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The map label for this gene is hisG

Identifier: 118581350

GI number: 118581350

Start: 3217316

End: 3218191

Strand: Direct

Name: hisG

Synonym: Ppro_2945

Alternate gene names: 118581350

Gene position: 3217316-3218191 (Clockwise)

Preceding gene: 118581349

Following gene: 118581351

Centisome position: 80.27

GC content: 62.21

Gene sequence:

>876_bases
ATGAGCAACATGCTGAAATTCGGCATCCCCAAGGGAAGCCTTGAAAACGCCACCGTTGAGCTGTTCAAAAAGTCGGGCTG
GCAGGTGAGCATCTCGTCGCGCAGCTATTTCCCAGGCATCGACGACAGTGAGATGACCTGTAAGTTGATCCGCCCCCAGG
AGATGGGGCGCTACGTGGAGCGCGCCACCATCGACGCCGGCATCGCCGGCCGCGACTGGGTCAGCGAGAACCAGTCCGAC
GTGGTGGAAGTCTGCGAGATGGTCTACTCCAAGGTTTCCCGGCGCCCGGCACGCTGGGTGCTGGTGGCAAACGGCGATTC
CAACGTCAAGGGGCCGGAGGACCTGGCCGGCGCCACCATCGCCACCGAACTGGTCGGCTTCACCAAGCGCTACTTTAGCG
AGCGCAACATCCCGGTCAACGTGGAGTTCTCCTGGGGCGCCACCGAAGCCAAGGTGGTTGACGGCCTGTGCGATGCCATC
GTGGAAGTCACCGAGACCGGCTCCACCATCAAGGCCAACGGCCTGCGCATCGTCTGCGAACTGATGGAGTCGGTGCCGGT
GCTGATCGCCAACAAGGCCTCCTGGGCCGACCCCTGGAAGCGGGAGAAGATCGAGCAGATCGCCACCCTGTTGAAATCAT
CCCTGGCTGCCGAGAACATGGTGGGGCTCAAGATGAACGCCCCCGGTGACAAGGTCGAGGCCATCACCAGCGTGCTGCCC
AGCCTGAAGAACGCCACCGTCTCCCACCTGTACAACTCCGACTGGCTCTCCATCGAGAGCGTCATGAGCGAGAAGGAGGT
GCGCCGCGTCATCCCCGAGCTGATCAAGCTGGGGGCCGAGGGGATCATCGAGTATCCGCTGAACAAGATCATCTGA

Upstream 100 bases:

>100_bases
AGCTGCTTCTACGTGAAATGGGAAAACGGCCAGTGGGTGGAGCACTCCAAACCCCTGTTCGATCCGGCCCAGGTCTACAA
GAAGTAAAGGGAGAGGGACA

Downstream 100 bases:

>100_bases
GCCGGAGTCCCAGAGCACCCCAAGGGGCATCCGAATACCTGCTTTACCAGATCCTGACCCGCTCAGCCGTTCTAACGGTT
GAGCGGTTTTTTTTGTTGTG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSNMLKFGIPKGSLENATVELFKKSGWQVSISSRSYFPGIDDSEMTCKLIRPQEMGRYVERATIDAGIAGRDWVSENQSD
VVEVCEMVYSKVSRRPARWVLVANGDSNVKGPEDLAGATIATELVGFTKRYFSERNIPVNVEFSWGATEAKVVDGLCDAI
VEVTETGSTIKANGLRIVCELMESVPVLIANKASWADPWKREKIEQIATLLKSSLAAENMVGLKMNAPGDKVEAITSVLP
SLKNATVSHLYNSDWLSIESVMSEKEVRRVIPELIKLGAEGIIEYPLNKII

Sequences:

>Translated_291_residues
MSNMLKFGIPKGSLENATVELFKKSGWQVSISSRSYFPGIDDSEMTCKLIRPQEMGRYVERATIDAGIAGRDWVSENQSD
VVEVCEMVYSKVSRRPARWVLVANGDSNVKGPEDLAGATIATELVGFTKRYFSERNIPVNVEFSWGATEAKVVDGLCDAI
VEVTETGSTIKANGLRIVCELMESVPVLIANKASWADPWKREKIEQIATLLKSSLAAENMVGLKMNAPGDKVEAITSVLP
SLKNATVSHLYNSDWLSIESVMSEKEVRRVIPELIKLGAEGIIEYPLNKII
>Mature_290_residues
SNMLKFGIPKGSLENATVELFKKSGWQVSISSRSYFPGIDDSEMTCKLIRPQEMGRYVERATIDAGIAGRDWVSENQSDV
VEVCEMVYSKVSRRPARWVLVANGDSNVKGPEDLAGATIATELVGFTKRYFSERNIPVNVEFSWGATEAKVVDGLCDAIV
EVTETGSTIKANGLRIVCELMESVPVLIANKASWADPWKREKIEQIATLLKSSLAAENMVGLKMNAPGDKVEAITSVLPS
LKNATVSHLYNSDWLSIESVMSEKEVRRVIPELIKLGAEGIIEYPLNKII

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=285, Percent_Identity=24.2105263157895, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320896, Length=295, Percent_Identity=25.7627118644068, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_PELPD (A1AT72)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902600.1
- ProteinModelPortal:   A1AT72
- SMR:   A1AT72
- STRING:   A1AT72
- GeneID:   4574485
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2945
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   SWGATEA
- PhylomeDB:   A1AT72
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32045; Mature: 31914

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNMLKFGIPKGSLENATVELFKKSGWQVSISSRSYFPGIDDSEMTCKLIRPQEMGRYVE
CCCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEECHHHHHHHHH
RATIDAGIAGRDWVSENQSDVVEVCEMVYSKVSRRPARWVLVANGDSNVKGPEDLAGATI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHH
ATELVGFTKRYFSERNIPVNVEFSWGATEAKVVDGLCDAIVEVTETGSTIKANGLRIVCE
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHH
LMESVPVLIANKASWADPWKREKIEQIATLLKSSLAAENMVGLKMNAPGDKVEAITSVLP
HHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHH
SLKNATVSHLYNSDWLSIESVMSEKEVRRVIPELIKLGAEGIIEYPLNKII
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SNMLKFGIPKGSLENATVELFKKSGWQVSISSRSYFPGIDDSEMTCKLIRPQEMGRYVE
CCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEECHHHHHHHHH
RATIDAGIAGRDWVSENQSDVVEVCEMVYSKVSRRPARWVLVANGDSNVKGPEDLAGATI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHH
ATELVGFTKRYFSERNIPVNVEFSWGATEAKVVDGLCDAIVEVTETGSTIKANGLRIVCE
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHH
LMESVPVLIANKASWADPWKREKIEQIATLLKSSLAAENMVGLKMNAPGDKVEAITSVLP
HHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHH
SLKNATVSHLYNSDWLSIESVMSEKEVRRVIPELIKLGAEGIIEYPLNKII
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA