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The map label for this gene is apt

Identifier: 118581148

GI number: 118581148

Start: 2999276

End: 2999794

Strand: Direct

Name: apt

Synonym: Ppro_2740

Alternate gene names: 118581148

Gene position: 2999276-2999794 (Clockwise)

Preceding gene: 118581147

Following gene: 118581149

Centisome position: 74.83

GC content: 59.15

Gene sequence:

>519_bases
ATGATGGAAGACCTGAAGAGCATCATTCGCGACATCCCCGATTTTCCCAAGAAGGGTATCGTATTCAAGGATATAACCAC
CCTGCTGCAGGATGCCCAGTCCTATCAGCGCATGATCGACCTGATAGCACACCGCTACGTGGGGCAACGCGTTGACAAGG
TGGTGGGGGTGGAGGCACGCGGCTTTATAATCGGCGCCGCCCTGGCCTATAAGCTGTGCGCCGGCGTGGTACTGGTGCGC
AAACCGGGCAAGCTCCCCTCGGAGACCTTCAGCAAGACCTACTCCCTGGAGTACGGCACCGACACCCTGGAAATTCACCG
CGACGCCATCAAACCGGGCGAGCGGGTGCTGATCGCAGACGACCTGCTGGCAACCGGTGGCACCATGGCGGCCGTGGTGG
ACATGGTGCTGAGCATGAGGGCCGAAATAGTGGATTGCTGCTTCATGACCGAACTCAACTTCCTCAACGGCCGCTCCAAG
CTACCGGCCGGCAAGGTATACTCGCTGCTCAACTTCTGA

Upstream 100 bases:

>100_bases
TCTCTGGAAAAGCTGTACGCCTGCGTGAAGCCCACCTAGCCGGCAAAGCACGGAGAAGCGGACCAAGCCGAACAATCAAA
CACAGAGGAGCATTCCCCGT

Downstream 100 bases:

>100_bases
TCGATGGGCATCCGCATGACACCAGCAGTGCCTCGCCGTCCACAGCGAAATACAGTTGAAAGCACCGCGCAACTCTGGTA
TACATAGCTCTCTTTCCCAC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MMEDLKSIIRDIPDFPKKGIVFKDITTLLQDAQSYQRMIDLIAHRYVGQRVDKVVGVEARGFIIGAALAYKLCAGVVLVR
KPGKLPSETFSKTYSLEYGTDTLEIHRDAIKPGERVLIADDLLATGGTMAAVVDMVLSMRAEIVDCCFMTELNFLNGRSK
LPAGKVYSLLNF

Sequences:

>Translated_172_residues
MMEDLKSIIRDIPDFPKKGIVFKDITTLLQDAQSYQRMIDLIAHRYVGQRVDKVVGVEARGFIIGAALAYKLCAGVVLVR
KPGKLPSETFSKTYSLEYGTDTLEIHRDAIKPGERVLIADDLLATGGTMAAVVDMVLSMRAEIVDCCFMTELNFLNGRSK
LPAGKVYSLLNF
>Mature_172_residues
MMEDLKSIIRDIPDFPKKGIVFKDITTLLQDAQSYQRMIDLIAHRYVGQRVDKVVGVEARGFIIGAALAYKLCAGVVLVR
KPGKLPSETFSKTYSLEYGTDTLEIHRDAIKPGERVLIADDLLATGGTMAAVVDMVLSMRAEIVDCCFMTELNFLNGRSK
LPAGKVYSLLNF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=46.1077844311377, Blast_Score=160, Evalue=6e-40,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=49.5867768595041, Blast_Score=125, Evalue=2e-29,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=51.7241379310345, Blast_Score=178, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=166, Percent_Identity=43.3734939759036, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=41.6184971098266, Blast_Score=130, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=31.2138728323699, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=39.4117647058824, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PELPD (A1ASM0)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902398.1
- ProteinModelPortal:   A1ASM0
- SMR:   A1ASM0
- STRING:   A1ASM0
- GeneID:   4574570
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2740
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   A1ASM0
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19048; Mature: 19048

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEDLKSIIRDIPDFPKKGIVFKDITTLLQDAQSYQRMIDLIAHRYVGQRVDKVVGVEAR
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFIIGAALAYKLCAGVVLVRKPGKLPSETFSKTYSLEYGTDTLEIHRDAIKPGERVLIAD
HHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEH
DLLATGGTMAAVVDMVLSMRAEIVDCCFMTELNFLNGRSKLPAGKVYSLLNF
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MMEDLKSIIRDIPDFPKKGIVFKDITTLLQDAQSYQRMIDLIAHRYVGQRVDKVVGVEAR
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFIIGAALAYKLCAGVVLVRKPGKLPSETFSKTYSLEYGTDTLEIHRDAIKPGERVLIAD
HHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEH
DLLATGGTMAAVVDMVLSMRAEIVDCCFMTELNFLNGRSKLPAGKVYSLLNF
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA