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The map label for this gene is clpP

Identifier: 118579613

GI number: 118579613

Start: 1235162

End: 1235761

Strand: Reverse

Name: clpP

Synonym: Ppro_1183

Alternate gene names: 118579613

Gene position: 1235761-1235162 (Counterclockwise)

Preceding gene: 118579614

Following gene: 118579612

Centisome position: 30.83

GC content: 59.17

Gene sequence:

>600_bases
ATGTACATTCCAATGGTTGTTGAACAGAGCGGCCGGGGCGAGCGGGCGTACGACATCTACTCCCGCCTGCTCAAAGAGCG
CATCATTTTCCTGGGCGGCGGCATCGATGACCAGGTTGCCAATCTGATCATCGCCCAGCTTCTTTTCTTGGAGGCAGAGG
ATCCCGACAAGGACATCCACCTCTACATAAATTCACCCGGCGGCGTGGTCACCTCCGGCATGGCGATCTACGACACCATG
CGCTACATCAAGGCGCCGGTCTCCACCATCTGCGTGGGCCAGGCCGCATCAATGGGCGCCGTGCTGCTGGCTGCCGGCGA
GAAGGGGAAGCGTTTCTCCCTCAACCACTCGCGCATCATGATTCATCAGCCTCTGGGCGGTTTCCAGGGGCAGGCAACGG
ACATCAGCATCCACGCCAAGGAAATTCTCCGTATGAAGGAGGAGCTCAACTCCATCCTGGCCGACCTGACCGGTCAGTCC
AAGGAGAGGATCGAGGCGGATACGGACCGCGACTACTTCATGTCAGCGACCGAAGCAGAGGAGTACGGACTGATCGACGC
AACCTTCACCAGAAAGCCTGACAGCGGAGGCACTCCATGA

Upstream 100 bases:

>100_bases
CACGACAGCAGATAGATCGAGGCCAAGGGGATCTCCGATCCGGCCGTGGAACCGGCCAAGCACGTCACACGGCATGCGTC
AGCACAAATGAAAGGGCATC

Downstream 100 bases:

>100_bases
GCCGACGGGAAACAACGCAGGAAAATCTGACCTGCTCGTTCTGCGGAAAGAGCCAGGAAGAGGTCAAGAAACTGATCGCC
GGACCGGCGGTGTACATCTG

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MYIPMVVEQSGRGERAYDIYSRLLKERIIFLGGGIDDQVANLIIAQLLFLEAEDPDKDIHLYINSPGGVVTSGMAIYDTM
RYIKAPVSTICVGQAASMGAVLLAAGEKGKRFSLNHSRIMIHQPLGGFQGQATDISIHAKEILRMKEELNSILADLTGQS
KERIEADTDRDYFMSATEAEEYGLIDATFTRKPDSGGTP

Sequences:

>Translated_199_residues
MYIPMVVEQSGRGERAYDIYSRLLKERIIFLGGGIDDQVANLIIAQLLFLEAEDPDKDIHLYINSPGGVVTSGMAIYDTM
RYIKAPVSTICVGQAASMGAVLLAAGEKGKRFSLNHSRIMIHQPLGGFQGQATDISIHAKEILRMKEELNSILADLTGQS
KERIEADTDRDYFMSATEAEEYGLIDATFTRKPDSGGTP
>Mature_199_residues
MYIPMVVEQSGRGERAYDIYSRLLKERIIFLGGGIDDQVANLIIAQLLFLEAEDPDKDIHLYINSPGGVVTSGMAIYDTM
RYIKAPVSTICVGQAASMGAVLLAAGEKGKRFSLNHSRIMIHQPLGGFQGQATDISIHAKEILRMKEELNSILADLTGQS
KERIEADTDRDYFMSATEAEEYGLIDATFTRKPDSGGTP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=194, Percent_Identity=61.8556701030928, Blast_Score=252, Evalue=2e-67,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=68.4210526315789, Blast_Score=283, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=184, Percent_Identity=58.1521739130435, Blast_Score=220, Evalue=4e-58,
Organism=Drosophila melanogaster, GI20129427, Length=193, Percent_Identity=58.5492227979275, Blast_Score=244, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_PELPD (A1AN85)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900863.1
- ProteinModelPortal:   A1AN85
- SMR:   A1AN85
- STRING:   A1AN85
- MEROPS:   S14.001
- GeneID:   4574653
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1183
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- PhylomeDB:   A1AN85
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21846; Mature: 21846

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 97-97 ACT_SITE 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIPMVVEQSGRGERAYDIYSRLLKERIIFLGGGIDDQVANLIIAQLLFLEAEDPDKDIH
CCCCEEEECCCCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTSGMAIYDTMRYIKAPVSTICVGQAASMGAVLLAAGEKGKRFSLNHSRIM
EEECCCCCEEECCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCEEECCCCEEE
IHQPLGGFQGQATDISIHAKEILRMKEELNSILADLTGQSKERIEADTDRDYFMSATEAE
EECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHEECCCHH
EYGLIDATFTRKPDSGGTP
HCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MYIPMVVEQSGRGERAYDIYSRLLKERIIFLGGGIDDQVANLIIAQLLFLEAEDPDKDIH
CCCCEEEECCCCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTSGMAIYDTMRYIKAPVSTICVGQAASMGAVLLAAGEKGKRFSLNHSRIM
EEECCCCCEEECCHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCEEECCCCEEE
IHQPLGGFQGQATDISIHAKEILRMKEELNSILADLTGQSKERIEADTDRDYFMSATEAE
EECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHEECCCHH
EYGLIDATFTRKPDSGGTP
HCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA