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The map label for this gene is gcvPB

Identifier: 119358264

GI number: 119358264

Start: 2862739

End: 2864199

Strand: Direct

Name: gcvPB

Synonym: Cpha266_2496

Alternate gene names: 119358264

Gene position: 2862739-2864199 (Clockwise)

Preceding gene: 119358263

Following gene: 119358265

Centisome position: 91.35

GC content: 50.79

Gene sequence:

>1461_bases
ATGAGAGAAAAACTGATTTTTGATTTATCCCGAAACGGACGAAAAGGGTACAGCCTTTCTAAAAACGATCTCCCTGAAAC
ATCCGTCGCCGCTGTTATCCCCTCTAAATTTCTCAGAACAACTCCGGCAGAACTCCCGGAAGTGCCTGAAAGTGAAGTGG
TTCGGCATTTTATCCGGCTCTCCAATCTGAACTACCATGTCGATAAAAACATGTACCCTCTGGGAAGCTGTACCATGAAA
TACAATCCCAAGGTTAACGACTACACCTGTGATCTTCCGGGTTTCAGCACGCTCCATCCTCTTCAGCCATCCGAAACCAC
ACAGGGAGCATTGCGGTTGATGTATGAGCTCAGCTCCATGCTCAGCGAAATCGCCGGAATGGCTGCCGTAAGCCTTCAAC
CGGCAGCAGGGGCTCATGGTGAACTGACCGGTATTCTGCTCATAAAAAAATACCATGAAGCTCAGGGAAAAATGCGCAAC
AAACTGCTCGTTGTCGATTCAGCGCACGGAACAAACCCGGCCTCGGCAGCAATCGCCGGATACGAAATCATCTCCGTCCG
AAGCAATGCCGATGGGCGAACCGATCTTGAAGATCTCAAGGCCAGGCTGCAAAGCGACGTTGCTGCGCTCATGCTGACCA
ATCCAAATACTATCGGACTGTTTGAGAAAGATATTCTTGCCATTGAGCGCATGGTTCATGAAAACGGCAGCCTGCTCTAT
ATGGACGGCGCCAATATGAATGCGCTGCTCGGCATTACCCGACCTGGCGATATGGGTTTCGATGTTGTTCACTACAACCT
GCATAAAACTTTTTCAGCTCCTCACGGTGGCGGCGGACCGGGAAGTGGGCCAATAGGGGTCAGCGCAAGGCTTGCCGGCT
ATCTTCCTGTACCGGTCATAGAAAAAGAGGAAAGCGCGACAGGCACGAGCTACCGACTCAATTATGATCGTCCGGAAAGT
ATTGGCAGGATGATCTCCTTCTACGGAAACTTTTCCGTCCTCGTCAGAGCATACACCTATATCCGCATGCTGGGCCCCGA
AGGTCTGCGCAGAGTTTCTGAAAACGCCATCATCAACGCCAATTACCTGCTCAGCCTTCTTCTGGAGCGCTACGACCTAC
CCTATCCAAAATCCGTCATGCATGAATTCTGTCTGTCCGGAGACCGGCAGAAAAAAGCCAACGGAGTCAAAACACTCGAT
ATGGCCAAACGTCTGCTCGACTATGGTTTTCATGCTCCGACAATCTACTTCCCGCTTATTGTCAGCGAAGCGCTGATGAT
CGAACCAACAGAGACTGAAACAAAAGAAACACTCGAGCGTTTTGCCGAAGCCATGATTGCGATCGCCGATGAAGCGGAAA
ACAATCCGGCTCTGGTAAAATCGGCTCCCGAAACAACACCGGTCAAACGTCTCGACGAGGCCCAGGCTTCGCGGCAGTTG
AATATCTGCTGTTCCCTGTAA

Upstream 100 bases:

>100_bases
CTTCCAAAAGCCCCCGACAAGTTCAGGATAGATGCAGGAAGATGAGAACAAATCAAGAGAGGATCCATCATACCCCTCCA
CTTCATGACCACTTTATACC

Downstream 100 bases:

>100_bases
CCTGTTTTTATCAAGATCTTTTACAGGAAGTGCCAAAAATTAACCAAATGTTCACCGCAATGGATCCAGGTTGTCGACCT
ATACTGTTATACTGTATAAA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MREKLIFDLSRNGRKGYSLSKNDLPETSVAAVIPSKFLRTTPAELPEVPESEVVRHFIRLSNLNYHVDKNMYPLGSCTMK
YNPKVNDYTCDLPGFSTLHPLQPSETTQGALRLMYELSSMLSEIAGMAAVSLQPAAGAHGELTGILLIKKYHEAQGKMRN
KLLVVDSAHGTNPASAAIAGYEIISVRSNADGRTDLEDLKARLQSDVAALMLTNPNTIGLFEKDILAIERMVHENGSLLY
MDGANMNALLGITRPGDMGFDVVHYNLHKTFSAPHGGGGPGSGPIGVSARLAGYLPVPVIEKEESATGTSYRLNYDRPES
IGRMISFYGNFSVLVRAYTYIRMLGPEGLRRVSENAIINANYLLSLLLERYDLPYPKSVMHEFCLSGDRQKKANGVKTLD
MAKRLLDYGFHAPTIYFPLIVSEALMIEPTETETKETLERFAEAMIAIADEAENNPALVKSAPETTPVKRLDEAQASRQL
NICCSL

Sequences:

>Translated_486_residues
MREKLIFDLSRNGRKGYSLSKNDLPETSVAAVIPSKFLRTTPAELPEVPESEVVRHFIRLSNLNYHVDKNMYPLGSCTMK
YNPKVNDYTCDLPGFSTLHPLQPSETTQGALRLMYELSSMLSEIAGMAAVSLQPAAGAHGELTGILLIKKYHEAQGKMRN
KLLVVDSAHGTNPASAAIAGYEIISVRSNADGRTDLEDLKARLQSDVAALMLTNPNTIGLFEKDILAIERMVHENGSLLY
MDGANMNALLGITRPGDMGFDVVHYNLHKTFSAPHGGGGPGSGPIGVSARLAGYLPVPVIEKEESATGTSYRLNYDRPES
IGRMISFYGNFSVLVRAYTYIRMLGPEGLRRVSENAIINANYLLSLLLERYDLPYPKSVMHEFCLSGDRQKKANGVKTLD
MAKRLLDYGFHAPTIYFPLIVSEALMIEPTETETKETLERFAEAMIAIADEAENNPALVKSAPETTPVKRLDEAQASRQL
NICCSL
>Mature_486_residues
MREKLIFDLSRNGRKGYSLSKNDLPETSVAAVIPSKFLRTTPAELPEVPESEVVRHFIRLSNLNYHVDKNMYPLGSCTMK
YNPKVNDYTCDLPGFSTLHPLQPSETTQGALRLMYELSSMLSEIAGMAAVSLQPAAGAHGELTGILLIKKYHEAQGKMRN
KLLVVDSAHGTNPASAAIAGYEIISVRSNADGRTDLEDLKARLQSDVAALMLTNPNTIGLFEKDILAIERMVHENGSLLY
MDGANMNALLGITRPGDMGFDVVHYNLHKTFSAPHGGGGPGSGPIGVSARLAGYLPVPVIEKEESATGTSYRLNYDRPES
IGRMISFYGNFSVLVRAYTYIRMLGPEGLRRVSENAIINANYLLSLLLERYDLPYPKSVMHEFCLSGDRQKKANGVKTLD
MAKRLLDYGFHAPTIYFPLIVSEALMIEPTETETKETLERFAEAMIAIADEAENNPALVKSAPETTPVKRLDEAQASRQL
NICCSL

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=430, Percent_Identity=41.8604651162791, Blast_Score=275, Evalue=5e-74,
Organism=Escherichia coli, GI1789269, Length=418, Percent_Identity=42.1052631578947, Blast_Score=283, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17535605, Length=413, Percent_Identity=43.0992736077482, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI32564013, Length=371, Percent_Identity=43.3962264150943, Blast_Score=257, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6323843, Length=453, Percent_Identity=43.4878587196468, Blast_Score=307, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24645648, Length=446, Percent_Identity=41.9282511210762, Blast_Score=300, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_CHLPD (A1BJA7)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912908.1
- ProteinModelPortal:   A1BJA7
- STRING:   A1BJA7
- GeneID:   4568549
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2496
- NMPDR:   fig|290317.7.peg.2612
- eggNOG:   COG1003
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 53463; Mature: 53463

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREKLIFDLSRNGRKGYSLSKNDLPETSVAAVIPSKFLRTTPAELPEVPESEVVRHFIRL
CCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SNLNYHVDKNMYPLGSCTMKYNPKVNDYTCDLPGFSTLHPLQPSETTQGALRLMYELSSM
CCCCEEECCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LSEIAGMAAVSLQPAAGAHGELTGILLIKKYHEAQGKMRNKLLVVDSAHGTNPASAAIAG
HHHHHHHHEEEECCCCCCCCCEEEEEEEEHHHHHHHHHCCEEEEEECCCCCCCHHHHHCC
YEIISVRSNADGRTDLEDLKARLQSDVAALMLTNPNTIGLFEKDILAIERMVHENGSLLY
EEEEEEECCCCCCCCHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
MDGANMNALLGITRPGDMGFDVVHYNLHKTFSAPHGGGGPGSGPIGVSARLAGYLPVPVI
ECCCCCCEEEEECCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
EKEESATGTSYRLNYDRPESIGRMISFYGNFSVLVRAYTYIRMLGPEGLRRVSENAIINA
ECCCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHCCCEECH
NYLLSLLLERYDLPYPKSVMHEFCLSGDRQKKANGVKTLDMAKRLLDYGFHAPTIYFPLI
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
VSEALMIEPTETETKETLERFAEAMIAIADEAENNPALVKSAPETTPVKRLDEAQASRQL
HCCHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHCEE
NICCSL
EEEECC
>Mature Secondary Structure
MREKLIFDLSRNGRKGYSLSKNDLPETSVAAVIPSKFLRTTPAELPEVPESEVVRHFIRL
CCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SNLNYHVDKNMYPLGSCTMKYNPKVNDYTCDLPGFSTLHPLQPSETTQGALRLMYELSSM
CCCCEEECCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LSEIAGMAAVSLQPAAGAHGELTGILLIKKYHEAQGKMRNKLLVVDSAHGTNPASAAIAG
HHHHHHHHEEEECCCCCCCCCEEEEEEEEHHHHHHHHHCCEEEEEECCCCCCCHHHHHCC
YEIISVRSNADGRTDLEDLKARLQSDVAALMLTNPNTIGLFEKDILAIERMVHENGSLLY
EEEEEEECCCCCCCCHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEE
MDGANMNALLGITRPGDMGFDVVHYNLHKTFSAPHGGGGPGSGPIGVSARLAGYLPVPVI
ECCCCCCEEEEECCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
EKEESATGTSYRLNYDRPESIGRMISFYGNFSVLVRAYTYIRMLGPEGLRRVSENAIINA
ECCCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHCCCEECH
NYLLSLLLERYDLPYPKSVMHEFCLSGDRQKKANGVKTLDMAKRLLDYGFHAPTIYFPLI
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
VSEALMIEPTETETKETLERFAEAMIAIADEAENNPALVKSAPETTPVKRLDEAQASRQL
HCCHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHCEE
NICCSL
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA