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The map label for this gene is pgl [H]

Identifier: 119357934

GI number: 119357934

Start: 2487550

End: 2488368

Strand: Direct

Name: pgl [H]

Synonym: Cpha266_2149

Alternate gene names: 119357934

Gene position: 2487550-2488368 (Clockwise)

Preceding gene: 119357933

Following gene: 119357945

Centisome position: 79.38

GC content: 53.72

Gene sequence:

>819_bases
ATGGCAAAAAACAGCATATTCCACCCGATCGGTGATGACAGGGAGCTGACTGCGATTGCAGCGGCAGTGATCATAAGCGC
AGCAAACAGGGCGGTAGCAACCCATGGCAAGTTCTCTCTTGTTCTTGCCGGAGGAAACTCGCCCCGTCGTCTTTATCAAC
AGCTTGCTGCGGGCGTCAACACCGGCGAACTGAGCGAAAGCTCCCTTTTGCTGCTTGCCGATAACGAAAACAGCCACTCC
GGACATCGTCACCTCTCTTTACCGTGGGAGCACACCTGGCTGTTCTGGGGAGATGAGCGATGCCTGCCGTCCAGCCATTC
CGACAGCAACTATCGCATGGCAGAAGAGAGTCTTCTCAAAGGTTCGTCCGTCAGGGAAAAGCAGCTGTTCAGAATGCCTG
CAACAGTTGAGCCGCCTGGCAGGGCCGCTGATCTGTACGAATCAACCATCCGGCATTTTTTTCAGCAAGAACGGGACGCT
CAGTCAACGGAAGCGCCGGTTTTCGATTTCATCATCCTTGGTCTCGGCGAAGACGGCCACACCGCATCACTGTTTCCACA
AAATCCCGCAGCTCTCGATGAGCAGGTTCGCTGGGTCATTGCGGTCAACGCTCCTGAAGCCAATCCCCCGGGACATCGGC
TCACTATAACACTGCCAGTCATCAATCATGCGAAAAACGTACTTTTTTTCACTTCGGGAATGAAAAAAAAGGCCGTGGCA
GAACGGATCATATCCCGAGAGGATAACGGGTTACCTGCAGGCAGAGTGCAACCCGTCAACGGAAACCTCTTCTGGTTTAC
GCTTCCCGGTATATTCTGA

Upstream 100 bases:

>100_bases
CGCCAGGCAACGTTACACTTGAAAAATTCGGCTTTACCGCATCTCATATTTTCGATACCGTACAATCGCTCCTGCATACA
GCCTGAATCGAAAAGTCTGC

Downstream 100 bases:

>100_bases
GCGCATCTTCAGGGCCCCATGAGTGTATAGCATAGGGAGCTGGCTCAGCGCCATGGAAAGCGTCCCTCAGGGCATCGACA
AGAGCCCATGAACTCTCCAC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MAKNSIFHPIGDDRELTAIAAAVIISAANRAVATHGKFSLVLAGGNSPRRLYQQLAAGVNTGELSESSLLLLADNENSHS
GHRHLSLPWEHTWLFWGDERCLPSSHSDSNYRMAEESLLKGSSVREKQLFRMPATVEPPGRAADLYESTIRHFFQQERDA
QSTEAPVFDFIILGLGEDGHTASLFPQNPAALDEQVRWVIAVNAPEANPPGHRLTITLPVINHAKNVLFFTSGMKKKAVA
ERIISREDNGLPAGRVQPVNGNLFWFTLPGIF

Sequences:

>Translated_272_residues
MAKNSIFHPIGDDRELTAIAAAVIISAANRAVATHGKFSLVLAGGNSPRRLYQQLAAGVNTGELSESSLLLLADNENSHS
GHRHLSLPWEHTWLFWGDERCLPSSHSDSNYRMAEESLLKGSSVREKQLFRMPATVEPPGRAADLYESTIRHFFQQERDA
QSTEAPVFDFIILGLGEDGHTASLFPQNPAALDEQVRWVIAVNAPEANPPGHRLTITLPVINHAKNVLFFTSGMKKKAVA
ERIISREDNGLPAGRVQPVNGNLFWFTLPGIF
>Mature_271_residues
AKNSIFHPIGDDRELTAIAAAVIISAANRAVATHGKFSLVLAGGNSPRRLYQQLAAGVNTGELSESSLLLLADNENSHSG
HRHLSLPWEHTWLFWGDERCLPSSHSDSNYRMAEESLLKGSSVREKQLFRMPATVEPPGRAADLYESTIRHFFQQERDAQ
STEAPVFDFIILGLGEDGHTASLFPQNPAALDEQVRWVIAVNAPEANPPGHRLTITLPVINHAKNVLFFTSGMKKKAVAE
RIISREDNGLPAGRVQPVNGNLFWFTLPGIF

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=174, Percent_Identity=39.0804597701149, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI52145310, Length=255, Percent_Identity=32.5490196078431, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI115533058, Length=258, Percent_Identity=27.906976744186, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI115533060, Length=258, Percent_Identity=27.906976744186, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324362, Length=187, Percent_Identity=34.2245989304813, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6319918, Length=186, Percent_Identity=32.258064516129, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321957, Length=257, Percent_Identity=25.6809338521401, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321687, Length=235, Percent_Identity=27.6595744680851, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24641119, Length=258, Percent_Identity=31.3953488372093, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 29936; Mature: 29805

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNSIFHPIGDDRELTAIAAAVIISAANRAVATHGKFSLVLAGGNSPRRLYQQLAAGVN
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCHHHHHHHHHCCCC
TGELSESSLLLLADNENSHSGHRHLSLPWEHTWLFWGDERCLPSSHSDSNYRMAEESLLK
CCCCCCCEEEEEECCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHC
GSSVREKQLFRMPATVEPPGRAADLYESTIRHFFQQERDAQSTEAPVFDFIILGLGEDGH
CCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCC
TASLFPQNPAALDEQVRWVIAVNAPEANPPGHRLTITLPVINHAKNVLFFTSGMKKKAVA
EEEECCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEECCCHHHHHH
ERIISREDNGLPAGRVQPVNGNLFWFTLPGIF
HHHHHCCCCCCCCCEEEECCCCEEEEECCCCC
>Mature Secondary Structure 
AKNSIFHPIGDDRELTAIAAAVIISAANRAVATHGKFSLVLAGGNSPRRLYQQLAAGVN
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCHHHHHHHHHCCCC
TGELSESSLLLLADNENSHSGHRHLSLPWEHTWLFWGDERCLPSSHSDSNYRMAEESLLK
CCCCCCCEEEEEECCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHC
GSSVREKQLFRMPATVEPPGRAADLYESTIRHFFQQERDAQSTEAPVFDFIILGLGEDGH
CCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCC
TASLFPQNPAALDEQVRWVIAVNAPEANPPGHRLTITLPVINHAKNVLFFTSGMKKKAVA
EEEECCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEECCCHHHHHH
ERIISREDNGLPAGRVQPVNGNLFWFTLPGIF
HHHHHCCCCCCCCCEEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]