCATGGACGAGGTGGCCGAGCCCTATATCCGCCGCCGCGCCGTCCGCCACCTGGAAAAGAAGCGCG
TCTGCATCTTCGCCGCCGGCACCGGCAACCCCTATTTCACCACCGACACCGCCGCCACGCTGCGCGCCAACGAGATGAAC
TGCGAGGCGATCTTCAAGGGCACCAAGGTCGACGGCGTCTACGACAAGGACCCGAACAAGTTCCCCGATGCCAAGCGCTA
CGACGACGTGACCTATGACGAGGTGCTGCAAAAGCACCTGGGCGTCATGGACGCCTCGGCCATCGCGCTGGCCCGCGACA
ACGACCTGCCGATCATCGTCTTCTCGCTGGACGAACCGGGCGGTTTCCGCGGAATCCTGGCGGGAAGCGGCACATATACG
CGCGTCCATGGGTAA

Upstream 100 bases:

>100_bases
GTGACGCAGGGTCATTTCGGCTCGGGTCGGCGGCGGTTGAACATGGGGCCTGTTTGCGACATTTTGCCCGGCAATGAAAC
AGCCGCAAAAAGGTGAACCC

Downstream 100 bases:

>100_bases
AATCCCCGTATAGGCTTTGCCATGCGGGCGTGGCTCGGCTAAAAGCGGCGAAAATCACAGCACAGAGGCCATGACCGAGC
ATGTCCGACGAGATCGAGAT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSESASKTPGSYSRVMLKISGEALMGDQGYGLHPPTVARIAQEVKSVHDMGIEICMVIGGGNIFRGLQGSAQGMERATAD
YMGMLATVMNALAMQAALEALKIHTRVISAIRMDEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMN
CEAIFKGTKVDGVYDKDPNKFPDAKRYDDVTYDEVLQKHLGVMDASAIALARDNDLPIIVFSLDEPGGFRGILAGSGTYT
RVHG

Sequences:

>Translated_244_residues
MSESASKTPGSYSRVMLKISGEALMGDQGYGLHPPTVARIAQEVKSVHDMGIEICMVIGGGNIFRGLQGSAQGMERATAD
YMGMLATVMNALAMQAALEALKIHTRVISAIRMDEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMN
CEAIFKGTKVDGVYDKDPNKFPDAKRYDDVTYDEVLQKHLGVMDASAIALARDNDLPIIVFSLDEPGGFRGILAGSGTYT
RVHG
>Mature_243_residues
SESASKTPGSYSRVMLKISGEALMGDQGYGLHPPTVARIAQEVKSVHDMGIEICMVIGGGNIFRGLQGSAQGMERATADY
MGMLATVMNALAMQAALEALKIHTRVISAIRMDEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMNC
EAIFKGTKVDGVYDKDPNKFPDAKRYDDVTYDEVLQKHLGVMDASAIALARDNDLPIIVFSLDEPGGFRGILAGSGTYTR
VHG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=47.6190476190476, Blast_Score=228, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PARDP (A1B965)

Other databases:

- EMBL:   CP000490
- RefSeq:   YP_917755.1
- ProteinModelPortal:   A1B965
- SMR:   A1B965
- STRING:   A1B965
- GeneID:   4582544
- GenomeReviews:   CP000490_GR
- KEGG:   pde:Pden_3993
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   A1B965
- ProtClustDB:   PRK00358
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26480; Mature: 26349

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: BINDING 60-60 BINDING 61-61 BINDING 65-65 BINDING 80-80 BINDING 168-168 BINDING 174-174 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESASKTPGSYSRVMLKISGEALMGDQGYGLHPPTVARIAQEVKSVHDMGIEICMVIGG
CCCCCCCCCCCCEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEC
GNIFRGLQGSAQGMERATADYMGMLATVMNALAMQAALEALKIHTRVISAIRMDEVAEPY
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMNCEAIFKGTKVDGVYDKDPNK
HHHHHHHHHHHCCEEEEEECCCCCEEECCCHHEEECCCCCHHHEEECCCCCCCCCCCCCC
FPDAKRYDDVTYDEVLQKHLGVMDASAIALARDNDLPIIVFSLDEPGGFRGILAGSGTYT
CCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEE
RVHG
EECC
>Mature Secondary Structure 
SESASKTPGSYSRVMLKISGEALMGDQGYGLHPPTVARIAQEVKSVHDMGIEICMVIGG
CCCCCCCCCCCEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEEC
GNIFRGLQGSAQGMERATADYMGMLATVMNALAMQAALEALKIHTRVISAIRMDEVAEPY
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMNCEAIFKGTKVDGVYDKDPNK
HHHHHHHHHHHCCEEEEEECCCCCEEECCCHHEEECCCCCHHHEEECCCCCCCCCCCCCC
FPDAKRYDDVTYDEVLQKHLGVMDASAIALARDNDLPIIVFSLDEPGGFRGILAGSGTYT
CCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEE
RVHG
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA