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The map label for this gene is yqeC [H]

Identifier: 119357936

GI number: 119357936

Start: 2489798

End: 2490697

Strand: Reverse

Name: yqeC [H]

Synonym: Cpha266_2151

Alternate gene names: 119357936

Gene position: 2490697-2489798 (Counterclockwise)

Preceding gene: 119357937

Following gene: 119357935

Centisome position: 79.48

GC content: 53.0

Gene sequence:

>900_bases
ATGAATACAGGATTAATAGGGTTGGGAAAGATGGGTCTCAATATGGTTGAAAACCTTCTTGATCACCGACGCAAGGTCGC
AGTTTTTGACCTTTCCCCGGAAGCTGTGGCGGCAGCGGTAGAAAAAGGCGCCGTAGCTGCGGAATCACCCGACACTCTTG
CCGGCATGCTTCAGCGCCCGCGCATTATCTGGATGATGGTTCCCGCAGGAAGACCGGTTGACACGGTTCTGGAGTTGATG
ATACCCCGTCTTGAACCTGGGGATGTTATTATTGACGGCGGTAATTCCCGGTATACCGATTCCGAGCGCAGGGCAAAACT
GCTCGAACAGCAGGGGATTTTTTTTCTCGATGCAGGTACGAGCGGCGGTCTTGACGGCGCTCGTTACGGAGCATGTGTCA
TGGTTGGCGGGGCGAAGGAGGCCTATGATCTTGTCGAACCGCTGTTGAGGGATATGTGCGTGGAAAAAGGGTATGGTTAT
ATGGGCCGATCCGGTTCCGGCCACTTTGTGAAAATGGTGCATAACGGTATTGAGTACGGCATGATGCAGGCGATTGGAGA
AGGGTTCGATCTGCTTGAATCAAGCGGCTATGACCTTGATCCCGAAGTGGTTGCAGGCGTTTGGGCCAATGGTTCCGTGA
TAAGGGGGTGGCTGATGGAGCTTGCCGAACAGGCGTTCAGCAAAGACCGGAAACTTGGTTATCTGAAGGGTGAGATTGCC
GATTCGGGAGAGGGGCGCTGGACGGTTGAGGCTGCCCTGGAGCAGAACGTTTCGATTCCCGTTATTGCCGGAGCTCTGTT
CAGACGATATCGATCCCGTAGCGAAGAGAATTTTTCTGACAAGGTTGTTGCCGCACTGCGTCATGAATTCGGTGGTCATG
GATTCAAGGCTAATCAATAA

Upstream 100 bases:

>100_bases
ATTTCTGAACGGTTTTTGTTTTTTATTTCCTCTATGCAATCCGATTCCGGTTATCCGCGAAGCGCAGCGGCACAGCAATG
AATAAATCTGAAAGGGAAGT

Downstream 100 bases:

>100_bases
GAGGTGATGGCAATGCATACAAGGCTTGATAATTTTACGCTCATTATTTTCGGGGCCAGCAGCGATCTTGCCGCACGTAA
ATTGTTTCCATCGGTTTACG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNTGLIGLGKMGLNMVENLLDHRRKVAVFDLSPEAVAAAVEKGAVAAESPDTLAGMLQRPRIIWMMVPAGRPVDTVLELM
IPRLEPGDVIIDGGNSRYTDSERRAKLLEQQGIFFLDAGTSGGLDGARYGACVMVGGAKEAYDLVEPLLRDMCVEKGYGY
MGRSGSGHFVKMVHNGIEYGMMQAIGEGFDLLESSGYDLDPEVVAGVWANGSVIRGWLMELAEQAFSKDRKLGYLKGEIA
DSGEGRWTVEAALEQNVSIPVIAGALFRRYRSRSEENFSDKVVAALRHEFGGHGFKANQ

Sequences:

>Translated_299_residues
MNTGLIGLGKMGLNMVENLLDHRRKVAVFDLSPEAVAAAVEKGAVAAESPDTLAGMLQRPRIIWMMVPAGRPVDTVLELM
IPRLEPGDVIIDGGNSRYTDSERRAKLLEQQGIFFLDAGTSGGLDGARYGACVMVGGAKEAYDLVEPLLRDMCVEKGYGY
MGRSGSGHFVKMVHNGIEYGMMQAIGEGFDLLESSGYDLDPEVVAGVWANGSVIRGWLMELAEQAFSKDRKLGYLKGEIA
DSGEGRWTVEAALEQNVSIPVIAGALFRRYRSRSEENFSDKVVAALRHEFGGHGFKANQ
>Mature_299_residues
MNTGLIGLGKMGLNMVENLLDHRRKVAVFDLSPEAVAAAVEKGAVAAESPDTLAGMLQRPRIIWMMVPAGRPVDTVLELM
IPRLEPGDVIIDGGNSRYTDSERRAKLLEQQGIFFLDAGTSGGLDGARYGACVMVGGAKEAYDLVEPLLRDMCVEKGYGY
MGRSGSGHFVKMVHNGIEYGMMQAIGEGFDLLESSGYDLDPEVVAGVWANGSVIRGWLMELAEQAFSKDRKLGYLKGEIA
DSGEGRWTVEAALEQNVSIPVIAGALFRRYRSRSEENFSDKVVAALRHEFGGHGFKANQ

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=310, Percent_Identity=36.7741935483871, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI23308751, Length=217, Percent_Identity=29.4930875576037, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1788341, Length=301, Percent_Identity=36.2126245847176, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI145693186, Length=204, Percent_Identity=31.3725490196078, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786719, Length=202, Percent_Identity=29.7029702970297, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=288, Percent_Identity=38.1944444444444, Blast_Score=177, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6321695, Length=301, Percent_Identity=36.5448504983389, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321977, Length=285, Percent_Identity=37.8947368421053, Blast_Score=163, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24639279, Length=285, Percent_Identity=35.7894736842105, Blast_Score=157, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24655230, Length=222, Percent_Identity=29.7297297297297, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922568, Length=222, Percent_Identity=29.7297297297297, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32449; Mature: 32449

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00895 3_HYDROXYISOBUT_DH ; PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTGLIGLGKMGLNMVENLLDHRRKVAVFDLSPEAVAAAVEKGAVAAESPDTLAGMLQRP
CCCCCEEHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHCCC
RIIWMMVPAGRPVDTVLELMIPRLEPGDVIIDGGNSRYTDSERRAKLLEQQGIFFLDAGT
EEEEEECCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEECCC
SGGLDGARYGACVMVGGAKEAYDLVEPLLRDMCVEKGYGYMGRSGSGHFVKMVHNGIEYG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHH
MMQAIGEGFDLLESSGYDLDPEVVAGVWANGSVIRGWLMELAEQAFSKDRKLGYLKGEIA
HHHHHHCCHHHHHCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCC
DSGEGRWTVEAALEQNVSIPVIAGALFRRYRSRSEENFSDKVVAALRHEFGGHGFKANQ
CCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNTGLIGLGKMGLNMVENLLDHRRKVAVFDLSPEAVAAAVEKGAVAAESPDTLAGMLQRP
CCCCCEEHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHCCC
RIIWMMVPAGRPVDTVLELMIPRLEPGDVIIDGGNSRYTDSERRAKLLEQQGIFFLDAGT
EEEEEECCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEECCC
SGGLDGARYGACVMVGGAKEAYDLVEPLLRDMCVEKGYGYMGRSGSGHFVKMVHNGIEYG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHH
MMQAIGEGFDLLESSGYDLDPEVVAGVWANGSVIRGWLMELAEQAFSKDRKLGYLKGEIA
HHHHHHCCHHHHHCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCC
DSGEGRWTVEAALEQNVSIPVIAGALFRRYRSRSEENFSDKVVAALRHEFGGHGFKANQ
CCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]