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The map label for this gene is hisI

Identifier: 118581349

GI number: 118581349

Start: 3216925

End: 3217302

Strand: Direct

Name: hisI

Synonym: Ppro_2944

Alternate gene names: 118581349

Gene position: 3216925-3217302 (Clockwise)

Preceding gene: 118581348

Following gene: 118581350

Centisome position: 80.26

GC content: 57.14

Gene sequence:

>378_bases
GTGATTCAGATCGATTTCAACAAGATGGGGGGACTTATCCCCGCCATCATCCAGGACTACCAGAACGGCGAAGTACTGAT
GGTGGCCTTCATGGACGAAAAGACCCTCAACCTGACCCTGGAGACGGGCAAGACCTGGTTCTTCAGCCGCAGCCGCAACA
AGTACTGGATGAAGGGTGAGGAGTCGGGCAACACCCAGGAGGTCATGGAAGTGCTGACCGACTGTGACGCCGATACCGTG
GTCATCAAGGTCAAGCAGAACGGCCCGGCCGCCTGCCATACCGGCAACCGCAGCTGCTTCTACGTGAAATGGGAAAACGG
CCAGTGGGTGGAGCACTCCAAACCCCTGTTCGATCCGGCCCAGGTCTACAAGAAGTAA

Upstream 100 bases:

>100_bases
AGCGAGACGGCGGCCCCCTGACTGACCTTCTTGCATTTTCAGCCGCTGCTCCCTATACTCGCCGCTTCCGCGGCATCCAC
ACACGAGCAAGGAGACCAAC

Downstream 100 bases:

>100_bases
AGGGAGAGGGACAATGAGCAACATGCTGAAATTCGGCATCCCCAAGGGAAGCCTTGAAAACGCCACCGTTGAGCTGTTCA
AAAAGTCGGGCTGGCAGGTG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MIQIDFNKMGGLIPAIIQDYQNGEVLMVAFMDEKTLNLTLETGKTWFFSRSRNKYWMKGEESGNTQEVMEVLTDCDADTV
VIKVKQNGPAACHTGNRSCFYVKWENGQWVEHSKPLFDPAQVYKK

Sequences:

>Translated_125_residues
MIQIDFNKMGGLIPAIIQDYQNGEVLMVAFMDEKTLNLTLETGKTWFFSRSRNKYWMKGEESGNTQEVMEVLTDCDADTV
VIKVKQNGPAACHTGNRSCFYVKWENGQWVEHSKPLFDPAQVYKK
>Mature_125_residues
MIQIDFNKMGGLIPAIIQDYQNGEVLMVAFMDEKTLNLTLETGKTWFFSRSRNKYWMKGEESGNTQEVMEVLTDCDADTV
VIKVKQNGPAACHTGNRSCFYVKWENGQWVEHSKPLFDPAQVYKK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=44.8979591836735, Blast_Score=98, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=98, Percent_Identity=32.6530612244898, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_PELPD (A1AT71)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902599.1
- ProteinModelPortal:   A1AT71
- SMR:   A1AT71
- STRING:   A1AT71
- GeneID:   4574484
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2944
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   SGHYQIV
- ProtClustDB:   PRK00051
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14361; Mature: 14361

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIDFNKMGGLIPAIIQDYQNGEVLMVAFMDEKTLNLTLETGKTWFFSRSRNKYWMKGE
CEEEECHHHCCHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCEEEEECCCCEEEECCC
ESGNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCFYVKWENGQWVEHSKPLFDPA
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCEEEEEECCCCEECCCCCCCCHH
QVYKK
HHHCC
>Mature Secondary Structure
MIQIDFNKMGGLIPAIIQDYQNGEVLMVAFMDEKTLNLTLETGKTWFFSRSRNKYWMKGE
CEEEECHHHCCHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCCEEEEECCCCEEEECCC
ESGNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCFYVKWENGQWVEHSKPLFDPA
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCEEEEEECCCCEECCCCCCCCHH
QVYKK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA