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The map label for this gene is pepA2 [H]

Identifier: 117921445

GI number: 117921445

Start: 3610178

End: 3611686

Strand: Direct

Name: pepA2 [H]

Synonym: Shewana3_3006

Alternate gene names: 117921445

Gene position: 3610178-3611686 (Clockwise)

Preceding gene: 117921442

Following gene: 117921446

Centisome position: 72.61

GC content: 51.56

Gene sequence:

>1509_bases
ATGGAGTTTAGCGTAAAGAGCGGTAGCCCCGAAAAACAACGCTCAGCCTGCATCGTTGTCGGTGTTTATGAACCCCGCCG
TCTATCCGGCATCGCCGAGCAATTAGACAAGATTAGCGAAGGTTATATCAGTAATCTACTGCGTCGCGGCGATTTAGAAG
GTAAGCCTGGCCAAATGTTATTACTGCACCACGTTCCTAACGTATTGAGTGAACGAGTGCTGTTAGTCGGTTGCGGCAAA
GAACGAGAACTAGACGAGCGCCAGTACAAGCAGATCATCACTAAAACCATCAACACCTTAAATGAAACGGGTTCAATGGA
GGCCGTGTGCTTCTTGACCGAGTTACACGTGAAAGGTCGTGATACCTATTGGAAAGTTCGCCAAGCCGTCGAAACGACCA
ATAGCAGTTTATACAGCTTCGATGCGCTCAAAACCCGTAAAGGTGAGACCCGTCGTCCACTGCGCAAGTTAGTGTTTAAT
GTCCCGACTCGCCGCGAACTGACCTTAGGTGAGCGTGCGATTGAGCACGGCATGGCCGTATCTGCCGGTATGCATTTATG
CCGCGATGTGGCTAACATGCCGCCAAATATCTGTAATCCAGCCTATTTAGCCTCTCAAGCTCGCCAATTGGCCGAAGTTC
ACGAAAACCTGCATGTCACGACTGTGGGCGAAGAGCAAATGGCGAAACTCGGCATGAACTCTTACCTTGCCGTTGGCCGC
GCCAGTGCCAATGAATCCATTATGACAGTGATGGAATACAAGGGTGCCGTTGACAGCACAGAGAAACCTATCGTGTTGAT
TGGTAAAGGCTTAACCTTCGACTCAGGCGGTATTTCATTAAAACCAGGCGAAGCCATGGATGAAATGAAATACGACATGG
GCGGCGCTGCTGGTGTTATCGGCACCATGAAAGCCATCTGTGATATGAAGCTGCCCATCAACGTCGTCGGTATTCTCGCG
GGCTGTGAAAACATGCCATCGGGCAATGCTTACCGCCCAGGTGACATTTTAACCACAATGTCGGGTCAGACCGTTGAAGT
ACTCAACACCGACGCCGAAGGCCGTCTGGTACTGTGTGACGTATTGACCTATGTTGAGCGTTTCGACCCAGAGCTGGTTA
TCGACACGGCAACACTGACGGGCGCCTGTGTGATTGCCTTAGGCAAACATGCCTCAGGCCTGTTCTCATCACACAATCCT
CTGGCTCACGAGTTGCTGAATGCAGGTGAGCAAAGTGGTGACCGCGCATGGCGCATGCCACTGTGGGATGAGTACCAAGA
TATGCTCGATAGCCCATTTGCCGACATGACCAACTTAGGTGGTCGTCCAGCGGGCGCGATTACCGCGGCTTGTTTCCTGT
CTCGTTTCGCCAAAAAGTACAACTGGGCTCACTTAGACGTGGCGGGTACTGCCTGGAACAGCGGCGCGAATAAAGGTTCA
ACCGGTCGCCCTGTGCCAATTTTGACTCAGTTCCTGATCAATCGAGCTGGCGTAGAATTAGGCGAGTAA

Upstream 100 bases:

>100_bases
GAATAAATCACCTTTGGAGTAATAACTTAGGCCCTTTTCGGGACAAGCAGACATTATCCAATAAATATAAAAATTTGTCT
TTAAGAATCTAGGAGTGCTC

Downstream 100 bases:

>100_bases
TCGCTAATAGCACTGAAAAGGCGAAGAATTTCTTCGCCTTTTTTATTGGGCTCGAAGGCGAAATGACGATTGGCTCAGGA
ATAATTGCAGCCTAGCAACG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase 2; LAP 2; Leucyl aminopeptidase 2 [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVETTNSSLYSFDALKTRKGETRRPLRKLVFN
VPTRRELTLGERAIEHGMAVSAGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLHVTTVGEEQMAKLGMNSYLAVGR
ASANESIMTVMEYKGAVDSTEKPIVLIGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGTMKAICDMKLPINVVGILA
GCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVIDTATLTGACVIALGKHASGLFSSHNP
LAHELLNAGEQSGDRAWRMPLWDEYQDMLDSPFADMTNLGGRPAGAITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
TGRPVPILTQFLINRAGVELGE

Sequences:

>Translated_502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVETTNSSLYSFDALKTRKGETRRPLRKLVFN
VPTRRELTLGERAIEHGMAVSAGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLHVTTVGEEQMAKLGMNSYLAVGR
ASANESIMTVMEYKGAVDSTEKPIVLIGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGTMKAICDMKLPINVVGILA
GCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVIDTATLTGACVIALGKHASGLFSSHNP
LAHELLNAGEQSGDRAWRMPLWDEYQDMLDSPFADMTNLGGRPAGAITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
TGRPVPILTQFLINRAGVELGE
>Mature_502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVETTNSSLYSFDALKTRKGETRRPLRKLVFN
VPTRRELTLGERAIEHGMAVSAGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLHVTTVGEEQMAKLGMNSYLAVGR
ASANESIMTVMEYKGAVDSTEKPIVLIGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGTMKAICDMKLPINVVGILA
GCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVIDTATLTGACVIALGKHASGLFSSHNP
LAHELLNAGEQSGDRAWRMPLWDEYQDMLDSPFADMTNLGGRPAGAITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
TGRPVPILTQFLINRAGVELGE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=496, Percent_Identity=34.0725806451613, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI47155554, Length=295, Percent_Identity=30.8474576271186, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1790710, Length=498, Percent_Identity=76.7068273092369, Blast_Score=808, Evalue=0.0,
Organism=Escherichia coli, GI87082123, Length=311, Percent_Identity=40.1929260450161, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=290, Percent_Identity=32.7586206896552, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17565172, Length=459, Percent_Identity=27.0152505446623, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355725, Length=324, Percent_Identity=34.5679012345679, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24661038, Length=324, Percent_Identity=34.8765432098765, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161077148, Length=502, Percent_Identity=28.8844621513944, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI20130057, Length=502, Percent_Identity=28.8844621513944, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI20129969, Length=524, Percent_Identity=28.8167938931298, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24662227, Length=508, Percent_Identity=28.5433070866142, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355645, Length=506, Percent_Identity=28.8537549407115, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24662223, Length=506, Percent_Identity=28.8537549407115, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI20129963, Length=507, Percent_Identity=28.0078895463511, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19922386, Length=498, Percent_Identity=29.1164658634538, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21357381, Length=293, Percent_Identity=33.1058020477816, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI221379063, Length=293, Percent_Identity=33.1058020477816, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI221379062, Length=293, Percent_Identity=33.1058020477816, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646701, Length=265, Percent_Identity=27.9245283018868, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646703, Length=265, Percent_Identity=27.9245283018868, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358201, Length=265, Percent_Identity=27.9245283018868, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54695; Mature: 54695

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHHVPNVLSERVLLVGCGKERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGR
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVETTNSSLYSFDALKTRKGETRRPLRKLVFNVPTRRELTLGERAIEHGMAV
CHHHHHHHHHHHHCCCCEEHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHH
SAGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLHVTTVGEEQMAKLGMNSYLAVGR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHCCCHHHEEEC
ASANESIMTVMEYKGAVDSTEKPIVLIGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVI
CCCCCHHHHHHHHCCCCCCCCCCEEEEECCCEECCCCEEECCCCHHHHHHHHCCCCHHHH
GTMKAICDMKLPINVVGILAGCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHH
VLTYVERFDPELVIDTATLTGACVIALGKHASGLFSSHNPLAHELLNAGEQSGDRAWRMP
HHHHHHHCCCCEEEECCHHHCEEEEEECCCHHCCCCCCCHHHHHHHHCCCCCCCCEECCC
LWDEYQDMLDSPFADMTNLGGRPAGAITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
CHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
TGRPVPILTQFLINRAGVELGE
CCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHHVPNVLSERVLLVGCGKERELDERQYKQIITKTINTLNETGSMEAVCFLTELHVKGR
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVETTNSSLYSFDALKTRKGETRRPLRKLVFNVPTRRELTLGERAIEHGMAV
CHHHHHHHHHHHHCCCCEEHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHH
SAGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLHVTTVGEEQMAKLGMNSYLAVGR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHCCCHHHEEEC
ASANESIMTVMEYKGAVDSTEKPIVLIGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVI
CCCCCHHHHHHHHCCCCCCCCCCEEEEECCCEECCCCEEECCCCHHHHHHHHCCCCHHHH
GTMKAICDMKLPINVVGILAGCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHH
VLTYVERFDPELVIDTATLTGACVIALGKHASGLFSSHNPLAHELLNAGEQSGDRAWRMP
HHHHHHHCCCCEEEECCHHHCEEEEEECCCHHCCCCCCCHHHHHHHHCCCCCCCCEECCC
LWDEYQDMLDSPFADMTNLGGRPAGAITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
CHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
TGRPVPILTQFLINRAGVELGE
CCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]