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The map label for this gene is mutA [H]

Identifier: 119356982

GI number: 119356982

Start: 1312879

End: 1314648

Strand: Reverse

Name: mutA [H]

Synonym: Cpha266_1165

Alternate gene names: 119356982

Gene position: 1314648-1312879 (Counterclockwise)

Preceding gene: 119356983

Following gene: 119356981

Centisome position: 41.95

GC content: 50.62

Gene sequence:

>1770_bases
ATGAGCACTCCTGAACCTGACACTCTCTTTGCAGAGTTTTCACCAGTCAGCAAAGCCGAGTGGAAAGCAAAGGCATCTGC
CGAGCTCGGAGAAAAACCATTTAACGCTATAGTATGGAAAACAGAGAACGGATTTGCTCTCGAACCATGGTACTCATCCG
ATGAGAGCAGCGACCTGCCGGTTCCTGTTGCGCCCGATCCGGAAACATGGAGGATGTGCAGAAAAATCCCTGTAACCGAT
ACCGGAAACGCAAACGAAAACGCCCGCCAGAGCCTTCGGGAAGGCGCAACCGCACTGGAGTTCGTGCTTTCAGGAAACGC
ATACTGTACGCATGAACAACTTCTTCTGCTCTTACAGGATATTGACACCACGCTCGTTCCCGTTTACTTTTCCGGAGAGT
TCTCCCCCACTCTGCTTCTCGATAATCTTCTTTCAATTACCGCCTTCAAAAACAACTCGGGAGGCTTTCTTGTCGAAAAG
CATGATGAGTATGAAGCTGTTGAAGCAGCTCTCGTCAATCATGGGTCGCTGCTTGAAAACTATCGCACCCTTTCGGTCTC
TGCCGTCAATGATCATGAAAACGGAGCTTCGGCAAGCGAAGAAATTGCTTTTCTGCTTGCAGGAGTAAGCGATTCGCTCT
ATCGCCTGCAAGCAGCAGGCATTCCTGCTGAAACCGCTGCCCGAAAAATCGAAATCGTTCTGGCCGTCGGGCCAAGCCAT
TTCACGGAACTTGCAAAAATACGGGCAGTGCGATTTCTCCTTCAGCATATCCTGAAAGCATACGGCGCTCCGACTGACCA
TCTGCCTCGCATTTTCGCCCGAACTTCAGAGAGAAACCTTTCGCGTCTCGATCCCTTCACAAACCTGCTCCGCCAAACCA
CCGAGGCTGTTTCCGCGATTTTCGGCGGATGCCAGACTCTGCAGATTTCGCCATTCGATAACGGACTATCCGTCTCTCAT
ACCATGGCCGAACGGGTCTCCGGAAACATCCATCTCCTGCTGCAGCGCGAAGCGGGACTTGATCGGGTGTCCGATCCGGC
CAGAGGTTCCTGTTACATCGAACAGATGACCAGGGAACTCTCCCGATCCGCATGGAGTCTTTTCAGGGATATCGAAACTG
CCGGCGGCCTGAACAATGCGCGCAAAAGCGGCATGATTGATTCGTTGATCCGGAAAACGTCCGAAAAGAGAGTCGCATCC
ATCAACACCCGAAGCAAAACAATAGTAGGGGTAAACCGTTATCCTGGAAACCTTACGATTCAGCAGGAGGAGAACCTTTC
CGAAATAAGGACTATTCTGGAAAAGAGAACAGAGGGTAATGAAAGCGGAGCTTTCGAGCTGCTCCGAATAAACACCATCA
TGAACAAAACGAAAACCGGGCATCATCCGGCAGTTTTTTTCTGGATGCAGGGCGATACCGCAACAAGCTTCCGACAGGCT
GCATTTGCTGAAGATTTTTTCAGATGCGGCGGTTTCGATATAGCCGGAAGCGCTCAGCTTGTGCCTGAAGAGTCATCATT
TCAAACCGTGCTCGACCATAAACCTGCTGTTCTGGTGCTCTGCATTGCTGAAAAAGATCCATGTTCCTCAGCAGAAACGA
TCGCCCGGAACCTTCACACTCTTGACCCTGAGCTTCTCATGGTCATGGCAGGAAAACCCCCGCAAGATCCGGAACCGCTT
TTCCGTGCCGGCATAGACAGCTTTATTCATACAGGAGTAAACATCATCGACCATTTGACCATGTACCAACATAAAACCGG
AGTACAATGA

Upstream 100 bases:

>100_bases
TTACCCGGCACGATAAAAAATGATATTTCAGCCATAATCACACAGAGCAGATCAAAAACGGCTTCACGCTTCTGCTGCAT
GAATCACTCAAAAACCAACC

Downstream 100 bases:

>100_bases
GACCGGATTTTTCAGGCATCGATATCTTTTCCGCCTTTTCAGCCAATAAGGATAATCCCATAGAAGTGCCCCGGCACTTC
ACCTCCGCTGAGGGAATCGA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MSTPEPDTLFAEFSPVSKAEWKAKASAELGEKPFNAIVWKTENGFALEPWYSSDESSDLPVPVAPDPETWRMCRKIPVTD
TGNANENARQSLREGATALEFVLSGNAYCTHEQLLLLLQDIDTTLVPVYFSGEFSPTLLLDNLLSITAFKNNSGGFLVEK
HDEYEAVEAALVNHGSLLENYRTLSVSAVNDHENGASASEEIAFLLAGVSDSLYRLQAAGIPAETAARKIEIVLAVGPSH
FTELAKIRAVRFLLQHILKAYGAPTDHLPRIFARTSERNLSRLDPFTNLLRQTTEAVSAIFGGCQTLQISPFDNGLSVSH
TMAERVSGNIHLLLQREAGLDRVSDPARGSCYIEQMTRELSRSAWSLFRDIETAGGLNNARKSGMIDSLIRKTSEKRVAS
INTRSKTIVGVNRYPGNLTIQQEENLSEIRTILEKRTEGNESGAFELLRINTIMNKTKTGHHPAVFFWMQGDTATSFRQA
AFAEDFFRCGGFDIAGSAQLVPEESSFQTVLDHKPAVLVLCIAEKDPCSSAETIARNLHTLDPELLMVMAGKPPQDPEPL
FRAGIDSFIHTGVNIIDHLTMYQHKTGVQ

Sequences:

>Translated_589_residues
MSTPEPDTLFAEFSPVSKAEWKAKASAELGEKPFNAIVWKTENGFALEPWYSSDESSDLPVPVAPDPETWRMCRKIPVTD
TGNANENARQSLREGATALEFVLSGNAYCTHEQLLLLLQDIDTTLVPVYFSGEFSPTLLLDNLLSITAFKNNSGGFLVEK
HDEYEAVEAALVNHGSLLENYRTLSVSAVNDHENGASASEEIAFLLAGVSDSLYRLQAAGIPAETAARKIEIVLAVGPSH
FTELAKIRAVRFLLQHILKAYGAPTDHLPRIFARTSERNLSRLDPFTNLLRQTTEAVSAIFGGCQTLQISPFDNGLSVSH
TMAERVSGNIHLLLQREAGLDRVSDPARGSCYIEQMTRELSRSAWSLFRDIETAGGLNNARKSGMIDSLIRKTSEKRVAS
INTRSKTIVGVNRYPGNLTIQQEENLSEIRTILEKRTEGNESGAFELLRINTIMNKTKTGHHPAVFFWMQGDTATSFRQA
AFAEDFFRCGGFDIAGSAQLVPEESSFQTVLDHKPAVLVLCIAEKDPCSSAETIARNLHTLDPELLMVMAGKPPQDPEPL
FRAGIDSFIHTGVNIIDHLTMYQHKTGVQ
>Mature_588_residues
STPEPDTLFAEFSPVSKAEWKAKASAELGEKPFNAIVWKTENGFALEPWYSSDESSDLPVPVAPDPETWRMCRKIPVTDT
GNANENARQSLREGATALEFVLSGNAYCTHEQLLLLLQDIDTTLVPVYFSGEFSPTLLLDNLLSITAFKNNSGGFLVEKH
DEYEAVEAALVNHGSLLENYRTLSVSAVNDHENGASASEEIAFLLAGVSDSLYRLQAAGIPAETAARKIEIVLAVGPSHF
TELAKIRAVRFLLQHILKAYGAPTDHLPRIFARTSERNLSRLDPFTNLLRQTTEAVSAIFGGCQTLQISPFDNGLSVSHT
MAERVSGNIHLLLQREAGLDRVSDPARGSCYIEQMTRELSRSAWSLFRDIETAGGLNNARKSGMIDSLIRKTSEKRVASI
NTRSKTIVGVNRYPGNLTIQQEENLSEIRTILEKRTEGNESGAFELLRINTIMNKTKTGHHPAVFFWMQGDTATSFRQAA
FAEDFFRCGGFDIAGSAQLVPEESSFQTVLDHKPAVLVLCIAEKDPCSSAETIARNLHTLDPELLMVMAGKPPQDPEPLF
RAGIDSFIHTGVNIIDHLTMYQHKTGVQ

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=455, Percent_Identity=24.1758241758242, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1789284, Length=258, Percent_Identity=29.4573643410853, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25144500, Length=240, Percent_Identity=30, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 64881; Mature: 64750

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPEPDTLFAEFSPVSKAEWKAKASAELGEKPFNAIVWKTENGFALEPWYSSDESSDLP
CCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCCCCCC
VPVAPDPETWRMCRKIPVTDTGNANENARQSLREGATALEFVLSGNAYCTHEQLLLLLQD
CCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCEECHHHHHHHHHH
IDTTLVPVYFSGEFSPTLLLDNLLSITAFKNNSGGFLVEKHDEYEAVEAALVNHGSLLEN
CCCEEEEEEECCCCCHHHHHHHHHEEEEEECCCCCEEEECCCHHHHHHHHHHCCHHHHHC
YRTLSVSAVNDHENGASASEEIAFLLAGVSDSLYRLQAAGIPAETAARKIEIVLAVGPSH
CEEEEEEEECCCCCCCCHHHHHHHHEECCCCHHHHHHCCCCCHHHCCCEEEEEEEECCHH
FTELAKIRAVRFLLQHILKAYGAPTDHLPRIFARTSERNLSRLDPFTNLLRQTTEAVSAI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHH
FGGCQTLQISPFDNGLSVSHTMAERVSGNIHLLLQREAGLDRVSDPARGSCYIEQMTREL
HCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
SRSAWSLFRDIETAGGLNNARKSGMIDSLIRKTSEKRVASINTRSKTIVGVNRYPGNLTI
HHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCEEE
QQEENLSEIRTILEKRTEGNESGAFELLRINTIMNKTKTGHHPAVFFWMQGDTATSFRQA
ECCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHCCCCCCCEEEEEECCCCHHHHHHH
AFAEDFFRCGGFDIAGSAQLVPEESSFQTVLDHKPAVLVLCIAEKDPCSSAETIARNLHT
HHHHHHHHCCCCCCCCCCEECCCCCCHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHC
LDPELLMVMAGKPPQDPEPLFRAGIDSFIHTGVNIIDHLTMYQHKTGVQ
CCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STPEPDTLFAEFSPVSKAEWKAKASAELGEKPFNAIVWKTENGFALEPWYSSDESSDLP
CCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCCCCCC
VPVAPDPETWRMCRKIPVTDTGNANENARQSLREGATALEFVLSGNAYCTHEQLLLLLQD
CCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCEECHHHHHHHHHH
IDTTLVPVYFSGEFSPTLLLDNLLSITAFKNNSGGFLVEKHDEYEAVEAALVNHGSLLEN
CCCEEEEEEECCCCCHHHHHHHHHEEEEEECCCCCEEEECCCHHHHHHHHHHCCHHHHHC
YRTLSVSAVNDHENGASASEEIAFLLAGVSDSLYRLQAAGIPAETAARKIEIVLAVGPSH
CEEEEEEEECCCCCCCCHHHHHHHHEECCCCHHHHHHCCCCCHHHCCCEEEEEEEECCHH
FTELAKIRAVRFLLQHILKAYGAPTDHLPRIFARTSERNLSRLDPFTNLLRQTTEAVSAI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHH
FGGCQTLQISPFDNGLSVSHTMAERVSGNIHLLLQREAGLDRVSDPARGSCYIEQMTREL
HCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
SRSAWSLFRDIETAGGLNNARKSGMIDSLIRKTSEKRVASINTRSKTIVGVNRYPGNLTI
HHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCEEE
QQEENLSEIRTILEKRTEGNESGAFELLRINTIMNKTKTGHHPAVFFWMQGDTATSFRQA
ECCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHCCCCCCCEEEEEECCCCHHHHHHH
AFAEDFFRCGGFDIAGSAQLVPEESSFQTVLDHKPAVLVLCIAEKDPCSSAETIARNLHT
HHHHHHHHCCCCCCCCCCEECCCCCCHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHC
LDPELLMVMAGKPPQDPEPLFRAGIDSFIHTGVNIIDHLTMYQHKTGVQ
CCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]