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The map label for this gene is mnhA1 [H]

Identifier: 118579026

GI number: 118579026

Start: 625851

End: 627293

Strand: Direct

Name: mnhA1 [H]

Synonym: Ppro_0587

Alternate gene names: 118579026

Gene position: 625851-627293 (Clockwise)

Preceding gene: 118579025

Following gene: 118579027

Centisome position: 15.62

GC content: 59.74

Gene sequence:

>1443_bases
ATGAAGAGTCAAGAATTGATCTGGTTGGCTGTGTTTGTGCCGATCATGGGAGCGTTCCTGCTGCCACTGGTCGGAACGGT
TTCAAAGGGGGCGCGCAATCTGAGCGCCCTTGCCCTGGTCGGGTTTTCGCTGTTCTGTTCCTGCGGGCTGATAGCTCCCG
TCCTGAACGGCGAAACAGTCGCCATTTCGATTCCCTTCCTGGGGGGGAACAACCTGTTCCTGGGTGACAGCCTGGCGGTT
TTCATGGCCATTGTCTCCAGTCTGGTGGGGGCGGTCATCGTGCTCTACTCCATGGGGTATATCAGCCATTACGAAAACCA
GAACGAGTACTACGTTATTGTCGTGCTGTTCCTGGGATCCATGATGGGGATCATCTATTCGGCCAACCTGATCCTGATCT
ACCTGTTCTGGGAGATCACCGCCTTTGCCTGCTGGCGATTGATCGGCTTCTTCAGGGAGAAGACCTGCATCGTCCGGGCC
GACAAGGCCTTCCTGGTCACCGGCTTCGGCGCCTTTGTCATGCTGATCGGGTTCGCCCTGGTCTACAGCCAGTACGGCTC
ATTTGACCTGCAGACCATACAGAGCGCATCGGCGACTGACCCGGTGGCCAACCTGGCCGTGCTGCTGATCCTGTTCGGCA
TCCTCTCCAAGTCCGCCACACTTCCCCTGCACACCTGGCTCCCGGATGCGGGCGTGGCCCCCACGCCGGTGACCGCCCTG
CTGCACGCCGCGGTGCTGGTCAAGATCGGCGTCTACGTCTACGCCCGGCTGTTCATCGCCTCCTTCAGCATCGATCCGGT
CTGGGAGACGGTTGTCCCGGCCATCGCGGGGATCAGTTCCCTGGTGGCCGGCGGAGCAGCCCTGATCGAGACCGACATGA
AGCGGATCATCGCCTACTCCACCGTCAGCCAGTTGGGCTTCATCCTGCTGGGACTCTCCATTGGCAACGATATCGGGGTG
GCCGGAGGGCTCTTGTACATCCTGATGCACAGCATCGCCAAGGGGGGGCTGTTCCTCTGCGCCGGCGTGGTGGAGCAGAA
GCTGCACGTGAAAGACATCACCAAGCTGGGCGGGCTGATCAGGACCATGCCGGTCACCGCGGTCTCCTTCCTGTTGTGTG
CCTTTTCGGTCATGGGCATACCCCCCTTTGGCGGGTTCTTCAGCAAATACATGGTCATATCCGGGGCCATCAGGAGCGGG
CAGCCGCTGATCAGCGTCATCTTCATCCTGGGGGCGTTTCTGACCATGATCTATCTCTTCAGGCTGTTCTCCATGATTTT
CCTCGGTGAAGCAAAAACGGAGCCGGTTGCCGAAGGCGCACCGGTCATGGTGGGAAGCGTGGCGCTGCTGGCGCTGCTCT
CCATCGCCGGCGGAATCCTGATTCAGTATCCCTCCGCCTACGTCCAGACCACTGTTCATCAGATCTTGAAGGTGGTGCAA
TGA

Upstream 100 bases:

>100_bases
CCCGAGTCAGAAGCCATCCGGCTTTTCCTCGGGCTTTTTGCGTTTCAGGGAGCGGGCCGGGTTAGTAACGACATCCTACA
TGAGGGGAGCATCGTTTGGT

Downstream 100 bases:

>100_bases
TGATAACAATGATGTTTCTGGTGATTGGCATACCGGTTGTCTGTGGCTTGGGGGCGCTGATCCTGCCCAGGGGGGTGAGG
GAAGCGCTGTCCTTTGCAGG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: Mnh complex subunit A1 [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MKSQELIWLAVFVPIMGAFLLPLVGTVSKGARNLSALALVGFSLFCSCGLIAPVLNGETVAISIPFLGGNNLFLGDSLAV
FMAIVSSLVGAVIVLYSMGYISHYENQNEYYVIVVLFLGSMMGIIYSANLILIYLFWEITAFACWRLIGFFREKTCIVRA
DKAFLVTGFGAFVMLIGFALVYSQYGSFDLQTIQSASATDPVANLAVLLILFGILSKSATLPLHTWLPDAGVAPTPVTAL
LHAAVLVKIGVYVYARLFIASFSIDPVWETVVPAIAGISSLVAGGAALIETDMKRIIAYSTVSQLGFILLGLSIGNDIGV
AGGLLYILMHSIAKGGLFLCAGVVEQKLHVKDITKLGGLIRTMPVTAVSFLLCAFSVMGIPPFGGFFSKYMVISGAIRSG
QPLISVIFILGAFLTMIYLFRLFSMIFLGEAKTEPVAEGAPVMVGSVALLALLSIAGGILIQYPSAYVQTTVHQILKVVQ

Sequences:

>Translated_480_residues
MKSQELIWLAVFVPIMGAFLLPLVGTVSKGARNLSALALVGFSLFCSCGLIAPVLNGETVAISIPFLGGNNLFLGDSLAV
FMAIVSSLVGAVIVLYSMGYISHYENQNEYYVIVVLFLGSMMGIIYSANLILIYLFWEITAFACWRLIGFFREKTCIVRA
DKAFLVTGFGAFVMLIGFALVYSQYGSFDLQTIQSASATDPVANLAVLLILFGILSKSATLPLHTWLPDAGVAPTPVTAL
LHAAVLVKIGVYVYARLFIASFSIDPVWETVVPAIAGISSLVAGGAALIETDMKRIIAYSTVSQLGFILLGLSIGNDIGV
AGGLLYILMHSIAKGGLFLCAGVVEQKLHVKDITKLGGLIRTMPVTAVSFLLCAFSVMGIPPFGGFFSKYMVISGAIRSG
QPLISVIFILGAFLTMIYLFRLFSMIFLGEAKTEPVAEGAPVMVGSVALLALLSIAGGILIQYPSAYVQTTVHQILKVVQ
>Mature_480_residues
MKSQELIWLAVFVPIMGAFLLPLVGTVSKGARNLSALALVGFSLFCSCGLIAPVLNGETVAISIPFLGGNNLFLGDSLAV
FMAIVSSLVGAVIVLYSMGYISHYENQNEYYVIVVLFLGSMMGIIYSANLILIYLFWEITAFACWRLIGFFREKTCIVRA
DKAFLVTGFGAFVMLIGFALVYSQYGSFDLQTIQSASATDPVANLAVLLILFGILSKSATLPLHTWLPDAGVAPTPVTAL
LHAAVLVKIGVYVYARLFIASFSIDPVWETVVPAIAGISSLVAGGAALIETDMKRIIAYSTVSQLGFILLGLSIGNDIGV
AGGLLYILMHSIAKGGLFLCAGVVEQKLHVKDITKLGGLIRTMPVTAVSFLLCAFSVMGIPPFGGFFSKYMVISGAIRSG
QPLISVIFILGAFLTMIYLFRLFSMIFLGEAKTEPVAEGAPVMVGSVALLALLSIAGGILIQYPSAYVQTTVHQILKVVQ

Specific function: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion [H]

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=418, Percent_Identity=28.9473684210526, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1788829, Length=450, Percent_Identity=31.1111111111111, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1788614, Length=450, Percent_Identity=33.7777777777778, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1788827, Length=421, Percent_Identity=30.166270783848, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788831, Length=343, Percent_Identity=32.3615160349854, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788613, Length=422, Percent_Identity=27.7251184834123, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI2367154, Length=400, Percent_Identity=27.25, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693160, Length=357, Percent_Identity=26.890756302521, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005663
- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 51151; Mature: 51151

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSQELIWLAVFVPIMGAFLLPLVGTVSKGARNLSALALVGFSLFCSCGLIAPVLNGETV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
AISIPFLGGNNLFLGDSLAVFMAIVSSLVGAVIVLYSMGYISHYENQNEYYVIVVLFLGS
EEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHH
MMGIIYSANLILIYLFWEITAFACWRLIGFFREKTCIVRADKAFLVTGFGAFVMLIGFAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECHHHHHHHHHHHH
VYSQYGSFDLQTIQSASATDPVANLAVLLILFGILSKSATLPLHTWLPDAGVAPTPVTAL
HHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
LHAAVLVKIGVYVYARLFIASFSIDPVWETVVPAIAGISSLVAGGAALIETDMKRIIAYS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TVSQLGFILLGLSIGNDIGVAGGLLYILMHSIAKGGLFLCAGVVEQKLHVKDITKLGGLI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RTMPVTAVSFLLCAFSVMGIPPFGGFFSKYMVISGAIRSGQPLISVIFILGAFLTMIYLF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RLFSMIFLGEAKTEPVAEGAPVMVGSVALLALLSIAGGILIQYPSAYVQTTVHQILKVVQ
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKSQELIWLAVFVPIMGAFLLPLVGTVSKGARNLSALALVGFSLFCSCGLIAPVLNGETV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
AISIPFLGGNNLFLGDSLAVFMAIVSSLVGAVIVLYSMGYISHYENQNEYYVIVVLFLGS
EEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHH
MMGIIYSANLILIYLFWEITAFACWRLIGFFREKTCIVRADKAFLVTGFGAFVMLIGFAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECHHHHHHHHHHHH
VYSQYGSFDLQTIQSASATDPVANLAVLLILFGILSKSATLPLHTWLPDAGVAPTPVTAL
HHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
LHAAVLVKIGVYVYARLFIASFSIDPVWETVVPAIAGISSLVAGGAALIETDMKRIIAYS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TVSQLGFILLGLSIGNDIGVAGGLLYILMHSIAKGGLFLCAGVVEQKLHVKDITKLGGLI
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RTMPVTAVSFLLCAFSVMGIPPFGGFFSKYMVISGAIRSGQPLISVIFILGAFLTMIYLF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RLFSMIFLGEAKTEPVAEGAPVMVGSVALLALLSIAGGILIQYPSAYVQTTVHQILKVVQ
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA