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The map label for this gene is srpG [H]

Identifier: 118580252

GI number: 118580252

Start: 1972400

End: 1973353

Strand: Direct

Name: srpG [H]

Synonym: Ppro_1832

Alternate gene names: 118580252

Gene position: 1972400-1973353 (Clockwise)

Preceding gene: 118580251

Following gene: 118580253

Centisome position: 49.21

GC content: 63.31

Gene sequence:

>954_bases
ATGAGTCGCATATTCTCGGACAACTCGCAATCCATCGGAAACACCCCGCTGGTCAGGCTCAATCGTGTCACGGATGGGGC
CAGGGGCATTGTGCTGGCTAAAATGGAGGGGCGTAATCCGGCCTATTCCATCAAGTGCCGCATCGGCGCCAACATGATCT
GGGACGCCGAAGAGCGCGGCATCCTCAAACCGGGCATGGAGATTGTGGAACCGACCAGCGGCAATACCGGCATTGCCCTG
GCCTATGTGGCCGCCGCCCGCGGCTACAACCTGACCCTGACCATGCCGGAAACCATGAGCGTGGAGCGCCGCCGAGTGGT
GGCGGCCCTGGGAGCCAACCTGATCCTGACGCCGGGCAACGAGGGGATGAAGGGAGCCATCCGGCGCGCCGAAGAGTTGG
CCGCATCCGATCCCGAGCGTTACTTCCTCCCCCAGCAGTTCAAGAATCCGGCCAACCCGGCCATTCACGAGAAAACCACC
GGGCCGGAGATATGGGATGACACTGACGGCGCCATCGACGTGCTGGTGTCCGGCGTGGGAACCGGGGGCACCATCTCCGG
TATCTCCCGCTACATAAAGAACAGCAGGGGCAAGCAGATCGTCTCCGTGGCCGTGGAGCCGCAGGAGAGCCCGGTCATCA
CCCAACAACTGGCTGGCCGGCCACTGCAACCCGGCCTGCACAAAATCCAGGGAATCGGCGCCGGCTTCATCCCCGAAACC
CTCGACCTCTCCATCATCGACCGGGTGGAGCTGGTGGAGAGCGGAGAGGCCGTCGACTTTGCTCGGCGACTGGCCAGGGA
GGAGGGGATGCTGGTGGGTATCTCGTCAGGGGCGGCAGCTGCCGCGGCGGTCAGATTGGCCAGTCTGGATGAATTTGCCG
GAAAAACCATTGTGGTGATCCTGCCCGACCTGGCGGAACGCTACCTCTCCACCCCGCTCTTCGATGGGGTCTAG

Upstream 100 bases:

>100_bases
TACATATTTTTTGACAAAAACAGAACCGTACCCTACAAGGGTACTACAGCGCATTCGCGATGATATTTCACGCGGCTGTG
GCTAGAAAAGGAGAGGCAGT

Downstream 100 bases:

>100_bases
GGTATTCGCTGTCGGCCATGGCGAGAGGTGATCCAGAAGCAGTAACACGCGAAGTAACAGCAGATATCTAGTTAAAAAAC
AGGAATTTTGAGAAATTGAT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSRIFSDNSQSIGNTPLVRLNRVTDGARGIVLAKMEGRNPAYSIKCRIGANMIWDAEERGILKPGMEIVEPTSGNTGIAL
AYVAAARGYNLTLTMPETMSVERRRVVAALGANLILTPGNEGMKGAIRRAEELAASDPERYFLPQQFKNPANPAIHEKTT
GPEIWDDTDGAIDVLVSGVGTGGTISGISRYIKNSRGKQIVSVAVEPQESPVITQQLAGRPLQPGLHKIQGIGAGFIPET
LDLSIIDRVELVESGEAVDFARRLAREEGMLVGISSGAAAAAAVRLASLDEFAGKTIVVILPDLAERYLSTPLFDGV

Sequences:

>Translated_317_residues
MSRIFSDNSQSIGNTPLVRLNRVTDGARGIVLAKMEGRNPAYSIKCRIGANMIWDAEERGILKPGMEIVEPTSGNTGIAL
AYVAAARGYNLTLTMPETMSVERRRVVAALGANLILTPGNEGMKGAIRRAEELAASDPERYFLPQQFKNPANPAIHEKTT
GPEIWDDTDGAIDVLVSGVGTGGTISGISRYIKNSRGKQIVSVAVEPQESPVITQQLAGRPLQPGLHKIQGIGAGFIPET
LDLSIIDRVELVESGEAVDFARRLAREEGMLVGISSGAAAAAAVRLASLDEFAGKTIVVILPDLAERYLSTPLFDGV
>Mature_316_residues
SRIFSDNSQSIGNTPLVRLNRVTDGARGIVLAKMEGRNPAYSIKCRIGANMIWDAEERGILKPGMEIVEPTSGNTGIALA
YVAAARGYNLTLTMPETMSVERRRVVAALGANLILTPGNEGMKGAIRRAEELAASDPERYFLPQQFKNPANPAIHEKTTG
PEIWDDTDGAIDVLVSGVGTGGTISGISRYIKNSRGKQIVSVAVEPQESPVITQQLAGRPLQPGLHKIQGIGAGFIPETL
DLSIIDRVELVESGEAVDFARRLAREEGMLVGISSGAAAAAAVRLASLDEFAGKTIVVILPDLAERYLSTPLFDGV

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=326, Percent_Identity=40.7975460122699, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI295821200, Length=326, Percent_Identity=40.7975460122699, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI4557415, Length=326, Percent_Identity=40.7975460122699, Blast_Score=205, Evalue=4e-53,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=67.9365079365079, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=42.2950819672131, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=48.6842105263158, Blast_Score=267, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=51.1400651465798, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17562970, Length=320, Percent_Identity=46.25, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI32566674, Length=312, Percent_Identity=46.7948717948718, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17561720, Length=317, Percent_Identity=46.3722397476341, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=47.5336322869955, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17534315, Length=321, Percent_Identity=39.2523364485981, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25147552, Length=321, Percent_Identity=38.006230529595, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17561716, Length=125, Percent_Identity=47.2, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=37.5796178343949, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=33.7461300309598, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24643623, Length=317, Percent_Identity=39.1167192429022, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI20129101, Length=317, Percent_Identity=39.1167192429022, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33774; Mature: 33643

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIFSDNSQSIGNTPLVRLNRVTDGARGIVLAKMEGRNPAYSIKCRIGANMIWDAEERG
CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEEEECCCEEECCCCCC
ILKPGMEIVEPTSGNTGIALAYVAAARGYNLTLTMPETMSVERRRVVAALGANLILTPGN
CCCCCCCEECCCCCCCCEEEEEEHHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCC
EGMKGAIRRAEELAASDPERYFLPQQFKNPANPAIHEKTTGPEIWDDTDGAIDVLVSGVG
CCHHHHHHHHHHHHCCCCHHEECCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEHEEECCC
TGGTISGISRYIKNSRGKQIVSVAVEPQESPVITQQLAGRPLQPGLHKIQGIGAGFIPET
CCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHCCCCCCCCCC
LDLSIIDRVELVESGEAVDFARRLAREEGMLVGISSGAAAAAAVRLASLDEFAGKTIVVI
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEE
LPDLAERYLSTPLFDGV
CCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SRIFSDNSQSIGNTPLVRLNRVTDGARGIVLAKMEGRNPAYSIKCRIGANMIWDAEERG
CCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEEEECCCEEECCCCCC
ILKPGMEIVEPTSGNTGIALAYVAAARGYNLTLTMPETMSVERRRVVAALGANLILTPGN
CCCCCCCEECCCCCCCCEEEEEEHHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCC
EGMKGAIRRAEELAASDPERYFLPQQFKNPANPAIHEKTTGPEIWDDTDGAIDVLVSGVG
CCHHHHHHHHHHHHCCCCHHEECCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEHEEECCC
TGGTISGISRYIKNSRGKQIVSVAVEPQESPVITQQLAGRPLQPGLHKIQGIGAGFIPET
CCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHCCCCCCCCCC
LDLSIIDRVELVESGEAVDFARRLAREEGMLVGISSGAAAAAAVRLASLDEFAGKTIVVI
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEE
LPDLAERYLSTPLFDGV
CCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]