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The map label for this gene is wecC [H]

Identifier: 118579484

GI number: 118579484

Start: 1100638

End: 1102320

Strand: Reverse

Name: wecC [H]

Synonym: Ppro_1051

Alternate gene names: 118579484

Gene position: 1102320-1100638 (Counterclockwise)

Preceding gene: 118579485

Following gene: 118579479

Centisome position: 27.5

GC content: 58.88

Gene sequence:

>1683_bases
ATGACAAAAAATGCGACTTCCGACGCACCAAAAACAACAGTAGAGTATTCAGTCAGCCCGGCAGGAGAAAAATTCGCCAT
ACCACGCAAGGAGGAATATGCAGAGGAGTTCCAACGCGTCGAAAAACTCGTTGTCAAGGCGCGGGCGGAAGGCAAGGAAA
TCGTGGTGGTAATGGGGGTGGGATTCGTGGGCGCGGTCATGGCCGCCATTATTGCCGACACCAAAAGCAAGGGGGGGCAC
CCGTCCAAATTCGTCATCGGGTGCCAGAGGCCCAGTACCCGAAGCTTCTGGAAAATCCCGCTGATCAACCGGGGCGAACC
TCCCGTCAAGGCGGAAGACCCCGAAGTCGAGGAGATCATCAAGCGCTGCGTACTGGAGAAGAAGACCCTTGTCGCCACCT
ACTCCTGCGACTGCATCAAGCTGGCGGATTGCGTCGTGGTAGACGTCCAGTGCGATTACAGCAAGAAAAGCCTCGGCAAC
ATGCGTGCCGGAGAAGCGGACATGGCTGCCCTGGAAACGACCATGCGCACCATCGGCATGCGCATCCAACCCTCCTGCCT
GGTGCTGATCGAGACGACGGTTGCGCCGGGCACTACCGAGTTCGTTGCCTGGCCGATCCTCAAGAAGGCGTTTGCCGCGC
GCGGCATCGATTCCGTACCACTCCTCGCCCACAGTTTCGAAAGGGTCATGCCCGGCAGGCACTATGTCTCAAGTATCCGT
GACTTCTGGCGGGTCTGCTCCGGCTGCAACGCCGAAGCGAAAAAGAGGGTGGTGAAGTTTCTCAAGGAGGTGCTGAATAC
CAAGGAGTATCCGCTGACGGTCATGGACCGGCCCATCGAGTCGGAAACGACCAAGATTGTCGAAAACTCCTACCGGGCGA
CGATCCTGGCCTACTTGAACGAATGGAGCCTGTTCGCCGAAAGAAACGGGGTGGATCTGACAAAAGTGATCGACGCCATC
AAGATGCGCCCCACCCACAGCAACATGATATTCCCCGGCCCCGGGATCGGCGGCTATTGCCTGCCCAAGGACGGAGGCCT
CGGCTACTGGTCCTACCGTCACATCTTGGGCTTCGAGGATGGGGAGAGCATTTTCAAGATCACTCCCCTGGCAATCGATA
TCAACGACACACGGGCGCTGCATGTGGCGCAACTCACCCGGGATGCGCTGCGCAACATGGGACGGTACATTGCCGGCGCG
GACGTCCTGATATGCGGGGCAAGTTACCGCCAGGACGTGGGCGACACCCGGTACAGCGGCAGCGAAATGGTTGTCCGCAA
ACTGACCGAGATGGGCGCGGAGATGCGCGTGCACGACCCCTACGTGGACCACTGGCATGAACTGGAGAACCAGGACGACT
ATCCCGCACCCGGGCAATCCTGGAAGCGCTTCTTCCGCAACCAGGACGGTTTGCAGAACATACGGGTCCAAAGCGACCTT
GCCGAAGCGCTCAAGGGTGTCGAAGCGGTTGTCTTCGCCGTTCCCCATTCCCCGTACCTGAAGCTGGAGCCGGAAGAGAT
AATCGACTGGACCGGCAAGCCGCTGGCGGTGATCGACTGTTTCGGAATACTCTCCGACAAGACTATCCGCCGTTATTTCG
AGCTGGGCTGCGAGGTTAAGGCCCTGGGCCGCGGGCATATCCAGCGCATCAAGGAAGAGGTACGCAAGGGAAGACGCGAT
TAA

Upstream 100 bases:

>100_bases
AATCCCCGCGCCCCGAATCGGGTCCGTTCATTTTTGGAAATGTGGCTGCGGATTTTTCATGTTTTCGTATGTGCCAACTT
TTTCCAGGGAGGTATCCAGG

Downstream 100 bases:

>100_bases
CCACTGCCCATCAGGAAACCCCGGTTCATGTGACCAGATGCTCCAACAGCAGGGGAGTGGCTTTGCTGCTGGCAAGCCGA
CGCTGTTTTCAGCGTTAGGG

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MTKNATSDAPKTTVEYSVSPAGEKFAIPRKEEYAEEFQRVEKLVVKARAEGKEIVVVMGVGFVGAVMAAIIADTKSKGGH
PSKFVIGCQRPSTRSFWKIPLINRGEPPVKAEDPEVEEIIKRCVLEKKTLVATYSCDCIKLADCVVVDVQCDYSKKSLGN
MRAGEADMAALETTMRTIGMRIQPSCLVLIETTVAPGTTEFVAWPILKKAFAARGIDSVPLLAHSFERVMPGRHYVSSIR
DFWRVCSGCNAEAKKRVVKFLKEVLNTKEYPLTVMDRPIESETTKIVENSYRATILAYLNEWSLFAERNGVDLTKVIDAI
KMRPTHSNMIFPGPGIGGYCLPKDGGLGYWSYRHILGFEDGESIFKITPLAIDINDTRALHVAQLTRDALRNMGRYIAGA
DVLICGASYRQDVGDTRYSGSEMVVRKLTEMGAEMRVHDPYVDHWHELENQDDYPAPGQSWKRFFRNQDGLQNIRVQSDL
AEALKGVEAVVFAVPHSPYLKLEPEEIIDWTGKPLAVIDCFGILSDKTIRRYFELGCEVKALGRGHIQRIKEEVRKGRRD

Sequences:

>Translated_560_residues
MTKNATSDAPKTTVEYSVSPAGEKFAIPRKEEYAEEFQRVEKLVVKARAEGKEIVVVMGVGFVGAVMAAIIADTKSKGGH
PSKFVIGCQRPSTRSFWKIPLINRGEPPVKAEDPEVEEIIKRCVLEKKTLVATYSCDCIKLADCVVVDVQCDYSKKSLGN
MRAGEADMAALETTMRTIGMRIQPSCLVLIETTVAPGTTEFVAWPILKKAFAARGIDSVPLLAHSFERVMPGRHYVSSIR
DFWRVCSGCNAEAKKRVVKFLKEVLNTKEYPLTVMDRPIESETTKIVENSYRATILAYLNEWSLFAERNGVDLTKVIDAI
KMRPTHSNMIFPGPGIGGYCLPKDGGLGYWSYRHILGFEDGESIFKITPLAIDINDTRALHVAQLTRDALRNMGRYIAGA
DVLICGASYRQDVGDTRYSGSEMVVRKLTEMGAEMRVHDPYVDHWHELENQDDYPAPGQSWKRFFRNQDGLQNIRVQSDL
AEALKGVEAVVFAVPHSPYLKLEPEEIIDWTGKPLAVIDCFGILSDKTIRRYFELGCEVKALGRGHIQRIKEEVRKGRRD
>Mature_559_residues
TKNATSDAPKTTVEYSVSPAGEKFAIPRKEEYAEEFQRVEKLVVKARAEGKEIVVVMGVGFVGAVMAAIIADTKSKGGHP
SKFVIGCQRPSTRSFWKIPLINRGEPPVKAEDPEVEEIIKRCVLEKKTLVATYSCDCIKLADCVVVDVQCDYSKKSLGNM
RAGEADMAALETTMRTIGMRIQPSCLVLIETTVAPGTTEFVAWPILKKAFAARGIDSVPLLAHSFERVMPGRHYVSSIRD
FWRVCSGCNAEAKKRVVKFLKEVLNTKEYPLTVMDRPIESETTKIVENSYRATILAYLNEWSLFAERNGVDLTKVIDAIK
MRPTHSNMIFPGPGIGGYCLPKDGGLGYWSYRHILGFEDGESIFKITPLAIDINDTRALHVAQLTRDALRNMGRYIAGAD
VLICGASYRQDVGDTRYSGSEMVVRKLTEMGAEMRVHDPYVDHWHELENQDDYPAPGQSWKRFFRNQDGLQNIRVQSDLA
EALKGVEAVVFAVPHSPYLKLEPEEIIDWTGKPLAVIDCFGILSDKTIRRYFELGCEVKALGRGHIQRIKEEVRKGRRD

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=496, Percent_Identity=23.3870967741935, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI296040443, Length=265, Percent_Identity=24.5283018867925, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI296040438, Length=265, Percent_Identity=24.5283018867925, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994968, Length=456, Percent_Identity=23.9035087719298, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788340, Length=390, Percent_Identity=21.7948717948718, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560350, Length=493, Percent_Identity=22.3123732251521, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 62705; Mature: 62574

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNATSDAPKTTVEYSVSPAGEKFAIPRKEEYAEEFQRVEKLVVKARAEGKEIVVVMGV
CCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GFVGAVMAAIIADTKSKGGHPSKFVIGCQRPSTRSFWKIPLINRGEPPVKAEDPEVEEII
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHH
KRCVLEKKTLVATYSCDCIKLADCVVVDVQCDYSKKSLGNMRAGEADMAALETTMRTIGM
HHHHHCCCCEEEEECCCCEEECCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCC
RIQPSCLVLIETTVAPGTTEFVAWPILKKAFAARGIDSVPLLAHSFERVMPGRHYVSSIR
EECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHH
DFWRVCSGCNAEAKKRVVKFLKEVLNTKEYPLTVMDRPIESETTKIVENSYRATILAYLN
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHH
EWSLFAERNGVDLTKVIDAIKMRPTHSNMIFPGPGIGGYCLPKDGGLGYWSYRHILGFED
HHHHHHCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCEECCCCCCCCCCHHHHEECCCC
GESIFKITPLAIDINDTRALHVAQLTRDALRNMGRYIAGADVLICGASYRQDVGDTRYSG
CCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCCC
SEMVVRKLTEMGAEMRVHDPYVDHWHELENQDDYPAPGQSWKRFFRNQDGLQNIRVQSDL
HHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
AEALKGVEAVVFAVPHSPYLKLEPEEIIDWTGKPLAVIDCFGILSDKTIRRYFELGCEVK
HHHHCCCEEEEEEECCCCCEEECHHHHHCCCCCCEEEEEHHHHHCHHHHHHHHHCCCCEE
ALGRGHIQRIKEEVRKGRRD
ECCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKNATSDAPKTTVEYSVSPAGEKFAIPRKEEYAEEFQRVEKLVVKARAEGKEIVVVMGV
CCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
GFVGAVMAAIIADTKSKGGHPSKFVIGCQRPSTRSFWKIPLINRGEPPVKAEDPEVEEII
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHH
KRCVLEKKTLVATYSCDCIKLADCVVVDVQCDYSKKSLGNMRAGEADMAALETTMRTIGM
HHHHHCCCCEEEEECCCCEEECCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCC
RIQPSCLVLIETTVAPGTTEFVAWPILKKAFAARGIDSVPLLAHSFERVMPGRHYVSSIR
EECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHH
DFWRVCSGCNAEAKKRVVKFLKEVLNTKEYPLTVMDRPIESETTKIVENSYRATILAYLN
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHH
EWSLFAERNGVDLTKVIDAIKMRPTHSNMIFPGPGIGGYCLPKDGGLGYWSYRHILGFED
HHHHHHCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCEECCCCCCCCCCHHHHEECCCC
GESIFKITPLAIDINDTRALHVAQLTRDALRNMGRYIAGADVLICGASYRQDVGDTRYSG
CCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCCC
SEMVVRKLTEMGAEMRVHDPYVDHWHELENQDDYPAPGQSWKRFFRNQDGLQNIRVQSDL
HHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
AEALKGVEAVVFAVPHSPYLKLEPEEIIDWTGKPLAVIDCFGILSDKTIRRYFELGCEVK
HHHHCCCEEEEEEECCCCCEEECHHHHHCCCCCCEEEEEHHHHHCHHHHHHHHHCCCCEE
ALGRGHIQRIKEEVRKGRRD
ECCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA