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The map label for this gene is metC [H]

Identifier: 119356566

GI number: 119356566

Start: 832530

End: 833732

Strand: Reverse

Name: metC [H]

Synonym: Cpha266_0732

Alternate gene names: 119356566

Gene position: 833732-832530 (Counterclockwise)

Preceding gene: 119356568

Following gene: 119356565

Centisome position: 26.6

GC content: 52.29

Gene sequence:

>1203_bases
ATGTTTCACGGCACAAACATAACCGTTAAAAAAAAGAATACCATGCAATTTGAAACCCTTGCGATCCATGACGGTCAGGC
ACCAGACAGCCGCACAGGGTCGGTCACCGTTCCTGTATTCCAGACTTCGACATTCGAACGGGAAAGCCTTTCCGAACGCC
GGGAGTTCTTCTATTCGAGAATAGGCAATCCTACGCGTCAAGCGCTCGAATCAACAATCGCACTGCTTGAGAACGGTCGC
TACGGACTTGCCTTCGCATCGGGAGTCGCAGCAACCATGGCGGCGCTCCAGGTGCTCAAACCCGGCGATCATGTTGTGTC
CGGTAACGATATATATGGCGGGAGCTATCGGATTTTCGAACAGCTCCTGCGTCCATGGGGCGTTACGACCACCTATAGTG
AAAATGCGACAACCGATAGTTATCTGGCTTGCATAACACCAGAAACCAGGCTCATATGGATAGAAACCCCGAGTAATCCG
CTTCTGCAAATTTCGGATATCTCAGCCCTTGCAGAACTGGCAAAACAACGAGGCATCATTCTTGCTGTCGACAATACCTT
TGCCTCTCCCTATTTTCAGCGACCGCTTGACCTCGGGGCGGAGATTGTCGTCCACAGCACCACAAAATATCTTGGCGGGC
ATAGCGATGTCATGGGAGGCGCGGTGGTCACAAACAATACCGCACTGCATACCGTGATAAAAAACTATCAGGCTGCGGCC
GGAGCTATTCCGGCACCCTGGGAGTGCTGGCTGATCATGCGCGGCATTAAAACACTGAAAATCCGGATGAAAGAGCATGA
ATCAAATGCCCTCTTCCTGGCGAAAGCTCTTGAAAATCACCCGGCAGTGCATAATGTTTACTACCCTGGCCTTGCATCGC
ACCCACAGCATGAACTGGCAAAACGCCAGATGAGCGGATTCGGCGGAATGATCACCCTTGCGCTCAAGGGAGGCGGTTCT
GCCGTTGAGCAACTGATTGACCAGGTCCGGCTGTTTGTGCTTGCCGACAGTCTGGGAGGAGTTGAATCGCTGATCGCCTC
TCCGGCAAGGATGACCCTTGCCGCACTCTCGGAAGATGAACGACAGCGCCGGGGATGTACAGATAACCTCGTTCGACTGT
CGGTCGGACTTGAAAACGCTCTTGACCTCAAAAAAGACCTGTTCGATGCGCTTGATGCAATAACGGAAACACAAACGCAA
TGA

Upstream 100 bases:

>100_bases
ATAAAACATGGTCATGGCTGGCAAAAGCCTTTCCGGTTACACTGTAAATCATATTCGTCAAAGGATTTTTGCCCGTTAAT
GATAACTTGCACTGTTGCCG

Downstream 100 bases:

>100_bases
ACCGAAATACCTTCATCATGCAATAAGGGAAGCTCTAACAAGTGCTGTGAGCGGTCTGAAAGCGAGGCGAATGGAGACCC
GACAGGTCGGGACAAACAAA

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFHGTNITVKKKNTMQFETLAIHDGQAPDSRTGSVTVPVFQTSTFERESLSERREFFYSRIGNPTRQALESTIALLENGR
YGLAFASGVAATMAALQVLKPGDHVVSGNDIYGGSYRIFEQLLRPWGVTTTYSENATTDSYLACITPETRLIWIETPSNP
LLQISDISALAELAKQRGIILAVDNTFASPYFQRPLDLGAEIVVHSTTKYLGGHSDVMGGAVVTNNTALHTVIKNYQAAA
GAIPAPWECWLIMRGIKTLKIRMKEHESNALFLAKALENHPAVHNVYYPGLASHPQHELAKRQMSGFGGMITLALKGGGS
AVEQLIDQVRLFVLADSLGGVESLIASPARMTLAALSEDERQRRGCTDNLVRLSVGLENALDLKKDLFDALDAITETQTQ

Sequences:

>Translated_400_residues
MFHGTNITVKKKNTMQFETLAIHDGQAPDSRTGSVTVPVFQTSTFERESLSERREFFYSRIGNPTRQALESTIALLENGR
YGLAFASGVAATMAALQVLKPGDHVVSGNDIYGGSYRIFEQLLRPWGVTTTYSENATTDSYLACITPETRLIWIETPSNP
LLQISDISALAELAKQRGIILAVDNTFASPYFQRPLDLGAEIVVHSTTKYLGGHSDVMGGAVVTNNTALHTVIKNYQAAA
GAIPAPWECWLIMRGIKTLKIRMKEHESNALFLAKALENHPAVHNVYYPGLASHPQHELAKRQMSGFGGMITLALKGGGS
AVEQLIDQVRLFVLADSLGGVESLIASPARMTLAALSEDERQRRGCTDNLVRLSVGLENALDLKKDLFDALDAITETQTQ
>Mature_400_residues
MFHGTNITVKKKNTMQFETLAIHDGQAPDSRTGSVTVPVFQTSTFERESLSERREFFYSRIGNPTRQALESTIALLENGR
YGLAFASGVAATMAALQVLKPGDHVVSGNDIYGGSYRIFEQLLRPWGVTTTYSENATTDSYLACITPETRLIWIETPSNP
LLQISDISALAELAKQRGIILAVDNTFASPYFQRPLDLGAEIVVHSTTKYLGGHSDVMGGAVVTNNTALHTVIKNYQAAA
GAIPAPWECWLIMRGIKTLKIRMKEHESNALFLAKALENHPAVHNVYYPGLASHPQHELAKRQMSGFGGMITLALKGGGS
AVEQLIDQVRLFVLADSLGGVESLIASPARMTLAALSEDERQRRGCTDNLVRLSVGLENALDLKKDLFDALDAITETQTQ

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=363, Percent_Identity=46.2809917355372, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI299473759, Length=363, Percent_Identity=41.5977961432507, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI25453487, Length=362, Percent_Identity=39.5027624309392, Blast_Score=265, Evalue=5e-71,
Organism=Escherichia coli, GI1790375, Length=381, Percent_Identity=37.007874015748, Blast_Score=264, Evalue=7e-72,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=28.5347043701799, Blast_Score=160, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17538055, Length=367, Percent_Identity=43.8692098092643, Blast_Score=323, Evalue=8e-89,
Organism=Caenorhabditis elegans, GI17560056, Length=367, Percent_Identity=42.2343324250681, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI71980708, Length=378, Percent_Identity=35.978835978836, Blast_Score=233, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6319307, Length=391, Percent_Identity=43.4782608695652, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6323333, Length=439, Percent_Identity=31.6628701594533, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321254, Length=405, Percent_Identity=30.1234567901235, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321170, Length=322, Percent_Identity=32.9192546583851, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6321904, Length=405, Percent_Identity=30.3703703703704, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322970, Length=259, Percent_Identity=29.3436293436293, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI19922554, Length=379, Percent_Identity=44.5910290237467, Blast_Score=357, Evalue=5e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43663; Mature: 43663

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHGTNITVKKKNTMQFETLAIHDGQAPDSRTGSVTVPVFQTSTFERESLSERREFFYSR
CCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
IGNPTRQALESTIALLENGRYGLAFASGVAATMAALQVLKPGDHVVSGNDIYGGSYRIFE
CCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHH
QLLRPWGVTTTYSENATTDSYLACITPETRLIWIETPSNPLLQISDISALAELAKQRGII
HHHHHCCCCEEECCCCCCCCEEEEECCCEEEEEEECCCCCCEEEHHHHHHHHHHHHCCEE
LAVDNTFASPYFQRPLDLGAEIVVHSTTKYLGGHSDVMGGAVVTNNTALHTVIKNYQAAA
EEECCCCCCHHHCCCHHCCCEEEEEECHHHHCCCCHHCCCEEEECCHHHHHHHHHHHHHC
GAIPAPWECWLIMRGIKTLKIRMKEHESNALFLAKALENHPAVHNVYYPGLASHPQHELA
CCCCCCHHHHHHHHCHHEEEEEEEECCCCEEEEEEHHHCCCCEEEEECCCCCCCCHHHHH
KRQMSGFGGMITLALKGGGSAVEQLIDQVRLFVLADSLGGVESLIASPARMTLAALSEDE
HHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHCHHH
RQRRGCTDNLVRLSVGLENALDLKKDLFDALDAITETQTQ
HHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFHGTNITVKKKNTMQFETLAIHDGQAPDSRTGSVTVPVFQTSTFERESLSERREFFYSR
CCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
IGNPTRQALESTIALLENGRYGLAFASGVAATMAALQVLKPGDHVVSGNDIYGGSYRIFE
CCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHH
QLLRPWGVTTTYSENATTDSYLACITPETRLIWIETPSNPLLQISDISALAELAKQRGII
HHHHHCCCCEEECCCCCCCCEEEEECCCEEEEEEECCCCCCEEEHHHHHHHHHHHHCCEE
LAVDNTFASPYFQRPLDLGAEIVVHSTTKYLGGHSDVMGGAVVTNNTALHTVIKNYQAAA
EEECCCCCCHHHCCCHHCCCEEEEEECHHHHCCCCHHCCCEEEECCHHHHHHHHHHHHHC
GAIPAPWECWLIMRGIKTLKIRMKEHESNALFLAKALENHPAVHNVYYPGLASHPQHELA
CCCCCCHHHHHHHHCHHEEEEEEEECCCCEEEEEEHHHCCCCEEEEECCCCCCCCHHHHH
KRQMSGFGGMITLALKGGGSAVEQLIDQVRLFVLADSLGGVESLIASPARMTLAALSEDE
HHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHCHHH
RQRRGCTDNLVRLSVGLENALDLKKDLFDALDAITETQTQ
HHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]