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The map label for this gene is hisI [H]

Identifier: 117920292

GI number: 117920292

Start: 2189352

End: 2190011

Strand: Reverse

Name: hisI [H]

Synonym: Shewana3_1847

Alternate gene names: 117920292

Gene position: 2190011-2189352 (Counterclockwise)

Preceding gene: 117920293

Following gene: 117920291

Centisome position: 44.05

GC content: 49.39

Gene sequence:

>660_bases
ATGACAACTGGAACCACTTCAAGCTGTTGCCAAGGCCCTGCAAGCGCAGAACTGGTTAATAGCCTCGACTGGGAAAAACA
ACAGGGGCTTATCCCTGCAGTTATCCAAAATCATCTATCGGGCAAAGTGTTAATGCTCGGATTTATGGATAAAGCCGCGC
TGCAGCACACACTGGCAACCGGTGATGTGACGTTTTTTAGCCGCTCTAAGCAACGTTTATGGACCAAGGGTGAAACCTCG
GGCCATACCCTAAAATTGGTTGCCATCGATAAAGACTGTGATAACGACAGCCTGTTAGTGCAGGTATTGCCCAATGGCCC
AACCTGCCATAAAGGCACCGAAAGCTGCTGGCTCGATGGCAATGCTCACCCGTTTTTAAATAATCTGGCCGAGCTTATCG
CCTCGCGTAAGGGGCAAAACCCTGAGTCGAGCTACACCGCTTCCCTTTTTGCCCGTGGTACTAAGCGCATCGCCCAAAAA
GTCGGTGAAGAAGGATTAGAAACCGCCTTGGCCGCTGCGACTCACGATAAGGATGAGCTGATTAACGAGGCATCGGATCT
GGTGTATCACTTATTAGTCTTACTTGAAGATCAATCACTAAGCTTAAGTGATATCAACGCCAATTTGCTCGCCCGCCATC
AAAAGGCGCAGCAAAAGTAG

Upstream 100 bases:

>100_bases
ATATCGGCGAGTTAAAACAGTATTTAGCGGCCGAAGGCATCGCCATCCGCCAGTAACTCAACATCAGTAGCGATTGATAG
AAATAATAAGGTATACAGAT

Downstream 100 bases:

>100_bases
TCCGCTTTCAAACATCGCAGTACCACTCTGTCGCATTCCTTTGGGTCTGCGGCAGAGTACTCTCCATTTAGCCCCATTTA
CATGCTTTTTACGTGTCAAT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTTGTTSSCCQGPASAELVNSLDWEKQQGLIPAVIQNHLSGKVLMLGFMDKAALQHTLATGDVTFFSRSKQRLWTKGETS
GHTLKLVAIDKDCDNDSLLVQVLPNGPTCHKGTESCWLDGNAHPFLNNLAELIASRKGQNPESSYTASLFARGTKRIAQK
VGEEGLETALAAATHDKDELINEASDLVYHLLVLLEDQSLSLSDINANLLARHQKAQQK

Sequences:

>Translated_219_residues
MTTGTTSSCCQGPASAELVNSLDWEKQQGLIPAVIQNHLSGKVLMLGFMDKAALQHTLATGDVTFFSRSKQRLWTKGETS
GHTLKLVAIDKDCDNDSLLVQVLPNGPTCHKGTESCWLDGNAHPFLNNLAELIASRKGQNPESSYTASLFARGTKRIAQK
VGEEGLETALAAATHDKDELINEASDLVYHLLVLLEDQSLSLSDINANLLARHQKAQQK
>Mature_218_residues
TTGTTSSCCQGPASAELVNSLDWEKQQGLIPAVIQNHLSGKVLMLGFMDKAALQHTLATGDVTFFSRSKQRLWTKGETSG
HTLKLVAIDKDCDNDSLLVQVLPNGPTCHKGTESCWLDGNAHPFLNNLAELIASRKGQNPESSYTASLFARGTKRIAQKV
GEEGLETALAAATHDKDELINEASDLVYHLLVLLEDQSLSLSDINANLLARHQKAQQK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=64.1025641025641, Blast_Score=252, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6319819, Length=206, Percent_Identity=31.5533980582524, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23751; Mature: 23620

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGTTSSCCQGPASAELVNSLDWEKQQGLIPAVIQNHLSGKVLMLGFMDKAALQHTLAT
CCCCCCCHHHCCCCHHHHHHHCCCHHHCCCCHHHHHHCCCCCEEEEEHHHHHHHHHHHHC
GDVTFFSRSKQRLWTKGETSGHTLKLVAIDKDCDNDSLLVQVLPNGPTCHKGTESCWLDG
CCCHHHHCCHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCEEECC
NAHPFLNNLAELIASRKGQNPESSYTASLFARGTKRIAQKVGEEGLETALAAATHDKDEL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
INEASDLVYHLLVLLEDQSLSLSDINANLLARHQKAQQK
HHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TTGTTSSCCQGPASAELVNSLDWEKQQGLIPAVIQNHLSGKVLMLGFMDKAALQHTLAT
CCCCCCHHHCCCCHHHHHHHCCCHHHCCCCHHHHHHCCCCCEEEEEHHHHHHHHHHHHC
GDVTFFSRSKQRLWTKGETSGHTLKLVAIDKDCDNDSLLVQVLPNGPTCHKGTESCWLDG
CCCHHHHCCHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCEEECC
NAHPFLNNLAELIASRKGQNPESSYTASLFARGTKRIAQKVGEEGLETALAAATHDKDEL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
INEASDLVYHLLVLLEDQSLSLSDINANLLARHQKAQQK
HHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]