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The map label for this gene is era

Identifier: 118580146

GI number: 118580146

Start: 1855119

End: 1856009

Strand: Direct

Name: era

Synonym: Ppro_1726

Alternate gene names: 118580146

Gene position: 1855119-1856009 (Clockwise)

Preceding gene: 118580145

Following gene: 118580147

Centisome position: 46.29

GC content: 62.07

Gene sequence:

>891_bases
ATGAAAAACAACGTCAACAGATTCGGCTATGTCTCCATCGTCGGTCGTCCCAACGTGGGCAAGTCCACGTTGCTCAACCG
CATCATCGGCGAGAAGATCGCCATCACCTCGGACAAGCCGCAGACCACCCGCAACCGCATCCAGGGGATTCACAACATCG
CCAACGGCCAGATCGTCTTCATCGATACCCCCGGCATTCATGCCTGCCATTCGCGCCTGAACAAGGGGATGGTGGACGCC
GCCCTGGCAGCACTGCGGGGGGTGGACCTGCTGCTTTTGGTGGTGGATGCGGGGGGCGCGATTGACGACCGGCTGGTGCG
CGACGTCCTGGGCGGCACAGGCACGCCGGTCATGCTGGTGCTCAACAAGGTCGACCTTTTGGCTGACAAGCGGGTTCTGC
TGGAGAGAATGGCGGCCTGGTCGCAACTGTACCCCTTCCGGGAGATCCTGCCGATCTCGGCCGGAAGCGGCGAGGGGGTG
GATGGGCTGATCGAGACGGTCTGCGGCTACCTCCCCGAGGGACAGCCCCTGTTCCCCGACGACATCCTCACCGATCTGCC
GGAGAGGTTCATCGTGGCCGAGATGATCCGCGAGAAGATCTTCCGCCTGACCCGCGATGAGATCCCCTATTCCACGGCTG
TCACGGTGGAGAGCTTCACCGAGCGCCCCAATGGCGTGGTGGCCATCTCCGCCGCCATCTGCCTGGAACGCCCCAACCAG
AAGGGGATCATCATCGGCAAGAAGGGGGAGATGCTGAAGAAGATCGGCAGCCAGGCCCGCCACGATATCGAGCGACTGCT
GGGAACGCGCGTTTTTCTGGAACTGTTCGTCAAGATCGAGGAGAACTGGAGCGAGCGCACCTCGAAACTGAGAGAGTTCG
GCTACGAGTAG

Upstream 100 bases:

>100_bases
CCGGGGACTCCCGGCCAGGCAGACTGGTCTTCAACCGTAGCGTGACCCTGAAAGATACCCGCGCCAAGAAGCTAGACATA
AAGGAACAGCATTCAACCAT

Downstream 100 bases:

>100_bases
GGAACTGCTTGAGATCGGCGGCCATTTAAGAGTTCAACCCCTGGAAGGAAACACATGAAACCTCTCGTCGCCCTGGTGGG
CCGTCCCAATGTGGGCAAAT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKNNVNRFGYVSIVGRPNVGKSTLLNRIIGEKIAITSDKPQTTRNRIQGIHNIANGQIVFIDTPGIHACHSRLNKGMVDA
ALAALRGVDLLLLVVDAGGAIDDRLVRDVLGGTGTPVMLVLNKVDLLADKRVLLERMAAWSQLYPFREILPISAGSGEGV
DGLIETVCGYLPEGQPLFPDDILTDLPERFIVAEMIREKIFRLTRDEIPYSTAVTVESFTERPNGVVAISAAICLERPNQ
KGIIIGKKGEMLKKIGSQARHDIERLLGTRVFLELFVKIEENWSERTSKLREFGYE

Sequences:

>Translated_296_residues
MKNNVNRFGYVSIVGRPNVGKSTLLNRIIGEKIAITSDKPQTTRNRIQGIHNIANGQIVFIDTPGIHACHSRLNKGMVDA
ALAALRGVDLLLLVVDAGGAIDDRLVRDVLGGTGTPVMLVLNKVDLLADKRVLLERMAAWSQLYPFREILPISAGSGEGV
DGLIETVCGYLPEGQPLFPDDILTDLPERFIVAEMIREKIFRLTRDEIPYSTAVTVESFTERPNGVVAISAAICLERPNQ
KGIIIGKKGEMLKKIGSQARHDIERLLGTRVFLELFVKIEENWSERTSKLREFGYE
>Mature_296_residues
MKNNVNRFGYVSIVGRPNVGKSTLLNRIIGEKIAITSDKPQTTRNRIQGIHNIANGQIVFIDTPGIHACHSRLNKGMVDA
ALAALRGVDLLLLVVDAGGAIDDRLVRDVLGGTGTPVMLVLNKVDLLADKRVLLERMAAWSQLYPFREILPISAGSGEGV
DGLIETVCGYLPEGQPLFPDDILTDLPERFIVAEMIREKIFRLTRDEIPYSTAVTVESFTERPNGVVAISAAICLERPNQ
KGIIIGKKGEMLKKIGSQARHDIERLLGTRVFLELFVKIEENWSERTSKLREFGYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=325, Percent_Identity=26.1538461538462, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788919, Length=289, Percent_Identity=41.8685121107266, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082120, Length=173, Percent_Identity=34.1040462427746, Blast_Score=82, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323665, Length=167, Percent_Identity=31.1377245508982, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646434, Length=309, Percent_Identity=26.2135922330097, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_PELPD (A1APR8)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901396.1
- ProteinModelPortal:   A1APR8
- SMR:   A1APR8
- STRING:   A1APR8
- GeneID:   4572827
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1726
- eggNOG:   COG1159
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- PhylomeDB:   A1APR8
- ProtClustDB:   PRK00089
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 32743; Mature: 32743

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNVNRFGYVSIVGRPNVGKSTLLNRIIGEKIAITSDKPQTTRNRIQGIHNIANGQIVF
CCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCEEEE
IDTPGIHACHSRLNKGMVDAALAALRGVDLLLLVVDAGGAIDDRLVRDVLGGTGTPVMLV
EECCCHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHH
LNKVDLLADKRVLLERMAAWSQLYPFREILPISAGSGEGVDGLIETVCGYLPEGQPLFPD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCHHHHHHHHHHCCCCCCCCCCH
DILTDLPERFIVAEMIREKIFRLTRDEIPYSTAVTVESFTERPNGVVAISAAICLERPNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCEEEEEHHHHHCCCCC
KGIIIGKKGEMLKKIGSQARHDIERLLGTRVFLELFVKIEENWSERTSKLREFGYE
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNNVNRFGYVSIVGRPNVGKSTLLNRIIGEKIAITSDKPQTTRNRIQGIHNIANGQIVF
CCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCEEEE
IDTPGIHACHSRLNKGMVDAALAALRGVDLLLLVVDAGGAIDDRLVRDVLGGTGTPVMLV
EECCCHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHH
LNKVDLLADKRVLLERMAAWSQLYPFREILPISAGSGEGVDGLIETVCGYLPEGQPLFPD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCHHHHHHHHHHCCCCCCCCCCH
DILTDLPERFIVAEMIREKIFRLTRDEIPYSTAVTVESFTERPNGVVAISAAICLERPNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCEEEEEHHHHHCCCCC
KGIIIGKKGEMLKKIGSQARHDIERLLGTRVFLELFVKIEENWSERTSKLREFGYE
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA