Click here to switch to the map view.

The map label for this gene is tyrP [H]

Identifier: 117920291

GI number: 117920291

Start: 2187474

End: 2188661

Strand: Reverse

Name: tyrP [H]

Synonym: Shewana3_1846

Alternate gene names: 117920291

Gene position: 2188661-2187474 (Counterclockwise)

Preceding gene: 117920292

Following gene: 117920290

Centisome position: 44.02

GC content: 51.94

Gene sequence:

>1188_bases
ATGACACAAAATAAATTTTTCGGCAGTTTGCTACTGATTGCAGGCACCACCATCGGCGCGGGCATGCTTGCACTTCCTAT
CGCCTCGGCAGGACTCGGTTTTGGTGTATCGAGCCTGATCATGTTGCTCCTCTGGGCGCTCATGGCCTACACCGCCCTGC
TGATGGTTGAAATCCATCAATTTGCCCCGAGCGATGCGAGTCTGAACCAATTAGCCCGCACGCTTTTGGGCGCCAAGGGC
CAAGTGATTGCCAGTATTGCACTGATGTTTTTACTCTACGCCCTGTGCGCCGCCTACATCGCAGGCGGCGGCGAGCAAGT
CAATCAAAAGCTCAATGCTTGGTTAGGGTTAGAACTGCCAACGCAGGCGGGCGCCATCTTCTTTACCCTGTTAATCGGCA
CCATAGTCGGCTTAGGCACCCATTGTGTCGATTTGATTAACCGCGTGCTCTTTAGTTTAAAAATCATTGCGTTGATCCTA
ATGCTGGCCCTATTACTGCCGCAGGTCGAAGGCACACATTTACTCGAGTTGCCACTAGAGCAAGGGCTTATCGTGTCAGC
TATTCCAGTGATTTTTACCTCCTTTGGATTTCATGGTTCGATTCCATCCGTGGTGCGCTACTTAGGCGTTGAGGTAAAAA
GCCTGCGTAAAATCATGCTGCTTGGCTCGGCGTTACCGCTACTGATTTACCTGCTGTGGCAACTGGGCAGCCAAGGCGTG
CTCAGCCAAAGCCAACTGATGACGAATCAGAGTCTTTCAGGCTTTATCAATCAGTTAGCCAGCGTTTTGCACAGCCAATA
CTTAAGTTCTGCCATCAGTGTGTTTGCCGATCTTGCACTGGCAACCTCCTTTTTAGGGGTGAGCCTAGGTCTGTTTGACT
TTATGGCGGCTAACTTAAGACAGCAGGATAATGCCGCGGGTCGCAGTATCACCGCCGCCATTACCTTCGTGCCACCTCTG
GGTTTTGCCCTCTTTTACCCGCAGGGATTTATTACCGCCCTCGGTTATGCGGCGATCGCCCTCGTGATCCTCGCGATTTT
TTTACCTGTGACCATGGTGTGGGTACAAAGACAAACGCGCGATAAGGCAAACCTACCTCAAGGTTACCGCGTCGCGGGGG
GGAAGCTTGGTTTATTGTTAGCTATGCTCTGCGGAGTGGCCGTGATTGGCGCTCAGCTCTTGGGATAA

Upstream 100 bases:

>100_bases
CCTTTAGATCCCAGTTTCACGCGCCACTCTGCACAGCTCCTCAATAAAGCACTCATCTAACACAGTTGAGCCATTAATAA
AGACGTTTGAGCGTAAAGTT

Downstream 100 bases:

>100_bases
GCTGCGCGGATAAACAATCGGGATAACGCTATTTTGCTTTAAGCCGTATAAGTGCCTGTAAAATCAAGATGAATAATGAC
AGACACTCAGTCTTGCTTCG

Product: aromatic amino acid transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTQNKFFGSLLLIAGTTIGAGMLALPIASAGLGFGVSSLIMLLLWALMAYTALLMVEIHQFAPSDASLNQLARTLLGAKG
QVIASIALMFLLYALCAAYIAGGGEQVNQKLNAWLGLELPTQAGAIFFTLLIGTIVGLGTHCVDLINRVLFSLKIIALIL
MLALLLPQVEGTHLLELPLEQGLIVSAIPVIFTSFGFHGSIPSVVRYLGVEVKSLRKIMLLGSALPLLIYLLWQLGSQGV
LSQSQLMTNQSLSGFINQLASVLHSQYLSSAISVFADLALATSFLGVSLGLFDFMAANLRQQDNAAGRSITAAITFVPPL
GFALFYPQGFITALGYAAIALVILAIFLPVTMVWVQRQTRDKANLPQGYRVAGGKLGLLLAMLCGVAVIGAQLLG

Sequences:

>Translated_395_residues
MTQNKFFGSLLLIAGTTIGAGMLALPIASAGLGFGVSSLIMLLLWALMAYTALLMVEIHQFAPSDASLNQLARTLLGAKG
QVIASIALMFLLYALCAAYIAGGGEQVNQKLNAWLGLELPTQAGAIFFTLLIGTIVGLGTHCVDLINRVLFSLKIIALIL
MLALLLPQVEGTHLLELPLEQGLIVSAIPVIFTSFGFHGSIPSVVRYLGVEVKSLRKIMLLGSALPLLIYLLWQLGSQGV
LSQSQLMTNQSLSGFINQLASVLHSQYLSSAISVFADLALATSFLGVSLGLFDFMAANLRQQDNAAGRSITAAITFVPPL
GFALFYPQGFITALGYAAIALVILAIFLPVTMVWVQRQTRDKANLPQGYRVAGGKLGLLLAMLCGVAVIGAQLLG
>Mature_394_residues
TQNKFFGSLLLIAGTTIGAGMLALPIASAGLGFGVSSLIMLLLWALMAYTALLMVEIHQFAPSDASLNQLARTLLGAKGQ
VIASIALMFLLYALCAAYIAGGGEQVNQKLNAWLGLELPTQAGAIFFTLLIGTIVGLGTHCVDLINRVLFSLKIIALILM
LALLLPQVEGTHLLELPLEQGLIVSAIPVIFTSFGFHGSIPSVVRYLGVEVKSLRKIMLLGSALPLLIYLLWQLGSQGVL
SQSQLMTNQSLSGFINQLASVLHSQYLSSAISVFADLALATSFLGVSLGLFDFMAANLRQQDNAAGRSITAAITFVPPLG
FALFYPQGFITALGYAAIALVILAIFLPVTMVWVQRQTRDKANLPQGYRVAGGKLGLLLAMLCGVAVIGAQLLG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=396, Percent_Identity=48.7373737373737, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1789552, Length=373, Percent_Identity=30.8310991957105, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1790145, Length=398, Percent_Identity=30.1507537688442, Blast_Score=175, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 41804; Mature: 41673

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNKFFGSLLLIAGTTIGAGMLALPIASAGLGFGVSSLIMLLLWALMAYTALLMVEIHQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FAPSDASLNQLARTLLGAKGQVIASIALMFLLYALCAAYIAGGGEQVNQKLNAWLGLELP
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
TQAGAIFFTLLIGTIVGLGTHCVDLINRVLFSLKIIALILMLALLLPQVEGTHLLELPLE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
QGLIVSAIPVIFTSFGFHGSIPSVVRYLGVEVKSLRKIMLLGSALPLLIYLLWQLGSQGV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSQSQLMTNQSLSGFINQLASVLHSQYLSSAISVFADLALATSFLGVSLGLFDFMAANLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQDNAAGRSITAAITFVPPLGFALFYPQGFITALGYAAIALVILAIFLPVTMVWVQRQTR
HHCCCCCCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKANLPQGYRVAGGKLGLLLAMLCGVAVIGAQLLG
HCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQNKFFGSLLLIAGTTIGAGMLALPIASAGLGFGVSSLIMLLLWALMAYTALLMVEIHQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FAPSDASLNQLARTLLGAKGQVIASIALMFLLYALCAAYIAGGGEQVNQKLNAWLGLELP
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
TQAGAIFFTLLIGTIVGLGTHCVDLINRVLFSLKIIALILMLALLLPQVEGTHLLELPLE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHH
QGLIVSAIPVIFTSFGFHGSIPSVVRYLGVEVKSLRKIMLLGSALPLLIYLLWQLGSQGV
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSQSQLMTNQSLSGFINQLASVLHSQYLSSAISVFADLALATSFLGVSLGLFDFMAANLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQDNAAGRSITAAITFVPPLGFALFYPQGFITALGYAAIALVILAIFLPVTMVWVQRQTR
HHCCCCCCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKANLPQGYRVAGGKLGLLLAMLCGVAVIGAQLLG
HCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]