| Definition | Pelobacter propionicus DSM 2379 chromosome, complete genome. |
|---|---|
| Accession | NC_008609 |
| Length | 4,008,000 |
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The map label for this gene is mrpA [H]
Identifier: 118579027
GI number: 118579027
Start: 627290
End: 629119
Strand: Direct
Name: mrpA [H]
Synonym: Ppro_0588
Alternate gene names: 118579027
Gene position: 627290-629119 (Clockwise)
Preceding gene: 118579026
Following gene: 118579028
Centisome position: 15.65
GC content: 61.31
Gene sequence:
>1830_bases ATGATGATAACAATGATGTTTCTGGTGATTGGCATACCGGTTGTCTGTGGCTTGGGGGCGCTGATCCTGCCCAGGGGGGT GAGGGAAGCGCTGTCCTTTGCAGGGGCAACGCTCAACCTGGTGATCTGCGGCCGGCTGTTCGGCCAGGAGGGCACGCTCT CCCTCCCCTGGGGCGGATTCGGCATCCTGTTCGAACTCCGGCTGTACCACTTCAGTTCGTTTATCCTGATCGCCGCGGCC GGTTTCGGATTCCTGATCTCTCTCTACTCCCTGCATTTCATGAAGAACAGGGAGAAGGGCAACCAGTTCTATGCCTACCT GCTGATCTCGCTGGGGATGGTCAACGGCGCGGTCCTGGCCGACAACCTGGTGCTGATGCTCTTCTTCTGGGAGGGGCTGC TGGGGACCATCTTCGGCCTGATCGCCATCGGCAACCGGGAGGCGTTCCGGTCGGGGGTCAAGGCCTTCATCCTGATCGGC GTTTCCGACGTGCTGATGATGGTGGGGATCATGATGACCGGCTATCTGGCCGGAACCCTGACCATTTCAAAGATCCACCA GCTGCCGCTGGATTCCCCCTTTGCCATCACCGCCTTTATCCTGCTGGCCATCGGCGCCACCTCCAAGGCGGGCTGCCTGC CGTTCCACAGCTGGATACCGGACGCTGCCGTGGATGCTCCGCTCCCCTTCATGGCCCTGATGCCGGCGGCTCTGGAAAAG CTTTTGGGGATCTACTTCCTGGCCCGCATCACCCTTGACCTGTTCGCCCTGCGCCACGGTTCCGGCATGAGCATGGCAAT GATGACCGTTGGTGTGGTGACCATTCTGGTGGCGGTCATGATGGCCCTGATCCAGAAGGACTACAAGCGGCTGCTCTCCT ACCACGCCATCAGCCAGGTTGGCTATATGATCCTGGGCATCGGCACGGCGGTTCCGGTGGGGATCGTGGGTGGTCTCTTC CACATGATCAACCATGCCATGTACAAGAGCTGCCTGTTCCTGACCGGTGGCTCGGTGGAAGCCCAAGCCGGCACCACCGA CCTGCGCAAGCTGGGTGGCATCGCTCGGCGCATGCCGGTCACCTTCACCTGCTTCATCGTCGCCGCCGCTGCCATCTCCG GCGTACCCCCCTTCAACGGCTTCTTCTCCAAGGAACTGATCTATGACGGTGCCCTGGAGTGCCACTGGATCTTCTACGCC GGGGCGCTTTTGGGGTCGTTCCTGACCGGCGCGTCATTCCTCAAGCTGGGGCACGCCGCCTTCCTGGGCAAGAACGAATA TCTGTCCTCCAGGGTCAAGGAGGCGCCGCTGACCATGCTGGTCCCGATGATCGTCATCGCCGCCGGCTGCGTGCTGTTCG GCGTTGCCAACCAGCTCCCGCTGGACACCCTGATCGTGCCGATCATCGGTCCCCAGATGGCCGCGGGGCATCATTTTGCC GGCTTCCCCGAGAATACGTTCCTGGTGATCATGACCATCACCGTTCTTCTGGCCTCCTGGTTCAACCATCAGTTTGGCGT CAGCCGGACCGGCAAAGGGGCGGGCGCCTGCGACCATATCCACCATGCGCCTCTCCTGCACGCCATCTATGACCGGGCCG AAAGGCGGGAGTTCGACCCCTATGACCGGGGCATGCAGGTCATCAACCTGATTTCGAGAGTTTCATGGGGCATCGACCGG GGCATCGACCGTCTCTACAACGTGCTGGTGGTGGGCATCAGCCAGAGCCTTTCCCGGACCGTGGGAGAGATGCACAACGG CAGTTTCGCCACCTATGTGGTATGGGCGAGCGTTGGGGGTGCGCTGGTATGTATGTACATGAACGCGTGA
Upstream 100 bases:
>100_bases TGGCGCTGCTGGCGCTGCTCTCCATCGCCGGCGGAATCCTGATTCAGTATCCCTCCGCCTACGTCCAGACCACTGTTCAT CAGATCTTGAAGGTGGTGCA
Downstream 100 bases:
>100_bases CGAAGCGTCTTGAAACGGCAGTTGCGAGCTGCCGGAGAGAGCGCATCAGGGCTATTTCGTCGTAATTCCCGGCGTAAATT ACGCGTCAACAGCCGATACT
Product: NADH dehydrogenase (quinone)
Products: NAD+; ubiquinol
Alternate protein names: Mrp complex subunit A; Multiple resistance and pH homeostasis protein A [H]
Number of amino acids: Translated: 609; Mature: 609
Protein sequence:
>609_residues MMITMMFLVIGIPVVCGLGALILPRGVREALSFAGATLNLVICGRLFGQEGTLSLPWGGFGILFELRLYHFSSFILIAAA GFGFLISLYSLHFMKNREKGNQFYAYLLISLGMVNGAVLADNLVLMLFFWEGLLGTIFGLIAIGNREAFRSGVKAFILIG VSDVLMMVGIMMTGYLAGTLTISKIHQLPLDSPFAITAFILLAIGATSKAGCLPFHSWIPDAAVDAPLPFMALMPAALEK LLGIYFLARITLDLFALRHGSGMSMAMMTVGVVTILVAVMMALIQKDYKRLLSYHAISQVGYMILGIGTAVPVGIVGGLF HMINHAMYKSCLFLTGGSVEAQAGTTDLRKLGGIARRMPVTFTCFIVAAAAISGVPPFNGFFSKELIYDGALECHWIFYA GALLGSFLTGASFLKLGHAAFLGKNEYLSSRVKEAPLTMLVPMIVIAAGCVLFGVANQLPLDTLIVPIIGPQMAAGHHFA GFPENTFLVIMTITVLLASWFNHQFGVSRTGKGAGACDHIHHAPLLHAIYDRAERREFDPYDRGMQVINLISRVSWGIDR GIDRLYNVLVVGISQSLSRTVGEMHNGSFATYVVWASVGGALVCMYMNA
Sequences:
>Translated_609_residues MMITMMFLVIGIPVVCGLGALILPRGVREALSFAGATLNLVICGRLFGQEGTLSLPWGGFGILFELRLYHFSSFILIAAA GFGFLISLYSLHFMKNREKGNQFYAYLLISLGMVNGAVLADNLVLMLFFWEGLLGTIFGLIAIGNREAFRSGVKAFILIG VSDVLMMVGIMMTGYLAGTLTISKIHQLPLDSPFAITAFILLAIGATSKAGCLPFHSWIPDAAVDAPLPFMALMPAALEK LLGIYFLARITLDLFALRHGSGMSMAMMTVGVVTILVAVMMALIQKDYKRLLSYHAISQVGYMILGIGTAVPVGIVGGLF HMINHAMYKSCLFLTGGSVEAQAGTTDLRKLGGIARRMPVTFTCFIVAAAAISGVPPFNGFFSKELIYDGALECHWIFYA GALLGSFLTGASFLKLGHAAFLGKNEYLSSRVKEAPLTMLVPMIVIAAGCVLFGVANQLPLDTLIVPIIGPQMAAGHHFA GFPENTFLVIMTITVLLASWFNHQFGVSRTGKGAGACDHIHHAPLLHAIYDRAERREFDPYDRGMQVINLISRVSWGIDR GIDRLYNVLVVGISQSLSRTVGEMHNGSFATYVVWASVGGALVCMYMNA >Mature_609_residues MMITMMFLVIGIPVVCGLGALILPRGVREALSFAGATLNLVICGRLFGQEGTLSLPWGGFGILFELRLYHFSSFILIAAA GFGFLISLYSLHFMKNREKGNQFYAYLLISLGMVNGAVLADNLVLMLFFWEGLLGTIFGLIAIGNREAFRSGVKAFILIG VSDVLMMVGIMMTGYLAGTLTISKIHQLPLDSPFAITAFILLAIGATSKAGCLPFHSWIPDAAVDAPLPFMALMPAALEK LLGIYFLARITLDLFALRHGSGMSMAMMTVGVVTILVAVMMALIQKDYKRLLSYHAISQVGYMILGIGTAVPVGIVGGLF HMINHAMYKSCLFLTGGSVEAQAGTTDLRKLGGIARRMPVTFTCFIVAAAAISGVPPFNGFFSKELIYDGALECHWIFYA GALLGSFLTGASFLKLGHAAFLGKNEYLSSRVKEAPLTMLVPMIVIAAGCVLFGVANQLPLDTLIVPIIGPQMAAGHHFA GFPENTFLVIMTITVLLASWFNHQFGVSRTGKGAGACDHIHHAPLLHAIYDRAERREFDPYDRGMQVINLISRVSWGIDR GIDRLYNVLVVGISQSLSRTVGEMHNGSFATYVVWASVGGALVCMYMNA
Specific function: Mnh complex is a Na(+)Li(+)/H(+) antiporter involved in Na(+) and/or Li(+) excretion and Na(+) resistance. Na(+)/H(+) antiport consumes a transmembrane electrical potential, and is thus inferred to be electrogenic. Does not transport K(+), Ca(2+) or Mg(2+
COG id: COG1009
COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family [H]
Homologues:
Organism=Homo sapiens, GI251831117, Length=397, Percent_Identity=26.448362720403, Blast_Score=117, Evalue=3e-26, Organism=Escherichia coli, GI1788827, Length=452, Percent_Identity=29.646017699115, Blast_Score=168, Evalue=9e-43, Organism=Escherichia coli, GI1788614, Length=540, Percent_Identity=30.1851851851852, Blast_Score=166, Evalue=6e-42, Organism=Escherichia coli, GI1788829, Length=335, Percent_Identity=34.9253731343284, Blast_Score=164, Evalue=2e-41, Organism=Escherichia coli, GI2367154, Length=552, Percent_Identity=28.0797101449275, Blast_Score=137, Evalue=3e-33, Organism=Escherichia coli, GI1788831, Length=325, Percent_Identity=28.3076923076923, Blast_Score=121, Evalue=1e-28, Organism=Escherichia coli, GI1788613, Length=391, Percent_Identity=26.0869565217391, Blast_Score=103, Evalue=3e-23,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005663 - InterPro: IPR001750 - InterPro: IPR001516 [H]
Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]
EC number: 1.6.5.3
Molecular weight: Translated: 65714; Mature: 65714
Theoretical pI: Translated: 8.60; Mature: 8.60
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 5.1 %Met (Translated Protein) 6.6 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 5.1 %Met (Mature Protein) 6.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MMITMMFLVIGIPVVCGLGALILPRGVREALSFAGATLNLVICGRLFGQEGTLSLPWGGF CHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHCCCHHEEEEEHHHHCCCCCEECCCCCH GILFELRLYHFSSFILIAAAGFGFLISLYSLHFMKNREKGNQFYAYLLISLGMVNGAVLA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHH DNLVLMLFFWEGLLGTIFGLIAIGNREAFRSGVKAFILIGVSDVLMMVGIMMTGYLAGTL HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH TISKIHQLPLDSPFAITAFILLAIGATSKAGCLPFHSWIPDAAVDAPLPFMALMPAALEK HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHH LLGIYFLARITLDLFALRHGSGMSMAMMTVGVVTILVAVMMALIQKDYKRLLSYHAISQV HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH GYMILGIGTAVPVGIVGGLFHMINHAMYKSCLFLTGGSVEAQAGTTDLRKLGGIARRMPV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCH TFTCFIVAAAAISGVPPFNGFFSKELIYDGALECHWIFYAGALLGSFLTGASFLKLGHAA HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH FLGKNEYLSSRVKEAPLTMLVPMIVIAAGCVLFGVANQLPLDTLIVPIIGPQMAAGHHFA HCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCC GFPENTFLVIMTITVLLASWFNHQFGVSRTGKGAGACDHIHHAPLLHAIYDRAERREFDP CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH YDRGMQVINLISRVSWGIDRGIDRLYNVLVVGISQSLSRTVGEMHNGSFATYVVWASVGG HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCC ALVCMYMNA EEEEEEECC >Mature Secondary Structure MMITMMFLVIGIPVVCGLGALILPRGVREALSFAGATLNLVICGRLFGQEGTLSLPWGGF CHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHCCCHHEEEEEHHHHCCCCCEECCCCCH GILFELRLYHFSSFILIAAAGFGFLISLYSLHFMKNREKGNQFYAYLLISLGMVNGAVLA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHH DNLVLMLFFWEGLLGTIFGLIAIGNREAFRSGVKAFILIGVSDVLMMVGIMMTGYLAGTL HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH TISKIHQLPLDSPFAITAFILLAIGATSKAGCLPFHSWIPDAAVDAPLPFMALMPAALEK HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHH LLGIYFLARITLDLFALRHGSGMSMAMMTVGVVTILVAVMMALIQKDYKRLLSYHAISQV HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH GYMILGIGTAVPVGIVGGLFHMINHAMYKSCLFLTGGSVEAQAGTTDLRKLGGIARRMPV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCH TFTCFIVAAAAISGVPPFNGFFSKELIYDGALECHWIFYAGALLGSFLTGASFLKLGHAA HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH FLGKNEYLSSRVKEAPLTMLVPMIVIAAGCVLFGVANQLPLDTLIVPIIGPQMAAGHHFA HCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCC GFPENTFLVIMTITVLLASWFNHQFGVSRTGKGAGACDHIHHAPLLHAIYDRAERREFDP CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH YDRGMQVINLISRVSWGIDRGIDRLYNVLVVGISQSLSRTVGEMHNGSFATYVVWASVGG HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCC ALVCMYMNA EEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NADH; H+; ubiquinone
Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11356194 [H]