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The map label for this gene is lpdG [H]

Identifier: 118579464

GI number: 118579464

Start: 1080403

End: 1081818

Strand: Direct

Name: lpdG [H]

Synonym: Ppro_1030

Alternate gene names: 118579464

Gene position: 1080403-1081818 (Clockwise)

Preceding gene: 118579463

Following gene: 118579465

Centisome position: 26.96

GC content: 62.64

Gene sequence:

>1416_bases
ATGAGTGAAGAGGTATTTGATCTTGTGGTGCTCGGAGCGGGACCGGGGGGCTATGTGGCCGCCATCCGCGCTTCCCAGCT
GGGGATGAAGGTTGCCGTGGTGGAACCGCGGCCGACCATGGGGGGCGCCTGCCTGAACGAGGGGTGTATCCCCAGCAAGG
CGCTGCTGGATTCCAGCGAGCATTTCTCCATGGCCCGCGACAAGTTCGCCAGCCACGGCGTTATCGTCAACCCGCCGAAA
CTGGACGTCGCCGTCATGCAGGCCCGCAAGGCCGATGTGGTCAAGAAACTCACCGACGGCGTCGCCTACCTGTTCAAGAA
GAACAAGGTCCAGGTGATCTGCGGCACGGGCAGGATCGTTCGTCCCGTAGCAGGAGAGCCCCACTGCGTGGAGGTGACGG
CCACGGGTGCCACCCAGACCGTCAAGGCCAGGAAAGTGCTGCTGGCAACGGGAGGGGTGCCGGTGGAGGTGCCCACGCTC
CCCTTTGACGGCACGCTGATCGTCAGTTCCAAGGATGCCCTGGAGTTCTGTAGCGTACCGGAACACCTGATCGTGGTGGG
CGCCGGTTATATCGGCCTGGAGTTGGGGTCGGTTTGGAGGCGCCTGGGGGCCAGGGTCACGGTTGTGGAGATGATGCCCA
AGATGCTCCCCTTCACCGACAGCGAGGTCACGGACGCCCTGATGAAGATCCTGAAAAAACAGGGAGTGGAATTCCGCATG
GCTACCAGCGTCACCAAGGTGGAGAAGGTCGGCGACAAGGCGCGGGTAAGCCTGACCGCCGGCGGCAAGACCGAGCTGGT
GGAGTGCGACAAGATCCTGGTGGCCATCGGCAGGAAACCGGTCACGGCCGGGCTGGGTCTGGAAGACGCCGGCGTTGCGG
TCAACGACAAGGGGCGCGTCGAGGTGGACGAAAACTACGAAACATCCGTGGCCGGTATCTACGCCATCGGTGACCTGATC
CCGGGACCGCTGCTTGCCCACAAGGCATCGGAAGAGGCGGTGGCCTTTGCCGAACGCCTGACCGGTATGAAATCCCAGGT
CCACTACGAAACCATTCCGGGCATCGCCTATACCTGGCCTGAGGCTGCCTCGGTGGGCAAGACCGAGCAGGCCCTGAAAG
AGGAGCAGATCCCCTACGCCGTGGGCAAATTCAACTTCATGGGCAATGGCCGGGCTCGGGCCATGGATGAAACCGAGGGT
TTCGTCAAGATCCTGGCCCACAAGGAGAACGATAAGGTTCTCGGCATCCACATCGTCGGGCCCCGGGCCTCGGACATGAT
CGCGGAAGGGGTGGCTGTCATGGTCTACGGCGGCACCTCCCACGACATCGCGGCCATGTTCCACGCCCATCCCACCCTGG
CCGAAGCAATCAAGGAAGCTGCGCTTGACGTGCATAAATCAGCCATTCATGCCTGA

Upstream 100 bases:

>100_bases
CACGAGGCTCGCGTGACGTTCACGTCATCCCCTCAGGGGGGGCAACAGGGCCGGGACGTTTGCGCGTGGCTTAAACCACG
AAAAACAAGAGGTGCAAGGA

Downstream 100 bases:

>100_bases
TGATGTGCATTGTTGCCCCCACCGGAGTCACCTTCCTCCGATTCCGGTGGGGGCTTTTTTGACCGTCCAGGTATGGCGGG
AATTCGGGAAGCGAACAATG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: E3 component of 2-oxoglutarate dehydrogenase complex; Glycine oxidation system L-factor; LPD-GLC [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSEEVFDLVVLGAGPGGYVAAIRASQLGMKVAVVEPRPTMGGACLNEGCIPSKALLDSSEHFSMARDKFASHGVIVNPPK
LDVAVMQARKADVVKKLTDGVAYLFKKNKVQVICGTGRIVRPVAGEPHCVEVTATGATQTVKARKVLLATGGVPVEVPTL
PFDGTLIVSSKDALEFCSVPEHLIVVGAGYIGLELGSVWRRLGARVTVVEMMPKMLPFTDSEVTDALMKILKKQGVEFRM
ATSVTKVEKVGDKARVSLTAGGKTELVECDKILVAIGRKPVTAGLGLEDAGVAVNDKGRVEVDENYETSVAGIYAIGDLI
PGPLLAHKASEEAVAFAERLTGMKSQVHYETIPGIAYTWPEAASVGKTEQALKEEQIPYAVGKFNFMGNGRARAMDETEG
FVKILAHKENDKVLGIHIVGPRASDMIAEGVAVMVYGGTSHDIAAMFHAHPTLAEAIKEAALDVHKSAIHA

Sequences:

>Translated_471_residues
MSEEVFDLVVLGAGPGGYVAAIRASQLGMKVAVVEPRPTMGGACLNEGCIPSKALLDSSEHFSMARDKFASHGVIVNPPK
LDVAVMQARKADVVKKLTDGVAYLFKKNKVQVICGTGRIVRPVAGEPHCVEVTATGATQTVKARKVLLATGGVPVEVPTL
PFDGTLIVSSKDALEFCSVPEHLIVVGAGYIGLELGSVWRRLGARVTVVEMMPKMLPFTDSEVTDALMKILKKQGVEFRM
ATSVTKVEKVGDKARVSLTAGGKTELVECDKILVAIGRKPVTAGLGLEDAGVAVNDKGRVEVDENYETSVAGIYAIGDLI
PGPLLAHKASEEAVAFAERLTGMKSQVHYETIPGIAYTWPEAASVGKTEQALKEEQIPYAVGKFNFMGNGRARAMDETEG
FVKILAHKENDKVLGIHIVGPRASDMIAEGVAVMVYGGTSHDIAAMFHAHPTLAEAIKEAALDVHKSAIHA
>Mature_470_residues
SEEVFDLVVLGAGPGGYVAAIRASQLGMKVAVVEPRPTMGGACLNEGCIPSKALLDSSEHFSMARDKFASHGVIVNPPKL
DVAVMQARKADVVKKLTDGVAYLFKKNKVQVICGTGRIVRPVAGEPHCVEVTATGATQTVKARKVLLATGGVPVEVPTLP
FDGTLIVSSKDALEFCSVPEHLIVVGAGYIGLELGSVWRRLGARVTVVEMMPKMLPFTDSEVTDALMKILKKQGVEFRMA
TSVTKVEKVGDKARVSLTAGGKTELVECDKILVAIGRKPVTAGLGLEDAGVAVNDKGRVEVDENYETSVAGIYAIGDLIP
GPLLAHKASEEAVAFAERLTGMKSQVHYETIPGIAYTWPEAASVGKTEQALKEEQIPYAVGKFNFMGNGRARAMDETEGF
VKILAHKENDKVLGIHIVGPRASDMIAEGVAVMVYGGTSHDIAAMFHAHPTLAEAIKEAALDVHKSAIHA

Specific function: Also acts in the glycine cleavage system [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=46.2039045553145, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=29.7644539614561, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI148277065, Length=458, Percent_Identity=27.0742358078603, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI33519430, Length=458, Percent_Identity=27.0742358078603, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI33519428, Length=458, Percent_Identity=27.0742358078603, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI33519426, Length=458, Percent_Identity=27.0742358078603, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI148277071, Length=458, Percent_Identity=27.0742358078603, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI22035672, Length=478, Percent_Identity=28.6610878661088, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI291045266, Length=486, Percent_Identity=26.5432098765432, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI291045268, Length=478, Percent_Identity=26.5690376569038, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI21389617, Length=144, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786307, Length=463, Percent_Identity=38.2289416846652, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI87082354, Length=476, Percent_Identity=31.3025210084034, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=27.3348519362187, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI87081717, Length=461, Percent_Identity=26.4642082429501, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=45, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=29.375, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71983429, Length=471, Percent_Identity=27.8131634819533, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=471, Percent_Identity=27.8131634819533, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=497, Percent_Identity=25.9557344064386, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17559934, Length=191, Percent_Identity=27.7486910994764, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=43.3609958506224, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=30.7855626326964, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=27.7185501066098, Blast_Score=146, Evalue=6e-36,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=47.0588235294118, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24640553, Length=482, Percent_Identity=29.4605809128631, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24640551, Length=482, Percent_Identity=29.4605809128631, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24640549, Length=482, Percent_Identity=29.4605809128631, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17737741, Length=485, Percent_Identity=27.6288659793814, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49942; Mature: 49810

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEVFDLVVLGAGPGGYVAAIRASQLGMKVAVVEPRPTMGGACLNEGCIPSKALLDSSE
CCCCEEEEEEEECCCCCEEEEEEHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCH
HFSMARDKFASHGVIVNPPKLDVAVMQARKADVVKKLTDGVAYLFKKNKVQVICGTGRIV
HHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCCEE
RPVAGEPHCVEVTATGATQTVKARKVLLATGGVPVEVPTLPFDGTLIVSSKDALEFCSVP
ECCCCCCEEEEEEECCCCHHHHEEEEEEEECCCEEEECCCCCCCEEEEECCCHHHHHCCC
EHLIVVGAGYIGLELGSVWRRLGARVTVVEMMPKMLPFTDSEVTDALMKILKKQGVEFRM
CEEEEEECCHHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEE
ATSVTKVEKVGDKARVSLTAGGKTELVECDKILVAIGRKPVTAGLGLEDAGVAVNDKGRV
HHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCEECCCCCCCCEEECCCCCE
EVDENYETSVAGIYAIGDLIPGPLLAHKASEEAVAFAERLTGMKSQVHYETIPGIAYTWP
EECCCCCCCHHHEEEHHHHCCCCHHHHCCCHHHHHHHHHHCCCHHHEEEECCCCEEEECC
EAASVGKTEQALKEEQIPYAVGKFNFMGNGRARAMDETEGFVKILAHKENDKVLGIHIVG
CHHCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHCCEEEEEEECCCCCEEEEEEEC
PRASDMIAEGVAVMVYGGTSHDIAAMFHAHPTLAEAIKEAALDVHKSAIHA
CCHHHHHHCCEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEEVFDLVVLGAGPGGYVAAIRASQLGMKVAVVEPRPTMGGACLNEGCIPSKALLDSSE
CCCEEEEEEEECCCCCEEEEEEHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCH
HFSMARDKFASHGVIVNPPKLDVAVMQARKADVVKKLTDGVAYLFKKNKVQVICGTGRIV
HHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCCEE
RPVAGEPHCVEVTATGATQTVKARKVLLATGGVPVEVPTLPFDGTLIVSSKDALEFCSVP
ECCCCCCEEEEEEECCCCHHHHEEEEEEEECCCEEEECCCCCCCEEEEECCCHHHHHCCC
EHLIVVGAGYIGLELGSVWRRLGARVTVVEMMPKMLPFTDSEVTDALMKILKKQGVEFRM
CEEEEEECCHHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEE
ATSVTKVEKVGDKARVSLTAGGKTELVECDKILVAIGRKPVTAGLGLEDAGVAVNDKGRV
HHHHHHHHHCCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCEECCCCCCCCEEECCCCCE
EVDENYETSVAGIYAIGDLIPGPLLAHKASEEAVAFAERLTGMKSQVHYETIPGIAYTWP
EECCCCCCCHHHEEEHHHHCCCCHHHHCCCHHHHHHHHHHCCCHHHEEEECCCCEEEECC
EAASVGKTEQALKEEQIPYAVGKFNFMGNGRARAMDETEGFVKILAHKENDKVLGIHIVG
CHHCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHCCEEEEEEECCCCCEEEEEEEC
PRASDMIAEGVAVMVYGGTSHDIAAMFHAHPTLAEAIKEAALDVHKSAIHA
CCHHHHHHCCEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1902462; 2914869 [H]