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The map label for this gene is lipB

Identifier: 118579465

GI number: 118579465

Start: 1081916

End: 1082545

Strand: Direct

Name: lipB

Synonym: Ppro_1031

Alternate gene names: 118579465

Gene position: 1081916-1082545 (Clockwise)

Preceding gene: 118579464

Following gene: 118579467

Centisome position: 26.99

GC content: 62.22

Gene sequence:

>630_bases
ATGATTCTGAATGATCTCGGTGTCGTCGACTATGCCGCCGCCTTCAGCCTACAGGAACGCATCGCTGATGGGGTGTACCG
CAACGCCACGCCGGAGACGCTACTGCTTCTGGAGCACCATCCGGTCTACACCATCGGACGGGCCGGCTGCGAAGAAAACA
TCTTGGACCACTCCATCCAGGCCATCCGCATCAGCCGGGGCGGGGATGTCACCTTTCACGGGCCGGGGCAGCTGGTGGGC
TATCCGCTGATCAACCTCAGGCCGCGGGGCTGCGATCTGCGGCATTACCTGAGGTTCCTGGAGGAACTGCTGATTTCGGT
GGTGGCTGATTTTGGTGTCAGCGCTTTCCGGGTGCCGGGAAAAACCGGTGTCTGGACCGACCAGGGCAAGTTGGCCGCCA
TCGGTGTAGGCGTGCGTCACTGGGTTACCATGCACGGTTTTGCCATGAACGTGAACAACGACCTCTCCTCCTTTGAGCGC
ATCAATCCCTGCGGCATTGCCACCTGTCCCATCGCTTCCCTGGAGCGCCTCTGTGGCTGCCCGATTGCCATGGATGAGGT
GAAGTCGCGCGTCGCCGGGCGCTTCCAGGGGCTGCTGGATGAGTGGCTCCCCGCAGCCGGAGCGCTGTAG

Upstream 100 bases:

>100_bases
TGATGATGTGCATTGTTGCCCCCACCGGAGTCACCTTCCTCCGATTCCGGTGGGGGCTTTTTTGACCGTCCAGGTATGGC
GGGAATTCGGGAAGCGAACA

Downstream 100 bases:

>100_bases
GCAGGGCGCTTCACCGCTGTCCTTACGTCTTCTCGTGCGAATTTCCGGACTCTTGAAATCACTCTCTCCCATGTGTCGCT
CGCCCTGCGCCGCTTCCCCT

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MILNDLGVVDYAAAFSLQERIADGVYRNATPETLLLLEHHPVYTIGRAGCEENILDHSIQAIRISRGGDVTFHGPGQLVG
YPLINLRPRGCDLRHYLRFLEELLISVVADFGVSAFRVPGKTGVWTDQGKLAAIGVGVRHWVTMHGFAMNVNNDLSSFER
INPCGIATCPIASLERLCGCPIAMDEVKSRVAGRFQGLLDEWLPAAGAL

Sequences:

>Translated_209_residues
MILNDLGVVDYAAAFSLQERIADGVYRNATPETLLLLEHHPVYTIGRAGCEENILDHSIQAIRISRGGDVTFHGPGQLVG
YPLINLRPRGCDLRHYLRFLEELLISVVADFGVSAFRVPGKTGVWTDQGKLAAIGVGVRHWVTMHGFAMNVNNDLSSFER
INPCGIATCPIASLERLCGCPIAMDEVKSRVAGRFQGLLDEWLPAAGAL
>Mature_209_residues
MILNDLGVVDYAAAFSLQERIADGVYRNATPETLLLLEHHPVYTIGRAGCEENILDHSIQAIRISRGGDVTFHGPGQLVG
YPLINLRPRGCDLRHYLRFLEELLISVVADFGVSAFRVPGKTGVWTDQGKLAAIGVGVRHWVTMHGFAMNVNNDLSSFER
INPCGIATCPIASLERLCGCPIAMDEVKSRVAGRFQGLLDEWLPAAGAL

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family

Homologues:

Organism=Homo sapiens, GI221554520, Length=201, Percent_Identity=36.81592039801, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI87081767, Length=177, Percent_Identity=36.1581920903955, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323268, Length=192, Percent_Identity=28.125, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355483, Length=204, Percent_Identity=32.3529411764706, Blast_Score=107, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LIPB_PELPD (A1AMT7)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900715.1
- ProteinModelPortal:   A1AMT7
- SMR:   A1AMT7
- STRING:   A1AMT7
- GeneID:   4572771
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1031
- eggNOG:   COG0321
- HOGENOM:   HBG716160
- OMA:   DLKRRRP
- PhylomeDB:   A1AMT7
- ProtClustDB:   CLSK828834
- GO:   GO:0005737
- HAMAP:   MF_00013
- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605
- PIRSF:   PIRSF016262
- TIGRFAMs:   TIGR00214

Pfam domain/function: PF03099 BPL_LipA_LipB

EC number: =2.3.1.181

Molecular weight: Translated: 22796; Mature: 22796

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS01313 LIPB

Important sites: ACT_SITE 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILNDLGVVDYAAAFSLQERIADGVYRNATPETLLLLEHHPVYTIGRAGCEENILDHSIQ
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCHHHHHHHCEE
AIRISRGGDVTFHGPGQLVGYPLINLRPRGCDLRHYLRFLEELLISVVADFGVSAFRVPG
EEEEECCCEEEECCCCCEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCC
KTGVWTDQGKLAAIGVGVRHWVTMHGFAMNVNNDLSSFERINPCGIATCPIASLERLCGC
CCCCCCCCCCEEEEECCHHHHHHHHCEEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHCC
PIAMDEVKSRVAGRFQGLLDEWLPAAGAL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MILNDLGVVDYAAAFSLQERIADGVYRNATPETLLLLEHHPVYTIGRAGCEENILDHSIQ
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCHHHHHHHCEE
AIRISRGGDVTFHGPGQLVGYPLINLRPRGCDLRHYLRFLEELLISVVADFGVSAFRVPG
EEEEECCCEEEECCCCCEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCC
KTGVWTDQGKLAAIGVGVRHWVTMHGFAMNVNNDLSSFERINPCGIATCPIASLERLCGC
CCCCCCCCCCEEEEECCHHHHHHHHCEEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHCC
PIAMDEVKSRVAGRFQGLLDEWLPAAGAL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA