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The map label for this gene is lpxA [H]

Identifier: 117921244

GI number: 117921244

Start: 3349655

End: 3350425

Strand: Reverse

Name: lpxA [H]

Synonym: Shewana3_2803

Alternate gene names: 117921244

Gene position: 3350425-3349655 (Counterclockwise)

Preceding gene: 117921245

Following gene: 117921243

Centisome position: 67.38

GC content: 48.9

Gene sequence:

>771_bases
GTGATAGATACATTAGCGTTTGTGCATCCCGATGCAAAAATTGGTAAAAACGTCACCATAGGTCCATGGAGTTATGTGGG
CGCGGGTGTCGAGATTGGCGACGATTGTTGGTTAAGCTCCCACGTAGTAGTGAAGGGGCCAACCATTATCGGTAAAGGCA
ACCGTATTTTCCAATTCGCCTCCGTGGGTGAAGAATGCCAAGACAAGAAATACGCTGGCGAGCCGACTCGACTCATTATT
GGCGATAACAACGTTATCCGTGAACATGTGACCATTCACCGTGGTACGGTTCAAGACAATAGCGAAACCCGTATCGGCTC
TAACAACCTGTTTATGAACTACGTGCATATTGCCCATGACTGTGTGGTCGGTAATAACGTGATTATGGCTAACAATGCCT
CTATCGCAGGCCATGTGCATGTGGGTGACTGGGCAATTCTCGGTGGTATGACTGGGGTTCACCAGTTTGTGCATATCGGT
GCCCACGCCTTTACCGCGGGGTGTTCGTTATTGCTACAGGATGTGCCACCCTTTGTGATGGCGGCGGGACAACCTGCTAT
TCCTCGTGGCTTAAACAGCGAAGGTATGAAGCGCCGTGGTTTCTCTAAGGAGAGCCAATTAGCGGTGCGCCGTGCCTATA
AAACCTTATATCGCAGTAGTTTAACTGTTGATGAAGCGATTGAAGCGCTTGCCGAAGATGCGCAGAACGATGAGCAAGTT
AAGTCGTTCATTGAGTTTGTTAAATCATCGGGTCGCGGCATTATTCGTTAA

Upstream 100 bases:

>100_bases
AAGAGCGCCGCGGGATTGGCGTTTTCTATGGTGAGGCCAAAGTGGATGGTGAAGTGGTTTGTTCCGCTGAAATCATGTGT
GCCCGCAGAGAGATTAATCA

Downstream 100 bases:

>100_bases
GAGTCCTAGACTCTACACTATGCCATTCATAGGCACTGCTCGTAATATTCTGCTTTAGACAATGCCATGGCAGAGATGCG
CTGCGGTGCCATTCACTTGT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MIDTLAFVHPDAKIGKNVTIGPWSYVGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFASVGEECQDKKYAGEPTRLII
GDNNVIREHVTIHRGTVQDNSETRIGSNNLFMNYVHIAHDCVVGNNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIG
AHAFTAGCSLLLQDVPPFVMAAGQPAIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVDEAIEALAEDAQNDEQV
KSFIEFVKSSGRGIIR

Sequences:

>Translated_256_residues
MIDTLAFVHPDAKIGKNVTIGPWSYVGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFASVGEECQDKKYAGEPTRLII
GDNNVIREHVTIHRGTVQDNSETRIGSNNLFMNYVHIAHDCVVGNNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIG
AHAFTAGCSLLLQDVPPFVMAAGQPAIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVDEAIEALAEDAQNDEQV
KSFIEFVKSSGRGIIR
>Mature_256_residues
MIDTLAFVHPDAKIGKNVTIGPWSYVGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFASVGEECQDKKYAGEPTRLII
GDNNVIREHVTIHRGTVQDNSETRIGSNNLFMNYVHIAHDCVVGNNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIG
AHAFTAGCSLLLQDVPPFVMAAGQPAIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVDEAIEALAEDAQNDEQV
KSFIEFVKSSGRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=58.0152671755725, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1786376, Length=237, Percent_Identity=26.5822784810127, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27764; Mature: 27764

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTLAFVHPDAKIGKNVTIGPWSYVGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFA
CCCCEEEECCCHHHCCEEEECCHHHHCCCCEECCCCEECCEEEEECCEEEECCCEEEEEH
SVGEECQDKKYAGEPTRLIIGDNNVIREHVTIHRGTVQDNSETRIGSNNLFMNYVHIAHD
HCCHHHHCCCCCCCCCEEEECCCCEEEEEEEEEECCCCCCCCCEECCCCEEEEEEEHHHH
CVVGNNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIGAHAFTAGCSLLLQDVPPFVM
EEECCCEEEECCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AAGQPAIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVDEAIEALAEDAQNDEQV
ECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
KSFIEFVKSSGRGIIR
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIDTLAFVHPDAKIGKNVTIGPWSYVGAGVEIGDDCWLSSHVVVKGPTIIGKGNRIFQFA
CCCCEEEECCCHHHCCEEEECCHHHHCCCCEECCCCEECCEEEEECCEEEECCCEEEEEH
SVGEECQDKKYAGEPTRLIIGDNNVIREHVTIHRGTVQDNSETRIGSNNLFMNYVHIAHD
HCCHHHHCCCCCCCCCEEEECCCCEEEEEEEEEECCCCCCCCCEECCCCEEEEEEEHHHH
CVVGNNVIMANNASIAGHVHVGDWAILGGMTGVHQFVHIGAHAFTAGCSLLLQDVPPFVM
EEECCCEEEECCCCEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
AAGQPAIPRGLNSEGMKRRGFSKESQLAVRRAYKTLYRSSLTVDEAIEALAEDAQNDEQV
ECCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHH
KSFIEFVKSSGRGIIR
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA