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The map label for this gene is thrC [H]

Identifier: 119358314

GI number: 119358314

Start: 2924140

End: 2925456

Strand: Direct

Name: thrC [H]

Synonym: Cpha266_2546

Alternate gene names: 119358314

Gene position: 2924140-2925456 (Clockwise)

Preceding gene: 119358313

Following gene: 119358315

Centisome position: 93.31

GC content: 52.09

Gene sequence:

>1317_bases
ATGATCTATTTCAGCACCAATAAATCATCCACCCCCGTTTCGATAAAAAAAGCGACCCTTGAAGGGCTTGCTCCCGACGG
CGGGCTCTATGTTCCCTCTGAAATACCGAAATTTTCAGCGCAGGAGCTTGCCCTGCTTGAAGACGCAAGCTTCTGCAATA
TCGCTCTTGCGATAGCAAAAAAATTTATCGGAGGAGCAATCCCTCCCGATCAGCTCAGCGACATGATTGAAAGCTGTTAC
CCTTTCGATACGCCGCTTGTCGAGCTCGAACAAAACACCTTTATCGAAGAACTTTTCTGTGGACCCACCCTGGCATTCAA
AGACTACGGCGCACGTTTTCTTGCCCGGCTCACCGGCTGGTTTGCCGCAGAAGACGACAGGCTGATCACCGTGCTTGTCG
CAACGTCAGGAGACACAGGCAGCGCCGTAGCCTACGGATTTCAGGGAATTGCGAACACACGGGTCGTGCTCCTCTACCCC
TCGGGAAAAGTAAGCCGACTGCAGGAACAACAGCTCACCACTGCAGGAAACAATGTCGAAGCGCTTGAAGTAAAAGGCGA
TTTCGACGACTGCCAGCGACTGGTCAAACAGGCATTTGTCGATCCCGCTCTCAAAGAGAGGCTCACCTTGACCTCGGCAA
ACTCGATCAACATATCAAGACTGATCCCCCAATCATTTTACTATGCCTGGGCGGCCATGCAACTGAAAACCGGATACGGG
TTGACCCATCCGGTATTCTCGGTGCCGAGCGGCAACTACGGAAACATCACGGCCGGCGTGCTTGCAAAGCTCATGGGTTT
CCCTGTCGGCCATTTCGTAGCCGCATCAAATGCAAACGACAGCGTCACCCGATACCTCGAAGACGGAAGATATGAACCGC
ACCCGACCATCACAACCATCTCAACGGCAATGGATGTAGGCGATCCGAGCAACTTCGCCCGCCTCAGATATCTCTACGGA
AACGATTACCGGGCCATGAAAAAAGAGATAACGGGAGTAGCCATATCGGACAAGGCGACCAGAGAAACAATTATCAAGCT
CCATAACGAGTTCGGCTATATTGCCGATCCCCATACCGCCGTCGGATTTCGCGCCCTTGAAGAGTACCGTAAAGCAAGCG
GAAACCGTTCGGCAGGAGTGGTACTCTCAACAGCTCATCCGGCAAAGTTTCTCGAAGCCATAGAGGAGACACTCAATAAA
AAAATCGCCATTCCCGATCGCCTGCAAGCCGTGCTCGAAAGAAAAAAACAGGCCACCCTCATCAACGCCAGCTATAACGA
ACTGGCCGGGTTTCTGGAACATCTCGACAAGCATTAA

Upstream 100 bases:

>100_bases
TCCTCCCTGAAACAAACCTCAAGTCAGATATGTGGGTATCACCGATCTGCAAGGAAGGCGCAAAAGTATTGTAACAAGTC
ACTCTGCCCAGTTAACCAAC

Downstream 100 bases:

>100_bases
ACCGTTGCACCGCCGCCATGAACTACAGAACCCTGCTCTTTTTTCTCATCCTGGTACCGATCATGATTATCGGGATGAGC
CTCTCGCTGCTCATCAACCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MIYFSTNKSSTPVSIKKATLEGLAPDGGLYVPSEIPKFSAQELALLEDASFCNIALAIAKKFIGGAIPPDQLSDMIESCY
PFDTPLVELEQNTFIEELFCGPTLAFKDYGARFLARLTGWFAAEDDRLITVLVATSGDTGSAVAYGFQGIANTRVVLLYP
SGKVSRLQEQQLTTAGNNVEALEVKGDFDDCQRLVKQAFVDPALKERLTLTSANSINISRLIPQSFYYAWAAMQLKTGYG
LTHPVFSVPSGNYGNITAGVLAKLMGFPVGHFVAASNANDSVTRYLEDGRYEPHPTITTISTAMDVGDPSNFARLRYLYG
NDYRAMKKEITGVAISDKATRETIIKLHNEFGYIADPHTAVGFRALEEYRKASGNRSAGVVLSTAHPAKFLEAIEETLNK
KIAIPDRLQAVLERKKQATLINASYNELAGFLEHLDKH

Sequences:

>Translated_438_residues
MIYFSTNKSSTPVSIKKATLEGLAPDGGLYVPSEIPKFSAQELALLEDASFCNIALAIAKKFIGGAIPPDQLSDMIESCY
PFDTPLVELEQNTFIEELFCGPTLAFKDYGARFLARLTGWFAAEDDRLITVLVATSGDTGSAVAYGFQGIANTRVVLLYP
SGKVSRLQEQQLTTAGNNVEALEVKGDFDDCQRLVKQAFVDPALKERLTLTSANSINISRLIPQSFYYAWAAMQLKTGYG
LTHPVFSVPSGNYGNITAGVLAKLMGFPVGHFVAASNANDSVTRYLEDGRYEPHPTITTISTAMDVGDPSNFARLRYLYG
NDYRAMKKEITGVAISDKATRETIIKLHNEFGYIADPHTAVGFRALEEYRKASGNRSAGVVLSTAHPAKFLEAIEETLNK
KIAIPDRLQAVLERKKQATLINASYNELAGFLEHLDKH
>Mature_438_residues
MIYFSTNKSSTPVSIKKATLEGLAPDGGLYVPSEIPKFSAQELALLEDASFCNIALAIAKKFIGGAIPPDQLSDMIESCY
PFDTPLVELEQNTFIEELFCGPTLAFKDYGARFLARLTGWFAAEDDRLITVLVATSGDTGSAVAYGFQGIANTRVVLLYP
SGKVSRLQEQQLTTAGNNVEALEVKGDFDDCQRLVKQAFVDPALKERLTLTSANSINISRLIPQSFYYAWAAMQLKTGYG
LTHPVFSVPSGNYGNITAGVLAKLMGFPVGHFVAASNANDSVTRYLEDGRYEPHPTITTISTAMDVGDPSNFARLRYLYG
NDYRAMKKEITGVAISDKATRETIIKLHNEFGYIADPHTAVGFRALEEYRKASGNRSAGVVLSTAHPAKFLEAIEETLNK
KIAIPDRLQAVLERKKQATLINASYNELAGFLEHLDKH

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=490, Percent_Identity=32.6530612244898, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI149193323, Length=430, Percent_Identity=29.7674418604651, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1786185, Length=408, Percent_Identity=43.1372549019608, Blast_Score=316, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6319901, Length=461, Percent_Identity=36.4425162689805, Blast_Score=249, Evalue=7e-67,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47920; Mature: 47920

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYFSTNKSSTPVSIKKATLEGLAPDGGLYVPSEIPKFSAQELALLEDASFCNIALAIAK
CEEEECCCCCCCEEEEHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
KFIGGAIPPDQLSDMIESCYPFDTPLVELEQNTFIEELFCGPTLAFKDYGARFLARLTGW
HHHCCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FAAEDDRLITVLVATSGDTGSAVAYGFQGIANTRVVLLYPSGKVSRLQEQQLTTAGNNVE
HCCCCCCEEEEEEEECCCCCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEE
ALEVKGDFDDCQRLVKQAFVDPALKERLTLTSANSINISRLIPQSFYYAWAAMQLKTGYG
EEEEECCHHHHHHHHHHHHCCHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHEEEECCCC
LTHPVFSVPSGNYGNITAGVLAKLMGFPVGHFVAASNANDSVTRYLEDGRYEPHPTITTI
CCCCEEECCCCCCCCCHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCCCCCCCCCEEEE
STAMDVGDPSNFARLRYLYGNDYRAMKKEITGVAISDKATRETIIKLHNEFGYIADPHTA
EHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCCCCCHH
VGFRALEEYRKASGNRSAGVVLSTAHPAKFLEAIEETLNKKIAIPDRLQAVLERKKQATL
HHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEE
INASYNELAGFLEHLDKH
EECCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIYFSTNKSSTPVSIKKATLEGLAPDGGLYVPSEIPKFSAQELALLEDASFCNIALAIAK
CEEEECCCCCCCEEEEHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
KFIGGAIPPDQLSDMIESCYPFDTPLVELEQNTFIEELFCGPTLAFKDYGARFLARLTGW
HHHCCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FAAEDDRLITVLVATSGDTGSAVAYGFQGIANTRVVLLYPSGKVSRLQEQQLTTAGNNVE
HCCCCCCEEEEEEEECCCCCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEE
ALEVKGDFDDCQRLVKQAFVDPALKERLTLTSANSINISRLIPQSFYYAWAAMQLKTGYG
EEEEECCHHHHHHHHHHHHCCHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHEEEECCCC
LTHPVFSVPSGNYGNITAGVLAKLMGFPVGHFVAASNANDSVTRYLEDGRYEPHPTITTI
CCCCEEECCCCCCCCCHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCCCCCCCCCEEEE
STAMDVGDPSNFARLRYLYGNDYRAMKKEITGVAISDKATRETIIKLHNEFGYIADPHTA
EHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCCCCCHH
VGFRALEEYRKASGNRSAGVVLSTAHPAKFLEAIEETLNKKIAIPDRLQAVLERKKQATL
HHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEE
INASYNELAGFLEHLDKH
EECCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]