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The map label for this gene is pepQ [H]

Identifier: 117921425

GI number: 117921425

Start: 3588962

End: 3590776

Strand: Direct

Name: pepQ [H]

Synonym: Shewana3_2986

Alternate gene names: 117921425

Gene position: 3588962-3590776 (Clockwise)

Preceding gene: 117921422

Following gene: 117921426

Centisome position: 72.18

GC content: 51.85

Gene sequence:

>1815_bases
ATGTCGTTAGAATCGTCATCATCCCAACAACCTAATAAGATTGCTAACCGTCTCGCCGCCATTCGTAGTGAACTCGCCAG
TGCCAATTTAGATGCCTTTATCATCCCGCGCGCGGATGAATACTTGGGCGAATATGTGCCTGAGCATAACGAGCGTCTGT
ACTGGGCAACCGATTTTACTGGCTCAGCAGGCATGGCCATTGTCTTAAAAGACAAAGCCGCCATCTTCACCGATGGTCGT
TATACGGTACAAGTTCGCTTACAGGTGGATGCAAATCTGTTTAGTTATGAAAGCCTGACCGACACACCACAAATCGAATG
GCTATGCGATACGCTTGCCGCAGGTTCACGTGTGGGCTTCGATGCCCGTTTACACACATTAGCGTGGTTTGAAAACGCCA
AAGCGATGTTAGCGAAGGCTCAAATTGAACTGGTTGCCGTCGAACAGAATCCGATTGATAAACACTGGCAAAACCGACCT
GCACCATCGAGTGCAGCAATCACGTTATTTAGTAATGAGAGTGCGGGTAAAACCAGCCTGCAAAAACGCACAGAGATTGG
CGCATTAGTCAAAAAAGCCGGCGCCGATGTCGCGCTGATCGCCGCTTTGGACTCCTTCTGCTGGCTACTCAATATCCGTG
GTAATGACGTGCCGCGTCTGCCGGTCGTACTCGGCTGCGCGCTACTTCACGCCAATGGCGATATGCAGCTATTTACCGAT
TTGAGCAAACTCCCTGAAGGCATTGAGGAACACGTTGGAGCGGGTGTGAGCTTTAAGAGCGAAGCTGCACTTGCCGATAC
CTTGGCAAGCTTACAGGGCGTGAAACTGCTCGCCGATCCGAACTCTGCCAACGCTTGGGCACAAAATATCGCCCGCGATG
CTGGCGCTAAGTTAATCGCCGGTATCGACCCCGTATCACTGCCTAAGGCACAGAAGAATGCCGCCGAATTAGCAGGCATG
CGCGCCAGCCATATCCGTGATGGTGTCGCCGTGAGCCGTTTCCTCGCTTGGCTCGATGCCGAAGTCGCCGCCAATCGTCT
GCACGATGAAGCAACCCTCGCCGATAAGTTAGAAAGCTTCCGCCTAGAAGATCCACAATATCGCGAGCCAAGTTTCGATA
CCATTTCCGCCGCAGGCGCCAATGCGGCCATGTGCCACTACAACCATAACAATGGCACGCCTGCCATGATGACGATGGAC
AGCATCTATCTTGTGGATTCTGGCGCTCAGTATCTGGACGGCACCACGGATGTCACTCGCACCATCGCCATTGGTAAAGT
GACCGATGAACAGAAGAAAATGGTCACCTTGGTATTGAAAGGCCATATCGCCTTAGATCAGGCTCGCTATCCGAAAGGCA
CAACGGGGCAACAACTCGATGCCTTCGCCCGCCAATATCTGTGGCAACATGGGTTTGATTACGACCACGGCACAGGCCAC
GGAGTTGGTCATTTCCTCAGCGTGCACGAAGGCCCGCAGCGCATCGGTAAAAATCTCAATGCCATCGCCCTAATGCCTGG
CATGGTGTTATCCAACGAGCCAGGTTATTACCGCGCCGACAGTTTTGGGATCCGCTTAGAAAACCTAGTGGTAGTGCAAC
ACTGCGAAGCCTTAAAGGGCGCCGAGCGTGAAATGTATGAATTTGATGCCTTAACGCTGATCCCAATGGATGCTCGCCTT
ATCGATAAGAGCCTGTTAACCCAAGGCGAAATCGACTGGTTTAATGCTTACCATCAGAAAGTGTTTAACACCTTATCGCC
ATTAATGTCGGGCAGTGAGCTTGAGTGGCTGACAAAGGTCACAAAAGCCATCTAA

Upstream 100 bases:

>100_bases
GCTTGCGATAATCGCCGCCAATTCGCATCCTTTTCGCCAGCATTACGCATTATAATTTGGTCGCCTACGTCAGCCGCCAA
TGCCAATATTTGGAGCCCCT

Downstream 100 bases:

>100_bases
CGTTAAGTGGCACAAAACTAAAGCCCAAGCCAATGCTTGGGCTTTTTATTTAGAGTCGCTTCAAGACCCGTTCCACCTAT
GATGTTACTGTTCTGACAAG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MSLESSSSQQPNKIANRLAAIRSELASANLDAFIIPRADEYLGEYVPEHNERLYWATDFTGSAGMAIVLKDKAAIFTDGR
YTVQVRLQVDANLFSYESLTDTPQIEWLCDTLAAGSRVGFDARLHTLAWFENAKAMLAKAQIELVAVEQNPIDKHWQNRP
APSSAAITLFSNESAGKTSLQKRTEIGALVKKAGADVALIAALDSFCWLLNIRGNDVPRLPVVLGCALLHANGDMQLFTD
LSKLPEGIEEHVGAGVSFKSEAALADTLASLQGVKLLADPNSANAWAQNIARDAGAKLIAGIDPVSLPKAQKNAAELAGM
RASHIRDGVAVSRFLAWLDAEVAANRLHDEATLADKLESFRLEDPQYREPSFDTISAAGANAAMCHYNHNNGTPAMMTMD
SIYLVDSGAQYLDGTTDVTRTIAIGKVTDEQKKMVTLVLKGHIALDQARYPKGTTGQQLDAFARQYLWQHGFDYDHGTGH
GVGHFLSVHEGPQRIGKNLNAIALMPGMVLSNEPGYYRADSFGIRLENLVVVQHCEALKGAEREMYEFDALTLIPMDARL
IDKSLLTQGEIDWFNAYHQKVFNTLSPLMSGSELEWLTKVTKAI

Sequences:

>Translated_604_residues
MSLESSSSQQPNKIANRLAAIRSELASANLDAFIIPRADEYLGEYVPEHNERLYWATDFTGSAGMAIVLKDKAAIFTDGR
YTVQVRLQVDANLFSYESLTDTPQIEWLCDTLAAGSRVGFDARLHTLAWFENAKAMLAKAQIELVAVEQNPIDKHWQNRP
APSSAAITLFSNESAGKTSLQKRTEIGALVKKAGADVALIAALDSFCWLLNIRGNDVPRLPVVLGCALLHANGDMQLFTD
LSKLPEGIEEHVGAGVSFKSEAALADTLASLQGVKLLADPNSANAWAQNIARDAGAKLIAGIDPVSLPKAQKNAAELAGM
RASHIRDGVAVSRFLAWLDAEVAANRLHDEATLADKLESFRLEDPQYREPSFDTISAAGANAAMCHYNHNNGTPAMMTMD
SIYLVDSGAQYLDGTTDVTRTIAIGKVTDEQKKMVTLVLKGHIALDQARYPKGTTGQQLDAFARQYLWQHGFDYDHGTGH
GVGHFLSVHEGPQRIGKNLNAIALMPGMVLSNEPGYYRADSFGIRLENLVVVQHCEALKGAEREMYEFDALTLIPMDARL
IDKSLLTQGEIDWFNAYHQKVFNTLSPLMSGSELEWLTKVTKAI
>Mature_603_residues
SLESSSSQQPNKIANRLAAIRSELASANLDAFIIPRADEYLGEYVPEHNERLYWATDFTGSAGMAIVLKDKAAIFTDGRY
TVQVRLQVDANLFSYESLTDTPQIEWLCDTLAAGSRVGFDARLHTLAWFENAKAMLAKAQIELVAVEQNPIDKHWQNRPA
PSSAAITLFSNESAGKTSLQKRTEIGALVKKAGADVALIAALDSFCWLLNIRGNDVPRLPVVLGCALLHANGDMQLFTDL
SKLPEGIEEHVGAGVSFKSEAALADTLASLQGVKLLADPNSANAWAQNIARDAGAKLIAGIDPVSLPKAQKNAAELAGMR
ASHIRDGVAVSRFLAWLDAEVAANRLHDEATLADKLESFRLEDPQYREPSFDTISAAGANAAMCHYNHNNGTPAMMTMDS
IYLVDSGAQYLDGTTDVTRTIAIGKVTDEQKKMVTLVLKGHIALDQARYPKGTTGQQLDAFARQYLWQHGFDYDHGTGHG
VGHFLSVHEGPQRIGKNLNAIALMPGMVLSNEPGYYRADSFGIRLENLVVVQHCEALKGAEREMYEFDALTLIPMDARLI
DKSLLTQGEIDWFNAYHQKVFNTLSPLMSGSELEWLTKVTKAI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=610, Percent_Identity=35.7377049180328, Blast_Score=358, Evalue=8e-99,
Organism=Homo sapiens, GI93141226, Length=604, Percent_Identity=35.2649006622517, Blast_Score=356, Evalue=4e-98,
Organism=Homo sapiens, GI264681565, Length=610, Percent_Identity=34.0983606557377, Blast_Score=325, Evalue=6e-89,
Organism=Escherichia coli, GI1788728, Length=190, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=598, Percent_Identity=33.4448160535117, Blast_Score=325, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI25149105, Length=627, Percent_Identity=29.6650717703349, Blast_Score=270, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6322999, Length=653, Percent_Identity=32.6186830015314, Blast_Score=308, Evalue=2e-84,
Organism=Drosophila melanogaster, GI17137632, Length=610, Percent_Identity=38.0327868852459, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI161078230, Length=633, Percent_Identity=29.3838862559242, Blast_Score=258, Evalue=1e-68,
Organism=Drosophila melanogaster, GI21357287, Length=633, Percent_Identity=29.3838862559242, Blast_Score=258, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65984; Mature: 65853

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLESSSSQQPNKIANRLAAIRSELASANLDAFIIPRADEYLGEYVPEHNERLYWATDFT
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEEECCC
GSAGMAIVLKDKAAIFTDGRYTVQVRLQVDANLFSYESLTDTPQIEWLCDTLAAGSRVGF
CCCCEEEEEECCEEEEECCEEEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHCCCCCCC
DARLHTLAWFENAKAMLAKAQIELVAVEQNPIDKHWQNRPAPSSAAITLFSNESAGKTSL
CHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCHHHHCCCCCCCCEEEEEEECCCCCHHHH
QKRTEIGALVKKAGADVALIAALDSFCWLLNIRGNDVPRLPVVLGCALLHANGDMQLFTD
HHHHHHHHHHHHCCCCEEEHHHHHHHEEEEEECCCCCCCHHHHHHHHHEECCCCHHHHHH
LSKLPEGIEEHVGAGVSFKSEAALADTLASLQGVKLLADPNSANAWAQNIARDAGAKLIA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCEEEE
GIDPVSLPKAQKNAAELAGMRASHIRDGVAVSRFLAWLDAEVAANRLHDEATLADKLESF
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLEDPQYREPSFDTISAAGANAAMCHYNHNNGTPAMMTMDSIYLVDSGAQYLDGTTDVTR
CCCCCCCCCCCCCCHHCCCCCEEEEEEECCCCCCEEEEECEEEEEECCCHHCCCCCHHHE
TIAIGKVTDEQKKMVTLVLKGHIALDQARYPKGTTGQQLDAFARQYLWQHGFDYDHGTGH
EEEEECCCCHHHHEEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
GVGHFLSVHEGPQRIGKNLNAIALMPGMVLSNEPGYYRADSFGIRLENLVVVQHCEALKG
CHHHHEECCCCHHHHCCCCCEEEECCCEEECCCCCCEECCCCCEEEHHHHHHHHHHHHCC
AEREMYEFDALTLIPMDARLIDKSLLTQGEIDWFNAYHQKVFNTLSPLMSGSELEWLTKV
CHHHHHHHCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TKAI
HHCC
>Mature Secondary Structure 
SLESSSSQQPNKIANRLAAIRSELASANLDAFIIPRADEYLGEYVPEHNERLYWATDFT
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEEECCC
GSAGMAIVLKDKAAIFTDGRYTVQVRLQVDANLFSYESLTDTPQIEWLCDTLAAGSRVGF
CCCCEEEEEECCEEEEECCEEEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHCCCCCCC
DARLHTLAWFENAKAMLAKAQIELVAVEQNPIDKHWQNRPAPSSAAITLFSNESAGKTSL
CHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCHHHHCCCCCCCCEEEEEEECCCCCHHHH
QKRTEIGALVKKAGADVALIAALDSFCWLLNIRGNDVPRLPVVLGCALLHANGDMQLFTD
HHHHHHHHHHHHCCCCEEEHHHHHHHEEEEEECCCCCCCHHHHHHHHHEECCCCHHHHHH
LSKLPEGIEEHVGAGVSFKSEAALADTLASLQGVKLLADPNSANAWAQNIARDAGAKLIA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCEEEE
GIDPVSLPKAQKNAAELAGMRASHIRDGVAVSRFLAWLDAEVAANRLHDEATLADKLESF
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLEDPQYREPSFDTISAAGANAAMCHYNHNNGTPAMMTMDSIYLVDSGAQYLDGTTDVTR
CCCCCCCCCCCCCCHHCCCCCEEEEEEECCCCCCEEEEECEEEEEECCCHHCCCCCHHHE
TIAIGKVTDEQKKMVTLVLKGHIALDQARYPKGTTGQQLDAFARQYLWQHGFDYDHGTGH
EEEEECCCCHHHHEEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
GVGHFLSVHEGPQRIGKNLNAIALMPGMVLSNEPGYYRADSFGIRLENLVVVQHCEALKG
CHHHHEECCCCHHHHCCCCCEEEECCCEEECCCCCCEECCCCCEEEHHHHHHHHHHHHCC
AEREMYEFDALTLIPMDARLIDKSLLTQGEIDWFNAYHQKVFNTLSPLMSGSELEWLTKV
CHHHHHHHCCEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TKAI
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]