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The map label for this gene is zwf [H]

Identifier: 119357935

GI number: 119357935

Start: 2488346

End: 2489785

Strand: Reverse

Name: zwf [H]

Synonym: Cpha266_2150

Alternate gene names: 119357935

Gene position: 2489785-2488346 (Counterclockwise)

Preceding gene: 119357936

Following gene: 119357932

Centisome position: 79.45

GC content: 48.4

Gene sequence:

>1440_bases
ATGCATACAAGGCTTGATAATTTTACGCTCATTATTTTCGGGGCCAGCAGCGATCTTGCCGCACGTAAATTGTTTCCATC
GGTTTACGAACTTGCCGCATGGGGACATCTTCCTGACCGGTATCGTGTTATCGGCGTTGGTCGATCGAATCTCTCCGATG
AGGATTTTCGCGGGTTGGTGCATGAAAAAATAACCCTCTTTGCCTCAAATCCTCTTCAGGATGGAGAGCAGTACAAGGCG
TTTCTCTCCCGTCTGTTTTATGTTCAGTTGGATTTTGACGATAGCGCAAGCTACCAGGCTCTTTACCGGAAAATTATGGA
GTCCGGGGATGAGGGGATGAGCGGCCACCTGCTGTTTTATCTCTCAACGCCTCCTCTGCTTGCGCCTGTTATTGTTAAAA
ACCTTGCTGCGGCAGATCTCGGCGGCAAGGTTTTGCCTGCAGGGGATTGGCGAAAAATCATTGTTGAAAAGCCTTACGGG
CAGAACCTTCAGACGGCGCTTGAGCTTAACCGGATCATCGGCGAGGGATTCCGTGAAGATCAGATTTTTCGCATCGATCA
TTATCTTGGAAAAGAGCCGGTACAGAATATTATGGTCTTTAGGTTTTCCAATGGTATTTTTGAACCGCTGTGGAATCGTC
ATTTCATTCAGAGTGTCGAGATTACGATAGCCGAGGATTTCGGGATCAGAAGCCGGGGCGCCTTTTATGAACAGGCCGGA
CTGGTTCGGGATATTATCCAGAATCATGGCCTTCAGTTGCTTGCGGCTATTGCCATGGAACCTCCTGTTGATCTTTCGTC
CGCATCGGTAAGAGACGAAAAATCAAAGCTGCTTCGTTCAATCCGCCCCTTTACAAGAGAATCCGCAATCGCTTCGGTGG
TTCTTGGCCAGTATGACGGATATCGTTCAGAACAAAATGTTGCTCGCGATTCGACGGTGGAAACGTTTGCGGCAATCAGG
TTCTTTATCGACAACTGGCGCTGGAAGGGAGTTCCTTTTTATATGAAAGCAGGCAAGAATCTTGCTGAAACGGTTACAGA
AATGGTGATTACGTTCAAGTGCCCACCGCAGAATTTTTTCGGGCCATCCGAAAGTTGCGGCATTACGGCAAATCAGGTAA
TTTTGCGTATTCAGCCTGAAGAGACCATTGCGATCCGCTTTGGCGCAAAACGACCGGGAGAAGAGATGATTACGGATCCC
GTCTATATGACCTTTGACTATAAAAAATCATTTACCGAAAAAGGGGTGACCCCCTATCATCGATTACTGCTGGATGCCTT
GACTGGCGATCAGATGAATTTTATCCGACAGGATAGTGTGGAGAGTTCATGGGCTCTTGTCGATGCCCTGAGGGACGCTT
TCCATGGCGCTGAGCCAGCTCCCTATGCTATACACTCATGGGGCCCTGAAGATGCGCTCAGAATATACCGGGAAGCGTAA

Upstream 100 bases:

>100_bases
ATCCCGTAGCGAAGAGAATTTTTCTGACAAGGTTGTTGCCGCACTGCGTCATGAATTCGGTGGTCATGGATTCAAGGCTA
ATCAATAAGAGGTGATGGCA

Downstream 100 bases:

>100_bases
ACCAGAAGAGGTTTCCGTTGACGGGTTGCACTCTGCCTGCAGGTAACCCGTTATCCTCTCGGGATATGATCCGTTCTGCC
ACGGCCTTTTTTTTCATTCC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MHTRLDNFTLIIFGASSDLAARKLFPSVYELAAWGHLPDRYRVIGVGRSNLSDEDFRGLVHEKITLFASNPLQDGEQYKA
FLSRLFYVQLDFDDSASYQALYRKIMESGDEGMSGHLLFYLSTPPLLAPVIVKNLAAADLGGKVLPAGDWRKIIVEKPYG
QNLQTALELNRIIGEGFREDQIFRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRHFIQSVEITIAEDFGIRSRGAFYEQAG
LVRDIIQNHGLQLLAAIAMEPPVDLSSASVRDEKSKLLRSIRPFTRESAIASVVLGQYDGYRSEQNVARDSTVETFAAIR
FFIDNWRWKGVPFYMKAGKNLAETVTEMVITFKCPPQNFFGPSESCGITANQVILRIQPEETIAIRFGAKRPGEEMITDP
VYMTFDYKKSFTEKGVTPYHRLLLDALTGDQMNFIRQDSVESSWALVDALRDAFHGAEPAPYAIHSWGPEDALRIYREA

Sequences:

>Translated_479_residues
MHTRLDNFTLIIFGASSDLAARKLFPSVYELAAWGHLPDRYRVIGVGRSNLSDEDFRGLVHEKITLFASNPLQDGEQYKA
FLSRLFYVQLDFDDSASYQALYRKIMESGDEGMSGHLLFYLSTPPLLAPVIVKNLAAADLGGKVLPAGDWRKIIVEKPYG
QNLQTALELNRIIGEGFREDQIFRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRHFIQSVEITIAEDFGIRSRGAFYEQAG
LVRDIIQNHGLQLLAAIAMEPPVDLSSASVRDEKSKLLRSIRPFTRESAIASVVLGQYDGYRSEQNVARDSTVETFAAIR
FFIDNWRWKGVPFYMKAGKNLAETVTEMVITFKCPPQNFFGPSESCGITANQVILRIQPEETIAIRFGAKRPGEEMITDP
VYMTFDYKKSFTEKGVTPYHRLLLDALTGDQMNFIRQDSVESSWALVDALRDAFHGAEPAPYAIHSWGPEDALRIYREA
>Mature_479_residues
MHTRLDNFTLIIFGASSDLAARKLFPSVYELAAWGHLPDRYRVIGVGRSNLSDEDFRGLVHEKITLFASNPLQDGEQYKA
FLSRLFYVQLDFDDSASYQALYRKIMESGDEGMSGHLLFYLSTPPLLAPVIVKNLAAADLGGKVLPAGDWRKIIVEKPYG
QNLQTALELNRIIGEGFREDQIFRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRHFIQSVEITIAEDFGIRSRGAFYEQAG
LVRDIIQNHGLQLLAAIAMEPPVDLSSASVRDEKSKLLRSIRPFTRESAIASVVLGQYDGYRSEQNVARDSTVETFAAIR
FFIDNWRWKGVPFYMKAGKNLAETVTEMVITFKCPPQNFFGPSESCGITANQVILRIQPEETIAIRFGAKRPGEEMITDP
VYMTFDYKKSFTEKGVTPYHRLLLDALTGDQMNFIRQDSVESSWALVDALRDAFHGAEPAPYAIHSWGPEDALRIYREA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=37.2670807453416, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=37.2670807453416, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI52145310, Length=368, Percent_Identity=33.1521739130435, Blast_Score=169, Evalue=7e-42,
Organism=Escherichia coli, GI1788158, Length=475, Percent_Identity=38.5263157894737, Blast_Score=329, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=33.4020618556701, Blast_Score=290, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6324088, Length=479, Percent_Identity=34.0292275574113, Blast_Score=276, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24643350, Length=494, Percent_Identity=32.9959514170041, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24643352, Length=490, Percent_Identity=32.0408163265306, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI221513548, Length=490, Percent_Identity=28.9795918367347, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54247; Mature: 54247

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTRLDNFTLIIFGASSDLAARKLFPSVYELAAWGHLPDRYRVIGVGRSNLSDEDFRGLV
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHH
HEKITLFASNPLQDGEQYKAFLSRLFYVQLDFDDSASYQALYRKIMESGDEGMSGHLLFY
HHHEEEEECCCCCCHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEE
LSTPPLLAPVIVKNLAAADLGGKVLPAGDWRKIIVEKPYGQNLQTALELNRIIGEGFRED
ECCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
QIFRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRHFIQSVEITIAEDFGIRSRGAFYEQAG
CEEEEHHHCCCCCHHHEEEEEECCCCHHHHHCCHHHEEEEEEEECCCCCCCCCCHHHHHH
LVRDIIQNHGLQLLAAIAMEPPVDLSSASVRDEKSKLLRSIRPFTRESAIASVVLGQYDG
HHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
YRSEQNVARDSTVETFAAIRFFIDNWRWKGVPFYMKAGKNLAETVTEMVITFKCPPQNFF
CCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHCCCHHHHHHHHHEEEEECCCCCCC
GPSESCGITANQVILRIQPEETIAIRFGAKRPGEEMITDPVYMTFDYKKSFTEKGVTPYH
CCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHCCCCEEEEEEHHHHHHHCCCCHHH
RLLLDALTGDQMNFIRQDSVESSWALVDALRDAFHGAEPAPYAIHSWGPEDALRIYREA
HHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MHTRLDNFTLIIFGASSDLAARKLFPSVYELAAWGHLPDRYRVIGVGRSNLSDEDFRGLV
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHH
HEKITLFASNPLQDGEQYKAFLSRLFYVQLDFDDSASYQALYRKIMESGDEGMSGHLLFY
HHHEEEEECCCCCCHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEE
LSTPPLLAPVIVKNLAAADLGGKVLPAGDWRKIIVEKPYGQNLQTALELNRIIGEGFRED
ECCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
QIFRIDHYLGKEPVQNIMVFRFSNGIFEPLWNRHFIQSVEITIAEDFGIRSRGAFYEQAG
CEEEEHHHCCCCCHHHEEEEEECCCCHHHHHCCHHHEEEEEEEECCCCCCCCCCHHHHHH
LVRDIIQNHGLQLLAAIAMEPPVDLSSASVRDEKSKLLRSIRPFTRESAIASVVLGQYDG
HHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
YRSEQNVARDSTVETFAAIRFFIDNWRWKGVPFYMKAGKNLAETVTEMVITFKCPPQNFF
CCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHCCCHHHHHHHHHEEEEECCCCCCC
GPSESCGITANQVILRIQPEETIAIRFGAKRPGEEMITDPVYMTFDYKKSFTEKGVTPYH
CCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHCCCCEEEEEEHHHHHHHCCCCHHH
RLLLDALTGDQMNFIRQDSVESSWALVDALRDAFHGAEPAPYAIHSWGPEDALRIYREA
HHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]