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The map label for this gene is iclR [H]

Identifier: 119386629

GI number: 119386629

Start: 1057325

End: 1058164

Strand: Direct

Name: iclR [H]

Synonym: Pden_3922

Alternate gene names: 119386629

Gene position: 1057325-1058164 (Clockwise)

Preceding gene: 119386619

Following gene: 119386630

Centisome position: 61.11

GC content: 70.24

Gene sequence:

>840_bases
ATGTCGGTTCAAATCCGCAAAAGGGGCCGTCCGAGGGGACGTGCCGGCGGCCTTGGCGCCGAGGATTCGGGCGGCATCCG
GGCGCTGGACCGGGCGCTGGACATCCTTGACCTGATCGCGGTCTCCAGCGGGTTGACCCTGACCGAGATCGCGCAGCGGC
TGGACATGGCGCCTTCGACCGTGCACCGGGTGCTGGTGACGCTGGCGGCGCGCGGGGTGGCGGAAAGCGACAGCCAGACG
CAGGCATGGCATGTCGGGCCGACGGCGTTCCGGCACGGCTCGGCCTTCATGCGCCGCTCGGGCCTGGTCGAGCGGGCGCG
GCCGCTTCTGCGCCGGCTGATGGAGGTGACGGGCGAGACGGCGAACCTGGGCATCCTGAACGGCGATGCGGTCCTGTTCC
TAAGCCAGGCCGAGACGCATGAGACGATCCGCGCCTTCTTTCCGCCCGGCACGCGCTCGGCGCTGCATGCCTCGGGGATC
GGCAAGGCGTTGCTGGCCCATGCCCGGCCCCTGGACCTGAAGCGGATGCTGCGCGAGATGCGGCTGGAGCGGTTCACCGA
CATGACCCTGACCGATCCCGCAGCACTGGTCGAGGATCTCGTGCAGATCCGCGCCCGCGGCTATGCGCTGGACAACGAGG
AGCGCACGCCCGGCATGCGCTGCATCGCCGCGCCGATCTTCGACCTTGCCGGCGAGGCGGCGGCGGGGATCTCGGTTTCG
GGGCCGACATTGCGCATGTCGGATGCCCGGCTTTCCGCCATGTCCGATGCGGTGATCGAGGCCGCGCGGGAGCTGTCCTT
CGGCATGGCGCCGCGCAAGGATGCCGGCGAAAGAGCCTGA

Upstream 100 bases:

>100_bases
AAAAATGACCTAAAGTGTCGTGGAATCAGATCGTTGCTCTTTTCCAAAGCCAAAGAGTGATTTTCAACAAACTCAGAAAG
TTGTCGAAAGGAAAAATTGA

Downstream 100 bases:

>100_bases
TTCGTCTAAACTTGACCAGGACATGCCCGGCTATTCAGGGGAGATTGCCGGGATTCGCGGGTGATTTGTATATTAACCGC
AGATTCACGTTCAGTTCACG

Product: regulatory proteins, IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MSVQIRKRGRPRGRAGGLGAEDSGGIRALDRALDILDLIAVSSGLTLTEIAQRLDMAPSTVHRVLVTLAARGVAESDSQT
QAWHVGPTAFRHGSAFMRRSGLVERARPLLRRLMEVTGETANLGILNGDAVLFLSQAETHETIRAFFPPGTRSALHASGI
GKALLAHARPLDLKRMLREMRLERFTDMTLTDPAALVEDLVQIRARGYALDNEERTPGMRCIAAPIFDLAGEAAAGISVS
GPTLRMSDARLSAMSDAVIEAARELSFGMAPRKDAGERA

Sequences:

>Translated_279_residues
MSVQIRKRGRPRGRAGGLGAEDSGGIRALDRALDILDLIAVSSGLTLTEIAQRLDMAPSTVHRVLVTLAARGVAESDSQT
QAWHVGPTAFRHGSAFMRRSGLVERARPLLRRLMEVTGETANLGILNGDAVLFLSQAETHETIRAFFPPGTRSALHASGI
GKALLAHARPLDLKRMLREMRLERFTDMTLTDPAALVEDLVQIRARGYALDNEERTPGMRCIAAPIFDLAGEAAAGISVS
GPTLRMSDARLSAMSDAVIEAARELSFGMAPRKDAGERA
>Mature_278_residues
SVQIRKRGRPRGRAGGLGAEDSGGIRALDRALDILDLIAVSSGLTLTEIAQRLDMAPSTVHRVLVTLAARGVAESDSQTQ
AWHVGPTAFRHGSAFMRRSGLVERARPLLRRLMEVTGETANLGILNGDAVLFLSQAETHETIRAFFPPGTRSALHASGIG
KALLAHARPLDLKRMLREMRLERFTDMTLTDPAALVEDLVQIRARGYALDNEERTPGMRCIAAPIFDLAGEAAAGISVSG
PTLRMSDARLSAMSDAVIEAARELSFGMAPRKDAGERA

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=264, Percent_Identity=37.8787878787879, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1786715, Length=264, Percent_Identity=37.1212121212121, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1788131, Length=239, Percent_Identity=33.0543933054393, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786468, Length=242, Percent_Identity=31.404958677686, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1788581, Length=245, Percent_Identity=31.8367346938775, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790752, Length=253, Percent_Identity=24.5059288537549, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789999, Length=262, Percent_Identity=25.9541984732824, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30013; Mature: 29882

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQIRKRGRPRGRAGGLGAEDSGGIRALDRALDILDLIAVSSGLTLTEIAQRLDMAPST
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHH
VHRVLVTLAARGVAESDSQTQAWHVGPTAFRHGSAFMRRSGLVERARPLLRRLMEVTGET
HHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCC
ANLGILNGDAVLFLSQAETHETIRAFFPPGTRSALHASGIGKALLAHARPLDLKRMLREM
CCEEEECCCEEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RLERFTDMTLTDPAALVEDLVQIRARGYALDNEERTPGMRCIAAPIFDLAGEAAAGISVS
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCCC
GPTLRMSDARLSAMSDAVIEAARELSFGMAPRKDAGERA
CCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SVQIRKRGRPRGRAGGLGAEDSGGIRALDRALDILDLIAVSSGLTLTEIAQRLDMAPST
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHH
VHRVLVTLAARGVAESDSQTQAWHVGPTAFRHGSAFMRRSGLVERARPLLRRLMEVTGET
HHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCC
ANLGILNGDAVLFLSQAETHETIRAFFPPGTRSALHASGIGKALLAHARPLDLKRMLREM
CCEEEECCCEEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RLERFTDMTLTDPAALVEDLVQIRARGYALDNEERTPGMRCIAAPIFDLAGEAAAGISVS
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCCC
GPTLRMSDARLSAMSDAVIEAARELSFGMAPRKDAGERA
CCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]