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The map label for this gene is nuoN [H]

Identifier: 118579028

GI number: 118579028

Start: 629351

End: 630772

Strand: Direct

Name: nuoN [H]

Synonym: Ppro_0589

Alternate gene names: 118579028

Gene position: 629351-630772 (Clockwise)

Preceding gene: 118579027

Following gene: 118579029

Centisome position: 15.7

GC content: 60.55

Gene sequence:

>1422_bases
GTGACACTGCTTTTATTGGTTATACCGCTGCTCGGTTTCATCCTGGTGAACATCCCGCCCGCCGGGAGCCTGAGGAAGCC
GCTGATCGCCTGTCCCCTGCTGTTGTCCCTGCTCCAGGTGGTGCTGATGATCTTTCCCGAGGCAGGATGGTGGACCGCCT
TCGAGGCCGGCCCCTCTGTTCTCCCCTTTCTGCGCGTGGACGGTATCAGCATGCTGATGCTGCTGGCCATCGGTCTTGTC
GTGGCGGCTTCATCCGCTATCAGCATCCCCATGATCCGTGACGACACACAACGCCACAACTTCGTCAATCTGGTGCTGCT
GTCGCTCCTGGGCATGAACGGTATGGTCATGGTCACCGACCTCTTCTCCCTGTACGTGTTCCTGGAGATCGTGTCGGTCT
GCTCCTTCATCCTGATCGCCCTGTGTGGCGAGCGTGAGATGTTCCAGGGCGCCTTCACCTACATCATTCTCTCCGCCGTG
GCCACCATGCTGATGCTGACCTCCATCGCTATCCTGTTCCTCTACGCCGGAAACACCTCCTTTACGACGCTGGCCGCGGC
CATCGCTGCCCAGCAGGGCAATGCCATGGTGCTGTTCGGGGTGGTCCTGTTCCTGATCGGCCTGTTCATCAAGGGGGGCA
TCGTTCCCTTCCACGGGTGGCTGCCCGACGCCTACAGTTCATCCGTTGCGCCGGTTTCCATTCTGCTGGCCGGGATCGTC
ACCAAGGTTTCCGGTGTGTACACCCTGATCCGCCTGGTCACGGAAGTCTTCGGGCCTACGCCCCGGACGAACGAGGTGCT
GCTCTTCGTCGGCACCCTCTCCATAGTTGCCGGCGCCTTGGGCGCCCTGGGTCAGAGGGATTTCAAACGCATGCTGGCCT
ACTCCAGCATCAGTCAGGTCGGTTACATTGTCCTCAGCCTGGGCGCGGGCAACGCCCTGGGCATCGCTGGCGCCATCTTC
CACCTGTTCAACCATACCGTCTTTAAGACCCAGCTCTTTATGAACGCCACGGCAGTGGAAGAACAGACCGGCAGCAGGGA
CCTGGAGCGCATGGGAGGGCTGGCGTCCCGCATGCCGGTCACCGGCTGGACTTCCATCATCGCCTTCCTCTCCGCCGCCG
GCATCCCGCCACTGGCAGGTTTCTGGAGCAAGCTGGTGATCGTGATGGCACTGGTGAGGTCCGGTCATGAGATCTACATG
ATGATCGCCATCCTGGCCAGCCTGCTGACCCTGGCCTACTTCCTGACCCTGCAGCGCAAGGTGTTCTTCGGCGAGATCGT
GGAGGAGTTCAAGGATGTGCGTGAGGCAGGCTGGCTCGTAACCGCACCCGCGCTTGTTTTTGCCGCTATCATCGTCATCA
CCGGTCTGGCCATACCGTTTCTGCTGAACACCATCATCCTTCCCATCGGGAGTATCCTATGA

Upstream 100 bases:

>100_bases
TGTAGCGAAATTAACCCTGGAATTACAGAAATAGCCCGTCCGCACGAACGCAGGCAGCTCGCAACTGCCGAATACAGCTC
CAGATAAGGAGGCCGCACCT

Downstream 100 bases:

>100_bases
CACCGACCACACTGCTGCTCTTGCTTGTGCTGGTGACCGGCCTGTACGCCGTGCTCTCCCCAAGCCTGATCAAGGCGGCC
ATCGGCTTGGCCGCCGTGAG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTLLLLVIPLLGFILVNIPPAGSLRKPLIACPLLLSLLQVVLMIFPEAGWWTAFEAGPSVLPFLRVDGISMLMLLAIGLV
VAASSAISIPMIRDDTQRHNFVNLVLLSLLGMNGMVMVTDLFSLYVFLEIVSVCSFILIALCGEREMFQGAFTYIILSAV
ATMLMLTSIAILFLYAGNTSFTTLAAAIAAQQGNAMVLFGVVLFLIGLFIKGGIVPFHGWLPDAYSSSVAPVSILLAGIV
TKVSGVYTLIRLVTEVFGPTPRTNEVLLFVGTLSIVAGALGALGQRDFKRMLAYSSISQVGYIVLSLGAGNALGIAGAIF
HLFNHTVFKTQLFMNATAVEEQTGSRDLERMGGLASRMPVTGWTSIIAFLSAAGIPPLAGFWSKLVIVMALVRSGHEIYM
MIAILASLLTLAYFLTLQRKVFFGEIVEEFKDVREAGWLVTAPALVFAAIIVITGLAIPFLLNTIILPIGSIL

Sequences:

>Translated_473_residues
MTLLLLVIPLLGFILVNIPPAGSLRKPLIACPLLLSLLQVVLMIFPEAGWWTAFEAGPSVLPFLRVDGISMLMLLAIGLV
VAASSAISIPMIRDDTQRHNFVNLVLLSLLGMNGMVMVTDLFSLYVFLEIVSVCSFILIALCGEREMFQGAFTYIILSAV
ATMLMLTSIAILFLYAGNTSFTTLAAAIAAQQGNAMVLFGVVLFLIGLFIKGGIVPFHGWLPDAYSSSVAPVSILLAGIV
TKVSGVYTLIRLVTEVFGPTPRTNEVLLFVGTLSIVAGALGALGQRDFKRMLAYSSISQVGYIVLSLGAGNALGIAGAIF
HLFNHTVFKTQLFMNATAVEEQTGSRDLERMGGLASRMPVTGWTSIIAFLSAAGIPPLAGFWSKLVIVMALVRSGHEIYM
MIAILASLLTLAYFLTLQRKVFFGEIVEEFKDVREAGWLVTAPALVFAAIIVITGLAIPFLLNTIILPIGSIL
>Mature_472_residues
TLLLLVIPLLGFILVNIPPAGSLRKPLIACPLLLSLLQVVLMIFPEAGWWTAFEAGPSVLPFLRVDGISMLMLLAIGLVV
AASSAISIPMIRDDTQRHNFVNLVLLSLLGMNGMVMVTDLFSLYVFLEIVSVCSFILIALCGEREMFQGAFTYIILSAVA
TMLMLTSIAILFLYAGNTSFTTLAAAIAAQQGNAMVLFGVVLFLIGLFIKGGIVPFHGWLPDAYSSSVAPVSILLAGIVT
KVSGVYTLIRLVTEVFGPTPRTNEVLLFVGTLSIVAGALGALGQRDFKRMLAYSSISQVGYIVLSLGAGNALGIAGAIFH
LFNHTVFKTQLFMNATAVEEQTGSRDLERMGGLASRMPVTGWTSIIAFLSAAGIPPLAGFWSKLVIVMALVRSGHEIYMM
IAILASLLTLAYFLTLQRKVFFGEIVEEFKDVREAGWLVTAPALVFAAIIVITGLAIPFLLNTIILPIGSIL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=357, Percent_Identity=27.7310924369748, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI251831116, Length=327, Percent_Identity=23.8532110091743, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788831, Length=415, Percent_Identity=27.9518072289157, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788827, Length=340, Percent_Identity=28.5294117647059, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1788613, Length=308, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI2367154, Length=372, Percent_Identity=28.494623655914, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788829, Length=385, Percent_Identity=27.2727272727273, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI145693160, Length=409, Percent_Identity=28.361858190709, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788614, Length=386, Percent_Identity=26.9430051813472, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 50695; Mature: 50564

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLLLVIPLLGFILVNIPPAGSLRKPLIACPLLLSLLQVVLMIFPEAGWWTAFEAGPSV
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCCC
LPFLRVDGISMLMLLAIGLVVAASSAISIPMIRDDTQRHNFVNLVLLSLLGMNGMVMVTD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHH
LFSLYVFLEIVSVCSFILIALCGEREMFQGAFTYIILSAVATMLMLTSIAILFLYAGNTS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
FTTLAAAIAAQQGNAMVLFGVVLFLIGLFIKGGIVPFHGWLPDAYSSSVAPVSILLAGIV
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
TKVSGVYTLIRLVTEVFGPTPRTNEVLLFVGTLSIVAGALGALGQRDFKRMLAYSSISQV
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GYIVLSLGAGNALGIAGAIFHLFNHTVFKTQLFMNATAVEEQTGSRDLERMGGLASRMPV
HEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCCCC
TGWTSIIAFLSAAGIPPLAGFWSKLVIVMALVRSGHEIYMMIAILASLLTLAYFLTLQRK
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VFFGEIVEEFKDVREAGWLVTAPALVFAAIIVITGLAIPFLLNTIILPIGSIL
HHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLLLLVIPLLGFILVNIPPAGSLRKPLIACPLLLSLLQVVLMIFPEAGWWTAFEAGPSV
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCCC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HHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA