Click here to switch to the map view.

The map label for this gene is iscS [H]

Identifier: 119358131

GI number: 119358131

Start: 2748129

End: 2749325

Strand: Reverse

Name: iscS [H]

Synonym: Cpha266_2363

Alternate gene names: 119358131

Gene position: 2749325-2748129 (Counterclockwise)

Preceding gene: 119358132

Following gene: 119358130

Centisome position: 87.73

GC content: 49.21

Gene sequence:

>1197_bases
ATGAAGGTTTATTTTGATAACAATGCCACAACGCCGCTTCATCCTGAAGTAAAAAAAGAGCTGACGGCTGCAATGGAAAT
GTTTGGCAATCCGTCGAGCATGCACTCCTATGGTCGTGAAGCGAAGGCAAATGTCGAGGATGCCAGAATTCGGGTTGCCA
GGTTTATCGGGGCTCATGAAAACGAGATCGTTTTTGTCGGAAGCGGTTCAGAGGCAAACAATACCGTGCTTTCGCTTTTT
GTCTGCTCATCCAGGCAGTGTATTCCCGGACTGAAAATGCGCAACACCATTATTACGACGAAAATCGAGCATCCCTGCGT
GCTTGAGACATCCGATTGTCTTGCGCATCGAGGGGTGAAGGTGAAGTATCTTGATGTTGATCAGTACGGTAAAATTTATC
TCGATCAGCTTGACTCGATGCTCGACGACAGTGTCGGTCTGGTTTCAGTCATGATGGCAAATAATGAAATTGGTACCATG
CAGGATATTGCGGCCATTACCGAAATGGTGCATGAACGCGGCGCGTATATGCATACCGATGCCGTTCAGGCGGTTGGCAA
AGTTCCTGTTGACGTCGGGGCGTTTGGTGTCGATTTTCTTACTATTTCAGGGCATAAAATATATGGGCCGAAAGGAGTCG
GTGCTCTTTATGTGAAAAACGGCATACCATACTGCCCGTTTATCAGAGGGGGCCATCAGGAGAAGGGCAGGCGAGCAGGA
ACCGAGAACACTCTCGGCATTATGGGTCTTGCCAGGGCTGTTGATATGCGAGTGCTTGAAATGGACGATGAACACCAGAG
GCTGCTTGTTCTTAAGCAGGCGTTGCGAAAGGGAATAGAGGAGCGTATTGATGATATTTATTTCAACGGTCATCCAACGG
ATTCACTTGCCGGCACGCTCAACGTCTCGTTTCCCGGAGCAGAGGGTGAAGCTATTCTTCTCTATCTTGATCTTGAGGGG
ATAGCGGTATCAACCGGGTCAGCCTGTGCATCAGGCTCACTTGATCCCTCGCATGTGCTGCTTGCGACCGGTGTTGACGC
CGAAAGAGCGCACGGATCCATCCGGCTGAGTCTCGGAAGAGAGAGCACGATGGAAGAGGTTGATTATGTGCTTGATGTTT
TACCACGAACTATCGAACGAATCAGAAACATGTCTACGGCATACATAAAAGGAGGACTCCATGCTACAAGCAGGTGA

Upstream 100 bases:

>100_bases
TTTCCACTTGGTTATTCGAAGAGCCGCAAGTATAGTATCTTGCAGAGCAGAAAACGGTTTAGGCCGCATTCAAGAATTTT
TTCAAAGAGAGTTAAGCGCC

Downstream 100 bases:

>100_bases
ATGGGCATATACGGAAAAACTGAAGGAACACTTCATGAGCCCGAAAAATATATTACAGGGTGAGAATACCGACGAATTTG
ACGGTGTCGGAATGGAGGGT

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKVYFDNNATTPLHPEVKKELTAAMEMFGNPSSMHSYGREAKANVEDARIRVARFIGAHENEIVFVGSGSEANNTVLSLF
VCSSRQCIPGLKMRNTIITTKIEHPCVLETSDCLAHRGVKVKYLDVDQYGKIYLDQLDSMLDDSVGLVSVMMANNEIGTM
QDIAAITEMVHERGAYMHTDAVQAVGKVPVDVGAFGVDFLTISGHKIYGPKGVGALYVKNGIPYCPFIRGGHQEKGRRAG
TENTLGIMGLARAVDMRVLEMDDEHQRLLVLKQALRKGIEERIDDIYFNGHPTDSLAGTLNVSFPGAEGEAILLYLDLEG
IAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRLSLGRESTMEEVDYVLDVLPRTIERIRNMSTAYIKGGLHATSR

Sequences:

>Translated_398_residues
MKVYFDNNATTPLHPEVKKELTAAMEMFGNPSSMHSYGREAKANVEDARIRVARFIGAHENEIVFVGSGSEANNTVLSLF
VCSSRQCIPGLKMRNTIITTKIEHPCVLETSDCLAHRGVKVKYLDVDQYGKIYLDQLDSMLDDSVGLVSVMMANNEIGTM
QDIAAITEMVHERGAYMHTDAVQAVGKVPVDVGAFGVDFLTISGHKIYGPKGVGALYVKNGIPYCPFIRGGHQEKGRRAG
TENTLGIMGLARAVDMRVLEMDDEHQRLLVLKQALRKGIEERIDDIYFNGHPTDSLAGTLNVSFPGAEGEAILLYLDLEG
IAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRLSLGRESTMEEVDYVLDVLPRTIERIRNMSTAYIKGGLHATSR
>Mature_398_residues
MKVYFDNNATTPLHPEVKKELTAAMEMFGNPSSMHSYGREAKANVEDARIRVARFIGAHENEIVFVGSGSEANNTVLSLF
VCSSRQCIPGLKMRNTIITTKIEHPCVLETSDCLAHRGVKVKYLDVDQYGKIYLDQLDSMLDDSVGLVSVMMANNEIGTM
QDIAAITEMVHERGAYMHTDAVQAVGKVPVDVGAFGVDFLTISGHKIYGPKGVGALYVKNGIPYCPFIRGGHQEKGRRAG
TENTLGIMGLARAVDMRVLEMDDEHQRLLVLKQALRKGIEERIDDIYFNGHPTDSLAGTLNVSFPGAEGEAILLYLDLEG
IAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRLSLGRESTMEEVDYVLDVLPRTIERIRNMSTAYIKGGLHATSR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=394, Percent_Identity=41.3705583756345, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI156713448, Length=422, Percent_Identity=34.8341232227488, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI48994898, Length=398, Percent_Identity=41.2060301507538, Blast_Score=280, Evalue=8e-77,
Organism=Escherichia coli, GI1787970, Length=370, Percent_Identity=28.9189189189189, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1789175, Length=406, Percent_Identity=26.3546798029557, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=394, Percent_Identity=40.8629441624365, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17533177, Length=328, Percent_Identity=29.8780487804878, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319831, Length=392, Percent_Identity=40.5612244897959, Blast_Score=268, Evalue=8e-73,
Organism=Drosophila melanogaster, GI20129463, Length=390, Percent_Identity=42.0512820512821, Blast_Score=283, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43343; Mature: 43343

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYFDNNATTPLHPEVKKELTAAMEMFGNPSSMHSYGREAKANVEDARIRVARFIGAHE
CEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHCCCCHHHHHHHHHHHCCCC
NEIVFVGSGSEANNTVLSLFVCSSRQCIPGLKMRNTIITTKIEHPCVLETSDCLAHRGVK
CCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEECHHHHHHCCCE
VKYLDVDQYGKIYLDQLDSMLDDSVGLVSVMMANNEIGTMQDIAAITEMVHERGAYMHTD
EEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEHH
AVQAVGKVPVDVGAFGVDFLTISGHKIYGPKGVGALYVKNGIPYCPFIRGGHQEKGRRAG
HHHHHCCCCCCCCCCCEEEEEECCCEEECCCCCCEEEEECCCCCCCCCCCCCHHHHCCCC
TENTLGIMGLARAVDMRVLEMDDEHQRLLVLKQALRKGIEERIDDIYFNGHPTDSLAGTL
CCCCHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEE
NVSFPGAEGEAILLYLDLEGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRLSLGR
EEECCCCCCCEEEEEEEECCEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEEECC
ESTMEEVDYVLDVLPRTIERIRNMSTAYIKGGLHATSR
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
>Mature Secondary Structure
MKVYFDNNATTPLHPEVKKELTAAMEMFGNPSSMHSYGREAKANVEDARIRVARFIGAHE
CEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHCCCCHHHHHHHHHHHCCCC
NEIVFVGSGSEANNTVLSLFVCSSRQCIPGLKMRNTIITTKIEHPCVLETSDCLAHRGVK
CCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEECHHHHHHCCCE
VKYLDVDQYGKIYLDQLDSMLDDSVGLVSVMMANNEIGTMQDIAAITEMVHERGAYMHTD
EEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEHH
AVQAVGKVPVDVGAFGVDFLTISGHKIYGPKGVGALYVKNGIPYCPFIRGGHQEKGRRAG
HHHHHCCCCCCCCCCCEEEEEECCCEEECCCCCCEEEEECCCCCCCCCCCCCHHHHCCCC
TENTLGIMGLARAVDMRVLEMDDEHQRLLVLKQALRKGIEERIDDIYFNGHPTDSLAGTL
CCCCHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEE
NVSFPGAEGEAILLYLDLEGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRLSLGR
EEECCCCCCCEEEEEEEECCEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEEECC
ESTMEEVDYVLDVLPRTIERIRNMSTAYIKGGLHATSR
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA