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The map label for this gene is lpxB [H]

Identifier: 117921243

GI number: 117921243

Start: 3348381

End: 3349538

Strand: Reverse

Name: lpxB [H]

Synonym: Shewana3_2802

Alternate gene names: 117921243

Gene position: 3349538-3348381 (Counterclockwise)

Preceding gene: 117921244

Following gene: 117921242

Centisome position: 67.37

GC content: 50.69

Gene sequence:

>1158_bases
ATGAGCAAAAAATCTCAATTAGTGTTTGCAATGGTCGCCGGAGAACTCTCCGGCGATATTTTAGGTGCAGGTTTAATGGC
CGCACTGCAAAAAACACACCCCAACGCTCGTTTTGTCGGTATTGGTGGACCTCGAATGGAAGCCCTAGGCTTCGAATCTC
TGTTCGCGATGGAAGAGTTAGCCGTGATGGGGATAGTCGAAGTGCTATCTCGTCTGCCACGCTTACTCCACGTGCGCTCA
TCCCTAATTAAGTCCATCACCGAACTTAAGCCCGATTGTTTTATCGGTATCGATGCACCGGATTTTAATATCGGTCTTGA
GCTTAAGTTAAAGGCGCAGGGGATTAAAACCGTTCACTATGTGAGCCCTTCGGTATGGGCATGGCGCCCTAAGCGGATTT
TTAAAATCGCTAAGGCCACCAATATGGTGCTGTCGTTATTGCCCTTTGAGAAGGCCTTTTACGATAAGCATCAGGTACCT
TGTACCTTTGTTGGCCATACCTTGGCTGACGATATTCCGTTAGAGAGTGATAAGGCGAGCGCTCGTCAGTTGCTTGAACT
CGATCCTGAGGCCGAATACCTCGCGATTTTACCCGGCTCACGCGGTGGCGAATTAAAGCAATTGGCCGAGCCTTTTGTGA
AGGCTGCGCTACTTATCAAGCAGCAATTTCCCGATATTCGCTTTGTGACGCCCTTAGTGAATCAAAAGCGCCGTGAGCAG
TTTGAGCAAGCATTAAAAGCGCATGCACCGGATCTGGAAATCCACATGGTGGAAGGCAAATCCCGCGAAGTGATGGCCGC
TGCCGATGGCATTTTACTGGCGTCGGGCACGGCAACGCTTGAGGCCATGCTGATCAAACGCCCTATGGTGGTGGCGTATC
GCGTGAGTCCGCTGACCTATCAGATCGCGAAAACCATGATGCAAGTGAACCGTTTCTCGCTGCCGAATCTGTTAGCGGGG
CGAGATGTGGTGCCAGAGCTTATCCAGCACGATTGCACCCCAGAAAAGATTGCCGAAGCGGTTGGCGTTGAGCTGAATCG
TGACTTTACGCCAATCAAAGCCGAGTTTGAGCGTTTACACCAAATGTTGCGCTGTGATGCCAGTCAAAAAGCGGCTGAGG
CAGTGTTAGCGCTCGTCGATGCTAAGGATGTGAACTAA

Upstream 100 bases:

>100_bases
ACTATGCCATTCATAGGCACTGCTCGTAATATTCTGCTTTAGACAATGCCATGGCAGAGATGCGCTGCGGTGCCATTCAC
TTGTCAGATATGATTGGTTT

Downstream 100 bases:

>100_bases
TGGCGGTATTTAAGACGTTGACCGACGCCGATATCGCTACCTTCTCTACAGGTTTAGTGGCGGGCGTGGATGAAGTCGGT
CGTGGCCCGCTGGTAGGGGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSKKSQLVFAMVAGELSGDILGAGLMAALQKTHPNARFVGIGGPRMEALGFESLFAMEELAVMGIVEVLSRLPRLLHVRS
SLIKSITELKPDCFIGIDAPDFNIGLELKLKAQGIKTVHYVSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDKHQVP
CTFVGHTLADDIPLESDKASARQLLELDPEAEYLAILPGSRGGELKQLAEPFVKAALLIKQQFPDIRFVTPLVNQKRREQ
FEQALKAHAPDLEIHMVEGKSREVMAAADGILLASGTATLEAMLIKRPMVVAYRVSPLTYQIAKTMMQVNRFSLPNLLAG
RDVVPELIQHDCTPEKIAEAVGVELNRDFTPIKAEFERLHQMLRCDASQKAAEAVLALVDAKDVN

Sequences:

>Translated_385_residues
MSKKSQLVFAMVAGELSGDILGAGLMAALQKTHPNARFVGIGGPRMEALGFESLFAMEELAVMGIVEVLSRLPRLLHVRS
SLIKSITELKPDCFIGIDAPDFNIGLELKLKAQGIKTVHYVSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDKHQVP
CTFVGHTLADDIPLESDKASARQLLELDPEAEYLAILPGSRGGELKQLAEPFVKAALLIKQQFPDIRFVTPLVNQKRREQ
FEQALKAHAPDLEIHMVEGKSREVMAAADGILLASGTATLEAMLIKRPMVVAYRVSPLTYQIAKTMMQVNRFSLPNLLAG
RDVVPELIQHDCTPEKIAEAVGVELNRDFTPIKAEFERLHQMLRCDASQKAAEAVLALVDAKDVN
>Mature_384_residues
SKKSQLVFAMVAGELSGDILGAGLMAALQKTHPNARFVGIGGPRMEALGFESLFAMEELAVMGIVEVLSRLPRLLHVRSS
LIKSITELKPDCFIGIDAPDFNIGLELKLKAQGIKTVHYVSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDKHQVPC
TFVGHTLADDIPLESDKASARQLLELDPEAEYLAILPGSRGGELKQLAEPFVKAALLIKQQFPDIRFVTPLVNQKRREQF
EQALKAHAPDLEIHMVEGKSREVMAAADGILLASGTATLEAMLIKRPMVVAYRVSPLTYQIAKTMMQVNRFSLPNLLAGR
DVVPELIQHDCTPEKIAEAVGVELNRDFTPIKAEFERLHQMLRCDASQKAAEAVLALVDAKDVN

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=380, Percent_Identity=57.8947368421053, Blast_Score=448, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42525; Mature: 42394

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKSQLVFAMVAGELSGDILGAGLMAALQKTHPNARFVGIGGPRMEALGFESLFAMEEL
CCCCHHEEEEEECCHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHH
AVMGIVEVLSRLPRLLHVRSSLIKSITELKPDCFIGIDAPDFNIGLELKLKAQGIKTVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCEEEEE
VSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDKHQVPCTFVGHTLADDIPLESDKAS
ECCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEEECCHHHCCCCCCCCHHH
ARQLLELDPEAEYLAILPGSRGGELKQLAEPFVKAALLIKQQFPDIRFVTPLVNQKRREQ
HHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHH
FEQALKAHAPDLEIHMVEGKSREVMAAADGILLASGTATLEAMLIKRPMVVAYRVSPLTY
HHHHHHHCCCCCEEEEECCCCCEEEEECCCEEEECCHHHHHHHHHCCCEEEEEEECCHHH
QIAKTMMQVNRFSLPNLLAGRDVVPELIQHDCTPEKIAEAVGVELNRDFTPIKAEFERLH
HHHHHHHHHHHCCCCCHHCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
QMLRCDASQKAAEAVLALVDAKDVN
HHHHCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKKSQLVFAMVAGELSGDILGAGLMAALQKTHPNARFVGIGGPRMEALGFESLFAMEEL
CCCHHEEEEEECCHHCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHH
AVMGIVEVLSRLPRLLHVRSSLIKSITELKPDCFIGIDAPDFNIGLELKLKAQGIKTVHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCEEEEE
VSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDKHQVPCTFVGHTLADDIPLESDKAS
ECCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEEECCHHHCCCCCCCCHHH
ARQLLELDPEAEYLAILPGSRGGELKQLAEPFVKAALLIKQQFPDIRFVTPLVNQKRREQ
HHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHH
FEQALKAHAPDLEIHMVEGKSREVMAAADGILLASGTATLEAMLIKRPMVVAYRVSPLTY
HHHHHHHCCCCCEEEEECCCCCEEEEECCCEEEECCHHHHHHHHHCCCEEEEEEECCHHH
QIAKTMMQVNRFSLPNLLAGRDVVPELIQHDCTPEKIAEAVGVELNRDFTPIKAEFERLH
HHHHHHHHHHHCCCCCHHCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHH
QMLRCDASQKAAEAVLALVDAKDVN
HHHHCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]