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The map label for this gene is cysK [H]

Identifier: 119358132

GI number: 119358132

Start: 2749391

End: 2750323

Strand: Reverse

Name: cysK [H]

Synonym: Cpha266_2364

Alternate gene names: 119358132

Gene position: 2750323-2749391 (Counterclockwise)

Preceding gene: 119358133

Following gene: 119358131

Centisome position: 87.76

GC content: 49.62

Gene sequence:

>933_bases
ATGAAAATATATGATTCCATAACCAAAACTGTTGGAAATACGCCTCTCGTGCGGCTGCAGAGACTCAAGGAGCCGCGCGG
AGCGGATATTCTGCTGAAACTCGAATCATTCAATCCTCTTTCAAGTGTAAAGGACAGGATCGGCATAGCCATGATCGAGG
ATGCTGAAAAAGCCGGCAGGATTACAAAAAACACGACAATCATCGAGCCAACAAGCGGTAATACCGGTATTGCGCTTGCT
TTTGCCTGCGCGGCAAAAGGGTACGATCTCATGCTCGTCATGCCCGATACGATGAGCATTGAGCGTCGTCGGCTGATGCA
GATGCTTGGAGCAAAGCTTGTGCTTACCGAAGGAGCCGGCGGCATGAAGCTTGCCATATCGGAGGCGGAGCGTCTTGCAG
CCGCTGTTCCCGATAGTCTCATTCTGCAACAATTTCAGAATCCGGCCAATCCGGCGATTCATCGTTCCACCACGGCAATG
GAAATCTGGAATGATACGGACGGCAAGGTTGATGTTTTTATTGCAGGCGTTGGTACCGGAGGAACGATAACCGGAGTGGG
CGAAGTGCTCAAGCAACATCGTCCCGACATCAGGGTTATTGCTGTGGAACCGGTTGATTCTCCTGTGCTTTCGGGTGGTC
AGTCAGGTCCTCATAAAATTCAGGGAATCGGAGCGGGTTTTGTCCCTTCCATTCTCAATCGCGACGTGATTGACGAAATT
ATTACCGTCAGTAACGACGATGCAGGTCGCACAGCTCGACTTCTTGCCTCTTCCGAAGGGATTCTTTGCGGAATATCTTC
AGGAGCAGCACTTTTTGCTGCGCTTCAGGTAGGAAAAAAAACTGAAATGGAAGGAAAAACCATTGTTGCTCTTTTACCGG
ATAGCGGAGAACGTTATGTTTCCACTTGGTTATTCGAAGAGCCGCAAGTATAG

Upstream 100 bases:

>100_bases
GTGTATGGAACAGGGTGATAGAGGCTATGACGTGTTGTTCCAAAAAAAGTTTATTTGCATTATTCGTTTTTCATAACCAG
AAAATTCAGGTCGAGGAAGC

Downstream 100 bases:

>100_bases
TATCTTGCAGAGCAGAAAACGGTTTAGGCCGCATTCAAGAATTTTTTCAAAGAGAGTTAAGCGCCATGAAGGTTTATTTT
GATAACAATGCCACAACGCC

Product: cysteine synthase

Products: NA

Alternate protein names: OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKIYDSITKTVGNTPLVRLQRLKEPRGADILLKLESFNPLSSVKDRIGIAMIEDAEKAGRITKNTTIIEPTSGNTGIALA
FACAAKGYDLMLVMPDTMSIERRRLMQMLGAKLVLTEGAGGMKLAISEAERLAAAVPDSLILQQFQNPANPAIHRSTTAM
EIWNDTDGKVDVFIAGVGTGGTITGVGEVLKQHRPDIRVIAVEPVDSPVLSGGQSGPHKIQGIGAGFVPSILNRDVIDEI
ITVSNDDAGRTARLLASSEGILCGISSGAALFAALQVGKKTEMEGKTIVALLPDSGERYVSTWLFEEPQV

Sequences:

>Translated_310_residues
MKIYDSITKTVGNTPLVRLQRLKEPRGADILLKLESFNPLSSVKDRIGIAMIEDAEKAGRITKNTTIIEPTSGNTGIALA
FACAAKGYDLMLVMPDTMSIERRRLMQMLGAKLVLTEGAGGMKLAISEAERLAAAVPDSLILQQFQNPANPAIHRSTTAM
EIWNDTDGKVDVFIAGVGTGGTITGVGEVLKQHRPDIRVIAVEPVDSPVLSGGQSGPHKIQGIGAGFVPSILNRDVIDEI
ITVSNDDAGRTARLLASSEGILCGISSGAALFAALQVGKKTEMEGKTIVALLPDSGERYVSTWLFEEPQV
>Mature_310_residues
MKIYDSITKTVGNTPLVRLQRLKEPRGADILLKLESFNPLSSVKDRIGIAMIEDAEKAGRITKNTTIIEPTSGNTGIALA
FACAAKGYDLMLVMPDTMSIERRRLMQMLGAKLVLTEGAGGMKLAISEAERLAAAVPDSLILQQFQNPANPAIHRSTTAM
EIWNDTDGKVDVFIAGVGTGGTITGVGEVLKQHRPDIRVIAVEPVDSPVLSGGQSGPHKIQGIGAGFVPSILNRDVIDEI
ITVSNDDAGRTARLLASSEGILCGISSGAALFAALQVGKKTEMEGKTIVALLPDSGERYVSTWLFEEPQV

Specific function: Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=40.8945686900958, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=40.8945686900958, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=40.8945686900958, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI11345492, Length=304, Percent_Identity=25.3289473684211, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=56.2300319488818, Blast_Score=306, Evalue=8e-85,
Organism=Escherichia coli, GI2367138, Length=306, Percent_Identity=41.1764705882353, Blast_Score=231, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=50, Blast_Score=289, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=47.8260869565217, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI115535073, Length=298, Percent_Identity=51.3422818791946, Blast_Score=273, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI32566674, Length=292, Percent_Identity=48.2876712328767, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=47.0588235294118, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=47.196261682243, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=37.5394321766561, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=36.1904761904762, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=44.8275862068966, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71996324, Length=338, Percent_Identity=25.7396449704142, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=316, Percent_Identity=36.7088607594937, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321449, Length=337, Percent_Identity=32.6409495548961, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24643623, Length=326, Percent_Identity=37.1165644171779, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129101, Length=326, Percent_Identity=37.1165644171779, Blast_Score=191, Evalue=4e-49,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32962; Mature: 32962

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYDSITKTVGNTPLVRLQRLKEPRGADILLKLESFNPLSSVKDRIGIAMIEDAEKAGR
CCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHCEEEEECHHHCCC
ITKNTTIIEPTSGNTGIALAFACAAKGYDLMLVMPDTMSIERRRLMQMLGAKLVLTEGAG
EECCCEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEECCC
GMKLAISEAERLAAAVPDSLILQQFQNPANPAIHRSTTAMEIWNDTDGKVDVFIAGVGTG
CEEEEHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEECCC
GTITGVGEVLKQHRPDIRVIAVEPVDSPVLSGGQSGPHKIQGIGAGFVPSILNRDVIDEI
CCCHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCEEEECCCCHHHHHHCHHHHHHH
ITVSNDDAGRTARLLASSEGILCGISSGAALFAALQVGKKTEMEGKTIVALLPDSGERYV
HCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEE
STWLFEEPQV
HEEEECCCCC
>Mature Secondary Structure
MKIYDSITKTVGNTPLVRLQRLKEPRGADILLKLESFNPLSSVKDRIGIAMIEDAEKAGR
CCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHCEEEEECHHHCCC
ITKNTTIIEPTSGNTGIALAFACAAKGYDLMLVMPDTMSIERRRLMQMLGAKLVLTEGAG
EECCCEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEECCC
GMKLAISEAERLAAAVPDSLILQQFQNPANPAIHRSTTAMEIWNDTDGKVDVFIAGVGTG
CEEEEHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEECCC
GTITGVGEVLKQHRPDIRVIAVEPVDSPVLSGGQSGPHKIQGIGAGFVPSILNRDVIDEI
CCCHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCEEEECCCCHHHHHHCHHHHHHH
ITVSNDDAGRTARLLASSEGILCGISSGAALFAALQVGKKTEMEGKTIVALLPDSGERYV
HCCCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEE
STWLFEEPQV
HEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]