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The map label for this gene is leuS

Identifier: 119356387

GI number: 119356387

Start: 612695

End: 615145

Strand: Reverse

Name: leuS

Synonym: Cpha266_0551

Alternate gene names: 119356387

Gene position: 615145-612695 (Counterclockwise)

Preceding gene: 119356388

Following gene: 119356386

Centisome position: 19.63

GC content: 47.08

Gene sequence:

>2451_bases
ATGCGTTACGATTTTTCAACGATCGAAAAAAAATGGCAGTCTTTCTGGCTGAAAAACAACTCCTTTTCTTCAGGTGAAAG
CACTGATAAACCAAAATACTATGTCCTCGACATGTTCCCCTATCCAAGCGGATCGGGACTTCACGTAGGACACCTTGAAG
GGTACACGGCTACCGACATCGTAGCCAGATACAAACGCAGTTGCGGATATAATGTTCTGCACCCGATGGGATGGGATGCC
TTCGGGCTTCCGGCAGAACAGTTTGCCATCAAAACCGGAACACATCCAAAAAATACTACTGAAAAAAATATCAGCAGTTT
CAGGGAAACACTGCAGGCAATGGGTTTTTCCTATGATTGGTCGCGAGAAATCAATACGACCAGCCCGGATTATTTCAGAT
GGACACAATGGATCTTTATCAAATTGTATGAACTGGGTCTCGCATACGTTTCGGAGGTAGACATTAACTGGTGCGAAGAG
TTGAAAACAGTTCTGGCTAATGAGGAGGTAGAGGAAAAGGTGAAGGAGGGGTACACGGTTATCCGTAAACCGCTGCGCCA
GTGGGTACTGAAAATTACCGCCTATGCCGAAAGGCTTCTCGACGACCTTGACGAACTCGACTGGCCTGAAAATGTCAAAC
AGATGCAGCGCAACTGGATCGGACGTTCCGAAGGCATGGAAATTGATTTCGAACTTCGCTGCCACAACCGTAAATTGAGG
GTCTATACAACCAGACCTGACACTCTTTTCGGTGCAACCTTTCTGGTAATTTCCCCTGAACACCCCCTTGCCTTGAAGCT
GGCAACGGCACAGCAGCTCGTTGCCGTAACACAATACATCAAAGAGGCTAAATTGAAGTCCGAACTGGAACGGACAGGTC
TGCAAAAAGATAAAACCGGCATCTTTACAGGTTCCTTTGCCATCAATCCTGCAACGGGCGACCCTCTGCCTGTATGGATC
TCCGACTTCGTTCTGACCAGTTATGGCACTGGAGCAATCATGTCAGTACCAGCTCATGACAGCAGGGACTGGGAGTTCGC
AAAGAAATTCGGGTTACCCATAATCGAGGTCATCAAAAGCCCTGATGGTGTTGACGATGCTGCGTTTGAAGGAAAGGAGA
GCGTCTCAATCAATTCATCGAACCCGGAAATCAGTATTGACGGACTCCATTTCAGCGAAGCATTTCAAATTATGGCCCAC
TGGCTGGAGACAAAAGGGCTTGGTGAACGCAAAGTCACCTACAAACTTCGAGACTGGATATTCAGCCGGCAACGTTACTG
GGGTGAACCGATTCCTGTAAAACATTATGAAGATGGCTCAATCCGAACAGAAAGCAATCTGCCGCTCCAGCTTCCTGAAG
TCGAAGCCTATCAACCCTCGGAAACAGGTGAATCGCCGCTTGCAACCATGCATGATTGGCTCTATGGTGCTGATGAATTC
GGATCATTCAGAAGAGAGACCAACACCATGCCCCAATGGGCCGGAAGCTGCTGGTACTACCTGCGCTTTATCGATCCGGA
AAATAATGCGCAGCTTATTGACCCGGCGAAAGAAAAGTACTGGATGAATGTCGATCTCTATATCGGAGGTGCGGAACATG
CCGTTCTGCATCTGCTCTATGCTCGATTCTGGCACAAGGTACTCTACGATCTCGGGGTCGTGAGCAGCAGAGAACCATTT
AAAAAACTCTTCAATCAGGGAATGATTCTTGGTGAAGACAATGAAAAAATGTCCAAATCACGAGGGAACGTCATCCCTGC
TGACCAGGTGCTGAAAGACTACGGGGCAGATGCTGTCCGGCTCTATGAAATGTTTCTCGGCCCTCTCGAACAGGTAAAAC
CATGGAATACCAATGGTATAGAAGGCATAAGCCGTTTTCTTGGAAAAGTCTGGAGACTTGTTTATCCGGATTCAGAAAAT
CCAGACCAAAGAGATCAGGCAGCTGTACTTGATGAAAACCCGTTGCCCGAAATACTGCAACGCAGAATGCATAAAACCAT
CAAAAAAGTTACTGAAGACACTGATCATCTCAAATTCAATACCGCCATCTCTGAAATGATGGTATTTGTCAATGAACTGC
AGAAAAACGGGTGCCGTCAGAAAAGCGCCGTCGAAAACCTGCTCCTCATGCTTGCACCATATGCGCCGCATATCACAGCA
GAGCTCTGGCAGGCAATAGGCCATACATCGCCAATCAGCGCAGAACCGTTTCCCGTATTTGATCCTGCAATTGCCGAAGA
CCCTGTTGTGACCATAGCCGTACAGGTCAACGGAAAACTCAGAGGCAGGTTTACGGCTCCGGCAAAAAGCCCTGAAGAAT
CACTTGTTGACATGGCAAAACACGTTGATACCGTTATTAAATTTCTGGAAGGACAGACGATTGTCAAAGAAATTGTCATC
CAGGACAAACTTGTAAATTTCGCTGTAAAACAATCAATTCCAAACCATTGA

Upstream 100 bases:

>100_bases
CTGGCACAGAAGGAAACTGACCGGTTAATCACAAAAAAAGCAGTGCAGGAAATCCTGCACTGCTTTTTTTATAAAATAAA
ATGCACGACATCAAGAGCAT

Downstream 100 bases:

>100_bases
AATCGGGCAGCCCCGGTGTAACGATTATTGAAATGTCCATTTATTTTATGTAAACTGAAGGTTACAATTATCGACTGCCC
TTTCGGCTTGTTCCTTATCC

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS

Number of amino acids: Translated: 816; Mature: 816

Protein sequence:

>816_residues
MRYDFSTIEKKWQSFWLKNNSFSSGESTDKPKYYVLDMFPYPSGSGLHVGHLEGYTATDIVARYKRSCGYNVLHPMGWDA
FGLPAEQFAIKTGTHPKNTTEKNISSFRETLQAMGFSYDWSREINTTSPDYFRWTQWIFIKLYELGLAYVSEVDINWCEE
LKTVLANEEVEEKVKEGYTVIRKPLRQWVLKITAYAERLLDDLDELDWPENVKQMQRNWIGRSEGMEIDFELRCHNRKLR
VYTTRPDTLFGATFLVISPEHPLALKLATAQQLVAVTQYIKEAKLKSELERTGLQKDKTGIFTGSFAINPATGDPLPVWI
SDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIIEVIKSPDGVDDAAFEGKESVSINSSNPEISIDGLHFSEAFQIMAH
WLETKGLGERKVTYKLRDWIFSRQRYWGEPIPVKHYEDGSIRTESNLPLQLPEVEAYQPSETGESPLATMHDWLYGADEF
GSFRRETNTMPQWAGSCWYYLRFIDPENNAQLIDPAKEKYWMNVDLYIGGAEHAVLHLLYARFWHKVLYDLGVVSSREPF
KKLFNQGMILGEDNEKMSKSRGNVIPADQVLKDYGADAVRLYEMFLGPLEQVKPWNTNGIEGISRFLGKVWRLVYPDSEN
PDQRDQAAVLDENPLPEILQRRMHKTIKKVTEDTDHLKFNTAISEMMVFVNELQKNGCRQKSAVENLLLMLAPYAPHITA
ELWQAIGHTSPISAEPFPVFDPAIAEDPVVTIAVQVNGKLRGRFTAPAKSPEESLVDMAKHVDTVIKFLEGQTIVKEIVI
QDKLVNFAVKQSIPNH

Sequences:

>Translated_816_residues
MRYDFSTIEKKWQSFWLKNNSFSSGESTDKPKYYVLDMFPYPSGSGLHVGHLEGYTATDIVARYKRSCGYNVLHPMGWDA
FGLPAEQFAIKTGTHPKNTTEKNISSFRETLQAMGFSYDWSREINTTSPDYFRWTQWIFIKLYELGLAYVSEVDINWCEE
LKTVLANEEVEEKVKEGYTVIRKPLRQWVLKITAYAERLLDDLDELDWPENVKQMQRNWIGRSEGMEIDFELRCHNRKLR
VYTTRPDTLFGATFLVISPEHPLALKLATAQQLVAVTQYIKEAKLKSELERTGLQKDKTGIFTGSFAINPATGDPLPVWI
SDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIIEVIKSPDGVDDAAFEGKESVSINSSNPEISIDGLHFSEAFQIMAH
WLETKGLGERKVTYKLRDWIFSRQRYWGEPIPVKHYEDGSIRTESNLPLQLPEVEAYQPSETGESPLATMHDWLYGADEF
GSFRRETNTMPQWAGSCWYYLRFIDPENNAQLIDPAKEKYWMNVDLYIGGAEHAVLHLLYARFWHKVLYDLGVVSSREPF
KKLFNQGMILGEDNEKMSKSRGNVIPADQVLKDYGADAVRLYEMFLGPLEQVKPWNTNGIEGISRFLGKVWRLVYPDSEN
PDQRDQAAVLDENPLPEILQRRMHKTIKKVTEDTDHLKFNTAISEMMVFVNELQKNGCRQKSAVENLLLMLAPYAPHITA
ELWQAIGHTSPISAEPFPVFDPAIAEDPVVTIAVQVNGKLRGRFTAPAKSPEESLVDMAKHVDTVIKFLEGQTIVKEIVI
QDKLVNFAVKQSIPNH
>Mature_816_residues
MRYDFSTIEKKWQSFWLKNNSFSSGESTDKPKYYVLDMFPYPSGSGLHVGHLEGYTATDIVARYKRSCGYNVLHPMGWDA
FGLPAEQFAIKTGTHPKNTTEKNISSFRETLQAMGFSYDWSREINTTSPDYFRWTQWIFIKLYELGLAYVSEVDINWCEE
LKTVLANEEVEEKVKEGYTVIRKPLRQWVLKITAYAERLLDDLDELDWPENVKQMQRNWIGRSEGMEIDFELRCHNRKLR
VYTTRPDTLFGATFLVISPEHPLALKLATAQQLVAVTQYIKEAKLKSELERTGLQKDKTGIFTGSFAINPATGDPLPVWI
SDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIIEVIKSPDGVDDAAFEGKESVSINSSNPEISIDGLHFSEAFQIMAH
WLETKGLGERKVTYKLRDWIFSRQRYWGEPIPVKHYEDGSIRTESNLPLQLPEVEAYQPSETGESPLATMHDWLYGADEF
GSFRRETNTMPQWAGSCWYYLRFIDPENNAQLIDPAKEKYWMNVDLYIGGAEHAVLHLLYARFWHKVLYDLGVVSSREPF
KKLFNQGMILGEDNEKMSKSRGNVIPADQVLKDYGADAVRLYEMFLGPLEQVKPWNTNGIEGISRFLGKVWRLVYPDSEN
PDQRDQAAVLDENPLPEILQRRMHKTIKKVTEDTDHLKFNTAISEMMVFVNELQKNGCRQKSAVENLLLMLAPYAPHITA
ELWQAIGHTSPISAEPFPVFDPAIAEDPVVTIAVQVNGKLRGRFTAPAKSPEESLVDMAKHVDTVIKFLEGQTIVKEIVI
QDKLVNFAVKQSIPNH

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7661872, Length=884, Percent_Identity=32.9185520361991, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI94721239, Length=192, Percent_Identity=28.125, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI94721241, Length=192, Percent_Identity=28.125, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1786861, Length=871, Percent_Identity=41.5614236509759, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71997517, Length=836, Percent_Identity=28.7081339712919, Blast_Score=289, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI71997510, Length=836, Percent_Identity=28.7081339712919, Blast_Score=289, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI212645227, Length=352, Percent_Identity=27.2727272727273, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17510661, Length=853, Percent_Identity=21.3364595545135, Blast_Score=102, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6323414, Length=873, Percent_Identity=33.1042382588774, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321531, Length=386, Percent_Identity=25.1295336787565, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325217, Length=357, Percent_Identity=24.6498599439776, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319395, Length=214, Percent_Identity=28.5046728971963, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355409, Length=862, Percent_Identity=31.6705336426914, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI28574730, Length=181, Percent_Identity=29.2817679558011, Blast_Score=67, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24668547, Length=181, Percent_Identity=29.2817679558011, Blast_Score=67, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24668543, Length=181, Percent_Identity=29.2817679558011, Blast_Score=67, Evalue=7e-11,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYL_CHLPD (A1BDY0)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911031.1
- ProteinModelPortal:   A1BDY0
- SMR:   A1BDY0
- STRING:   A1BDY0
- GeneID:   4569418
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0551
- NMPDR:   fig|290317.7.peg.576
- eggNOG:   COG0495
- HOGENOM:   HBG693845
- OMA:   ERGNFPV
- ProtClustDB:   PRK00390
- GO:   GO:0005737
- HAMAP:   MF_00049_B
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11946:SF7
- PRINTS:   PR00985
- TIGRFAMs:   TIGR00396

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1; SSF47323 tRNAsyn_1a_bind; SSF50677 ValRS_IleRS_edit

EC number: =6.1.1.4

Molecular weight: Translated: 93336; Mature: 93336

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 579-579

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDFSTIEKKWQSFWLKNNSFSSGESTDKPKYYVLDMFPYPSGSGLHVGHLEGYTATDI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCHHHHH
VARYKRSCGYNVLHPMGWDAFGLPAEQFAIKTGTHPKNTTEKNISSFRETLQAMGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC
SREINTTSPDYFRWTQWIFIKLYELGLAYVSEVDINWCEELKTVLANEEVEEKVKEGYTV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHH
IRKPLRQWVLKITAYAERLLDDLDELDWPENVKQMQRNWIGRSEGMEIDFELRCHNRKLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCEEE
VYTTRPDTLFGATFLVISPEHPLALKLATAQQLVAVTQYIKEAKLKSELERTGLQKDKTG
EEECCCCCEECCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IFTGSFAINPATGDPLPVWISDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIIEVIKS
EEECCEEECCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHCCHHHHHHCC
PDGVDDAAFEGKESVSINSSNPEISIDGLHFSEAFQIMAHWLETKGLGERKVTYKLRDWI
CCCCCHHHCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
FSRQRYWGEPIPVKHYEDGSIRTESNLPLQLPEVEAYQPSETGESPLATMHDWLYGADEF
HHHHHHCCCCCCCEECCCCCEEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCHHH
GSFRRETNTMPQWAGSCWYYLRFIDPENNAQLIDPAKEKYWMNVDLYIGGAEHAVLHLLY
HHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEECCCCCCEEEEEEEEECCHHHHHHHHHH
ARFWHKVLYDLGVVSSREPFKKLFNQGMILGEDNEKMSKSRGNVIPADQVLKDYGADAVR
HHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCHHHHHHCCCCCCHHHHHHHHCCHHHH
LYEMFLGPLEQVKPWNTNGIEGISRFLGKVWRLVYPDSENPDQRDQAAVLDENPLPEILQ
HHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCHHHCCCCCCCHHHHH
RRMHKTIKKVTEDTDHLKFNTAISEMMVFVNELQKNGCRQKSAVENLLLMLAPYAPHITA
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHH
ELWQAIGHTSPISAEPFPVFDPAIAEDPVVTIAVQVNGKLRGRFTAPAKSPEESLVDMAK
HHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCCCHHHHHHHHHH
HVDTVIKFLEGQTIVKEIVIQDKLVNFAVKQSIPNH
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRYDFSTIEKKWQSFWLKNNSFSSGESTDKPKYYVLDMFPYPSGSGLHVGHLEGYTATDI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCHHHHH
VARYKRSCGYNVLHPMGWDAFGLPAEQFAIKTGTHPKNTTEKNISSFRETLQAMGFSYDW
HHHHHHHCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC
SREINTTSPDYFRWTQWIFIKLYELGLAYVSEVDINWCEELKTVLANEEVEEKVKEGYTV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHH
IRKPLRQWVLKITAYAERLLDDLDELDWPENVKQMQRNWIGRSEGMEIDFELRCHNRKLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCEEE
VYTTRPDTLFGATFLVISPEHPLALKLATAQQLVAVTQYIKEAKLKSELERTGLQKDKTG
EEECCCCCEECCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IFTGSFAINPATGDPLPVWISDFVLTSYGTGAIMSVPAHDSRDWEFAKKFGLPIIEVIKS
EEECCEEECCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHCCHHHHHHCC
PDGVDDAAFEGKESVSINSSNPEISIDGLHFSEAFQIMAHWLETKGLGERKVTYKLRDWI
CCCCCHHHCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
FSRQRYWGEPIPVKHYEDGSIRTESNLPLQLPEVEAYQPSETGESPLATMHDWLYGADEF
HHHHHHCCCCCCCEECCCCCEEECCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCHHH
GSFRRETNTMPQWAGSCWYYLRFIDPENNAQLIDPAKEKYWMNVDLYIGGAEHAVLHLLY
HHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEECCCCCCEEEEEEEEECCHHHHHHHHHH
ARFWHKVLYDLGVVSSREPFKKLFNQGMILGEDNEKMSKSRGNVIPADQVLKDYGADAVR
HHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCHHHHHHCCCCCCHHHHHHHHCCHHHH
LYEMFLGPLEQVKPWNTNGIEGISRFLGKVWRLVYPDSENPDQRDQAAVLDENPLPEILQ
HHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCCCCHHHCCCCCCCHHHHH
RRMHKTIKKVTEDTDHLKFNTAISEMMVFVNELQKNGCRQKSAVENLLLMLAPYAPHITA
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHH
ELWQAIGHTSPISAEPFPVFDPAIAEDPVVTIAVQVNGKLRGRFTAPAKSPEESLVDMAK
HHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCEEEEEEECCCCCHHHHHHHHHH
HVDTVIKFLEGQTIVKEIVIQDKLVNFAVKQSIPNH
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA