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The map label for this gene is hisA

Identifier: 118581459

GI number: 118581459

Start: 3342519

End: 3343256

Strand: Reverse

Name: hisA

Synonym: Ppro_3056

Alternate gene names: 118581459

Gene position: 3343256-3342519 (Counterclockwise)

Preceding gene: 118581460

Following gene: 118581458

Centisome position: 83.41

GC content: 60.7

Gene sequence:

>738_bases
ATGCTTGTAATTCCTGCGATTGACCTGAAAGACGGGGTTTGTGTTCGCCTTGAACAGGGGCTGATGGACAGGGACACGGT
TTTCAACGACAACCCCGCCAGTCAGGCCCTGGAGTGGCAGAACCAGGGGGCTGAGCTGCTGCACATCGTCGATCTGGATG
GGGCCTTTGCTGGCACACCGCGGAACAAGGCGGCCATCGAGGCCATCGTGAAGGCCATCAGCATACCCGCCCAGTTGGGT
GGCGGTATCCGCGACCTTGCCACCATCGAATCCTATCTCTCCTTGGGGCTCTCGCGGGTCATTATCGGTACGGCAGCCCA
GCGCAACCCGCAGTTGGTGAAAGAGGCCTGCGCAAAATTCCCCGGCAGGATCGTTGTCGGCATCGATGCCAAGGCCGGCA
TGGTTGCCGTGCAGGGATGGGCCGAGGTCACCGGGATCACGGCTGTTGACCTGGCGCGGAAATTCGAGGACTGCGGGGTC
GCTGCCATCATTTATACCGATATCAGTCGCGATGGCATGCTGCAGGGGCCCAATATCGAGGCGACCCGCTCACTGGCCGA
GGCGGTGGCCATTCCGGTGATTGCCTCGGGAGGGGTCTCTACACTGAAGGATATCGAGAATCTGATGACCATCGAGCGGA
GCGGGGTAACCGGGGTGATCACCGGCAAGGCGATCTACACCGGGGCTATCAGGCTGCATGAGGCCATCGCGCTCACCGGG
AAGGATAATCAGGAATAG

Upstream 100 bases:

>100_bases
AACATCGTTGCCACCCAGTTCCATCCGGAAAAGTCCCAGCATGCGGGCTTAAGCATACTGAAAAATTTCGCGGCACAAAA
TTGATACTGAAAGGTGCACC

Downstream 100 bases:

>100_bases
GCTATGCTGACAAAGAGAATCATTCCCTGTCTGGATGTCAAGGGTGGCCGGGTCGTCAAGGGCGTGCAGTTTCTGGAATT
GCGTGATGCCGGTGATCCGG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLVIPAIDLKDGVCVRLEQGLMDRDTVFNDNPASQALEWQNQGAELLHIVDLDGAFAGTPRNKAAIEAIVKAISIPAQLG
GGIRDLATIESYLSLGLSRVIIGTAAQRNPQLVKEACAKFPGRIVVGIDAKAGMVAVQGWAEVTGITAVDLARKFEDCGV
AAIIYTDISRDGMLQGPNIEATRSLAEAVAIPVIASGGVSTLKDIENLMTIERSGVTGVITGKAIYTGAIRLHEAIALTG
KDNQE

Sequences:

>Translated_245_residues
MLVIPAIDLKDGVCVRLEQGLMDRDTVFNDNPASQALEWQNQGAELLHIVDLDGAFAGTPRNKAAIEAIVKAISIPAQLG
GGIRDLATIESYLSLGLSRVIIGTAAQRNPQLVKEACAKFPGRIVVGIDAKAGMVAVQGWAEVTGITAVDLARKFEDCGV
AAIIYTDISRDGMLQGPNIEATRSLAEAVAIPVIASGGVSTLKDIENLMTIERSGVTGVITGKAIYTGAIRLHEAIALTG
KDNQE
>Mature_245_residues
MLVIPAIDLKDGVCVRLEQGLMDRDTVFNDNPASQALEWQNQGAELLHIVDLDGAFAGTPRNKAAIEAIVKAISIPAQLG
GGIRDLATIESYLSLGLSRVIIGTAAQRNPQLVKEACAKFPGRIVVGIDAKAGMVAVQGWAEVTGITAVDLARKFEDCGV
AAIIYTDISRDGMLQGPNIEATRSLAEAVAIPVIASGGVSTLKDIENLMTIERSGVTGVITGKAIYTGAIRLHEAIALTG
KDNQE

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=34.0163934426229, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1788336, Length=243, Percent_Identity=25.1028806584362, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_PELPD (A1ATI1)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902709.1
- ProteinModelPortal:   A1ATI1
- SMR:   A1ATI1
- STRING:   A1ATI1
- GeneID:   4574101
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3056
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   A1ATI1
- ProtClustDB:   PRK00748
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25729; Mature: 25729

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIPAIDLKDGVCVRLEQGLMDRDTVFNDNPASQALEWQNQGAELLHIVDLDGAFAGTP
CEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCC
RNKAAIEAIVKAISIPAQLGGGIRDLATIESYLSLGLSRVIIGTAAQRNPQLVKEACAKF
CCHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
PGRIVVGIDAKAGMVAVQGWAEVTGITAVDLARKFEDCGVAAIIYTDISRDGMLQGPNIE
CCEEEEEECCCCCEEEEECHHHHHCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCH
ATRSLAEAVAIPVIASGGVSTLKDIENLMTIERSGVTGVITGKAIYTGAIRLHEAIALTG
HHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHEEEEEEEECC
KDNQE
CCCCC
>Mature Secondary Structure
MLVIPAIDLKDGVCVRLEQGLMDRDTVFNDNPASQALEWQNQGAELLHIVDLDGAFAGTP
CEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCC
RNKAAIEAIVKAISIPAQLGGGIRDLATIESYLSLGLSRVIIGTAAQRNPQLVKEACAKF
CCHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
PGRIVVGIDAKAGMVAVQGWAEVTGITAVDLARKFEDCGVAAIIYTDISRDGMLQGPNIE
CCEEEEEECCCCCEEEEECHHHHHCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCH
ATRSLAEAVAIPVIASGGVSTLKDIENLMTIERSGVTGVITGKAIYTGAIRLHEAIALTG
HHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHEEEEEEEECC
KDNQE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA