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The map label for this gene is rnc [H]

Identifier: 119358263

GI number: 119358263

Start: 2861718

End: 2862539

Strand: Direct

Name: rnc [H]

Synonym: Cpha266_2495

Alternate gene names: 119358263

Gene position: 2861718-2862539 (Clockwise)

Preceding gene: 119358262

Following gene: 119358264

Centisome position: 91.31

GC content: 48.18

Gene sequence:

>822_bases
ATGGAGCAATTCTGGCAAAAACTGACCTTGTTTGCCTTCAAGCGTTCTGATACTAGCGGGGAGTCCTGTATAAAAAAAAT
CGATCAGGAAGATTCGGTTATTACCATCACTCCCGAAACTGCCGATTTTCTTGAAACCTGTGCCGGCAGCAAGGGCGGAA
ACCTCTTTCTCTACCAGACAGCCCTCACCCATCGTTCGGTAGTCCATGACTACGAACATGCAACTCCTGCAGTTCAGTCA
AATCAGCGGCTTGAATTTCTTGGTGACGCCGTCCTCGGTCTGTTGATTTCCGACTATCTTTTCAGAAATTTTCCCGACAG
CCGGGAAGGAGAGCTTTCAAGCAACCGGGCGAAAATAGTCAATCGAAAATCTCTTGCAGGCTTTGCCCGGAGCATCGGGC
TCGGCAAACACCTTATTATCGGAGAATCTGCCGACAAGAACAAGATCAGATCCAGCGAATCAGCTCTCGCCGATGCATTT
GAATCACTTATCGGAGCGATCTATCTCGACAAAGGCCTTGATGCCGCATTTGCCTTCGTCATGAAACAGATTACGGAACA
TGCGGATTTCAGAAGCATCGTTGCCGCAGAACATAATTATAAAAGTCAGTTGATCGAATACACACAGTCACACCATCTTC
CGCCACCAGTCTATAAGGTTATCGCTGAAGAAGGTGCTGAACATGAAAAAACATTTACCATAGAGGTCTCTGTGGACGAC
CGGCAGATGGGACAGGGAACGGCCCCCAGAAAAAAAGATGCCGAACAACTTGCTGCAAGAGAGGCCATTGATCGAATCTT
GACAGACGGTCACACCCCCTGA

Upstream 100 bases:

>100_bases
ACAATCGAATACGCGTTGAACAACGGATTCGGTTTTGGCGGCCATAATGCCTCACTCATATTCAGAAACGGCTCATCGAT
TTCATAACAACTCCTTCCCC

Downstream 100 bases:

>100_bases
ACAAGGCTGAAAAAAAGCAGACCATCTTTTTTTATCGATTATCTTGAGCATTTCTTTTCCGTCCTCTATATTACTGTTCT
TAAGAGAAACCGCTCTACCC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MEQFWQKLTLFAFKRSDTSGESCIKKIDQEDSVITITPETADFLETCAGSKGGNLFLYQTALTHRSVVHDYEHATPAVQS
NQRLEFLGDAVLGLLISDYLFRNFPDSREGELSSNRAKIVNRKSLAGFARSIGLGKHLIIGESADKNKIRSSESALADAF
ESLIGAIYLDKGLDAAFAFVMKQITEHADFRSIVAAEHNYKSQLIEYTQSHHLPPPVYKVIAEEGAEHEKTFTIEVSVDD
RQMGQGTAPRKKDAEQLAAREAIDRILTDGHTP

Sequences:

>Translated_273_residues
MEQFWQKLTLFAFKRSDTSGESCIKKIDQEDSVITITPETADFLETCAGSKGGNLFLYQTALTHRSVVHDYEHATPAVQS
NQRLEFLGDAVLGLLISDYLFRNFPDSREGELSSNRAKIVNRKSLAGFARSIGLGKHLIIGESADKNKIRSSESALADAF
ESLIGAIYLDKGLDAAFAFVMKQITEHADFRSIVAAEHNYKSQLIEYTQSHHLPPPVYKVIAEEGAEHEKTFTIEVSVDD
RQMGQGTAPRKKDAEQLAAREAIDRILTDGHTP
>Mature_273_residues
MEQFWQKLTLFAFKRSDTSGESCIKKIDQEDSVITITPETADFLETCAGSKGGNLFLYQTALTHRSVVHDYEHATPAVQS
NQRLEFLGDAVLGLLISDYLFRNFPDSREGELSSNRAKIVNRKSLAGFARSIGLGKHLIIGESADKNKIRSSESALADAF
ESLIGAIYLDKGLDAAFAFVMKQITEHADFRSIVAAEHNYKSQLIEYTQSHHLPPPVYKVIAEEGAEHEKTFTIEVSVDD
RQMGQGTAPRKKDAEQLAAREAIDRILTDGHTP

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=221, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI155030236, Length=221, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1788920, Length=198, Percent_Identity=35.3535353535354, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17506883, Length=274, Percent_Identity=27.7372262773723, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193202651, Length=274, Percent_Identity=27.7372262773723, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137682, Length=267, Percent_Identity=28.4644194756554, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 30318; Mature: 30318

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQFWQKLTLFAFKRSDTSGESCIKKIDQEDSVITITPETADFLETCAGSKGGNLFLYQT
CHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCEEEEEH
ALTHRSVVHDYEHATPAVQSNQRLEFLGDAVLGLLISDYLFRNFPDSREGELSSNRAKIV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
NRKSLAGFARSIGLGKHLIIGESADKNKIRSSESALADAFESLIGAIYLDKGLDAAFAFV
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MKQITEHADFRSIVAAEHNYKSQLIEYTQSHHLPPPVYKVIAEEGAEHEKTFTIEVSVDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEEEECH
RQMGQGTAPRKKDAEQLAAREAIDRILTDGHTP
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEQFWQKLTLFAFKRSDTSGESCIKKIDQEDSVITITPETADFLETCAGSKGGNLFLYQT
CHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCEEEEEH
ALTHRSVVHDYEHATPAVQSNQRLEFLGDAVLGLLISDYLFRNFPDSREGELSSNRAKIV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
NRKSLAGFARSIGLGKHLIIGESADKNKIRSSESALADAFESLIGAIYLDKGLDAAFAFV
HHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MKQITEHADFRSIVAAEHNYKSQLIEYTQSHHLPPPVYKVIAEEGAEHEKTFTIEVSVDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEEEECH
RQMGQGTAPRKKDAEQLAAREAIDRILTDGHTP
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA