Click here to switch to the map view.

The map label for this gene is fkpA [H]

Identifier: 117921422

GI number: 117921422

Start: 3583973

End: 3584443

Strand: Direct

Name: fkpA [H]

Synonym: Shewana3_2983

Alternate gene names: 117921422

Gene position: 3583973-3584443 (Clockwise)

Preceding gene: 117921420

Following gene: 117921425

Centisome position: 72.08

GC content: 45.86

Gene sequence:

>471_bases
ATGAAAATGTTACTTGCCGTTGTTGTGATTGCTGGGGTGATTTTTTACTTCTTTACCTCGATGAATAACCAAAAAGCGGC
CCAAGAAAATATCCGTTTAGGTAATGAGTTTTTAGCGCAAAACAAAAACCAAGAAGGGGTGAAAACCACCGCCTCGGGAT
TGCAATATCAAGTGTTACAGCAAGGCACTGGCACTGTTCATCCTAAGGCGAGTGATACAGTGACTGTGCATTACCACGGC
ACCTTAATTGATGGCACTGTGTTCGATAGCTCGGTCGAGCGCGGTGAACCCATTGCTTTCCCACTCAATCGCGTGATTAA
AGGCTGGACTGAAGGCGTGCAACTGATGGTCGAAGGCGATAAGTACCGCTTCTTTATTCCAAGCGAACTGGCATATGGCA
ACCGCAGCACTGGCAAAATTGGCGGCGGTTCGGTACTGATTTTTGATGTTGAGCTGCTAAAGATTAATTAA

Upstream 100 bases:

>100_bases
ATGTAACGCGGATCATCCAGTACCGCGCCAAACCGAGGCGCTAGCCACTTCGGCTAAAAAACTGATAACATGGCCAAAAT
TGACTGAGGTGCTCCTTAAA

Downstream 100 bases:

>100_bases
TCTGACGCTGTAATCCTTAATAAAAAGCCCTGCATTGCAGGGCTTTTTTAATGTATTTAATCCCTATCGACTAAGGGCAA
GACGCCGCGCCGATATCCGT

Product: peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKMLLAVVVIAGVIFYFFTSMNNQKAAQENIRLGNEFLAQNKNQEGVKTTASGLQYQVLQQGTGTVHPKASDTVTVHYHG
TLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVEGDKYRFFIPSELAYGNRSTGKIGGGSVLIFDVELLKIN

Sequences:

>Translated_156_residues
MKMLLAVVVIAGVIFYFFTSMNNQKAAQENIRLGNEFLAQNKNQEGVKTTASGLQYQVLQQGTGTVHPKASDTVTVHYHG
TLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVEGDKYRFFIPSELAYGNRSTGKIGGGSVLIFDVELLKIN
>Mature_156_residues
MKMLLAVVVIAGVIFYFFTSMNNQKAAQENIRLGNEFLAQNKNQEGVKTTASGLQYQVLQQGTGTVHPKASDTVTVHYHG
TLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVEGDKYRFFIPSELAYGNRSTGKIGGGSVLIFDVELLKIN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=94, Percent_Identity=47.8723404255319, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI17149844, Length=94, Percent_Identity=47.8723404255319, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI17149842, Length=94, Percent_Identity=47.8723404255319, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=42.0560747663551, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=42.0560747663551, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4503727, Length=139, Percent_Identity=33.0935251798561, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4503729, Length=102, Percent_Identity=39.2156862745098, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=37.7358490566038, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI224809329, Length=99, Percent_Identity=41.4141414141414, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI224809327, Length=99, Percent_Identity=41.4141414141414, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI4758384, Length=99, Percent_Identity=41.4141414141414, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI224809331, Length=99, Percent_Identity=41.4141414141414, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=41.304347826087, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI192448443, Length=111, Percent_Identity=36.9369369369369, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI33469985, Length=90, Percent_Identity=36.6666666666667, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI87082390, Length=123, Percent_Identity=54.4715447154472, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI1789745, Length=133, Percent_Identity=48.1203007518797, Blast_Score=117, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=48, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540882, Length=107, Percent_Identity=44.8598130841121, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=41.1214953271028, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324194, Length=101, Percent_Identity=47.5247524752475, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320727, Length=89, Percent_Identity=53.9325842696629, Blast_Score=85, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=44.3396226415094, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356629, Length=96, Percent_Identity=46.875, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=45.0549450549451, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=45.0549450549451, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=40.3846153846154, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17129; Mature: 17129

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMLLAVVVIAGVIFYFFTSMNNQKAAQENIRLGNEFLAQNKNQEGVKTTASGLQYQVLQ
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHCCCCCCCCHHHHCCCEEEEEC
QGTGTVHPKASDTVTVHYHGTLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVEGD
CCCCCCCCCCCCEEEEEEECEEEECEEECCCCCCCCCCEECHHHHHHHHCCCEEEEEECC
KYRFFIPSELAYGNRSTGKIGGGSVLIFDVELLKIN
EEEEEECCHHCCCCCCCCCCCCCEEEEEEEEEEEEC
>Mature Secondary Structure
MKMLLAVVVIAGVIFYFFTSMNNQKAAQENIRLGNEFLAQNKNQEGVKTTASGLQYQVLQ
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHCCCCCCCCHHHHCCCEEEEEC
QGTGTVHPKASDTVTVHYHGTLIDGTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVEGD
CCCCCCCCCCCCEEEEEEECEEEECEEECCCCCCCCCCEECHHHHHHHHCCCEEEEEECC
KYRFFIPSELAYGNRSTGKIGGGSVLIFDVELLKIN
EEEEEECCHHCCCCCCCCCCCCCEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]