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The map label for this gene is mutB [H]

Identifier: 119356981

GI number: 119356981

Start: 1310741

End: 1312882

Strand: Reverse

Name: mutB [H]

Synonym: Cpha266_1164

Alternate gene names: 119356981

Gene position: 1312882-1310741 (Counterclockwise)

Preceding gene: 119356982

Following gene: 119356980

Centisome position: 41.89

GC content: 51.77

Gene sequence:

>2142_bases
ATGAGACCGGATTTTTCAGGCATCGATATCTTTTCCGCCTTTTCAGCCAATAAGGATAATCCCATAGAAGTGCCCCGGCA
CTTCACCTCCGCTGAGGGAATCGACATACAATCCTTTTACCCCGGGCACAATAGCGAGTCCTCCGCAATAACGCATTTTG
CGCCGGGATTTCCCCCCTTCAACGGAGGCCCCTACTCAACAATGTACACCTCGCGGCCATGGACTATCCGCCAGTATGCC
GGATTTTCAACCGCTGAAGAGTCAAACCGGTTTTACCGCCAGAACCTTGCGGCTGGCCAGAAAGGCCTTTCGGTTGCCTT
TGACCTCCCGACGCACCGAGGTTATGATTCCGATCATGAACGGGTTATCGGAGATGTCGGCAAAGCCGGCGTTGCAATCG
ACACGGTCGAGGATATGAAAATCCTCTTCGACAGCATCCCGCTTGACGACATATCGGTATCGATGACCATGAACGGCGCC
GTTCTTCCTGTTATGGCATTTTATATCGTTGCCGCCGAAGAGCAGGGCGTTCCGCCTGAAAAGCTGAGCGGCACCATTCA
GAACGACATTCTCAAAGAGTTCATGGTGCGCAATACCTATATCTACCCGCCTGAACCATCCATGCGAATTATTGCCGACA
TATTTCAATACACAAGCCGCAGGATGCCGAAATTCAACTCGATCAGCATTTCAGGATACCATATGCAGGAGGCTGGAGCG
ACGGCTGATCTTGAACTTGCTTACACGCTGGCCGACGGACTTGAGTATATCCGTACCGGCCTCAAGGCAGGGCTTGATAT
TGATGCCTTTGCGCCAAGACTCTCCTTTTTCTGGGGCATAGGGATGAACTACTTCATGGAGATAGCCAAGCTGCGTGCCG
CAAGAATGCTCTGGGCTAAAATTGTCCGGACGTTCAATCCGAAAAACAAGAAATCACTGATGCTTCGATCCCACTGCCAG
ACCTCAGGATGGAGTCTCACCGCACAGGATCCATTCAACAACATCACAAGAACCTGTCTTGAAGCCCTTGCCGCATCGCT
CGGTCACACCCAGTCGCTGCACACCAATGCGCTCGACGAAGCAATAGCGCTTCCCTCCCCTTTTTCAGCCCGCATTGCCA
GAAACACCCAACTCTTCCTTCAGGAAGAGACCGATATCACCCGAAGCATCGATCCCTGGGCAGGCTCATTTTATGTGGAA
AATCTGACGGCGAAACTTGCTGAAAAAGCATGGAACATCATCACTGCCATCGAAGAGGCCGGCGGAATGGTAAAAGCCAT
TGAACGAGGCATTCCTCAACTGCAGATTGAAGAGGCTGCCACCAGAAAACAGGCCCGTATCGATAGCGGCGAAGACATGA
TCATCGGAGTTAACGGTTTCACGACTGCAAGTACGACTGAAATCGACCTGCTTGAGGTCGACAATACCATGGTACTCCGC
CAGCAGCTTGACCGCCTTAAAACCGTCAAGGCGCGACGTCATGAAGAAGAGACAGCCCAAGCCCTGCTGGCCATTGAGCA
GTGTGCGGCCTCAGGCAAAGGGAATCTGCTTGAACTTGCCGTTGACGCAGCAAGAAAACGAGCCACATTGGGTGAAATAT
GCATGGCATGTGAAAATATTTACGGAAGATATCGTGCCCGAACAAAGCTCAACACCACCGTCTATATGTCTGAAATGCAG
AATAACACGCTCTTCAGGGAGGCGCAGCAACTTGCCGATACCTTTGCATCCCTCGAAGGAAGACGGCCGAGAATCATGGT
AGCGAAAGTAGGCCAGGACGGTCACGACCGCGGGGCAAAGGTTATTGCGGCGGGATTTGCCGATATTGGCTTTGACGTTG
ATATCAGCCCGCTTTTTCAGACACCTGAAGAGATCGTCAGCCAGGCGCTTGACAATGATGTCCACCTTATCGGAATATCC
AGTCTTGCCGGAGGACATAAAACCCTTATCCCGAAAATCATCGAGACGCTTCACCTGCAGGATAGAAAAGACATCCTTGT
CGTTGTCGGGGGAATCATTCCCGACAACGATCACGCGTTTCTGTACGAGCAGGGTGTTGCGGGAATTTTCGGCCCGGGAA
CGGTCATTTCCGAAGCGGCGATCAAACTGCTCAACCTTTTGATGGCAAAGTTTTCGACATGA

Upstream 100 bases:

>100_bases
ATCCGGAACCGCTTTTCCGTGCCGGCATAGACAGCTTTATTCATACAGGAGTAAACATCATCGACCATTTGACCATGTAC
CAACATAAAACCGGAGTACA

Downstream 100 bases:

>100_bases
AAAGCGCAGAAAAAATCAGCTCTGATGGCAATAACCAGGAACCGGACGTTGAGAAAATGGTCTGCGGGATCATGAACGGC
AACCGGCAGATGCTTGCCCG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MRPDFSGIDIFSAFSANKDNPIEVPRHFTSAEGIDIQSFYPGHNSESSAITHFAPGFPPFNGGPYSTMYTSRPWTIRQYA
GFSTAEESNRFYRQNLAAGQKGLSVAFDLPTHRGYDSDHERVIGDVGKAGVAIDTVEDMKILFDSIPLDDISVSMTMNGA
VLPVMAFYIVAAEEQGVPPEKLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIFQYTSRRMPKFNSISISGYHMQEAGA
TADLELAYTLADGLEYIRTGLKAGLDIDAFAPRLSFFWGIGMNYFMEIAKLRAARMLWAKIVRTFNPKNKKSLMLRSHCQ
TSGWSLTAQDPFNNITRTCLEALAASLGHTQSLHTNALDEAIALPSPFSARIARNTQLFLQEETDITRSIDPWAGSFYVE
NLTAKLAEKAWNIITAIEEAGGMVKAIERGIPQLQIEEAATRKQARIDSGEDMIIGVNGFTTASTTEIDLLEVDNTMVLR
QQLDRLKTVKARRHEEETAQALLAIEQCAASGKGNLLELAVDAARKRATLGEICMACENIYGRYRARTKLNTTVYMSEMQ
NNTLFREAQQLADTFASLEGRRPRIMVAKVGQDGHDRGAKVIAAGFADIGFDVDISPLFQTPEEIVSQALDNDVHLIGIS
SLAGGHKTLIPKIIETLHLQDRKDILVVVGGIIPDNDHAFLYEQGVAGIFGPGTVISEAAIKLLNLLMAKFST

Sequences:

>Translated_713_residues
MRPDFSGIDIFSAFSANKDNPIEVPRHFTSAEGIDIQSFYPGHNSESSAITHFAPGFPPFNGGPYSTMYTSRPWTIRQYA
GFSTAEESNRFYRQNLAAGQKGLSVAFDLPTHRGYDSDHERVIGDVGKAGVAIDTVEDMKILFDSIPLDDISVSMTMNGA
VLPVMAFYIVAAEEQGVPPEKLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIFQYTSRRMPKFNSISISGYHMQEAGA
TADLELAYTLADGLEYIRTGLKAGLDIDAFAPRLSFFWGIGMNYFMEIAKLRAARMLWAKIVRTFNPKNKKSLMLRSHCQ
TSGWSLTAQDPFNNITRTCLEALAASLGHTQSLHTNALDEAIALPSPFSARIARNTQLFLQEETDITRSIDPWAGSFYVE
NLTAKLAEKAWNIITAIEEAGGMVKAIERGIPQLQIEEAATRKQARIDSGEDMIIGVNGFTTASTTEIDLLEVDNTMVLR
QQLDRLKTVKARRHEEETAQALLAIEQCAASGKGNLLELAVDAARKRATLGEICMACENIYGRYRARTKLNTTVYMSEMQ
NNTLFREAQQLADTFASLEGRRPRIMVAKVGQDGHDRGAKVIAAGFADIGFDVDISPLFQTPEEIVSQALDNDVHLIGIS
SLAGGHKTLIPKIIETLHLQDRKDILVVVGGIIPDNDHAFLYEQGVAGIFGPGTVISEAAIKLLNLLMAKFST
>Mature_713_residues
MRPDFSGIDIFSAFSANKDNPIEVPRHFTSAEGIDIQSFYPGHNSESSAITHFAPGFPPFNGGPYSTMYTSRPWTIRQYA
GFSTAEESNRFYRQNLAAGQKGLSVAFDLPTHRGYDSDHERVIGDVGKAGVAIDTVEDMKILFDSIPLDDISVSMTMNGA
VLPVMAFYIVAAEEQGVPPEKLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIFQYTSRRMPKFNSISISGYHMQEAGA
TADLELAYTLADGLEYIRTGLKAGLDIDAFAPRLSFFWGIGMNYFMEIAKLRAARMLWAKIVRTFNPKNKKSLMLRSHCQ
TSGWSLTAQDPFNNITRTCLEALAASLGHTQSLHTNALDEAIALPSPFSARIARNTQLFLQEETDITRSIDPWAGSFYVE
NLTAKLAEKAWNIITAIEEAGGMVKAIERGIPQLQIEEAATRKQARIDSGEDMIIGVNGFTTASTTEIDLLEVDNTMVLR
QQLDRLKTVKARRHEEETAQALLAIEQCAASGKGNLLELAVDAARKRATLGEICMACENIYGRYRARTKLNTTVYMSEMQ
NNTLFREAQQLADTFASLEGRRPRIMVAKVGQDGHDRGAKVIAAGFADIGFDVDISPLFQTPEEIVSQALDNDVHLIGIS
SLAGGHKTLIPKIIETLHLQDRKDILVVVGGIIPDNDHAFLYEQGVAGIFGPGTVISEAAIKLLNLLMAKFST

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=687, Percent_Identity=61.1353711790393, Blast_Score=882, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=682, Percent_Identity=59.8240469208211, Blast_Score=818, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=686, Percent_Identity=59.7667638483965, Blast_Score=845, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 78619; Mature: 78619

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPDFSGIDIFSAFSANKDNPIEVPRHFTSAEGIDIQSFYPGHNSESSAITHFAPGFPPF
CCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCCCC
NGGPYSTMYTSRPWTIRQYAGFSTAEESNRFYRQNLAAGQKGLSVAFDLPTHRGYDSDHE
CCCCCCCEECCCCEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHH
RVIGDVGKAGVAIDTVEDMKILFDSIPLDDISVSMTMNGAVLPVMAFYIVAAEEQGVPPE
HHHHHCCCCCEEEECHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCHH
KLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIFQYTSRRMPKFNSISISGYHMQEAGA
HHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECEEECCCCC
TADLELAYTLADGLEYIRTGLKAGLDIDAFAPRLSFFWGIGMNYFMEIAKLRAARMLWAK
CCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
IVRTFNPKNKKSLMLRSHCQTSGWSLTAQDPFNNITRTCLEALAASLGHTQSLHTNALDE
HHHHCCCCCHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AIALPSPFSARIARNTQLFLQEETDITRSIDPWAGSFYVENLTAKLAEKAWNIITAIEEA
HHCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GGMVKAIERGIPQLQIEEAATRKQARIDSGEDMIIGVNGFTTASTTEIDLLEVDNTMVLR
CCHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHH
QQLDRLKTVKARRHEEETAQALLAIEQCAASGKGNLLELAVDAARKRATLGEICMACENI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
YGRYRARTKLNTTVYMSEMQNNTLFREAQQLADTFASLEGRRPRIMVAKVGQDGHDRGAK
HHHHHHCEECCCEEEEEHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCE
VIAAGFADIGFDVDISPLFQTPEEIVSQALDNDVHLIGISSLAGGHKTLIPKIIETLHLQ
EEEECHHHCCCCCCCHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
DRKDILVVVGGIIPDNDHAFLYEQGVAGIFGPGTVISEAAIKLLNLLMAKFST
CCCCEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRPDFSGIDIFSAFSANKDNPIEVPRHFTSAEGIDIQSFYPGHNSESSAITHFAPGFPPF
CCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCCCC
NGGPYSTMYTSRPWTIRQYAGFSTAEESNRFYRQNLAAGQKGLSVAFDLPTHRGYDSDHE
CCCCCCCEECCCCEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHH
RVIGDVGKAGVAIDTVEDMKILFDSIPLDDISVSMTMNGAVLPVMAFYIVAAEEQGVPPE
HHHHHCCCCCEEEECHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCHH
KLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIFQYTSRRMPKFNSISISGYHMQEAGA
HHCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECEEECCCCC
TADLELAYTLADGLEYIRTGLKAGLDIDAFAPRLSFFWGIGMNYFMEIAKLRAARMLWAK
CCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
IVRTFNPKNKKSLMLRSHCQTSGWSLTAQDPFNNITRTCLEALAASLGHTQSLHTNALDE
HHHHCCCCCHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AIALPSPFSARIARNTQLFLQEETDITRSIDPWAGSFYVENLTAKLAEKAWNIITAIEEA
HHCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GGMVKAIERGIPQLQIEEAATRKQARIDSGEDMIIGVNGFTTASTTEIDLLEVDNTMVLR
CCHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHH
QQLDRLKTVKARRHEEETAQALLAIEQCAASGKGNLLELAVDAARKRATLGEICMACENI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
YGRYRARTKLNTTVYMSEMQNNTLFREAQQLADTFASLEGRRPRIMVAKVGQDGHDRGAK
HHHHHHCEECCCEEEEEHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCE
VIAAGFADIGFDVDISPLFQTPEEIVSQALDNDVHLIGISSLAGGHKTLIPKIIETLHLQ
EEEECHHHCCCCCCCHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
DRKDILVVVGGIIPDNDHAFLYEQGVAGIFGPGTVISEAAIKLLNLLMAKFST
CCCCEEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]