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The map label for this gene is thrB

Identifier: 119358313

GI number: 119358313

Start: 2923151

End: 2924113

Strand: Direct

Name: thrB

Synonym: Cpha266_2545

Alternate gene names: 119358313

Gene position: 2923151-2924113 (Clockwise)

Preceding gene: 119358308

Following gene: 119358314

Centisome position: 93.28

GC content: 55.04

Gene sequence:

>963_bases
ATGAAAACAGTCAGAGGATTCGCTTCAGCAACCGTAGGAAACGTCGCCTGCGGTTTCGATGTTTTGGGATTCGCCATTAC
CGAACCGGGCGATGAGGTAATACTCACGCTCCATGAAGAACGAAAAAGCGAGTGCCCGGTCTCCATCACCGCCATTTCCG
GAGATGGAGGAGCGCTGCCTCTCGATCCGAAAAAAAACACCTCGAGCTTTGTCGTTCTGAAGTTCCTCGAATACATACGA
ACAAGCAAAGGAATTGACTTCAAAGGACACATCGACCTTGAGCTGAAAAAAAACCTTCCCCTGAGCAGCGGCATGGGCAG
CAGTGCGGCAAGTGCGGCAGCGGCGCTTGCCGCCGCAAACGAGCTCCTCGGTCAACCCTGCTCAAAAATGGAACTGGTAC
ACTTCGCCGTTGAAGGAGAACGCGTTGCCTGCGGCTCAGCCCATGCCGACAACGCAGCGCCGGCGATTCTCGGCAATTTC
GTGCTTATCCGCAGCTACGCGCCGCTTGATCTCATCACGATACCCTCGCCCGAGCATCTCTTCTGCACCCTTGTGCACCC
GCATACCGAGCTGAAAACATCCTTTGCCCGCTCAGTACTGCCAAGGTCCATACCGCTTAAAACAGCAACCCAGCAATGGG
GAAACGTCGGCGCACTTATCGCCGGACTTCTGAAATCGGATTACGATCTCATAGGCCGCGCACTCGTCGATGTAGTAGCC
GAACCCAAACGAGCGCCGCTGATTCCGGGCTTTCTCGACGTCAAACATGCAGCGATCGACTGCGGAGCGCTCGGATGCAG
CATTGCCGGTTCAGGCCCCTCCGTCTTTGCCTTTTCCTCCTCAAAAGAGACGGCAGAACGCGTCGGCCAAGCCATGCGAG
AGGCATTTCTCCTCCCTGAAACAAACCTCAAGTCAGATATGTGGGTATCACCGATCTGCAAGGAAGGCGCAAAAGTATTG
TAA

Upstream 100 bases:

>100_bases
CTTTTAGTTATTCAAATCTCTGTTTCACTTTGAACCCCATACTTTCGAATCGTCAACCCTGGCACCCTTTAACTAACGGT
GTTCTCTTGCATCAAACGGT

Downstream 100 bases:

>100_bases
CAAGTCACTCTGCCCAGTTAACCAACATGATCTATTTCAGCACCAATAAATCATCCACCCCCGTTTCGATAAAAAAAGCG
ACCCTTGAAGGGCTTGCTCC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKTVRGFASATVGNVACGFDVLGFAITEPGDEVILTLHEERKSECPVSITAISGDGGALPLDPKKNTSSFVVLKFLEYIR
TSKGIDFKGHIDLELKKNLPLSSGMGSSAASAAAALAAANELLGQPCSKMELVHFAVEGERVACGSAHADNAAPAILGNF
VLIRSYAPLDLITIPSPEHLFCTLVHPHTELKTSFARSVLPRSIPLKTATQQWGNVGALIAGLLKSDYDLIGRALVDVVA
EPKRAPLIPGFLDVKHAAIDCGALGCSIAGSGPSVFAFSSSKETAERVGQAMREAFLLPETNLKSDMWVSPICKEGAKVL

Sequences:

>Translated_320_residues
MKTVRGFASATVGNVACGFDVLGFAITEPGDEVILTLHEERKSECPVSITAISGDGGALPLDPKKNTSSFVVLKFLEYIR
TSKGIDFKGHIDLELKKNLPLSSGMGSSAASAAAALAAANELLGQPCSKMELVHFAVEGERVACGSAHADNAAPAILGNF
VLIRSYAPLDLITIPSPEHLFCTLVHPHTELKTSFARSVLPRSIPLKTATQQWGNVGALIAGLLKSDYDLIGRALVDVVA
EPKRAPLIPGFLDVKHAAIDCGALGCSIAGSGPSVFAFSSSKETAERVGQAMREAFLLPETNLKSDMWVSPICKEGAKVL
>Mature_320_residues
MKTVRGFASATVGNVACGFDVLGFAITEPGDEVILTLHEERKSECPVSITAISGDGGALPLDPKKNTSSFVVLKFLEYIR
TSKGIDFKGHIDLELKKNLPLSSGMGSSAASAAAALAAANELLGQPCSKMELVHFAVEGERVACGSAHADNAAPAILGNF
VLIRSYAPLDLITIPSPEHLFCTLVHPHTELKTSFARSVLPRSIPLKTATQQWGNVGALIAGLLKSDYDLIGRALVDVVA
EPKRAPLIPGFLDVKHAAIDCGALGCSIAGSGPSVFAFSSSKETAERVGQAMREAFLLPETNLKSDMWVSPICKEGAKVL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=317, Percent_Identity=30.2839116719243, Blast_Score=138, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_CHLPD (A1BJF6)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912957.1
- ProteinModelPortal:   A1BJF6
- STRING:   A1BJF6
- GeneID:   4569735
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2545
- NMPDR:   fig|290317.7.peg.2661
- eggNOG:   COG0083
- HOGENOM:   HBG646290
- OMA:   GSAHADN
- ProtClustDB:   PRK01212
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 33665; Mature: 33665

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVRGFASATVGNVACGFDVLGFAITEPGDEVILTLHEERKSECPVSITAISGDGGALP
CCCCHHHHHHHHCCHHHCHHHHEEEEECCCCEEEEEEEHHCCCCCCEEEEEECCCCCCCC
LDPKKNTSSFVVLKFLEYIRTSKGIDFKGHIDLELKKNLPLSSGMGSSAASAAAALAAAN
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
ELLGQPCSKMELVHFAVEGERVACGSAHADNAAPAILGNFVLIRSYAPLDLITIPSPEHL
HHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHCEEEEECCCCEEEEECCCCCCE
FCTLVHPHTELKTSFARSVLPRSIPLKTATQQWGNVGALIAGLLKSDYDLIGRALVDVVA
EEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHC
EPKRAPLIPGFLDVKHAAIDCGALGCSIAGSGPSVFAFSSSKETAERVGQAMREAFLLPE
CCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHCCCC
TNLKSDMWVSPICKEGAKVL
CCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure
MKTVRGFASATVGNVACGFDVLGFAITEPGDEVILTLHEERKSECPVSITAISGDGGALP
CCCCHHHHHHHHCCHHHCHHHHEEEEECCCCEEEEEEEHHCCCCCCEEEEEECCCCCCCC
LDPKKNTSSFVVLKFLEYIRTSKGIDFKGHIDLELKKNLPLSSGMGSSAASAAAALAAAN
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
ELLGQPCSKMELVHFAVEGERVACGSAHADNAAPAILGNFVLIRSYAPLDLITIPSPEHL
HHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHCEEEEECCCCEEEEECCCCCCE
FCTLVHPHTELKTSFARSVLPRSIPLKTATQQWGNVGALIAGLLKSDYDLIGRALVDVVA
EEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHC
EPKRAPLIPGFLDVKHAAIDCGALGCSIAGSGPSVFAFSSSKETAERVGQAMREAFLLPE
CCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEEECCCHHHHHHHHHHHHHHHCCCC
TNLKSDMWVSPICKEGAKVL
CCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA