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The map label for this gene is thrC [H]

Identifier: 117919590

GI number: 117919590

Start: 1346293

End: 1347576

Strand: Direct

Name: thrC [H]

Synonym: Shewana3_1141

Alternate gene names: 117919590

Gene position: 1346293-1347576 (Clockwise)

Preceding gene: 117919589

Following gene: 117919591

Centisome position: 27.08

GC content: 49.77

Gene sequence:

>1284_bases
ATGGAACTATATAATTTAAAACACCCTTCGCAGAAAGTGAGCTTTAAGGAAGCGGTGCAATTAGGACTCGGTAAAGACAG
AGGGCTGTTTTTTCCTACTCAAATCCCTGTGTTGCACGATATCGAGGCGCTGCTGGCGATGCCTTTTGTCGAGCGCAGTA
AAAAAGTACTCGGCGCTTGGCTTGCCTCAGAGCTTGGGCAAGACGCGGTAGATAAACTGGTCGAGCGTGCCTTTAATTTC
GATTTGCCCTTGGTGGCGGTCGATGAGCAGCGCTCGTGCCTCGAGCTTTTCCATGGGCCAACTTTAGCATTCAAGGATTT
TGGTGCGCGCTTTATGGCGCAATGCATCAATGCCTTTGCTCAAGACTCGCGCTTAACCATTCTAACCGCGACCTCGGGTG
ACACTGGGGCGGCGGTGGCCGATGCCTTTTACGGCCTAGATAAAGTCAATGTCGTCGTGCTCTATCCTAAGGGCAAAATC
AGTGAGCTACAGGAAAAGATGTTCACCACCTTAGGTAAGAACATTCACACTGTGGCAGTAGCGTCCGATTTCGATGCTTG
CCAGCACTTAGTCAAACAGGCTTTTGAAGATAGCGATGTGCGTGATGGCTTGCATTTAAACTCGGCCAACTCAATCAATA
TCAGTCGTTTGCTGGCACAGATTTGTTATTACTTCGAAGCGGTCGCCCAATCGAAACAGCGCCATGAGGCCGATCCTGTG
ATTGCTGTGCCCAGTGGTAATTTTGGTAATCTCACCGCGGGCTTGTTTGCCAAAGCCATGGGCTTACCTGTTAAACGTTT
TATTGCCGCGACCAACGCCAATGACACTGTCCCACGTTATTTAGAGAGTGGTGATTGGCAGCCTAATCCTACTCAAGCGA
CTATGTCCAATGCGATGGATGTGAGCGAGCCAAGTAACTGGCCGCGCGTCGAGGCAATTTGCGAGAAACTCGGTTGGCCA
TTGGCGGACCTAGTGGGGATTCGTTTATCAGAGGCGCAAACCTCGGAGGCGCTGGCGGAGTTACATGCAAAAGGTTATGT
GTCCGAACCCCATGCAGCGATTGCTGCCAGAGCCTTAACGCTTAACTTAGTGCCTGATGAAGTGGGGATATTTTTAGGTA
CAGCACATCCTGCCAAGTTTAAGGACGTCGTAGATAGAGAGCTTAACCTCGATTTACCTCTGCCTGCAGAACTTAAAGCG
GTGGAGCATAAACCCATACTCTCGGCTGAATTAGCCGCCGATTTTGCTCAGTTAAAGTCACATTTATTTGCGGTGTTAAG
CTGA

Upstream 100 bases:

>100_bases
GCCTCGATGAGCAAGGTACGCGCCGAGTCGATTAATTTTCTTACTTTTAAAAGCATTAAGCCCAAGCCTAACGGCTTGGC
ACTGATAAGGTCGAGTGAGC

Downstream 100 bases:

>100_bases
GGTGGCGAATCGCCATTAAACCATTGGTAAAAGGGAGTCGATTGACTCCCTTTTTTACAAGTGTAAATGAGGCTCGAGAG
AATTAATCAAAGCTTATCAT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAWLASELGQDAVDKLVERAFNF
DLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFAQDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMDVSEPSNWPRVEAICEKLGWP
LADLVGIRLSEAQTSEALAELHAKGYVSEPHAAIAARALTLNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKA
VEHKPILSAELAADFAQLKSHLFAVLS

Sequences:

>Translated_427_residues
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAWLASELGQDAVDKLVERAFNF
DLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFAQDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMDVSEPSNWPRVEAICEKLGWP
LADLVGIRLSEAQTSEALAELHAKGYVSEPHAAIAARALTLNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKA
VEHKPILSAELAADFAQLKSHLFAVLS
>Mature_427_residues
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAWLASELGQDAVDKLVERAFNF
DLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFAQDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKI
SELQEKMFTTLGKNIHTVAVASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMDVSEPSNWPRVEAICEKLGWP
LADLVGIRLSEAQTSEALAELHAKGYVSEPHAAIAARALTLNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKA
VEHKPILSAELAADFAQLKSHLFAVLS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=451, Percent_Identity=31.9290465631929, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI149193323, Length=439, Percent_Identity=30.751708428246, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1786185, Length=421, Percent_Identity=59.144893111639, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319901, Length=456, Percent_Identity=33.3333333333333, Blast_Score=210, Evalue=3e-55,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46548; Mature: 46548

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAW
CCCCCCCCCCHHCCHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LASELGQDAVDKLVERAFNFDLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFA
HHHHHCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKISELQEKMFTTLGKNIHTVAV
CCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
ECCHHHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMD
EEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHCCC
VSEPSNWPRVEAICEKLGWPLADLVGIRLSEAQTSEALAELHAKGYVSEPHAAIAARALT
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKAVEHKPILSAELAADFAQLKS
EEECCCHHCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
HLFAVLS
HHHHHCC
>Mature Secondary Structure
MELYNLKHPSQKVSFKEAVQLGLGKDRGLFFPTQIPVLHDIEALLAMPFVERSKKVLGAW
CCCCCCCCCCHHCCHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LASELGQDAVDKLVERAFNFDLPLVAVDEQRSCLELFHGPTLAFKDFGARFMAQCINAFA
HHHHHCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QDSRLTILTATSGDTGAAVADAFYGLDKVNVVVLYPKGKISELQEKMFTTLGKNIHTVAV
CCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ASDFDACQHLVKQAFEDSDVRDGLHLNSANSINISRLLAQICYYFEAVAQSKQRHEADPV
ECCHHHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
IAVPSGNFGNLTAGLFAKAMGLPVKRFIAATNANDTVPRYLESGDWQPNPTQATMSNAMD
EEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHCCC
VSEPSNWPRVEAICEKLGWPLADLVGIRLSEAQTSEALAELHAKGYVSEPHAAIAARALT
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHE
LNLVPDEVGIFLGTAHPAKFKDVVDRELNLDLPLPAELKAVEHKPILSAELAADFAQLKS
EEECCCHHCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
HLFAVLS
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]