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The map label for this gene is moaA [H]

Identifier: 119356568

GI number: 119356568

Start: 834720

End: 835721

Strand: Reverse

Name: moaA [H]

Synonym: Cpha266_0734

Alternate gene names: 119356568

Gene position: 835721-834720 (Counterclockwise)

Preceding gene: 119356569

Following gene: 119356566

Centisome position: 26.67

GC content: 48.9

Gene sequence:

>1002_bases
TTGAACAGCCCCAAACAGAAAAATGCCCCCCTTGTAGACCAGTTCCAGCGACACATCGAGTATGCCCGGATTGCCGTTAC
GGCACACTGCAACCTCAGGTGCACCTACTGCATGAGGGAAGAACACGAATATCATACTATTGCCGACCCGGAACTGAGCT
CCCGGGAGGTCGGCAAAATCATTGTCGCACTCGCATCCATCGGAATAAAAAAGATAAGGTTTACCGGAGGAGAACCGCTT
CTGCGAAAGGATATTTCAGTTCTTGTCAGACAGGCAAAAAGCATTGCGGGAATTAAAACCGTATCCCTCACCACAAACGG
CATACTGCTTGACCGGCATCTGGATGAGCTTATTGACGCAGGGCTTGACGCCATCAATCTCAGTCTCGACACGCTTGACA
GAGAGCGCTATCTTGCCATAACCCGCCGCAACGAGTTTGACCGGGTTATGAGCAATCTTGAAACACTGCTTGCAAAAGCA
ACATTCCCCGTGAAACTCAACGTTGTCATGATGCGAGGCGTAAACGGCGATGAAATCAAAGACTTTATTGAACTGACAAG
AACACACTCCCTGACGGTCAGGTTCATGGAATTGCAACCGTTTGACGACAATCAGATATGGAAAACAGGAAAATTCATGG
GTATCGACAAAATTACTGAGCAACTGCGAAGCCTTAATCCGGGAGTACAGAAAAAACAGGGGAAATCGACAGAGTATTTC
AGTTTTTCCCTGCCCGGCCACCAGGGATCCATAGCTGTCATACCCGCTTATACCAGAAATTTCTGCAGCTCCTGCAACAG
GATCAGGATAACATCCCACGGAAAAATAATCAGTTGCCTCTACGACAAAGAGGGCCTTGATCTGATGCCTCTGCTCAGAA
ACAACGCGGATAATAACATGCTGACCGAGTTGTTCAGGCATGCTGCAGCACACAAGCCCGCAGATGGAAAAAGCGCTGCG
GAAGGTCAGACACGAACCAGCATGTCTGAAATCGGAGGGTGA

Upstream 100 bases:

>100_bases
ATGCGATCGCTGATCCCGCCCTGAATCATGCACATGATAACCTTTGCCCGATAAATCAATTGACACACGAGTTTCCCGTC
AGTATTAAAACGATTCGCCG

Downstream 100 bases:

>100_bases
AAAAATCCGGAAGGAGTGTTGCTATCCCTCAACAATATGTTCACTCCCGGAGCGTTCAATTCTCATATCAGGCGTTACTC
TTCCACCCTGCAGAACCTTG

Product: GTP cyclohydrolase subunit MoaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MNSPKQKNAPLVDQFQRHIEYARIAVTAHCNLRCTYCMREEHEYHTIADPELSSREVGKIIVALASIGIKKIRFTGGEPL
LRKDISVLVRQAKSIAGIKTVSLTTNGILLDRHLDELIDAGLDAINLSLDTLDRERYLAITRRNEFDRVMSNLETLLAKA
TFPVKLNVVMMRGVNGDEIKDFIELTRTHSLTVRFMELQPFDDNQIWKTGKFMGIDKITEQLRSLNPGVQKKQGKSTEYF
SFSLPGHQGSIAVIPAYTRNFCSSCNRIRITSHGKIISCLYDKEGLDLMPLLRNNADNNMLTELFRHAAAHKPADGKSAA
EGQTRTSMSEIGG

Sequences:

>Translated_333_residues
MNSPKQKNAPLVDQFQRHIEYARIAVTAHCNLRCTYCMREEHEYHTIADPELSSREVGKIIVALASIGIKKIRFTGGEPL
LRKDISVLVRQAKSIAGIKTVSLTTNGILLDRHLDELIDAGLDAINLSLDTLDRERYLAITRRNEFDRVMSNLETLLAKA
TFPVKLNVVMMRGVNGDEIKDFIELTRTHSLTVRFMELQPFDDNQIWKTGKFMGIDKITEQLRSLNPGVQKKQGKSTEYF
SFSLPGHQGSIAVIPAYTRNFCSSCNRIRITSHGKIISCLYDKEGLDLMPLLRNNADNNMLTELFRHAAAHKPADGKSAA
EGQTRTSMSEIGG
>Mature_333_residues
MNSPKQKNAPLVDQFQRHIEYARIAVTAHCNLRCTYCMREEHEYHTIADPELSSREVGKIIVALASIGIKKIRFTGGEPL
LRKDISVLVRQAKSIAGIKTVSLTTNGILLDRHLDELIDAGLDAINLSLDTLDRERYLAITRRNEFDRVMSNLETLLAKA
TFPVKLNVVMMRGVNGDEIKDFIELTRTHSLTVRFMELQPFDDNQIWKTGKFMGIDKITEQLRSLNPGVQKKQGKSTEYF
SFSLPGHQGSIAVIPAYTRNFCSSCNRIRITSHGKIISCLYDKEGLDLMPLLRNNADNNMLTELFRHAAAHKPADGKSAA
EGQTRTSMSEIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=306, Percent_Identity=39.2156862745098, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI116734668, Length=306, Percent_Identity=39.2156862745098, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI1786999, Length=297, Percent_Identity=31.3131313131313, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI32566329, Length=329, Percent_Identity=37.3860182370821, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32566331, Length=308, Percent_Identity=37.987012987013, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17561210, Length=337, Percent_Identity=37.0919881305638, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI28574490, Length=317, Percent_Identity=36.2776025236593, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI28574488, Length=309, Percent_Identity=36.5695792880259, Blast_Score=204, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37405; Mature: 37405

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPKQKNAPLVDQFQRHIEYARIAVTAHCNLRCTYCMREEHEYHTIADPELSSREVGKI
CCCCCCCCCCHHHHHHHHHHHEEEEEEEECCEEEEEEECCCCCCCCCCCCCCCHHHHHHH
IVALASIGIKKIRFTGGEPLLRKDISVLVRQAKSIAGIKTVSLTTNGILLDRHLDELIDA
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEHHHHHHHHHC
GLDAINLSLDTLDRERYLAITRRNEFDRVMSNLETLLAKATFPVKLNVVMMRGVNGDEIK
CCCEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHH
DFIELTRTHSLTVRFMELQPFDDNQIWKTGKFMGIDKITEQLRSLNPGVQKKQGKSTEYF
HHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEE
SFSLPGHQGSIAVIPAYTRNFCSSCNRIRITSHGKIISCLYDKEGLDLMPLLRNNADNNM
EEECCCCCCCEEEEEHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCHHHHHCCCCCHH
LTELFRHAAAHKPADGKSAAEGQTRTSMSEIGG
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MNSPKQKNAPLVDQFQRHIEYARIAVTAHCNLRCTYCMREEHEYHTIADPELSSREVGKI
CCCCCCCCCCHHHHHHHHHHHEEEEEEEECCEEEEEEECCCCCCCCCCCCCCCHHHHHHH
IVALASIGIKKIRFTGGEPLLRKDISVLVRQAKSIAGIKTVSLTTNGILLDRHLDELIDA
HHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEHHHHHHHHHC
GLDAINLSLDTLDRERYLAITRRNEFDRVMSNLETLLAKATFPVKLNVVMMRGVNGDEIK
CCCEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHH
DFIELTRTHSLTVRFMELQPFDDNQIWKTGKFMGIDKITEQLRSLNPGVQKKQGKSTEYF
HHHHHHHCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEE
SFSLPGHQGSIAVIPAYTRNFCSSCNRIRITSHGKIISCLYDKEGLDLMPLLRNNADNNM
EEECCCCCCCEEEEEHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCHHHHHCCCCCHH
LTELFRHAAAHKPADGKSAAEGQTRTSMSEIGG
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]