BacMap

Definition	Shewanella sp. ANA-3 chromosome chromosome 1, complete sequence.
Accession	NC_008577
Length	4,972,204

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The map label for this gene is fadH [H]

Identifier: 117920427

GI number: 117920427

Start: 2360297

End: 2361124

Strand: Direct

Name: fadH [H]

Synonym: Shewana3_1982

Alternate gene names: 117920427

Gene position: 2360297-2361124 (Clockwise)

Preceding gene: 117920426

Following gene: 117920428

Centisome position: 47.47

GC content: 51.93

Gene sequence:

>828_bases
ATGCTGAATACTACGATGTTTAATTATCAAGGTAAGAATGTTGTCGTTGTCGGTGGTACGAGTGGAATTAACCTCGCGAT
AGCCAACGCCTTTGCGCAGGCTGGCGCGAATGTGACGGTGGCGAGTCGCAGTCAAGACAAGATTGATGCCGCCGTGTTGC
AACTCAAACAGTCAAATCCAGATGGGATCCACCTCGGGGTGAGTTTTGATGTCAGGGATTTGGCTGCGGTTGAGCAGGGC
TTTGAAGCCATCGCCTCCGAATTTGGCTTTATCGATGTGTTGGTCAGTGGCGCGGCAGGCAACTTTCCGGCGACTGCGGC
AAAACTCTCTGCTAATGGCTTTAAGGCCGTGATGGATATTGACTTGTTGGGCAGTTTTCAAGTGCTAAAGACGGCTTATC
CTTTACTGCGTCGCCCCCAAGGGAATATTATTCAAATCTCGGCGCCGCAGGCATCCATAGCAATGCCAATGCAAGCCCAT
GTGTGCGCCGCCAAAGCGGGCGTAGACATGCTCACTCGGACACTGGCGGTAGAATGGGGCTGCGAAGGGATCCGCATAAA
CTCCATTATTCCTGGACCAATCGCGGACACTGAAGGATTTAACCGTTTAGCACCGAGCGCCGCGCTGCAACAGCAAGTTG
CACAGTCTGTACCGTTAAAACGCAATGGCGAAGGGCAAGATATTGCTAATGCCGCGATGTTTTTAGGATCAGAATATGCC
TCGTACATTACAGGGGTTGTGTTACCCGTCGATGGTGGCTGGTCACTTGGCGGAGCGAGCATTGCAATGACGGCATTAGG
CGAGTTGGCGATTAAAGCTCAGCAGTAA

Upstream 100 bases:

>100_bases
GCAGGCGATTCATCAATCTCTCGCTTGAGTGCCATGATGAAAGCCATTGCGGCTTAAGCACTCATTCGCGCGTTAATTTG
ACCGTTCACGGAGAATGCCC

Downstream 100 bases:

>100_bases
TAGTGCAATATTTGAACGTTGTAACTTATTTATTTGATAGAGAAATCGGGTGAAAATCCATGGCGAATGCATTACAAGAG
CAGCTGCTTAAGGCTGGCCT

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MLNTTMFNYQGKNVVVVGGTSGINLAIANAFAQAGANVTVASRSQDKIDAAVLQLKQSNPDGIHLGVSFDVRDLAAVEQG
FEAIASEFGFIDVLVSGAAGNFPATAAKLSANGFKAVMDIDLLGSFQVLKTAYPLLRRPQGNIIQISAPQASIAMPMQAH
VCAAKAGVDMLTRTLAVEWGCEGIRINSIIPGPIADTEGFNRLAPSAALQQQVAQSVPLKRNGEGQDIANAAMFLGSEYA
SYITGVVLPVDGGWSLGGASIAMTALGELAIKAQQ

Sequences:

>Translated_275_residues
MLNTTMFNYQGKNVVVVGGTSGINLAIANAFAQAGANVTVASRSQDKIDAAVLQLKQSNPDGIHLGVSFDVRDLAAVEQG
FEAIASEFGFIDVLVSGAAGNFPATAAKLSANGFKAVMDIDLLGSFQVLKTAYPLLRRPQGNIIQISAPQASIAMPMQAH
VCAAKAGVDMLTRTLAVEWGCEGIRINSIIPGPIADTEGFNRLAPSAALQQQVAQSVPLKRNGEGQDIANAAMFLGSEYA
SYITGVVLPVDGGWSLGGASIAMTALGELAIKAQQ
>Mature_275_residues
MLNTTMFNYQGKNVVVVGGTSGINLAIANAFAQAGANVTVASRSQDKIDAAVLQLKQSNPDGIHLGVSFDVRDLAAVEQG
FEAIASEFGFIDVLVSGAAGNFPATAAKLSANGFKAVMDIDLLGSFQVLKTAYPLLRRPQGNIIQISAPQASIAMPMQAH
VCAAKAGVDMLTRTLAVEWGCEGIRINSIIPGPIADTEGFNRLAPSAALQQQVAQSVPLKRNGEGQDIANAAMFLGSEYA
SYITGVVLPVDGGWSLGGASIAMTALGELAIKAQQ

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=42.741935483871, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI19923817, Length=252, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4503301, Length=248, Percent_Identity=32.258064516129, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI59889578, Length=236, Percent_Identity=32.6271186440678, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=32.258064516129, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI7705925, Length=247, Percent_Identity=27.9352226720648, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=29.6747967479675, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=30.327868852459, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=30.3643724696356, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI20149619, Length=186, Percent_Identity=26.8817204301075, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI126723750, Length=249, Percent_Identity=27.3092369477912, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI66933014, Length=234, Percent_Identity=27.3504273504274, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI7706318, Length=199, Percent_Identity=24.6231155778894, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=31.0756972111554, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787905, Length=261, Percent_Identity=30.6513409961686, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=27.2, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=29.5019157088123, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=28.1746031746032, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=26.7441860465116, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789057, Length=253, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=28.957528957529, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=29.8039215686275, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=27.3092369477912, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=28.3400809716599, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=26.6932270916335, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787820, Length=192, Percent_Identity=27.6041666666667, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787545, Length=270, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=249, Percent_Identity=31.3253012048193, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17561272, Length=234, Percent_Identity=32.9059829059829, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=30.8, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=28.7313432835821, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=29.1044776119403, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=29.8507462686567, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=28.8888888888889, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=32.0158102766798, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=267, Percent_Identity=28.4644194756554, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=29.6, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562990, Length=267, Percent_Identity=28.4644194756554, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=29.368029739777, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=27.7153558052434, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=29.3877551020408, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=29.9212598425197, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=25.8426966292135, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=27.3408239700375, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=24.6963562753036, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=25.1012145748988, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=27.0676691729323, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=277, Percent_Identity=27.4368231046931, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=25.3787878787879, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=274, Percent_Identity=27.3722627737226, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=26.2172284644195, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=27.4509803921569, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=28.4132841328413, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=284, Percent_Identity=26.7605633802817, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=259, Percent_Identity=25.4826254826255, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=199, Percent_Identity=27.1356783919598, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=252, Percent_Identity=40.4761904761905, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322861, Length=215, Percent_Identity=27.906976744186, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355319, Length=254, Percent_Identity=31.8897637795276, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=29.3436293436293, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21357041, Length=257, Percent_Identity=29.1828793774319, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=29.0836653386454, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571526, Length=264, Percent_Identity=28.4090909090909, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24644337, Length=253, Percent_Identity=30.0395256916996, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24643142, Length=247, Percent_Identity=26.7206477732794, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=28.9156626506024, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356301, Length=207, Percent_Identity=25.6038647342995, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21357673, Length=205, Percent_Identity=28.2926829268293, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 28491; Mature: 28491

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTTMFNYQGKNVVVVGGTSGINLAIANAFAQAGANVTVASRSQDKIDAAVLQLKQSNP
CCCCEEEEECCCEEEEEECCCCCEEHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCC
DGIHLGVSFDVRDLAAVEQGFEAIASEFGFIDVLVSGAAGNFPATAAKLSANGFKAVMDI
CEEEEEEEECHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHEEECCCCCEEEEEE
DLLGSFQVLKTAYPLLRRPQGNIIQISAPQASIAMPMQAHVCAAKAGVDMLTRTLAVEWG
EHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCC
CEGIRINSIIPGPIADTEGFNRLAPSAALQQQVAQSVPLKRNGEGQDIANAAMFLGSEYA
CCCEEECCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
SYITGVVLPVDGGWSLGGASIAMTALGELAIKAQQ
HHHCEEEEECCCCCCCCCHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MLNTTMFNYQGKNVVVVGGTSGINLAIANAFAQAGANVTVASRSQDKIDAAVLQLKQSNP
CCCCEEEEECCCEEEEEECCCCCEEHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCC
DGIHLGVSFDVRDLAAVEQGFEAIASEFGFIDVLVSGAAGNFPATAAKLSANGFKAVMDI
CEEEEEEEECHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHEEECCCCCEEEEEE
DLLGSFQVLKTAYPLLRRPQGNIIQISAPQASIAMPMQAHVCAAKAGVDMLTRTLAVEWG
EHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCC
CEGIRINSIIPGPIADTEGFNRLAPSAALQQQVAQSVPLKRNGEGQDIANAAMFLGSEYA
CCCEEECCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
SYITGVVLPVDGGWSLGGASIAMTALGELAIKAQQ
HHHCEEEEECCCCCCCCCHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]