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The map label for this gene is mro [H]

Identifier: 117920516

GI number: 117920516

Start: 2480124

End: 2481179

Strand: Direct

Name: mro [H]

Synonym: Shewana3_2072

Alternate gene names: 117920516

Gene position: 2480124-2481179 (Clockwise)

Preceding gene: 117920515

Following gene: 117920517

Centisome position: 49.88

GC content: 43.09

Gene sequence:

>1056_bases
ATGCAACTCTCTGTTACTCAAAAAAGCCTACAACACGCCGCATTTGCGGATGAACTACAATTAGTCACGCTCACTAATAG
CCACGGGCTTGAAGTGGTTCTGTCAAATTACGGCGCCAGTATTTGGTCGGTCAAACTTTATGGTCAAGCGCAAGAACCTA
TTTCATTAAGTCTGGGCTATCAAGATATTAAAGATTGGGTGACTAATCCGTATTATTTTGGTATTACCGCCGGCCGTGTC
GCAAATCGCATTGGTAAAGCACAATTCCCCTTAGCAGGTAAAACAATTCAATTAGTCGCCAATGAAGGCAATAATCAACT
TCACGGCGGACCTAAAGGATTAAGCCATTGCACTTGGCAGGTTGAGATGCTGCAGGACAATGACAGTGTGGCGGCGGTTT
TCAGCATTACCAGCCCCGATGGCGATCAAGGATTTCCGGGGAATCTTGCGATTACGCTCGAGTACCGCCTCAATGAAAAC
AATGAATTAACTCTGAACTATCAAGCCGTTTGCGATCAAACCACACCCGTCTGTTTAACTAATCATGCTTACTGGAATCT
TGCCTCCAACAAACAGCAAGGCATTTTAGGGCACGAACTCTCCATTCAAGCCAGTCATTTCTTGGCGCTCGATAATGAAC
AGATCCCGACGGGCGAATTAATCTTAGTCGACGATGGCGCATACGATTTCAAACAACCGAAGCTAATTGCCACGGATATT
AAGCAATTAACCAATGGTTATGATCATTATTTTGTGATGGATAGAAACCCAGACAATAAAAACAGTTTGCAGACTATTGC
GGTATTAAAAGATCCGCTTTCTGGCCGAGAACTCGAAATTAGTACCACAGAAGTCGGCGTGCAATTTTATAGTGGCAACT
TTCTCGATGGCAGCCATATTGATGATGAAGGTTATAGCATTAATCAATTCCATGGCCTGTGTTTAGAAACCCACGGTTAT
CCGAACGCGGTAAACATTGACCATTTCCCGAGTGTCATGCTTGAGGCAAATACTCAATATCAACAAATTACGGTACATAA
GTTTAAGAATATTTAA

Upstream 100 bases:

>100_bases
GTCGATGGTGGTTGGATTTAAATATCACAATAAAATTTCAGTTCATTAAATAATGAGGTGAGTGCTGAGTTTATTTTAAA
TAAAAGGTAAAGCACTCACC

Downstream 100 bases:

>100_bases
TTCAATCAAGGCGAAATAACATTTATTTGTACGAGTTAGTCTGCAGTTAACAGCAGGCTAGGGGATCTCTGTTACCTAAA
ATTATAAAGGGAATAATAAT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MQLSVTQKSLQHAAFADELQLVTLTNSHGLEVVLSNYGASIWSVKLYGQAQEPISLSLGYQDIKDWVTNPYYFGITAGRV
ANRIGKAQFPLAGKTIQLVANEGNNQLHGGPKGLSHCTWQVEMLQDNDSVAAVFSITSPDGDQGFPGNLAITLEYRLNEN
NELTLNYQAVCDQTTPVCLTNHAYWNLASNKQQGILGHELSIQASHFLALDNEQIPTGELILVDDGAYDFKQPKLIATDI
KQLTNGYDHYFVMDRNPDNKNSLQTIAVLKDPLSGRELEISTTEVGVQFYSGNFLDGSHIDDEGYSINQFHGLCLETHGY
PNAVNIDHFPSVMLEANTQYQQITVHKFKNI

Sequences:

>Translated_351_residues
MQLSVTQKSLQHAAFADELQLVTLTNSHGLEVVLSNYGASIWSVKLYGQAQEPISLSLGYQDIKDWVTNPYYFGITAGRV
ANRIGKAQFPLAGKTIQLVANEGNNQLHGGPKGLSHCTWQVEMLQDNDSVAAVFSITSPDGDQGFPGNLAITLEYRLNEN
NELTLNYQAVCDQTTPVCLTNHAYWNLASNKQQGILGHELSIQASHFLALDNEQIPTGELILVDDGAYDFKQPKLIATDI
KQLTNGYDHYFVMDRNPDNKNSLQTIAVLKDPLSGRELEISTTEVGVQFYSGNFLDGSHIDDEGYSINQFHGLCLETHGY
PNAVNIDHFPSVMLEANTQYQQITVHKFKNI
>Mature_351_residues
MQLSVTQKSLQHAAFADELQLVTLTNSHGLEVVLSNYGASIWSVKLYGQAQEPISLSLGYQDIKDWVTNPYYFGITAGRV
ANRIGKAQFPLAGKTIQLVANEGNNQLHGGPKGLSHCTWQVEMLQDNDSVAAVFSITSPDGDQGFPGNLAITLEYRLNEN
NELTLNYQAVCDQTTPVCLTNHAYWNLASNKQQGILGHELSIQASHFLALDNEQIPTGELILVDDGAYDFKQPKLIATDI
KQLTNGYDHYFVMDRNPDNKNSLQTIAVLKDPLSGRELEISTTEVGVQFYSGNFLDGSHIDDEGYSINQFHGLCLETHGY
PNAVNIDHFPSVMLEANTQYQQITVHKFKNI

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=320, Percent_Identity=36.5625, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI1786971, Length=340, Percent_Identity=33.8235294117647, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17557428, Length=334, Percent_Identity=31.1377245508982, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI115533334, Length=334, Percent_Identity=31.1377245508982, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319493, Length=345, Percent_Identity=28.695652173913, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6322004, Length=353, Percent_Identity=28.8951841359773, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324399, Length=348, Percent_Identity=28.1609195402299, Blast_Score=116, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=34.7826086956522, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24583720, Length=362, Percent_Identity=33.9779005524862, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24668278, Length=340, Percent_Identity=33.5294117647059, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24668282, Length=346, Percent_Identity=31.5028901734104, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24641876, Length=348, Percent_Identity=28.1609195402299, Blast_Score=152, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38908; Mature: 38908

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSVTQKSLQHAAFADELQLVTLTNSHGLEVVLSNYGASIWSVKLYGQAQEPISLSLGY
CCCCCCHHHHHHHHHHCCEEEEEEECCCCEEEEEECCCCEEEEEEEECCCCCCEEEEECH
QDIKDWVTNPYYFGITAGRVANRIGKAQFPLAGKTIQLVANEGNNQLHGGPKGLSHCTWQ
HHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEE
VEMLQDNDSVAAVFSITSPDGDQGFPGNLAITLEYRLNENNELTLNYQAVCDQTTPVCLT
EEEEECCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEEEEECCCCCEEEE
NHAYWNLASNKQQGILGHELSIQASHFLALDNEQIPTGELILVDDGAYDFKQPKLIATDI
CCEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHH
KQLTNGYDHYFVMDRNPDNKNSLQTIAVLKDPLSGRELEISTTEVGVQFYSGNFLDGSHI
HHHHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEEHEEEEEEEECCCCCCCCC
DDEGYSINQFHGLCLETHGYPNAVNIDHFPSVMLEANTQYQQITVHKFKNI
CCCCCEEECCCCEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCC
>Mature Secondary Structure
MQLSVTQKSLQHAAFADELQLVTLTNSHGLEVVLSNYGASIWSVKLYGQAQEPISLSLGY
CCCCCCHHHHHHHHHHCCEEEEEEECCCCEEEEEECCCCEEEEEEEECCCCCCEEEEECH
QDIKDWVTNPYYFGITAGRVANRIGKAQFPLAGKTIQLVANEGNNQLHGGPKGLSHCTWQ
HHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEE
VEMLQDNDSVAAVFSITSPDGDQGFPGNLAITLEYRLNENNELTLNYQAVCDQTTPVCLT
EEEEECCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEEEEECCCCCEEEE
NHAYWNLASNKQQGILGHELSIQASHFLALDNEQIPTGELILVDDGAYDFKQPKLIATDI
CCEEEEECCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHH
KQLTNGYDHYFVMDRNPDNKNSLQTIAVLKDPLSGRELEISTTEVGVQFYSGNFLDGSHI
HHHHCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCEEEEEEHEEEEEEEECCCCCCCCC
DDEGYSINQFHGLCLETHGYPNAVNIDHFPSVMLEANTQYQQITVHKFKNI
CCCCCEEECCCCEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]