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The map label for this gene is aroK

Identifier: 119356668

GI number: 119356668

Start: 950866

End: 951438

Strand: Reverse

Name: aroK

Synonym: Cpha266_0837

Alternate gene names: 119356668

Gene position: 951438-950866 (Counterclockwise)

Preceding gene: 119356669

Following gene: 119356667

Centisome position: 30.36

GC content: 45.38

Gene sequence:

>573_bases
ATGAAACATCACTCTCTCATCTTTTTAACCGGATTCAGCGGATCTGGCAAATCCACCATTGGTCCGCTACTGGCGAACTC
TCTTGGTTACGACTTTATTGATCTCGATCAGGCCATTGAAGCAATTACCGGTAAGTCGGTATCGAGAATTTTTGCCGAAG
AGGGCGAATCATACTTCAGAAAACTTGAACTTGACACACTGAAAACAGTGACCAACAGAGAAGAGCTTATCGTCTCGCTT
GGAGGCGGAGCGCTTGAAAGCAATGAGTGCTATACGTTAATCAAGGAAAAGGGCACACTGGTTTATCTGAAATCAGGTTC
AGGAACCCTGACAAAAAGGCTCTGCCATAAAACCGACCGACCGCTCCTGAAGAGTGAACAGGGTGGCAAGCTCTCAAACG
GAGAGATTGAACAGAAAATAAGAGAACTCCTTGCCCGTCGGGAACCAAGGTACAACAGCGCAACAATTACCGTTCAAACC
GATACCGGAAGAATAGGTTCAACGGTCGAAGAACTTACCCGAAAAATAAACCGGTATGTAAGAAAAACAACCGGAAATTC
AAGGGCGAAATAA

Upstream 100 bases:

>100_bases
TCTTTGATTGAGCTTTTTTACTATATTTGGCGCAGAGCTTATAGCGAATAATTTTTTGTAACCGTAACGTTCCCGGTCAT
TTTTCAGGGCATCATGGGCC

Downstream 100 bases:

>100_bases
ACCCAAAGCAACGTTATTCGTGAACACCATCATAGTCAAGACACCGGTCACCCGACATCTCGGAGAGCTCTTCAGCAAAA
ACGGTCTTTCAAAAAAAACC

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKHHSLIFLTGFSGSGKSTIGPLLANSLGYDFIDLDQAIEAITGKSVSRIFAEEGESYFRKLELDTLKTVTNREELIVSL
GGGALESNECYTLIKEKGTLVYLKSGSGTLTKRLCHKTDRPLLKSEQGGKLSNGEIEQKIRELLARREPRYNSATITVQT
DTGRIGSTVEELTRKINRYVRKTTGNSRAK

Sequences:

>Translated_190_residues
MKHHSLIFLTGFSGSGKSTIGPLLANSLGYDFIDLDQAIEAITGKSVSRIFAEEGESYFRKLELDTLKTVTNREELIVSL
GGGALESNECYTLIKEKGTLVYLKSGSGTLTKRLCHKTDRPLLKSEQGGKLSNGEIEQKIRELLARREPRYNSATITVQT
DTGRIGSTVEELTRKINRYVRKTTGNSRAK
>Mature_190_residues
MKHHSLIFLTGFSGSGKSTIGPLLANSLGYDFIDLDQAIEAITGKSVSRIFAEEGESYFRKLELDTLKTVTNREELIVSL
GGGALESNECYTLIKEKGTLVYLKSGSGTLTKRLCHKTDRPLLKSEQGGKLSNGEIEQKIRELLARREPRYNSATITVQT
DTGRIGSTVEELTRKINRYVRKTTGNSRAK

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=163, Percent_Identity=34.9693251533742, Blast_Score=85, Evalue=2e-18,
Organism=Escherichia coli, GI1786587, Length=145, Percent_Identity=30.3448275862069, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_CHLPD (A1BER1)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911312.1
- ProteinModelPortal:   A1BER1
- SMR:   A1BER1
- STRING:   A1BER1
- GeneID:   4570374
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0837
- NMPDR:   fig|290317.7.peg.890
- eggNOG:   COG0703
- HOGENOM:   HBG335815
- OMA:   MIISERV
- ProtClustDB:   PRK00131
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 21029; Mature: 21029

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 36-36 BINDING 60-60 BINDING 82-82 BINDING 120-120 BINDING 147-147

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHHSLIFLTGFSGSGKSTIGPLLANSLGYDFIDLDQAIEAITGKSVSRIFAEEGESYFR
CCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHH
KLELDTLKTVTNREELIVSLGGGALESNECYTLIKEKGTLVYLKSGSGTLTKRLCHKTDR
HHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHCCC
PLLKSEQGGKLSNGEIEQKIRELLARREPRYNSATITVQTDTGRIGSTVEELTRKINRYV
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
RKTTGNSRAK
HHCCCCCCCC
>Mature Secondary Structure
MKHHSLIFLTGFSGSGKSTIGPLLANSLGYDFIDLDQAIEAITGKSVSRIFAEEGESYFR
CCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHH
KLELDTLKTVTNREELIVSLGGGALESNECYTLIKEKGTLVYLKSGSGTLTKRLCHKTDR
HHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHCCC
PLLKSEQGGKLSNGEIEQKIRELLARREPRYNSATITVQTDTGRIGSTVEELTRKINRYV
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
RKTTGNSRAK
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA